Researchers from the Stowers Institute for Medical Research have uncovered new details about several proteins implicated in tumor growth and metastasis, opening a potential avenue for the development of treatments for diseases such as breast cancer.
Small-cell clones in proliferating epithelia – tissues that line all body surfaces – organize very differently than their normal-sized counterparts, according to a recent study from the Stowers Institute for Medical Research. Published online September 5, 2019, in Developmental Cell, these findings from the laboratory of Matthew Gibson, PhD, may contribute to a better understanding of how some human diseases progress.
This October, the Stowers Institute for Medical Research will host a session of the EMBO Laboratory Leadership for Group Leaders Course at its campus in Kansas City, Missouri.
KANSAS CITY, MO—Thanks to super-resolution microscopy, scientists have now been able to unambiguously identify physical associations between human chromosomes. The findings have brought to light a new understanding to a curious observation first made more than 50 years ago. The Stowers Institute for Medical Research scientists probed these physical connections between five of the chromosomes in the human karyotype in a report recently published online in the Journal of Cell Biology.
Researchers from the Stowers Institute for Medical Research have discovered a new function of ribosomes in human cells that may show the protein-making particle’s role in destroying healthy mRNAs, the messages that decode DNA into protein.
Researchers from the Stowers Institute for Medical Research have created a novel way to define individual protein associations in a quick, efficient, and informative way. These findings, published in the March 8, 2019, issue of Nature Communications, show how the topological scoring (TopS) algorithm, created by Stowers researchers, can – by combining data sets – identify proteins that come together.
New research from the Stowers Institute for Medical Research has identified a backup for an important biological system – the hematopoietic system, whose adult stem cells constantly replenish the body’s blood supply.
Researchers at the Stowers Institute for Medical Research have identified "navigator" neurons that are key to setting up connections in the system responsible for the sense of smell. The new study builds on a breakthrough 2014 report from the laboratory of Stowers Investigator Ron Yu, Ph.D., which showed a critical period in olfactory wiring using mice as a model system.
Researchers from the Stowers Institute for Medical Research have opened a window on another piece of evolutionary biology. They have found that Hox genes, which are key regulators of the way the bodies of bilaterally symmetrical animals form, also play a role in controlling the radially symmetric body plan of the starlet sea anemone, Nematostella vectensis.
Researchers from the Stowers Institute for Medical Research and collaborators have identified a way to expand blood-forming, adult stem cells from human umbilical cord blood (hUCB).
Motivated by a desire to better understand the molecular circuitry underlying neuroblastoma and limitations of current methods for predicting disease progression and outcome, researchers from the Kulesa Lab at the Stowers Institute for Medical Research and collaborators at the University of Michigan and Oxford University set out to construct a logic-based model incorporating information about developmental signaling pathways implicated in the disease.
Scientists at the Stowers Institute for Medical Research have identified a physical basis for the spread of corrupted proteins known as prions inside cells. Their research findings are reported in the July 5, 2018, issue of the scientific journal Molecular Cell.
Researchers at the Stowers Institute for Medical Research have captured the one cell that is capable of regenerating an entire organism.
New research from the Stowers Institute for Medical Research reveals that a DNA regulatory element within the Hoxb cluster globally mediates signals to the majority of Hoxb genes to control their expression in blood-forming stem cells.
The Stowers Institute for Medical Research is pleased to announce that Alejandro Sánchez Alvarado, Ph.D., a Stowers and Howard Hughes Medical Institute (HHMI) investigator, has been elected a member of the prestigious National Academy of Sciences (NAS) for his distinguished and continuing achievements in original scientific research.
In a study published online in the journal eLife, the researchers identified a molecular signature of approximately 1300 genes differentially expressed in an aggressive subset of migrating neural crest cells termed as “trailblazers” in a vertebrate model system of development. These genes appear to play a critical role in migration and may be part of a broader molecular signature of cell invasion in a number of phenomena.
Researchers at the Stowers Institute for Medical Research have solved the three-dimensional structure of a complex that is essential for the correct sorting of chromosomes into eggs and sperm during reproductive cell division or meiosis.
Research from the Stowers Institute provides evidence suggesting that cancer cells might streamline their genomes in order to proliferate more easily. The study, conducted in both human and mouse cells, shows that cancer genomes lose copies of repetitive sequences known as ribosomal DNA. While downsizing might enable these cells to replicate faster, it also seems to render them less able to withstand DNA damage.
Researchers from the Stowers Institute for Medical Research in collaboration with Fred Hutchinson Cancer Research Center researchers have identified an unprecedented genetic survival strategy that would be right at home in an Agatha Christie murder mystery novel.
In a study published in the June 5, 2017, issue of the Proceedings of the National Academy of Sciences, Stowers scientists Bony De Kumar, Ph.D., and Robb Krumlauf, Ph.D., provide evidence of direct cross-regulatory feedback, or cross-talk, between Nanog and Hox genes.
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