In experiments in mice, Johns Hopkins Medicine researchers say they have developed a way to successfully transplant certain protective brain cells without the need for lifelong anti-rejection drugs.
Sixteen years ago, a research group at Mayo Medical School published results showing that a protein called TRAIL can kill cells that cause liver fibrosis but no one seemed to follow up on these findings. Now, researchers at Johns Hopkins Medicine have improved on this protein and shown that it selectively kills cells that cause the hardening of skin associated with scleroderma, effectively reversing the condition in mice genetically engineered to mimic the disease. A report on these results was published earlier this year in Nature Communications.
In a report on their findings in the Journal of General Internal Medicine (JGIM), the researchers say their survey of 1,000 randomly selected PCPs revealed significant gaps in the group’s overall knowledge of risk factors, diagnostic criteria and recommended management/prevention practices for prediabetes.
By combing through the entire genetic sequences of a person with a lung scarring disease and 13 of the person’s relatives, Johns Hopkins Medicine researchers say they have found a coding error in a single gene that is likely responsible for a rare form of the disease and the abnormally short protective DNA caps on chromosomes long associated with it.
Researchers at the Johns Hopkins Kimmel Cancer Center discovered that a cell adhesion protein, E-cadherin, allows breast cancer cells to survive as they travel through the body and form new tumors, a process termed metastasis.
On July 10, the Department of Health and Human Services (HHS) announced they were aiming to reduce the number of Americans developing end-stage renal disease by 25% by 2030. But, the results of a focus group study done by Johns Hopkins researchers of more than 30 veteran primary care physicians across the United States
Johns Hopkins Medicine researchers report they have developed and validated a tablet-based app that offers a faster, easier and more accurate way for health care providers who don’t have specialized training to assess the cognitive function of people with multiple sclerosis (MS). Multiple sclerosis is a chronic neurologic illness that affects the central nervous system, resulting in a variety of symptoms including motor issues, fatigue, visual disturbance, memory and concentration concerns, and mood changes.
A premier educational event sponsored by the Johns Hopkins Kelly Gynecologic Oncology Service and the Division of Gynecologic Oncology at Sibley Memorial Hospital, this one-day conference gathers more than 25 experts to provide cancer survivors and their caregivers
Immune checkpoint inhibitors are a type of therapy that uses the immune system to fight cancer. They have been hailed as game changing, garnering a Nobel Prize last year and quickly becoming the standard of care for many tumor types such as melanoma and certain lung and head and neck cancers.
A group of private donors has given $17 million to start the Center for Psychedelic and Consciousness Research at Johns Hopkins Medicine, making it what’s believed to be the first such research center in the U.S., and the largest research center of its kind in the world.
A group of private donors has gifted funds to start the Center for Psychedelic and Consciousness Research at Johns Hopkins Medicine, making it what’s believed to be the first such research center in the U.S., and the largest research center of its kind in the world.
A couple of molecules that nerve cells use to grow during development could help explain why the most common pancreatic cancers are so difficult to contain and for patients to survive
Legend states that after the Greek army defeated the invading Persian forces near the city of Marathon in 490 B.C.E., the courier Pheidippides ran to Athens to report the victory and then immediately dropped dead.
In a bid to further explore how a mother-to-be’s diet might affect her offspring’s brain health, Johns Hopkins Medicine researchers have found that pregnant and nursing rats fed high fat diets have offspring that grow up to be slower than expected learners and that have persistently abnormal levels of the components needed for healthy brain development and metabolism.
As a disposable version of the instrument used in one of the most common medical procedures in the United States inches closer to widespread availability, a team of Johns Hopkins data researchers is studying the economic and safety implications associated with the devices used to perform colonoscopies.
Many parents are probably thinking about their child’s school attire, lunch needs and doctor visits in preparation for the upcoming school year.
A patient-centered, community-engaged program featuring home visits by nurses and mobile phone links to caregivers works better than traditional adult-focused and patient self-managed care systems for treating and managing pelvic inflammatory disease, or PID, among historically underserved teens and young women, a Johns Hopkins Medicine study shows.
In an extensive “data mining” analysis of British medical records, researchers at the Johns Hopkins Kimmel Cancer Center conclude that taking even a single course of antibiotics might boost—albeit slightly—the risk of developing colon cancer—but not rectal cancer—a decade later. The findings, reported in the August 20 issue of the journal Gut, highlight the need for judicious use of this broad category of drugs, which are frequently improperly or overprescribed, the report authors say.
Johns Hopkins researchers report that prurigo nodularis (PN), a skin disease characterized by severely itchy, firm bumps on the skin, may be associated with other inflammatory skin disorders as well as systemic and mental health disorders. Compared with other skin diseases, however, not much is known about PN. While symptoms of PN can be managed, no cures exist. Researchers were looking to determine associated conditions that are more common in patients with PN, compared with similar patients without PN.
In a new study of seven people with Parkinson’s disease, Johns Hopkins Medicine researchers report evidence that deep brain stimulation using electrical impulses jumpstarts the nerve cells that produce the chemical messenger dopamine to reduce tremors and muscle rigidity that are the hallmark of Parkinson’s disease, and increases feelings of well-being.
Scientists from Johns Hopkins and elsewhere have been selected to receive more than $940,000 to study cellular “packages” that can be used to diagnose disease, track disease status and potentially deliver therapies. The packages, called extracellular vesicles, are ubiquitous among all types of human cells and are being studied for their use in cancer, neurocognitive disorders and other conditions.
A new study shows that tumor cells depleted of ARID1A — a protein that acts as a cancer suppressor — become highly sensitive to anticancer poly ADP ribose polymerase (PARP) inhibitor drugs after radiation treatment. The research, led by Johns Hopkins Kimmel Cancer Center researchers, could advance efforts to treat many human cancers with loss of ARID1A that are resistant to current standard treatments, the study team suggests.
Using questionnaire answers from thousands of internal medicine residents, primarily from U.S. training programs, a research team at Johns Hopkins Medicine says it has added to the evidence that bullying of medical trainees is fairly widespread. Bullying affects about 14% of medical trainees overall, but is particularly more prevalent among foreign-born trainees.
Johns Hopkins Community Physicians (JHCP) announced today that it will open an Urbana, Maryland, location in mid-October. The new site’s address is 3501 John Simmons St., near the corner of Worthington Boulevard and Sugarloaf Parkway.
In a study that spanned two and a half decades and looked at data from more than 4,700 participants, Johns Hopkins researchers have added to evidence that abnormal blood pressure in midlife persisting into late life increases the likelihood of developing dementia. Although not designed to show cause and effect, the study suggests that maintaining a healthy blood pressure throughout life may be one way to help decrease one’s risk of losing brain function.
Physicians have long suspected that red blood cell transfusions given to premature infants with anemia may put them in danger of developing necrotizing enterocolitis, or NEC, a potentially lethal inflammatory disease of the intestines. However, solid evidence for the connection has been difficult to obtain in part because of the lack of a practical animal model able to accurately represent what physically occurs when a baby gets NEC.
Mosquitoes can harbor thousands of malaria-causing parasites in their bodies, yet while slurping blood from a victim, they transmit just a tiny fraction of them. In an effort to define precisely the location of the parasite bottleneck, Johns Hopkins Medicine scientists say they have discovered that the parasites are stopped by a roadblock along the escape route in the insect’s spit glands, a barrier that could potentially serve as a novel target for preventing or reducing malarial infection.
In studies in mice, Johns Hopkins Medicine researchers report they have found that bilirubin, a bile pigment most commonly known for yellowing the skin of people with jaundice, may play an unexpected role in protecting brain cells from damage from oxidative stress.
Using genetic tools in mice, researchers at Johns Hopkins Medicine say they have identified a pair of proteins that precisely control when sound-detecting cells, known as hair cells, are born in the mammalian inner ear. The proteins, described in a report published June 12 in eLife, may hold a key to future therapies to restore hearing in people with irreversible deafness.
A new analysis of data on more than 900 Baltimore adults by Johns Hopkins Medicine researchers has linked stressful life experiences among middle-aged women but not men to greater memory decline in later life.
Ketamine has gotten a bad rap as an opioid when there’s plenty of evidence suggesting it isn’t one, Johns Hopkins experts say. They believe this reputation may hamper patients from getting necessary treatment for the kinds of depression that don’t respond to typical antidepressants. In a new paper, the researchers clarify the mechanism behind ketamine’s mechanism of action in hopes of restoring the therapy’s standing among health care professionals and the public.
Heat Safety for Young Athletes Heat illness injuries are preventable, says Raj Deu, M.D., assistant professor of orthopaedic surgery at the Johns Hopkins University School of Medicine. “Ideally, athletes should avoid strenuous exercise in high temperatures,” Deu says. “If that is not possible, then proper preparation with heat acclimatization, maintenance of hydration, multiple breaks from activity and knowledge of medication side effects
Working with mouse and human tissue, Johns Hopkins Medicine researchers report new evidence that a protein pumped out of some — but not all — populations of “helper” cells in the brain, called astrocytes, plays a specific role in directing the formation of connections among neurons needed for learning and forming new memories.
BALTIMORE –The Johns Hopkins Hospital is once again ranked #3 in the nation out of more than 4,600 hospitals reviewed for U.S. News & World Report’s 2019–20 Best Hospitals list, which was released today.
Paul B. Rothman, M.D., dean of the Johns Hopkins University School of Medicine and CEO of Johns Hopkins Medicine, on Wednesday presented 12 East Baltimore neighborhood-based groups with grants designed to help them in their missions of community revitalization, education, employment, health and public safety.
A research team led by experts at the Bloomberg~Kimmel Institute for Cancer Immunotherapy at the Johns Hopkins Kimmel Cancer Center reports favorable five-year survival rates from the first multidose clinical trial of the immunotherapy drug nivolumab (anti-PD-1) as a treatment for patients whose previous therapies failed to stem their advanced melanoma, renal cell carcinoma (RCC) or non-small-cell lung cancer (NSCLC). The study, which followed 270 adult men and women, reports survival rates substantially higher than what was expected from cancer therapies available in 2008 at the start of the clinical trial, including chemotherapies, kinase inhibitors, biologic therapies, antiangiogenic therapies, biologic therapies and other clinical trials.
Delivering two federally approved immunity-altering drugs together significantly extended the lives of mice injected with human ovarian cancer cells, an early proof-of-concept experiment that may advance treatment for the most deadly — although rare — gynecologic malignancy in humans, according to scientists at the Johns Hopkins Kimmel Cancer Center who performed the research.
A team led by Johns Hopkins Kimmel Cancer Center investigators reports that a new laboratory test they developed to identify chemical changes to a group of cancer-related genes can accurately detect which breast tumors are cancerous or benign, and do it in far less time than gold-standard tests on biopsied breast tissue.
Mammal brains — including those of humans — store and recall impressive amounts of information based on our good and bad decisions and interactions in an ever-changing world. Now, in a series of new experiments with mice, scientists at Johns Hopkins Medicine report they have added to evidence that such “decision-based” memories are stored in very particular parts of the brain.
Johns Hopkins Medicine and University of Alabama at Birmingham (UAB) researchers will lead a multicenter, multinational study of acute flaccid myelitis (AFM), the “poliolike” condition affecting children that causes loss of muscle control. The National Institutes of Health’s National Institute of Allergy and Infectious Diseases awarded an approximate $10 million contract to UAB that will fund at least 38 research sites across the United States, Canada, the United Kingdom and Peru.
In a study using yeast cells and data from cancer cell lines, Johns Hopkins University scientists report they have found a potential weak spot among cancer cells that have extra sets of chromosomes, the structures that carry genetic material. The vulnerability, they say, is rooted in a common feature among cancer cells — their high intracellular protein concentrations — that make them appear bloated and overstuffed, and which could be used as possible new targets for cancer treatments.
On an ice hockey team, the players all start off with identical uniforms, skates and a stick. But if you take one of them, add padding, a glove, and a mask; and switch the stick to one with a larger blade, then you get a goalie. Now, the player has morphed — or differentiated — into a one with a specific function: protect the goal from invading pucks.
On June 30, the Centers for Medicare & Medicaid Services (CMS) announced that the Johns Hopkins University School of Medicine has been designated a so-called “qualified provider-led entity.” This allows Johns Hopkins to develop criteria that meet the requirements of the federal Protecting Access to Medicare Act of 2014 when ordering diagnostic imaging tests such as computed tomography (CT) scans
Johns Hopkins Kimmel Cancer Center study coauthors Anne Marie Lennon, Simeon Springer, Marco Dal Molin, Christopher Wolfgang and Bert Vogelstein will participate in a press teleconference organized by the American Association for the Advancement of Science at 11 a.m. Tuesday, July 16. To RSVP, send an email to [email protected]. An audio recording and transcript will be available on the MedPak webpage (eurekalert.org/journls/scitransmed/) at the end of the teleconference.
In a massive new analysis of findings from 277 clinical trials using 24 different interventions, Johns Hopkins Medicine researchers say they have found that almost all vitamin, mineral and other nutrient supplements or diets cannot be linked to longer life or protection from heart disease.
Want to smooth out your wrinkles, erase scars and sunspots, and look years younger? Millions of Americans a year turn to lasers and prescription drugs to rejuvenate their skin, but exactly how that rejuvenation works has never been fully explained. Now, Johns Hopkins researchers have discovered that laser treatments and the drug retinoic acid share a common molecular pathway. Moreover, that pathway — which lets skin cells sense loose RNA molecules — is also turned up in mice when they regenerate hair follicles. Results are described in the June 26 issue of Nature Communications.
For a patient, a diagnostic error can mean the difference between life and death. While estimates vary, likely more than 100,000 Americans die or are permanently disabled each year due to medical diagnoses that initially miss conditions or are wrong or delayed.
To better facilitate research on appropriately determining prognosis after cardiac arrest and to establish better treatments for recovering from brain injury, a working group with neurologist Romer Geocadin and other American Heart Association (AHA) experts have released a scientific statement that provides best practices on how to predict recovery in comatose survivors.
Watching fireworks is a great way to celebrate Independence Day, and most cities have events that safely display fireworks. To avoid life-threatening injuries, Johns Hopkins pediatric surgeon Alejandro Garcia, M.D., says consider attending one of these displays instead of lighting fireworks yourself.
Over the past decades, the idea that all adults should get regularly screened for cancer — with mammograms, colonoscopies and prostate specific antigen blood tests — has been conveyed to the public time after time. But current clinical guidelines recommend against screening many older adults, such as those with less than 10 years’ life expectancy. For doctors, talking to a patient about the idea that they’ve “aged out” of cancer screening can be a challenging conversation.
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