Michigan Medicine is one of the nation's leading academic medical centers, with three hospitals, one of the 10 largest biomedical research budgets, and national-level strength in a broad range of specialties. It includes the University Hospital, C.S. Mott Children's Hospital, Von Voigtlander Women's Hospital, the U-M Medical School and the group practice for medical faculty, and specialty centers in cancer, cardiovascular disease, depression, diabetes, eye conditions, geriatrics, health policy, neurosciences and organ transplant. Michigan Medicine is part of the University of Michigan, and has a close affiliation with the VA Ann Arbor Healthcare System.

The clinical portion of Michigan Medicine, called U-M Health, includes the hospitals and ambulatory health centers centered around Ann Arbor, Micihgan, and a statewide network of care including UM Health-Sparrow in the Lansing area and UM Health-West in the Grand Rapids area.