Explore how research targeting EP300/CBP protein in Group 3 medulloblastoma may advance targeted pediatric brain tumor treatments by inhibiting bromodomains.
Learn how ancestry changes genetic risk variants’ impact on type 2 diabetes in childhood cancer survivors & alkylating agent exposure magnifies diabetes risk.
Poor metabolic health or dysfunction, not obesity, leads to poor anti-influenza immune responses. Learn about the new St. Jude influenza vaccination research.
Smith is a nationally recognized academic radiologist with expertise in body and oncologic imaging, clinical trials and imaging research and the application of artificial intelligence (AI) in imaging and medicine.
Findings show a newly created drug can prevent runaway inflammation while still allowing the immune system to handle the virus, even when given late into infection.
St. Jude Children’s Research Hospital today announces the survivorship portal, part of the St. Jude Cloud ecosystem, for unparalleled data analysis and visualization.
Recent work by St. Jude Children’s Research Hospital scientists discovered which tumor cells resist treatment and why. By characterizing B-cells’ developmental stages, they designed and tested a drug combination to effectively treat resistant B-cell leukemia.
St. Jude Children’s Research Hospital scientists studying bilateral Wilms tumor found that chemotherapy resistance correlates with tumors favorable to surgery, reducing the need for additional therapy.
St. Jude Children’s Research Hospital scientists reversed an aggressive cancer, reverting malignant cells towards a more normal state.
Scientists at St. Jude Children’s Research Hospital and Dana-Farber Cancer Institute found a small set of proteins that maintain anaplastic large cell lymphoma (ALCL) identity, representing potential future therapeutic targets.
Scientists at St. Jude Children’s Research Hospital showed that the MYCN protein promotes a switch in the cellular state within the tumor microenvironment, with slow-growing mesenchymal cells swapping to the more dangerous and faster-growing adrenergic state.
Researchers from St. Jude Children’s Research Hospital and The University of Tennessee Health Sciences Center discovered two T-cell receptors in a single patient that recognizes the fusion and can guide T cells to kill all tumor cells carrying the hybrid protein in a mouse model.
Scientists at St. Jude Children’s Research Hospital have uncovered a metabolic role for cell-survival protein MCL-1, potentially explaining previous clinical trial setbacks.
St. Jude Children’s Research Hospital scientists showed inhibiting both JAK1 and JAK2 proteins improved hemophagocytic lymphohistiocytosis in models of the inflammatory syndrome.
Jordan will work with researchers to bring a greater number of new technologies, innovations and scientific breakthroughs to the clinic, enabling breakthroughs from St. Jude laboratories to benefit more patients.
Findings from St. Jude Children’s Research Hospital showed a novel dual targeting approach, where a single molecule can recognize two potential cancer-related proteins, is more effective than the single targeting approach, preventing immune escape.
Established clinician researcher will focus on novel treatments and clinical trials for difficult-to-treat childhood cancers.
The initiative aims to provide support for early-career scientists to study pediatric cancer, addressing a funding gap that drives top talent to seek more prevalent opportunities in adult cancer research or the pharmaceutical sector.
As outlined in the 2022-2027 Strategic Plan, the St. Jude Research Collaboratives program is part of an overall effort by the institution to fund collaborative research addressing complex scientific problems with transformative potential for the diseases treated at St. Jude.
The home health agency for St. Jude Children's Research Hospital outpatients earned dual certifications in both pediatrics and home health, the nation’s first such agency to achieve that distinction.
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