In a preliminary finding (abstract 5568) presented Monday, June 6, at the 2016 American Society of Clinical Oncology Annual Meeting in Chicago, researchers revealed they have found bacteria in the upper female reproductive tract.
Researchers report preliminary findings at the American Society of Clinical Oncology Annual Meeting 2016 that 26 percent of a survey of adult cancer patients reported they paid more for medical care than they could afford. Those patients also reported missing appointments and prescriptions because of affordability issues.
Researchers from the University of North Carolina at Chapel Hill and East Carolina University report in the American Journal of Preventive Medicine that in all nine regions of the country, a majority of adults supported increasing the minimum legal age for tobacco product sales.
In the journal npj Breast Cancer, researchers reported they identified a particular gene expression pattern in normal-appearing breast tissue around tumors that was linked to lower 10-year survival rates for women with estrogen receptor-positive breast cancer.
In the journal The Oncologist, researchers report that the median survival for a group of Medicare patients on the drug sorafenib was three months, which was significantly lower than the median survival of nearly 11 months for patients treated with the drug during a phase III clinical trial.
UNC School of Medicine scientists create SEWING, a technique inspired by natural evolutionary mechanisms to recombine portions of known proteins to produce new structures with the distinctive features that proteins require to carry out specific biological functions.
Rebecca S. Williams, a researcher with the University of North Carolina Lineberger Comprehensive Cancer Center and a leading expert in the study of Internet tobacco sales, including e-cigarettes, applauds the FDA’s ruling.
Compound found to be highly active against cancer driven by EZH2 mutation in laboratory models
An analysis by a University of North Carolina at Chapel Hill researcher reports in JAMA Oncology that a month of treatment with orally-administered cancer drugs introduced in 2014 were, on average, six times more expensive at launch than cancer drugs introduced in 2000 after adjusting for medical inflation. Drugs approved in 2000 cost an average of $1,869 per month compared to $11,325 for those approved in 2014.
Satish Gopal, MD, MPH, a UNC Lineberger Comprehensive Cancer Center member, has called for a commitment to contribute resources and energy to control cancer in less-resourced countries n a perspective published in the April 28 issue of the New England Journal of Medicine.
A study by researchers from the University of North Carolina Lineberger Comprehensive Cancer Center and other institutions found a link between higher intake of dietary saturated fat, a type of fat found commonly in foods such as fatty beef and cheese, and risk of aggressive prostate cancer.
Scientists at the University of North Carolina School of Medicine have developed a way to embed light-responsive switches into proteins so that researchers can use lasers to manipulate protein movement and activity within living cells and animals.
A UNC Lineberger Comprehensive Cancer Center-led study has found that women who have had a false-positive mammogram result are more or less likely to get screened at recommended intervals depending on the timing of their last screen.
New research of old data suggests that using vegetable oils high in linoleic acid failed to reduce heart disease and overall mortality even though the intervention reduced cholesterol levels. And consuming vegetable oils might actually be worse than eating butter.
Study raises concerns about access to proven, yet expensive, drug therapy for HER2 subtype
Scientists at the UNC School of Medicine have found a class of commonly used fungicides that produce gene expression changes similar to those in people with autism and neurodegenerative conditions, including Alzheimer’s disease and Huntington’s disease.
Researchers with the UNC Lineberger Comprehensive Cancer Center examined whether weight loss via four different diets was linked to reduced tumor growth in laboratory models of breast cancer. Their preliminary findings will be presented tat the 2016 American Association for Cancer Research Annual Meeting in New Orleans.
Weight loss surgery was more effective than a low-fat diet at reversing the cancer-promoting effects of chronic obesity in mice, according to a study led by UNC Lineberger Comprehensive Cancer Center researchers. The preliminary findings will be presented at the 2016 American Association of Cancer Research Annual Meeting in New Orleans.
A University of North Carolina Lineberger Comprehensive Cancer Center-led study has identified genetic differences in tumors of African-Americans with the most common type of kidney cancer compared with whites.
This study has helped determine that UBE3A gene loss specifically from GABAergic neurons is what’s critical for seizures in Angelman patients. But UBE3A loss from other neuron types may drive other phenotypes associated with the condition.
In an effort to minimize obstacles to adherence and prevent vaginal HIV transmission, UNC researchers and collaborators from Merck demonstrated the effectiveness of a new long-acting formulation of the HIV drug raltegravir in animal models.
Researchers at UNC Lineberger Comprehensive Cancer Center, UNC Eshelman School of Pharmacy, the Aflac Cancer & Blood Disorders Center in Atlanta, Emory University School of Medicine, and at other institutions report that a novel compound MRX-2843 more than doubled the median days of survival in laboratory models with a drug-resistant form of the acute myeloid leukemia.
UNC researchers uncovered a cellular mechanism by which kappa opioid receptors drive anxiety. These proteins inhibit the release of the neurotransmitter glutamate in a part of the brain that regulates emotion. KORs are targets for the treatment of addiction and anxiety disorders.
For decades, researchers have tried to duplicate the function of beta cells, which don’t work properly in patients with diabetes. Now, researchers have devised another option: a synthetic patch filled with natural beta cells that can secrete doses of insulin to control blood sugar levels on demand.
In the journal Cell Reports, UNC Lineberger researchers reported they found markedly low levels of the protein NLRX1 in multiple laboratory models of colorectal cancer, and in samples of human tissue. Studies have shown that the protein is known to be involved in regulating immune system signals in order to prevent hyperactive inflammatory responses by the immune system, but UNC Lineberger researchers believe their finding also points to a role for the protein in preventing colorectal cancer growth. Based on their findings, they believe they’ve identified a potential treatment for colorectal cancer with low NLRX1.
Patients with heart failure often have a buildup of scar tissue that leads to a gradual loss of heart function. In a new study, UNC researchers report significant progress toward a novel approach that could shrink the amount of heart scar tissue while replenishing the supply of healthy heart muscle.
Research led by UNC’s John Buse showed that IDegLira injections were more effective than basal insulin glargine injections at reducing the average amount of blood sugar over the course of several months. IDegLira was also associated with weight loss and a substantially lower rate of hypoglycemia.
In a first-of-its-kind-study, researchers at the University of North Carolina Lineberger Comprehensive Cancer Center discovered and applied a new screening technique capable of testing thousands of potential drug compounds to see if those compounds can reverse abnormal DNA unwinding in Ewing sarcoma, a bone and soft tissue cancer that’s most common in teens and young adults.
Copies of the mouse gene R2d2 can spread quickly through lab and wild mouse populations, despite the fact that the genes cause females to have fewer offspring. This is the first time scientists have used mice to show that a selfish gene responsible for infertility can become fixed in a population.
Preliminary findings from a study examining the genetic alterations in HPV-positive oropharyngeal squamous cell carcinoma were presented Thursday at the 2016 Multidisciplinary Head and Neck Cancer Symposium. The researchers found differences in the genetic mutations of HPV-positive oropharyngeal cancer based on whether patients were heavy versus light smokers.
A UNC Lineberger researcher was first-author of a report published in the Journal of Clinical Oncology that details guidelines for the active surveillance of men with low-risk prostate cancer. The guidelines, originally authored by Cancer Care Ontario, were reviewed and endorsed by the American Society of Clinical Oncology with some revisions.
UNC School of Medicine scientists studying one of the world’s most virulent pathogens and a separate very common bacterium have discovered a new way that some bacteria can spread rapidly throughout the body – by hitchhiking on our own immune cells.
Ilona Jaspers, PhD, from the UNC School of Medicine, recently completed research showing how the chemicals in e-cigarettes can change immune responses in our airways. She will present her findings at the AAAS annual meeting February 11-16.
Implantable device delivers first-line treatment for pancreatic cancer directly to tumors, bypassing bloodstream and limiting widespread side effects.
For the first time, investigators in the Division of Infectious Diseases at the University of North Carolina School of Medicine have determined how antiretroviral therapy (ART) affects the way HIV disseminates and establishes infection in the female reproductive tract. These observations have significant implications for future HIV prevention, vaccine and cure studies.
Mutations in the gene TBX5 have been shown to cause both rare and more prevalent forms of congenital heart disease, yet the underlying mechanisms have remained unclear. A team led by researchers at the University of North Carolina at Chapel Hill has now found evidence pointing to a culprit.
Harvard's Christopher Walsh wins the 16th Perl UNC Neuroscience Prize for the "discovery of genes and mechanisms regulating human cortical development" from the University of North Carolina School of Medicine.
A new report from the American College of Physicians’ High Value Care Task Force issues advice for physicians on how to detect and evaluate blood found in the urine, which is known as hematuria. The report, which was first-authored by a UNC Lineberger Comprehensive Cancer Center member, also raises questions about the potential harms associated with diagnostic tests that are commonly employed to evaluate this condition.
A new study evaluated the relationship between common genetic variants implicated in schizophrenia and those associated with subcortical brain volumes, and found no evidence of genetic overlap between schizophrenia risk and subcortical volume measures.
– A first-of-its-kind national registry to improve treatment for women with uterine fibroids is being implemented across the U.S., including in the Triangle-area. Uterine fibroids are non-cancerous tumors that nearly 80 percent of American women will get in their lifetimes.
A single injection. That’s all someone with a factor VII deficiency would need for a life-long cure, thanks to a new gene therapy treatment developed in a collaboration of researchers at the University of North Carolina (UNC) and The Children’s Hospital of Philadelphia (CHOP).
CHAPEL HILL, NC– An interdisciplinary team at the University of North Carolina at Chapel Hill has been approved for a Eugene Washington PCORI Engagement Award by the Patient-Centered Outcomes Research Institute (PCORI) to define unmet patient-centered health care needs in what is known as the “fourth trimester,” the three months after a mother gives birth.
A UNC Lineberger Comprehensive Cancer Center-led study published in PLOS ONE found that the diabetes drug metformin failed to show any benefit against pancreatic cancer, despite excitement about the drug for its potential anti-cancer benefits. Researchers believe the study underscores the importance of testing new therapies in preclinical animal models that incorporate actual tumor tissue to predict patient response.
New research findings from the UNC School of Medicine add further clarity to a question that has polarized the cystic fibrosis research community.
In a study published in the journal Annals of Surgery, researchers report that breast cancer patients surveyed about their knowledge of breast reconstruction were only moderately informed about the procedure, and their knowledge of complications was low.
In the journal Cancer Cell, UNC Lineberger researchers report findings of a promising strategy to treat KRAS-mutant pancreatic cancers. Preclinical studies showed promise for using a type of investigational drug that works by inhibiting the protein ERK, the last of a series of signals of a signaling pathway that drives drive abnormal growth of cells with KRAS mutations.
In the journal Cell Reports, UNC Lineberger researchers report that when they removed Dicer from preclinical models of medulloblastoma, a common type of brain cancer in children, they found high levels of DNA damage in the cancer cells, leading to the cells’ death. The tumor cells were smaller, and also more sensitive to chemotherapy.
Researchers announced the first-ever evidence-based description of the neuronal protein clumps thought to be important in ALS, also known as Lou Gehrig’s disease, a fatal neurodegenerative condition. This could be a crucial step toward developing drugs to stem the progression of the disease.
When we get cold sores, the reason is likely related to stress. For the first time, researchers discovered a cellular mechanism that allows the herpes simplex virus to reactivate. They also found how brain cells are duped into allowing this to happen so that the virus can cause disease.
Two UNC physicians join experts in gynecology from across the country in asking the FDA to rescind or revise a warning it issued severely restricting use of a device commonly employed in minimally invasive procedures to treat uterine fibroids.
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