In preliminary findings that will be presented Sunday, April 2, at the American Association for Cancer Research Annual Meeting 2017, UNC Lineberger Comprehensive Cancer Center researchers report on a preclinical study into the use of nanoparticles to improve the efficacy of immunotherapy drugs known as checkpoint inhibitors.
In an abstract that will be presented at a poster session to be held from 1 to 5 p.m. April 3 at the American Association for Cancer Research Annual Meeting 2017, UNC Lineberger Comprehensive Cancer Center researchers will report their preliminary findings that breast cancer cancer cells grew larger when they were transplanted into fatty, obese tissue.
A UNC Lineberger Comprehensive Cancer Center-led study found broad support, even among smokers, for increasing the size of health warnings on cigarette packs.
With a more accurate understanding of the characteristics and function of the receptor MRGRPX2, University of North Carolina School of Medicine researchers were also able to create chemical probe that will allow them study the receptor more precisely.
Researchers at the University of North Carolina at Chapel Hill have received a three-year, $1.8 million grant from the National Institutes of Health to develop a new implantable drug delivery system for long-lasting HIV-prevention.
A new study by UNC School of Medicine researchers suggests that food scarcity and poor oral health are major risk factors for malnutrition that leads an older adult – already at high risk of functional decline, decreased quality of life, and increased mortality – to land in the emergency department.
In a study published in the journal JAMA Oncology, UNC Lineberger Comprehensive Cancer Center researchers report that women diagnosed and treated for cancer during their childbearing years more commonly gave birth prematurely, and to babies whose weights were below normal ranges. Cancer survivors also had a slightly higher rate of cesarean section deliveries.
University of North Carolina scientists found that mucin proteins, which make mucus thick and sticky, fail to unfold properly in the airways of people with cystic fibrosis. And they found the lack of water in the lung can trigger the misfolding mucins.
A new study led by UNC Lineberger Comprehensive Cancer Center researchers identifies distinct patterns of side effects for prostate cancer treatments that patients could use to guide their choices.
In a study published in journal Nature Immunology, UNC Lineberger researchers describe how inflammation can go unchecked in the absence of a certain inflammation inhibitor called NLRP12. In a harmful feedback loop, this inflammation can upset the balance of bacteria living in the gut.
In an MRI study, researchers found that many toddlers diagnosed with autism at age 2 had a substantially greater amount of extra-axial cerebrospinal fluid (CSF) at six and 12 months of age, before diagnosis is possible. Researchers also linked increased severity of symptoms to increased CSF.
UNC scientists found that as mice learn to associate a particular sound with a rewarding sugary drink, one set of prefrontal neurons becomes more active and promotes reward-seeking behavior while other prefrontal neurons are silenced, and those neurons act like a brake on reward-seeking.
UNC Lineberger researchers and colleagues report in the journal Clinical Cancer Research that a measure of muscle mass and muscle quality developed at UNC could potentially help doctors better identify patients at high risk for toxic side effects that could require hospitalizations.
The UNC AARP Sprint aims to find digital health solutions to the challenge of: How can wearables be used to seamlessly galvanize the 50+ population to take the right medications as prescribed?
Scientists have struggled to trace the specific biology behind diabetes-associated heart disease risk or find ways to intervene. Now, UNC researchers have hunted down a possible culprit – a protein called IRS-1, which is crucial for the smooth muscle cells that make up veins and arteries.
A UNC-Chapel Hill researcher has published a study in Lancet Oncology online that identifies sentinel-lymph-node mapping as a safer and less-invasive method of staging endometrial cancer that is equally as accurate as the more traditional lymphadenectomy.
Using magnetic resonance imaging (MRI) in infants with older siblings with autism, researchers from around the country were able to correctly predict 80 percent of those infants who would later meet criteria for autism at two years of age.
Day in and day out, the DNA in our cells is damaged for a variety of reasons, and thus DNA-repair systems are fundamental to the maintenance of life. Now UNC scientists have confirmed and clarified key molecular details of one of these repair systems, known as nucleotide excision repair.
Researchers at the UNC School of Medicine believe they have isolated a protein that, when missing or depleted, can cause airway constriction, production of mucus, chest tightness, and difficulty breathing for the 334 million people worldwide who suffer from asthma.
UNC Medical Center is the first in the Mid Atlantic U.S. to treat patients with the EnSite Precision™ cardiac mapping system, a next-generation platform designed to provide automation, flexibility and accuracy for diagnostic mapping used in ablation procedures to treat patients with abnormal heart rhythms (cardiac arrhythmias). UNC Medical Center was among the first sites in the United States to utilize this technology, which recently received FDA clearance.
The ancient impulse to procreate is necessary for survival and must be hardwired into our brains. Now scientists from the University of North Carolina School of Medicine have discovered an important clue about the neurons involved in that wiring.
UNC School of Medicine researchers crystalized the structure of LSD attached to a human serotonin receptor of a brain cell, and they may have discovered why an “acid trip” lasts so long.
After surgery to remove a cancerous tumor – even if the surgery is considered “successful” – it’s nearly impossible to ensure that all microtumors have been removed from the surgical site. Cancer recurrence is always a major concern. Meanwhile, tiny blood cells called platelets rush in to start the post-surgical healing process. What if those platelets could carry anti-cancer drugs to wipe out those microtumors? UNC and NC State scientists have developed a way to do just that, and they have shown success in animal studies, published today in Nature Biomedical Engineering.
The UNC School of Medicine has awarded the 17th Perl-UNC Neuroscience Prize to David Anderson, PhD, the Seymour Benzer Professor of Biology at the California Institute of Technology for “his discovery of neural circuit mechanisms controlling emotional behaviors.”
Unmasking a previously misunderstood gene, Gpr182, University of North Carolina scientists discover an unlikely potential drug target for gastrointestinal cancers.
In the late 1990s, the World Health Organization (WHO) issued a policy requiring the establishment of centralized blood banking facilities in Sub-Saharan African countries. Anthony Charles, MD, MPH, associate professor of surgery at the UNC School of Medicine, says that this policy is now having unintended negative consequences.
In the journal Cancer Discovery, UNC Lineberger Comprehensive Cancer Center researchers and colleagues report findings of how triple negative breast cancer cells are able to bypass treatment with trametinib, a U.S. Food and Drug Administration-approved drug that belongs to a class of commonly used anti-cancer drugs called kinase inhibitors. The researchers also reported findings from laboratory models of breast cancer testing a potential treatment approach that could prevent the onset of resistance.
A national consortium of clinical geneticists is studying the ins and outs of potentially using genome sequencing for newborn health screenings and beyond.
In a perspective published in the New England Journal of Medicine, a UNC Lineberger Comprehensive Cancer Center researcher addresses the need for – and the barriers preventing – electronic reporting of patients’ symptoms between visits.
A research team at the UNC School of Medicine found that the Graduate Record Exam (GRE), which is required for admission to graduate and doctorate programs across the country, is not the best indicator for predicting a student’s success while pursuing a doctorate in the experimental life sciences. And from that research, the team recommends devaluing – if not eliminating altogether – the GRE from the applications process for biomedical PhD candidates.
UNC scientists found more clues about the evolving brains of baby mammals as eyesight comes online. Using an imaging system to get neuron-level resolution, they showed how one specific brain circuit in mice came online immediately after birth, but another needed visual stimuli in order to mature.
Researchers have found iron deficiency anemia protects children against the blood-stage of Plasmodium falciparum malaria in Africa, and treating anemia with iron supplementation removes this protective effect.
Scientists at the University of North Carolina School of Medicine have developed a method to control proteins inside live cells with the flick of a switch, giving researchers an unprecedented tool for pinpointing the causes of disease using the simplest of tools: light.
Scientists have few good methods for manipulating and investigating G-protein signaling. Now, UNC scientists have developed small proteins to selectively block a certain type of G-protein signaling, creating a unique and powerful tool for studying cell processes that depend on this signaling.
A new study led by University of North Carolina School of Medicine researchers concluded that patterns of white matter microstructure present at birth and that develop after birth predict the cognitive function of children at ages 1 and 2.
Significant differences exist in the believability of specific cigar warnings, suggesting that more work is needed to establish the best warnings to dissuade youth from smoking cigars.
UNC Lineberger Comprehensive Cancer Center researchers and collaborators report Wednesday at the San Antonio Breast Cancer Symposium that they have identified biomarkers they believe can be used as part of a larger model to predict how patients with HER2-positive operative breast cancer will respond to the targeted treatment trastuzumab, commercially known as Herceptin, and chemotherapy.
A study presented Wednesday at the 2016 San Antonio Breast Cancer Symposium examined the incidence of brain metastasis after diagnosis for three groups of patients with HER2-positive breast cancer.
In a preliminary findings presented at the 2016 San Antonio Breast Cancer Symposium, researchers reported that older patients were as likely as younger patients to receive targeted therapy and enroll in therapeutic trials based on their sequencing results.
In a study presented at the 2016 San Antonio Breast Cancer Symposium, researchers report they developed a model that can predict which triple negative breast cancer patients will respond to chemotherapy.
Results from a new study show that online group therapy can be just as effective as face-to-face treatment, although the pace of recovery may be slower.
Lack of paid leave and outdated maternity care are barriers to breastfeeding that disproportionately impact families of color. This is the first study to show how these disparities translate into differences in health outcomes.
When Manda Miller called her parents to tell them she was pregnant, she knew it would be unexpected. But, starting a family was more than just a life detail on which Manda and Douglas Miller had been mum – Manda was a two-time survivor of Hodgkin’s Lymphoma. The aggressive treatment saved her life, but had taken her chance for children.
In the journal Tobacco Control, researchers report the results of a systematic review of 40 studies completed in the United States and internationally that looked at the impact of non-menthol tobacco flavors on consumers’ perceptions and tobacco use behaviors.
A malaria parasite in the Democratic Republic of the Congo is able to avoid rapid test detection through a gene deletion. In the first nationwide study, researchers at the University of North Carolina at Chapel Hill showed how the deletion prevents a positive test result in asymptomatic children.
We caught up with Qian, assistant professor of pathology and laboratory medicine at the UNC School of Medicine and member of the McAllister Heart Institute, to discuss her research in cardiac reprogramming, her goal to inspire young women to pursue careers in science, and how and why she chose the UNC School of Medicine. By Caroline Curran, caroline.
CHAPEL HILL, NC – Do you have questions about the Zika virus and how it spreads? If you’re traveling this holiday season, do you know how to protect yourself from Zika? Do you have questions about Zika and pregnancy? Do you know all the ways the virus can be transmitted? What about the likelihood of a Zika epidemic here in North Carolina?
Muscular dystrophies, congenital heart muscle defects, and other muscle disorders often arise for reasons that scientists don’t fully understand. Now researchers from the UNC School of Medicine and Baylor College of Medicine have discovered that alternative splicing could play an important role in these disorders.
Two researchers at the UNC School of Medicine have been named to a global consortium for Zika research and vaccine development.
During stroke or heart attack, tissue damage can be limited because “collateral” vessels connect the tissue to other arteries. Collateral vessels can vary greatly in size and number from one person to the next. Scientists have now implicated the Rabep2 gene as a major contributor to variation.
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