Curated News: Cell (journal)

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Released: 17-Jun-2021 10:45 AM EDT
Immune system protein may defend against deadly intestinal disease in babies
Washington University in St. Louis

A study led by researchers at Washington University School of Medicine in St. Louis has identified a protein in the immune system that may protect babies from necrotizing enterocolitis, a leading cause of death among premature infants.

15-Jun-2021 2:05 PM EDT
New Cleveland Clinic Research Identifies Link Between Gut Microbes and Stroke
Cleveland Clinic

New findings from Cleveland Clinic researchers show for the first time that the gut microbiome impacts stroke severity and functional impairment following stroke. The results, published in Cell Host & Microbe, lay the groundwork for potential new interventions to help treat or prevent stroke. The research was led by Weifei Zhu, Ph.D., and Stanley Hazen, M.D., Ph.D., of Cleveland Clinic’s Lerner Research Institute.

Released: 15-Jun-2021 2:40 PM EDT
Obesity and hypertension: Researchers discover novel mechanisms
Helmholtz Zentrum Muenchen - German Research Center for Environmental Health

Hypertension is a widespread comorbidity of patients with obesity that greatly increases the risk of mortality and disability.

14-Jun-2021 5:20 PM EDT
What makes us sneeze?
Washington University in St. Louis

What exactly triggers a sneeze? A team led by researchers at Washington University School of Medicine in St. Louis has identified, in mice, specific cells and proteins that control the sneeze reflex. Better understanding of what causes us to sneeze — specifically how neurons behave in response to allergens and viruses — may point to treatments capable of slowing the spread of infectious respiratory diseases.

10-Jun-2021 11:05 AM EDT
Ludwig Cancer Research Study Shows How Certain Macrophages Dampen Anti-Tumor Immunity
Ludwig Cancer Research

A Ludwig Cancer Research study adds to growing evidence that immune cells known as macrophages inhabiting the body cavities that house our vital organs can aid tumor growth by distracting the immune system’s cancer-killing CD8+ T cells. Reported in the current issue of Cancer Cell and led by Ludwig investigators Taha Merghoub and Jedd Wolchok at Memorial Sloan Kettering (MSK) and Charles Rudin of MSK, the study shows that cavity-resident macrophages express high levels of Tim-4, a receptor for phosphatidylserine (PS), a molecule that they surprisingly found on the surface of highly activated, cytotoxic and proliferative CD8+ T-cells.

9-Jun-2021 12:55 PM EDT
Could Neutrophils be the Secret to Cancer’s Achilles’ Heel?
University of Chicago Medical Center

A study published in the June 10, 2021 issue of Cell describes a remarkable new mechanism by which the body’s own immune system can eliminate cancer cells without damaging host cells. The findings have the potential to develop first-in-class medicines that are designed to be selective for cancer cells and non-toxic to normal cells and tissues.

Released: 3-Jun-2021 6:05 PM EDT
Single gene boosts climate resilience, yield and carbon capture in crops
Oak Ridge National Laboratory

Scientists at Oak Ridge National Laboratory have discovered a single gene that simultaneously boosts plant growth and tolerance for stresses such as drought and salt, all while tackling the root cause of climate change by enabling plants to pull more carbon dioxide from the atmosphere.

Released: 1-Jun-2021 1:20 PM EDT
Diet Plays Critical Role in NASH Progressing to Liver Cancer in Mouse Model
UC San Diego Health

Researchers at University of California San Diego School of Medicine found in a mouse model that when fed a Western diet rich in calories, fat and cholesterol, the mice progressively became obese, diabetic and developed NASH, which progressed to HCC, chronic kidney and cardiovascular disease.

25-May-2021 2:50 PM EDT
Global Study Finds Each City Has Unique Microbiome Fingerprint of Bacteria and Viruses
University of Maryland Medical Center

Each city has its own unique microbiome, a "fingerprint" of viruses and bacteria that uniquely identify it, according to a new study from an international consortium of researchers that included a team from the University of Maryland School of Medicine (UMSOM). The international project, which sequenced and analyzed samples collected from public transit systems and hospitals in 60 cities around the world, was published today in the journal Cell.

   
Released: 26-May-2021 3:55 PM EDT
Study shows SARS-CoV-2 variants unlikely to affect T cell responses
Hong Kong University of Science and Technology

In a new study, scientists at The Hong Kong University of Science and Technology (HKUST) have revealed that most T cell epitopes known to be targeted upon natural infection are seemingly unaffected by current SARS-CoV-2 variants.

Released: 26-May-2021 3:10 PM EDT
NIH scientists find that salmonella use intestinal epithelial cells to colonize the gut
NIH, National Institute of Allergy and Infectious Diseases (NIAID)

The immune system's attempt to eliminate Salmonella bacteria from the gastrointestinal (GI) tract instead facilitates colonization of the intestinal tract and fecal shedding, according to National Institutes of Health scientists.

Released: 21-May-2021 12:55 PM EDT
How Human Cells And Pathogenic Shigella Engage in Battle
UT Southwestern Medical Center

DALLAS – May 21, 2021 – One member of a large protein family that is known to stop the spread of bacterial infections by prompting infected human cells to self-destruct appears to kill the infectious bacteria instead, a new study led by UT Southwestern scientists shows. However, some bacteria have their own mechanism to thwart this attack, nullifying the deadly protein by tagging it for destruction.

17-May-2021 3:35 PM EDT
Western diet may increase risk of gut inflammation, infection
Washington University in St. Louis

Eating a Western diet impairs the immune system in the gut in ways that could increase risk of infection and inflammatory bowel disease, according to a study from researchers at Washington University School of Medicine in St. Louis and Cleveland Clinic.

Released: 17-May-2021 2:20 PM EDT
Wistar and Peter Mac Scientists Discover Fundamental Mechanism That Fine-tunes Gene Expression and Is Disrupted in Cancer
Wistar Institute

A team of scientists from The Wistar Institute in Philadelphia and the Peter MacCallum Cancer Center in Melbourne, Australia, discovered a new checkpoint mechanism that fine-tunes gene transcription.

Released: 17-May-2021 9:40 AM EDT
Comprehensive Mount Sinai Study Shows Direct Evidence That COVID-19 Can Infect Cells in Eye
Mount Sinai Health System

Study Has Implications for Preventive Measures to Slow Spread of Virus

Released: 13-May-2021 1:00 PM EDT
Cancer has ripple effect on distant tissues
Washington University in St. Louis

A new study with zebrafish shows that a deadly form of skin cancer — melanoma — alters the metabolism of healthy tissues elsewhere in the body. The research from Washington University in St. Louis suggests that these other tissues could potentially be targeted to help treat cancer.“Tumors rely on a constant supply of nutrients to grow.

6-May-2021 2:45 PM EDT
Food Dyes May Cause Disease When the Immune System is Dysregulated, Mount Sinai Researchers Report
Mount Sinai Health System

Artificial food colorants can cause disease when the immune system has become dysregulated, Icahn School of Medicine at Mount Sinai researchers report. The study, published in Cell Metabolism in May, was the first to show this phenomenon.

7-May-2021 3:40 PM EDT
For the Brain, Timing Is Everything
Columbia University School of Engineering and Applied Science

New study from Joshua Jacobs (Columbia Engineering) and Itzhak Fried (UCLA) demonstrates the existence of phase precession in the human brain for the first time, and shows that this neural code not only links sequential positions, as in animals, but also abstract progression towards specific goals. Says lead author Salman Qasim, “We were convinced that phase precession held a lot of promise as a widespread neural code that could be used for learning and cognition.”

Released: 10-May-2021 2:45 PM EDT
Errors at the start of life
Max Planck Society (Max-Planck-Gesellschaft)

Only one in three fertilizations leads to a successful pregnancy. Many embryos fail to progress beyond early development.

   
Released: 5-May-2021 11:05 AM EDT
UCI biomedical engineers spotlight disparities in knee and jaw joint treatments
University of California, Irvine

Irvine, Calif., May 5, 2021 – If you haven’t had knee surgery, you may have a friend or relative who has. But do you know anyone who has had an operation on their jaw? Although the temporomandibular joint is crucial to speaking, chewing and even breathing, treatments for TMJ disorders are far less common than those for the knee.



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