Dr. Keith Vossel, who is known for his discovery that many Alzheimer’s patients experience nighttime seizures that disrupt their sleep, is the new director of the Mary S. Easton Center for Alzheimer’s Disease Research at UCLA.
UCLA researchers and their colleagues from two other institutions have been awarded a $52 million grant from the National Institutes of Health to lead an international study to better understand the cause and effect of schizophrenia in high-risk youth.
UCLA researchers shed light on how interferon-gamma (IFN-y) guides the treatment response in people with advanced melanoma who are treated with one of the leading immunotherapies — immune checkpoint blockade.
UCLA researchers and colleagues who analyzed electronic health records found that there was a significant increase in patients with coughs and acute respiratory failure at UCLA Health hospitals and clinics beginning in late December 2019, suggesting that COVID-19 may have been circulating in the area months before the first definitive cases in the U.S. were identified. This sudden spike in patients with these symptoms, which continued through February 2020, represents an unexpected 50% increase in such cases when compared with the same time period in each of the previous five years.
A new UCLA study shows partially overlapping patterns of brain function in people with anorexia nervosa and those with body dysmorphic disorder, a related psychiatric condition characterized by misperception that particular physical characteristics are defective.
The Simms/Mann-UCLA Center for Integrative Oncology has received a $50,000 grant from Los Angeles-based PHASE ONE Foundation to support psychosocial care for people with cancer, their families and frontline healthcare workers during the COVID-19 pandemic.
A test designed by UCLA researchers can pinpoint which people with gonorrhea will respond successfully to the inexpensive oral antibiotic ciprofloxacin, which had previously been sidelined over concerns the bacterium that causes the infection was becoming resistant to it.
UCLA researchers have found that chemotherapy is not commonly used when treating adults with localized sarcoma, a rare type of cancer of the soft tissues or bone. In a nationwide analysis of nearly 20,000 patients whose cancer had not yet spread to other organs, the scientists learned that only 22% were treated with some form of chemotherapy.
The AIDS Clinical Trials Group (ACTG) has initiated the ACTIV-2 Outpatient Monoclonal Antibodies and Other Therapies Trial. ACTIV-2 includes both phase 2 and phase 3 evaluations of multiple promising investigational agents for treating early COVID-19 in a single trial.
Although discomfort, confusion and even political affiliation are often cited as reasons that make people less likely to wear a mask in public, the psychological traits that shape a person’s behavioral choices may also factor into the decision.
Researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have identified the process by which stem cells in the airways of the lungs switch between two distinct phases — creating more of themselves and producing mature airway cells — to regenerate lung tissue after an injury.
In a new study looking at adoptive cell transfer products bearing a transgenic T-cell receptor (TCR), researchers at the UCLA Jonsson Comprehensive Cancer Center have identified a discordant phenomenon in which a subset of patients displayed profoundly decreased expression of the transgenic TCR over time, despite the transgenic TCR being present at the DNA level.
A study by UCLA researchers shows that in people with mild cases of COVID-19, antibodies against SARS-CoV-2 — the virus that causes the disease — drop sharply over the first three months after infection, decreasing by roughly half every 36 days on average. If sustained at that rate, the antibodies would disappear within about a year.
Researchers at the UCLA Jonsson Comprehensive Cancer Center and UCLA School of Dentistry have identified a potential new combination therapy to treat advanced head and neck squamous cell carcinoma, the most common type of head and neck cancer.
A UCLA-led study has found that dermatopathologists, who specialize in diagnosing skin diseases at the microscopic level, are motivated both by patient safety concerns and by malpractice fears — often simultaneously — when ordering multiple tests and obtaining second opinions, with a higher proportion of these doctors reporting patient safety as a concern.
When ordering additional microscopic tests for patients, 90% of the dermatopathologists surveyed cited patient safety as a concern and 71% of them reported malpractice fears. Similarly, when obtaining second reviews from a consulting pathologist or recommending additional surgical sampling, 91% cited safety concerns and 78% malpractice concerns.
In response to the COVID-19 pandemic, UCLA Mattel Children’s Hospital launched an innovative project to support the emotional needs of children through a new AI powered robot. Robin’s technology enables the robot to build what is called associative memory — it recognizes a child’s emotions by interpreting his or her facial expressions and builds responsive dialogue by replicating patterns formed from previous experiences.
New UCLA research conducted in mice could explain why some people suffer more extensive scarring than others after a heart attack. The study, published in the journal Cell, reveals that a protein known as type 5 collagen plays a critical role in regulating the size of scar tissue in the heart.
Scientists discovered that histones act as an enzyme that converts copper into a form that can be used by the cells. The finding refutes earlier theories that copper spontaneously converts in the body into a usable state.
A UCLA-led study has found that in 2 of 3 states and jurisdictions with policies that require students entering school to receive the human papillomavirus vaccine, vaccination rates among 13-to-17-year-olds were significantly higher than in surrounding states without such policies.
As California prepares for a potential surge of COVID-19, there is a pressing need to determine how critical care resources should be allocated, especially if there is an extreme shortage of those resources.
Youth who are Black, Indigenous and people of color (BIPOC) that also identify as LGBTQ+ representation of sexual orientations and gender identities experience higher rates of social discrimination and isolation, including bullying, family rejection and a lack of social support. Here are ways that family and friends can support them.
States with the highest level of income inequality had a larger number of COVID-19-related deaths compared with states with lower income inequality. New York state, with the highest income inequality, had a mortality rate of 51.7 deaths per 100,000 vs. Utah, the state with the lowest income inequality and which had a mortality of 0.41 per 100,000.
UCLA scientists have developed a method for restoring oxygen-consumption activity to previously frozen mitochondria samples. By speeding up research, investigators hope to accelerate the diagnosis of people living with mitochondrial diseases and secondary disorders in which mitochondria play a key role, including diseases related to aging, metabolism and the heart.
Topics include the efficacy and safety of third-line treatment regimens in resource-limited settings, viral rebound rates after treatment interruption of modern ART, and whether a standardized frailty score can improve clinicians’ ability to estimate cardiovascular risk among older people with HIV.
Researchers from UCLA, Harvard Medical School and the University of Tokyo found that during a recent six-year period, homeless people in New York state were more likely to hospitalized and treated with mechanical ventilators for respiratory infections than people who are not homeless. These findings have implications for the COVID-19 pandemic.
UCLA researchers and colleagues have received a $13.65 million grant from the National Institutes of Health to investigate and further develop an immunotherapy known as CAR T, which uses genetically modified stem cells to target and destroy HIV.
In the June 11 issue of the New England Journal of Medicine, a team of UCLA physicians and scientists describes the first case of immune modulation being used to cure a severe and often fatal fungal infection. The team “retuned” a 4-year-old’s immune system so that it could fight off disseminated coccidioidomycosis.
Researchers at the UCLA Jonsson Comprehensive Cancer Center analyzed gene-expression patterns in the most aggressive prostate cancer grade group — known as Gleason grade group 5 — and found that this grade of cancer can actually be subdivided into four subtypes with distinct differences. The findings may affect how people are treated for the disease.
A UCLA research team has identified a new paradigm for understanding the regulation of the immune system, potentially paving the way for new approaches to treating infections and immune-related diseases such as type 1 diabetes and certain cancers.
A new study from researchers at the UCLA Jonsson Comprehensive Cancer Center helps explain how disruptions in genes can lead to the resistance to one of the leading immunotherapies, PD-1 blockade, and how new drug combinations could help overcome resistance to the anti-PD-1 therapy in a mechanistically-based way.
A team of researchers from the UCLA Jonsson Comprehensive Cancer Center and peer institutions has been awarded a $5.75 million grant from the National Cancer Institute to study the correlation between obesity, inflammation and pancreatic cancer. The scientists hope their findings may help people avoid getting this cancer.