UCLA scientists have discovered a new genetic risk factor for Alzheimer's disease by screening people's DNA and then using an advanced type of scan to visualize their brains' connections.
Researchers at the University of Michigan have found a new potential benefit of a molecule in green tea: preventing the misfolding of specific proteins in the brain.
Researchers have identified a possible treatment window of several years for plaques in the brain that are thought to cause memory loss in diseases such as Alzheimer’s. The Mayo Clinic study is published in the Feb. 27 online issue of Neurology, the medical journal of the American Academy of Neurology.
A novel way to image the brain’s glymphatic pathway may provide the basis for a new strategy to evaluate Alzheimer's disease susceptibility, according to a research paper published in The Journal of Clinical Investigation.
New findings by Columbia researchers suggest that along with amyloid deposits, white matter hyperintensities (WMHs) may be a second necessary factor for the development of Alzheimer’s disease.
Scientists are getting serious about tackling Alzheimer's disease with multiple drugs. Going after one target at a time has not proven successful, and some researchers believe that new drugs may not work well alone. Instead, they want to develop combination therapies. It worked for AIDS and cancer—why not Alzheimer’s?
At the 7th Human Amyloid Imaging conference held in Miami, Florida, 250 experts discussed the hottest topics in Alzheimer’s brain imaging. What’s in store for 2013? Read about new compounds that image tau—one of the disease’s toxic proteins, ground rules for scanning patients for plaques, and a plan to unify scan measures.
The number of people with Alzheimer’s disease is expected to triple in the next 40 years, according to a new study published in the February 6, 2013, online issue of Neurology®, the medical journal of the American Academy of Neurology.
The number of people with Alzheimer’s disease is expected to triple in the next 40 years, according to a new study by researchers from Rush University Medical Center published in the February 6, 2013, online issue of Neurology, the medical journal of the American Academy of Neurology.
A team of academic researchers has pinpointed how vitamin D3 and omega-3 fatty acids may enhance the immune system's ability to clear the brain of amyloid plaques, one of the hallmarks of Alzheimer's disease. In a small pilot study, the scientists identified key genes and signaling networks regulated by vitamin D3 and the omega-3 fatty acid DHA (docosahexaenoic acid) that may help control inflammation and improve plaque clearance.
A group of recipients of cadaver-derived human growth hormone (c-hGH) does not appear to be at increased risk for Alzheimer and Parkinson disease despite their likely exposure to neurodegenerative disease (ND)-associated proteins and elevated risk of infectious prion protein-related disease, according to a report published Online First by JAMA Neurology, a JAMA Network publication.
A research team in Israel has devised a novel approach to identifying the molecular basis for designing a drug that might one day decrease the risk diabetes patients face of developing Alzheimer's disease. The team will present its work at the 57th Annual Meeting of the Biophysical Society (BPS), held Feb. 2-6, 2013, in Philadelphia, Pa.
New evidence shows the root of heart failure lies in misfolded proteins in the heart’s cells, according to University of North Carolina School of Medicine researchers. The finding may pave the way for dramatically new treatment approaches.
In experiments on rats outfitted with tiny goggles, scientists say they have learned that the brain’s initial vision processing center not only relays visual stimuli, but also can “learn” time intervals and create specifically timed expectations of future rewards. The research sheds new light on learning and memory-making, the investigators say, and could help explain why people with Alzheimer’s disease have trouble remembering recent events.
For decades now, researchers have been trying, without success, to develop drugs that slow or prevent Alzheimer’s. Now research at UCLA suggests that while the protein they have been focusing on-- amyloid-beta—is the right one, what’s needed is to direct a drug to a very specific location, which they’ve discovered, on that protein.
During a five-hour surgery last October at The Ohio State University Wexner Medical Center, Kathy Sanford became the first Alzheimer’s patient in the United States to have a pacemaker implanted in her brain. She is the first of up to 10 patients who will be enrolled in an FDA-approved study at Ohio State’s Wexner Medical Center.
For the first time, UCLA researchers have used a brain-imaging tool to identify the abnormal tau proteins associated with sports concussion in five retired National Football League players who are still living. Previously, confirmation of the presence of this protein could only be established by an autopsy. Follow-up studies will help determine the impact and usefulness of identifying these proteins early.
By using synthetic fibrils made from pure recombinant protein, Penn researchers provide the first direct and compelling evidence that tau fibrils alone are entirely sufficient to recruit and convert soluble tau within cells into pathological clumps in neurons, followed by transmission of tau pathology to other inter-connected brain regions from a single injection site in an animal model of tau brain disease.
Electrodes implanted inside the brain are helping patients with Parkinson's disease. Called deep brain stimulation, the treatment often gives patients control over their movements that cannot be achieved with currently approved drugs. But the surgery is delicate and the treatment does not work for everyone. Alzforum explores the procedure and its potential use for Alzheimer's disease.
University of Utah Team creates startup company and secures $125,000 grant to provide personalized Alzheimer's care and address caregiver education shortage via mobile devices.
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