Curated News: The Lancet

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Newswise: Raising awareness of Long Covid ‘blue legs’ symptom
Released: 14-Aug-2023 1:20 PM EDT
Raising awareness of Long Covid ‘blue legs’ symptom
University of Leeds

An unusual case of a Long Covid patient’s legs turning blue after 10 minutes of standing highlights the need for greater awareness of this symptom among people with the condition, according to new research published in the Lancet.

10-Aug-2023 12:10 PM EDT
"The Israeli Override Clause: Threatening the Health in All Policies Approach"
George Washington University

On July 24, 2023, Israel's Parliament sanctioned a substantial amendment to the Basic Law, prompting apprehensions regarding power equilibrium and its potential influence on public well-being. In response, a coalition of prominent Israeli and global public health experts has united to dissect the profound ramifications of this revision.

Released: 19-Jul-2023 12:00 PM EDT
MD Anderson Research Highlights for July 19, 2023
University of Texas MD Anderson Cancer Center

The University of Texas MD Anderson Cancer Center’s Research Highlights showcases the latest breakthroughs in cancer care, research and prevention. These advances are made possible through seamless collaboration between MD Anderson’s world-leading clinicians and scientists, bringing discoveries from the lab to the clinic and back.

Released: 13-Jul-2023 5:30 PM EDT
New talking therapy for depression could be more effective and cheaper than CBT
University of Exeter

A new talking therapy for depression has shown encouraging early signs of being more effective and cheaper to deliver than the current best practice of Cognitive Behavioural Therapy (CBT).

Released: 12-Jul-2023 1:15 PM EDT
Research uncovers why people who have Down’s Syndrome age prematurely
Queen Mary University of London

The molecular processes responsible for natural ageing of cells are poorly understood. Studying conditions in humans where ageing is accelerated due to genetic causes presents opportunities to learn about the mechanisms that control ageing and devise strategies to slow down the ageing process.

Newswise: Significant variations in hip fracture health costs and care between NHS hospitals and regions, study finds
10-Jul-2023 8:25 AM EDT
Significant variations in hip fracture health costs and care between NHS hospitals and regions, study finds
University of Bristol

There are significant variations in healthcare spending and care delivery across NHS hospitals in England and Wales following hip fracture, a new University of Bristol-led study aimed at understanding how hospital care impacts patients’ outcomes and costs has revealed.

Newswise: Pediatric Early Warning Systems save lives in Latin American hospitals
Released: 10-Jul-2023 8:15 AM EDT
Pediatric Early Warning Systems save lives in Latin American hospitals
St. Jude Children's Research Hospital

Scientists at St. Jude Children’s Research Hospital and colleagues in Latin America found that early identification of clinical deterioration saves lives, especially in hospitals with the greatest need.

Released: 6-Jul-2023 11:15 AM EDT
Wastewater monitoring could act as pandemic early warning system
Murdoch Childrens Research Institute

Wastewater monitoring could act as an early warning system to help countries better prepare for future pandemics, according to a new study.

5-Jul-2023 8:50 AM EDT
Lack of sleep lessens cognitive benefits of physical activity
University College London

Regular physical activity may protect against cognitive decline as we get older, but this protective effect may be diminished for people who are not getting enough sleep, according to a new study by UCL researchers.

15-Jun-2023 2:20 PM EDT
Patients with refractory metastatic colorectal cancer experience survival benefits with fruquintinib
University of Texas MD Anderson Cancer Center

Researchers from The University of Texas MD Anderson Cancer Center reported study results showing that the targeted therapy fruquintinib significantly improved overall survival (OS) and progression-free survival (PFS) in patients with refractory metastatic colorectal cancer. Findings from the global FRESCO-2 trial, published today in The Lancet, were first presented at the European Society for Medical Oncology (ESMO) Congress 2022.

Released: 9-Jun-2023 3:25 PM EDT
Study shows metformin lowers the risk of getting long COVID
University of Minnesota Medical School

In a new study published in The Lancet Infectious Diseases, University of Minnesota researchers found that metformin, a drug commonly used to treat diabetes, prevents the development of long COVID.

1-Jun-2023 3:20 PM EDT
Children With Drug-Resistant Epilepsy Live Longer After Cranial Surgery
Ann and Robert H. Lurie Children's Hospital of Chicago

Survival rate beyond 10 years in children with drug-resistant epilepsy (DRE) was highest after cranial epilepsy surgery and lowest when treated only with antiseizure medications, according to a study published in The Lancet Child and Adolescent Health. This large, retrospective study was the first to compare long-term survival in children with DRE among cohorts treated with medications only, vagus nerve stimulation plus medications, and cranial epilepsy surgery plus medications. Results show that risk of early death was reduced by over 80 percent after surgery and by 40 percent after vagus nerve stimulation, compared to medication-only treatment.

Newswise: ASCO: Targeted therapy induces responses in HER2-amplified biliary tract cancer
31-May-2023 3:20 PM EDT
ASCO: Targeted therapy induces responses in HER2-amplified biliary tract cancer
University of Texas MD Anderson Cancer Center

An MD Anderson-led Phase II trial showed the HER2-targeted therapy zanidatamab demonstrated durable responses in patients with advanced HER2-positive biliary tract cancer. The data were presented at the 2023 ASCO Annual Meeting.

Released: 15-May-2023 1:00 PM EDT
Clinically relevant deficiency of the “bonding hormone” oxytocin demonstrated
University of Basel

The hormone oxytocin is important for social interaction and to control emotions. A deficiency of this hormone has previously been assumed in various diseases such as autism, but has never been proven.

Released: 12-May-2023 4:25 PM EDT
Cervical cancer screening doubles when under-screened women are mailed testing kits
UNC Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill

Researchers at the UNC Gillings School of Global Public Health and UNC Lineberger Comprehensive Cancer Center found mailing human papillomavirus (HPV) self-collection tests and offering assistance to book in-clinic screening appointments to under-screened, low-income women improved cervical cancer screening nearly two-fold compared to scheduling assistance alone.

Newswise: New Study Shows Trastuzumab Deruxtecan Improves Survival for Patients with HER2-positive Metastatic Breast Cancer
Released: 3-May-2023 12:00 PM EDT
New Study Shows Trastuzumab Deruxtecan Improves Survival for Patients with HER2-positive Metastatic Breast Cancer
Yale Cancer Center/Smilow Cancer Hospital

A new phase III study has demonstrated the efficacy of trastuzumab deruxtecan (Enhertu) in patients with HER2-positive metastatic breast cancer whose cancers were resistant to previous treatment with trastuzumab emtansine. Both trastuzumab deruxtecan and trastuzumab emtansine are antibody-drug conjugates, a relatively new type of drug that delivers chemotherapy directly to the cancer cell, minimizing damage to normal tissues.

Released: 21-Apr-2023 7:05 PM EDT
Surgery most effective treatment of metabolic liver disease
King's College London

Metabolic (bariatric) surgery is more effective than medications and lifestyle interventions for the treatment of advanced non-alcoholic fatty liver disease.

Released: 19-Apr-2023 3:25 PM EDT
Minimum unit pricing for alcohol associated with a 13% decrease in deaths from alcohol consumption in Scotland, study suggests
The Lancet

The implementation of minimum unit pricing (MUP) legislation is associated with significant reductions in alcohol-specific deaths among those from the most socio-economically deprived areas in Scotland, suggests a new study published in The Lancet.

Released: 14-Apr-2023 2:40 PM EDT
Hearing aids may protect against a higher risk of dementia associated with hearing loss, study suggests

People experiencing hearing loss who are not using a hearing aid may have a higher risk of dementia than people without hearing loss, suggests a new study published in The Lancet Public Health journal. However, using a hearing aid may reduce this risk to the same level as people without hearing loss.

Released: 13-Apr-2023 5:10 PM EDT
Study: Misfolded alpha-synuclein protein key to early detection of Parkinson’s disease
University of Texas Health Science Center at Houston

The presence of a misfolded alpha-synuclein protein can be used to determine if people have Parkinson’s disease, according to a new study using technology developed by a researcher at UTHealth Houston. This biomarker could pave the way for the development of better diagnostic tools and new treatment options for the disease.

Released: 11-Apr-2023 3:20 PM EDT
Longer shelf life for insulin has major bearing on global health
University of Gothenburg

An international study shows that it is likely that insulin can be stored at room temperature, and for considerably longer than drug companies have counted on to date. Access to this vital medicine can thereby be significantly improved for the world’s poorest inhabitants. Researchers at the University of Gothenburg are among the scientists presenting these results.

Newswise: Healthy lifestyle associated with reduced mortality risk in childhood cancer survivors
5-Apr-2023 2:10 PM EDT
Healthy lifestyle associated with reduced mortality risk in childhood cancer survivors
St. Jude Children's Research Hospital

St. Jude Children’s Research Hospital researchers found childhood cancer survivors have higher mortality than the public, but survivors with a healthy lifestyle and fewer heart disease risk factors had lower risk.

31-Mar-2023 4:05 PM EDT
Combination therapy a promising option for advanced kidney cancer patients already treated with immunotherapy
Dana-Farber Cancer Institute

In this study led by Dana-Farber Cancer Institute, interim results of the combination of cabozantinib, a VEGF TKI, plus belzutifan, a HIF-2α inhibitor, show promising anti-tumor activity in this pre-treated patient group. The results suggest that the combination might fill and unmet need and provides a rationale for further study of combining a VEGF TKI and a HIF-2 inhibitor.

Newswise: image.jpg
Released: 24-Mar-2023 1:30 PM EDT
THE LANCET: Health experts call for bold action to prioritize health over profit

A new Series published in The Lancet describes how, although commercial entities can contribute positively to health and society, the products and practices of some commercial actors are responsible for escalating rates of avoidable ill health, planetary damage, and social and health inequity.

21-Mar-2023 12:05 PM EDT
CHOP Researchers Develop First-Of-Its-Kind Prediction Model for Newborn Seizures
Children's Hospital of Philadelphia

Researchers have developed a prediction model that determines which newborn babies are likely to experience seizures in the Neonatal Intensive Care Unit (NICU). This model could be incorporated into routine care to help the clinical team decide which babies will need electroencephalograms (EEGs) and which babies can be safely managed in the Neonatal Care Unit without monitoring through EEGs. This would allow families and providers to care for babies without intrusive and unnecessary procedures.

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Released: 21-Mar-2023 2:05 PM EDT
Defunding prevention and climate change drive rebound of malaria in Peru
Duke University

Malaria control programs in Amazonian Peru helped reduce the incidence of the deadly parasitic disease by 78 percent. That is, until the programs ceased to operate.

Released: 20-Mar-2023 3:45 PM EDT
Stigma-coping intervention empowers people with HIV and drug use to engage in health, substance use care
Boston University School of Medicine

A new study from Boston University Chobanian & Avedisian School of Medicine has found that a brief stigma intervention that specifically targets people with HIV who inject drugs was effective in increasing engagement in substance use care as well as improving their ART adherence.

Released: 16-Mar-2023 7:10 PM EDT
Paxlovid associated with lower risk of hospital admission
Kaiser Permanente

A Kaiser Permanente study confirms the benefit of nirmatrelvir-ritonavir, also known as Paxlovid, as an early-stage treatment to prevent hospitalization for people with mild to moderate COVID-19, regardless of prior immunity or age. The study was published March 15, 2023, in Lancet ID.

Released: 14-Mar-2023 6:45 PM EDT
COVID-19 pandemic has long-lasting effects on adolescent mental health and substance use
Columbia University, Mailman School of Public Health

The COVID-19 pandemic has had a long-lasting impact on adolescent mental health and substance use according to a new population-based study are based on survey responses from a nationwide sample of over 64,000 13–18-year-old North American and Icelandic adolescents assessed prior to and up to two years into the pandemic.

Released: 10-Mar-2023 3:45 PM EST
Emergency department visits for attempted suicides rose globally among youth during pandemic
University of Calgary

Even though pediatric emergency department visits decreased greatly overall during the COVID-19 pandemic, a newly published study led out of the University of Calgary shows there was also a sharp increase in emergency department visits for attempted suicide and suicide ideation among children and adolescents in that same period of social isolation.

6-Mar-2023 5:25 PM EST
Increased hospitalizations for heart attacks, heart failure seen in older adults living near fracking sites
University of Chicago Medical Center

Research shows connection between hospitalization rates for cardiovascular disease and proximity to fracking, providing evidence that exposure to airborne pollutants from unconventional natural gas development may impact human health

Newswise: Incidence Rates of Diabetes Continue to Increase in Children, Young Adults
Released: 6-Mar-2023 3:25 PM EST
Incidence Rates of Diabetes Continue to Increase in Children, Young Adults
Wake Forest University School of Medicine

New findings from researchers at Wake Forest University School of Medicine confirm that the rates of Type 1 and Type 2 diabetes continue to increase in children and young adults. Non-Hispanic Black and Hispanic children and young adults also had higher incidence rates of diabetes.

Released: 6-Mar-2023 2:55 PM EST
Electronic Messages Improved Influenza Vaccination Rates in Nationwide Danish Study
Brigham and Women’s Hospital

To evaluate best strategies for increasing vaccination rates, researchers from Brigham and Women’s Hospital, a founding member of the Mass General Brigham healthcare system, collaborated with Danish researchers to develop and implement a nationwide trial in Denmark testing nine different electronic messaging tactics among adults over age 65.

Released: 6-Mar-2023 12:35 PM EST
Exposure to green space linked to reduced risk of postpartum depression
University of California, Irvine

In an analysis of more than 415,00 electronic health records of healthy, full-term births in Southern California, a team of researchers led by the University of California, Irvine determined that exposure to green space and tree coverage was associated with a decreased risk of postpartum depression among mothers.

Released: 3-Mar-2023 6:05 PM EST
Health policy experts call for confronting anti-vaccine activism with life-saving counter narratives
Boston University School of Public Health

Public and private sector health officials and public policymakers should team up immediately with community leaders to more effectively disseminate accurate narratives regarding the life-saving benefits of vaccines to counter widespread, harmful misinformation from anti-vaccine activists in the United States.

Released: 24-Feb-2023 2:55 PM EST
First-of-its-Kind Study Examines the Impact of Cannabis Use on Surgical Patients' Post-Procedure Healthcare Needs
Beth Israel Deaconess Medical Center

In patients who underwent non-cardiac surgery in Boston between 2008 and 2020, those with a diagnosed cannabis use disorder more often required advanced postprocedural healthcare compared to non-users. However, patients whose use of cannabis was not classified as a disorder had lower odds of requiring advanced healthcare after surgery compared to patients who never use cannabis.

Released: 23-Feb-2023 2:55 PM EST
Phase 3 Trial Finds Oral Empagliflozin Provided Safe Glycemic Control in Children with Type 2 Diabetes
Joslin Diabetes Center

Researchers recently completed a phase 3 clinical trial that assessed the efficacy and safety of two different classes of oral agents for the treatment of type 2 diabetes in young people aged 10-17 years.

Released: 21-Feb-2023 8:00 PM EST
Air pollution speeds bone loss from osteoporosis: Large study
Columbia University, Mailman School of Public Health

Elevated levels of air pollutants are associated with bone damage among postmenopausal women, according to new research led by scientists at Columbia University Mailman School of Public Health. The effects were most evident on the lumbar spine, with nitrous oxides twice as damaging to the area than seen with normal aging.

Newswise: Researchers Uncover Mechanisms of Brexanolone and the Role of Inflammation in Post-partum Depression
Released: 20-Feb-2023 2:45 PM EST
Researchers Uncover Mechanisms of Brexanolone and the Role of Inflammation in Post-partum Depression
University of North Carolina Health Care System

Brexanolone, an IV infusion comprised of a derivative of progesterone, was approved by the U.S. Food and Drug Administration for the treatment of PPD in 2019. The fast-acting medication significantly reduces depression symptoms and provides effects for up to 90 days. However, exactly how the drug provides these therapeutic effects has remained a mystery – until now.

Released: 17-Feb-2023 8:05 AM EST
Three doses of COVID-19 mRNA vaccine associated with better outcomes for patients with cancer
Dana-Farber Cancer Institute

This study shows vaccination against COVID-19 is an essential strategy to improve outcomes in this high-risk population. The results support guidelines that patients with cancer should receive at least 3 COVID-19 vaccine doses.

Newswise: HIV Treatment and Prevention in Zambian Prisons May be Model for Prisons Worldwide
Released: 15-Feb-2023 1:15 PM EST
HIV Treatment and Prevention in Zambian Prisons May be Model for Prisons Worldwide
Institute of Human Virology at the University of Maryland School of Medicine

A recent study performed in Zambia by University of Maryland School of Medicine’s (UMSOM) Institute of Human Virology researchers found that high uptake of HIV preventative medicine, known as pre-exposure prophylaxis (PrEP), is possible in prison populations with adequate resources and support from the criminal justice health system.

Newswise: Survivors of Utah’s Eugenic Sterilization Program Still Alive in 2023
7-Feb-2023 11:00 AM EST
Survivors of Utah’s Eugenic Sterilization Program Still Alive in 2023
University of Utah

At least 830 men, women and children were coercively sterilized in Utah, approximately 54 of whom may still be alive. They were victims of a sterilization program that lasted for fifty years in the state and targeted people confined to state institutions. Many were teenagers or younger when operated upon; at least one child was under the age of ten.

Released: 10-Feb-2023 3:10 PM EST
Why South African moms buy commercial milk formula when breast is best
University of the Witwatersrand, Johannesburg

This is amongst the findings of the 2023 Lancet Series on Breastfeeding, which comprises three papers launched in South Africa on 10 February and in the UK on 8 February.

3-Feb-2023 8:05 AM EST
Study Finds Adverse Impact of Climate on Mental Health in Bangladesh
Georgetown University Medical Center

Extreme heat and humidity and other climate-related events have an alarming impact on mental health outcomes in terms of depression and anxiety in Bangladesh, the world’s seventh most vulnerable country to climate change.

Released: 6-Feb-2023 6:05 PM EST
Matching medication to DNA leads to 30% fewer side effects
University of Liverpool

According to an international group of researchers including a team from the University of Liverpool, patients experience 30% fewer side effects when medication doses are tailored to their DNA.

Newswise: Over 4% of summer mortality in European cities is attributable to urban heat islands
Released: 1-Feb-2023 1:05 PM EST
Over 4% of summer mortality in European cities is attributable to urban heat islands
Barcelona Institute for Global Health, ISGlobal

Over four percent of deaths in cities during the summer months are due to urban heat islands, and one third of these deaths could be prevented by reaching a tree cover of 30%, according to a modelling study published in The Lancet and led by the Barcelona Institute for Global Health (ISGlobal), an institution supported by “la Caixa” Foundation.

27-Jan-2023 2:55 PM EST
Targeted therapy momelotinib provides significant symptom and anemia improvements in patients with myelofibrosis
University of Texas MD Anderson Cancer Center

Patients with myelofibrosis had clinically significant improvement in disease-related symptoms, including anemia and spleen enlargement, when treated with the targeted therapy momelotinib, according to results from the international Phase III MOMENTUM trial led by researchers at The University of Texas MD Anderson Cancer Center.

Newswise: Vaccines protected pregnant women during Omicron surge
Released: 27-Jan-2023 3:35 PM EST
Vaccines protected pregnant women during Omicron surge
University of Washington School of Medicine and UW Medicine

The main point of the study, which was completed before other variants came on the scene, is for pregnant women to get vaccinated and receive all their boosters, including the bivalent booster.

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