The combination approach uses immune checkpoint inhibitors with ATRA, a safe medication that is widely used to treat leukemia.
Johnese Spisso, president of UCLA Health and CEO of UCLA Hospital System, has joined forces with nine other U.S. health system leaders to form the CEO Coalition and set new safety standards for the nation’s health care workers.
A UCLA-led study shows that physicians frequently order preventive medical services for adult Medicare beneficiaries that are considered unnecessary and of “low value” by the U.S. Preventive Services Task Force — at a cost of $478 million per year.
Patients with advanced colorectal cancer may be spared from a toxic side effect caused by a type of targeted therapy used to treat the cancer with the help of another drug normally used to treat melanoma, according to a study led by researchers at the UCLA Jonsson Comprehensive Cancer Center and Memorial Sloan Kettering Cancer Center.
The AIDS Clinical Trials Group (ACTG), the largest global HIV research network, has added SAB-185, a polyclonal antibody therapy, to the COVID-19 outpatient treatment study.
A one-time injection of an experimental stem cell therapy can repair brain damage and improve memory function in mice with conditions that replicate human strokes and dementia, a new UCLA study finds.
The proportion of physicians who are Black in the U.S. has increased by only 4 percentage points over the past 120 years, and that the share of doctors who are Black men remains unchanged since 1940. The research also spotlights a significant income gap between white and Black male physicians
Elderly patients of female physicians are more likely than those of male physicians in the same outpatient practice to be vaccinated against the flu. This trend holds for all racial and ethnic groups studied and could provide insight into improving vaccination rates for influenza, COVID-19 and other illnesses
Early results from a new, pioneering CAR T cell immunotherapy trial led by researchers at the UCLA Jonsson Comprehensive Cancer Center found using a bilateral attack instead of the conventional single-target approach helps minimizes treatment resistance, resulting in long-lasting remission for people with non-Hodgkin's B-cell lymphoma.
A UCLA research team has shown that using a truncated form of the CD4 molecule as part of a gene therapy to combat HIV yielded superior and longer-lasting results in mouse models than previous similar therapies using the CD4 molecule.
A study led by researchers at UCLA and CHLA has shown that a combination of modest dietary changes and exercise can dramatically improve survival outcomes for those with acute lymphoblastic leukemia, the most common childhood cancer.
For middle-aged women, exercise has many health benefits, but it may not help maintain cognitive function over the long term, according to a new UCLA Health study.
Researchers will study vaccinated and non-vaccinated health workers who get tested for the virus after experiencing common COVID-19 symptoms like fever, cough or a loss of sense of taste or smell. They will compare the incidence of positive tests and severity of illness in those who test positive.
New UCLA study shows that image guided needle based thermal ablation is a safe and effective approach for patients with localized metastatic gynecologic cancers throughout the body.
A team of researchers from the UCLA Jonsson Comprehensive Cancer Center has been awarded two research grants totaling $6 million from the National Institutes of Health to identify new ways to treat pancreatic cancer.
New research suggests that the COVID-19 crisis has exacerbated existing racial health care disparities and that during the pandemic, African Americans may have had worse access than whites to outpatient care that could have helped prevent deterioration of their non–COVID-19 health conditions
A UCLA-led research team has identified a chemical cocktail that enables the production of large numbers of muscle stem cells, which can self-renew and give rise to all types of skeletal muscle cells.
A new study involving UCLA researchers finds that mobile stroke units (MSUs) – state-of-the-art ambulances built to provide stroke patients with emergency neurological diagnosis and treatment prior to hospital arrival -- improve patient outcomes and lessen the chance for disability by delivering care faster than standard stroke care.
A new UCLA study shows that while men and women who have high muscle mass are less likely to die from heart disease, it also appears that women who have higher levels of body fat — regardless of their muscle mass — have a greater degree of protection than women with less fat.
Dr. Corey Arnold and his graduate student, Karthik Sarma, explain how federated learning can enable more powerful AI models while enhancing the protection of patient data
Dr. Peter Goadsby, professor of neurology at the David Geffen School of Medicine at UCLA, has been chosen as one of four recipients of the Brain Prize 2021. The prize honors scientists who have made outstanding contributions to the field of neuroscience. Dr. Goadsby will receive a personal prize of 2.5 million Danish kroner, or about $400,000.
The AIDS Clinical Trials Group (ACTG), the largest global HIV research network, will present four oral and 20 scientific spotlight sessions at the Conference on Retroviruses and Opportunistic Infections (CROI 2021) held virtually, March 6-10.
UCLA researchers found that patients’ decision-making about how and when to seek treatment for kidney stones was driven by logistical barriers and patients’ reluctance to risk exposure to COVID-19 in health care facilities.
When physicians failed to verbally provide information about potential side effects, older people incorrectly assumed that about 55% of their prescribed medications had none. When they did provide the information, patients incorrectly assumed there were no side effects for 22% of the medications.
A new study from UCLA and Stanford University researchers finds that three-dimensional human stem cell-derived brain organoids can mature in a manner that is strikingly similar to human brain development.
UCLA Jonsson Comprehensive Cancer Center researchers have uncovered a potential new way to target pancreatic tumors that express high intratumoral interferon signaling (IFN).
A new study led by researchers at the UCLA Jonsson Comprehensive Cancer Center helps identify which patients with prostate cancer will benefit most from the use of prostate-specific membrane antigen PET imaging, PSMA PET, a novel imaging technique that recently was approved by the U.S. Food and Drug Administration.
The AIDS Clinical Trials Group has added rapid infusion, intramuscular injection, an inhalant, and an oral agent to its ACTIV-2 phase 2 and 3 evaluations of multiple investigational agents for treating early, symptomatic COVID-19 in a single trial for outpatient treatment.
Despite a Mexican government initiative launched in 2015 to improve access to prescription opioids among palliative care patients, the country has seen only a marginal increase in dispensing levels, and inequities in dispensing have left many of the nation’s poorest residents without comfort in their final days
The center will build on UCLA’s efforts in precision health to leverage large data sets and genomic technologies such as CRISPR engineering and develop individually targeted treatments for genetic disorders such as cancer, cardiovascular disease, Parkinson's and autism.
In a study of mice, researchers at the UCLA Jonsson Comprehensive Cancer Center have identified a new approach that combines an anti-psychotic drug, a statin used to lower high cholesterol levels, and radiation to improve the overall survival in mice with glioblastoma.
UCLA researchers are seeking participants for an innovative study examining the impact of COVID-19 on survivors who continue battling health issues long after they were infected and thought to have recovered, known informally as “long COVID” and “longhaulers.”
A study led by researchers at the UCLA Jonsson Comprehensive Cancer Center found shortening a traditional 45-day course of radiation to a five-day course delivered in larger doses is safe and as effective as conventional radiation for men with high-risk forms of prostate cancer.
Scientists from the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have developed a technique that will enable researchers to more efficiently isolate and identify rare T cells that are capable of targeting viruses, cancer and other diseases.
Improving imaging processes will lead to more successful treatments and help reduce morbidity in men with the disease.
The AIDS Clinical Trials Group (ACTG) has added a new agent to the ACTIV-2 Outpatient Monoclonal Antibodies and Other Therapies Trial. This phase 2 study, which is being led by the ACTG, will evaluate the combination of the two monoclonal antibodies BRII-196 and BRII-198 to treat early COVID-19.
A growing number of women forgoing reconstruction after a mastectomy say they’re satisfied with their choice, even as some did not feel supported by their physician, according to a study led by researchers at the UCLA Jonsson Comprehensive Cancer Center.
Scientists from the UCLA Jonsson Comprehensive Cancer Center have developed a simple, high-throughput method for transferring isolated mitochondria and their associated mitochondrial DNA into mammalian cells. This approach enables researchers to tailor a key genetic component of cells, to study and potentially treat debilitating diseases such as cancer, diabetes and metabolic disorders.
As COVID cases rise, physically distancing yourself from other people has never been more important. Now a Nature study reveals how your brain navigates places and monitors someone else in the same location.
A UCLA-led study may help explain how COVID-19 increases the risk for stroke. Scientists made the finding by running fluid spiked with a COVID-19–like protein through a 3D-printed model of the arteries of a patient who had suffered a stroke.
UCLA scientists describe a new combination therapy that suppresses the MAPK pathway by holding cancer-driving proteins in a death grip. This combination of two small molecules has the potential to treat not only BRAF mutated melanoma but also additional aggressive subtypes of cancers, including melanoma, lung, pancreatic and colon cancers that harbor common mutations in cancer genes called RAS or NF1.
UCLA researchers have identified a potential diagnostic marker that could help predict how likely someone with cervical cancer is to respond to the standard treatment of chemotherapy and radiation.
Older people who undergo emergency surgeries on their operating surgeon’s birthday may be more likely to die within a month than patients who go through similar procedures on other days, a new UCLA-led study suggests.
New UCLA-led research shows that behavioral interventions — mindfulness meditation and survivorship education classes — are effective in reducing depressive symptoms in younger breast cancer survivors, who often experience the highest levels of depression, stress and fatigue that can persist for as long as a decade after their diagnosis.
UCLA researchers are the first to create a version of COVID-19 in mice that shows how the disease damages organs other than the lungs. Using their model, the scientists discovered that the SARS-CoV-2 virus can shut down energy production in cells of the heart, kidneys, spleen and other organs.
UCLA researchers studying cancer evolution have created a framework to help determine which tool combinations are best for pinpointing the exact timing of DNA mutations in cancer genomes.
The University of California’s two nationally ranked medical centers, UCSF and UCLA, and their nuclear medicine teams have obtained approval from the U.S. Food and Drug Administration to offer a new imaging technique for prostate cancer that locates cancer lesions in the pelvic area and other parts of the body to which the tumors have migrated.
In July 2019, Evie Junior enrolled in a clinical trial for an experimental stem cell gene therapy for sickle cell disease. The study is led by UCLA Broad Stem Cell Research Center physician-scientists Dr. Donald Kohn and Dr. Gary Schiller and funded by the California Institute for Regenerative Medicine.
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