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Study examines the role of small molecule in children with a rare liver disease

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A molecule identified by UCLA researchers helps maintain a healthy balance of cells in airway and lung tissue. If the compound, so far only studied in isolated human and mouse cells, has the same effect in people, it may lead to new drugs to treat or prevent lung cancer.

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UCLA researchers have found that it is possible to assess a person’s ability to feel empathy by studying their brain activity while they are resting rather than while they are engaged in specific tasks.

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In 1988, a 6.9 magnitude earthquake struck near the northern Armenian city of Spitak. The temblor destroyed cities and is estimated to have killed between 25,000 and 35,000 people, many of whom were schoolchildren.

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The emotional distress that often accompanies a breakup is called social pain, and it may cause sadness, depression and loneliness, as well as actual physical pain, research has shown. A study, published recently in the Annals of Behavioral Medicine may have found an antidote – forgiveness combined with acetaminophen, the active ingredient in Tylenol.

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A new study led by researchers UCLA found that treating soft tissue sarcoma with radiation over a significantly shorter period of time is safe, and likely just as effective, as a much longer conventional course of treatment.

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A UCLA-led study reveals a new role for a gene that’s associated with autism spectrum disorder, intellectual disability and language impairment.

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In a UCLA-led phase I clinical trial, a new plant-based drug called APG-157 showed signs of helping patients fight oral and oropharyngeal cancers. These cancers are located in the head and the neck. APG-157 is made up of multiple compounds produced by plants, including curcumin. UCLA Jonsson Comprehensive Cancer Center researchers found that treatment with this botanical drug resulted in high concentrations of curcumin and its byproducts circulating in the blood and absorbed by tumor tissues within three hours after being taken orally.

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An interdisciplinary team of researchers at the UCLA Jonsson Comprehensive Cancer Center has developed a medicated patch that can deliver immune checkpoint inhibitors and cold plasma directly to tumors to help boost the immune response and kill cancer cells.

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A UCLA-led study has found that levels of six proteins in the blood can be used to gauge a person’s risk for cerebral small vessel disease, or CSVD, a brain disease that affects an estimated 11 million older adults in the U.S.

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Using an immunotherapy drug in combination with an infusion of anti-tumor immune cells may produce a stronger immune response that could help fight advanced melanoma.

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An $18 million commitment from the Simms/Mann Family Foundation will support UCLA’s expansion of integrative psychosocial care for people with cancer and their families into communities throughout Southern California.

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The study reveals a detailed epigenetic mechanism for how interleukin-1-beta, a common cytokine that helps fight infections during inflammation, plays a critical role in cancer metastasis.

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UCLA researchers are part of an international team that reported the use of a stem cell gene therapy to treat nine people with the rare, inherited blood disease known as X-linked chronic granulomatous disease, or X-CGD. Six of those patients are now in remission and have stopped other treatments. Before now, people with X-CGD – which causes recurrent infections, prolonged hospitalizations for treatment, and a shortened lifespan – had to rely on bone marrow donations for a chance at remission.

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Rhinoplasty may make a woman appear to be three years younger, machine learning shows

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A new study finds that an interactive voice application using artificial intelligence is as accurate at tracking the wellbeing of patients being treated for serious mental illness as their physicians.

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In a UCLA-led study, children and adolescents with a high risk for developing bipolar disorder stayed healthier for longer periods when their family members participated in their psychotherapy sessions.

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New research from the WORLD Policy Analysis Center at the UCLA Fielding School of Public Health (WORLD) shows that the United States is falling behind its global peers when it comes to guarantees for key constitutional rights. Researchers identified key gaps in the U.S. including guarantees of the right to health, gender equality, and rights for persons with disabilities.

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An international team of researchers led by UCLA’s Paul Boutros, have created a new way to accurately estimate how fast an individual cancer is evolving using open-source software.

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A UCLA-led study revealed a new way to predict which patients with “stable” heart failure — those who have heart injury but do not require hospitalization — have a higher risk of dying within one to three years.

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UCLA Health experts weigh in on the most significant healthcare advances of the last ten years and what exciting developments we can look forward to in the decade ahead.

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UCLA scientists have discovered one reason why autoimmune diseases are more prevalent in women than in men.

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A team led by Dr. Brigitte Gomperts at UCLA has developed a “scar in a dish” model that uses multiple types of cells derived from human stem cells to closely mimic the progressive scarring that occurs in human organs. The researchers used this model to identify a drug candidate that stopped the progression of and even reversed fibrosis in animal models.

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A new study from scientists at UCLA helps explain why some people with advanced cancer may not respond to one of the leading immunotherapies, PD-1 blockade, and how a new combination approach may help overcome resistance to the immunotherapy drug.

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Scientists from 22 institutions, including UCLA, are recommending early diagnosis, prevention and treatment of severe chronic inflammation to reduce the risk of chronic disease and death worldwide.

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UCLA Jonsson Comprehensive Cancer Center researchers have developed a new automated method for testing hundreds of molecules at a time to find out which ones block cancer cells from consuming glucose — the sugars they need to spread and grow.

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UCLA scientists have discovered a link between a protein and the ability of human blood stem cells to self-renew. In a study published today in the journal Nature, the team reports that activating the protein causes blood stem cells to self-renew at least twelvefold in laboratory conditions

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UCLA study finds even a short-term visit to a severely polluted city is bad for your health

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A new screening system developed by scientists at the UCLA Jonsson Comprehensive Cancer Center leverages redundancy in an important component of a cell – nucleotide metabolism – to help identify new drugs that specifically and potently block processes that are essential for cancer cell growth.

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It's Lung Cancer Awareness Month and there are few stories about women who are diagnosed with lung cancer. Here’s one story about a 42-year-old, non-smoking Mom of two who was surprised with a lung cancer diagnosis last Thanksgiving. The story also features tips from a UCLA pulmonologist on the signs and symptoms of lung cancer.

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Ziva Cooper, research director of the UCLA Cannabis Research Initiative, has been awarded a $3.5 million grant from the National Institutes of Health to conduct a five-year study assessing the pain-relieving effects of cannabis and cannabinoids, the chemicals in the cannabis plant.

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UCLA has received $27.2 million from the National Institutes of Health to spearhead the new phase of an initiative to enhance the diversity of the U.S.’s biomedical workforce.

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Dr. Linda Liau, chair of neurosurgery at the David Geffen School of Medicine at UCLA, has been appointed chair of the American Board of Neurological Surgery. She is the first woman to lead the organization in its 80-year history.

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UCLA researcher Sandra Loo was a principal investigator on the study that led to FDA approval of the first non-drug ADHD treatment. In this Q&A, Loo discusses the device and its potential in ADHD treatment.

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Three researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have received awards totaling more than $18 million from the California Institute for Regenerative Medicine, the state’s stem cell agency.

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The prostate cancer program at the UCLA Jonsson Comprehensive Cancer Center and UCLA Health has been awarded an $8.7 million Specialized Program of Research Excellence, or SPORE, grant from the National Cancer Institute.

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Researchers at the UCLA Jonsson Comprehensive Cancer Center have identified a new biomarker using a noninvasive imaging method that tracks mitochondrial activity in lung tumors.

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