An interdisciplinary team of scientists at University of Utah Health are using animals' unique traits to pinpoint regions of the human genome that might affect health. The results of this project are available in the March 6 issue of the journal Cell Reports.
University of Utah Health developed the HER Salt Lake Contraceptive Initiative to evaluate women's contraception choices if cost is not a factor. The research findings are published in the February 22 issue of the American Journal of Public Health.
Scientists at University of Utah Health believe they identified a mechanism that activates T cells, a key component of the immune system, which could explain the elusive link between a tick bite and persistent Lyme arthritis. The results are published online in the February 5th issue of The Journal of Immunology.
A new study revealed patients receiving radiofrequency catheter ablation compared to traditional drug therapies for atrial fibrillation (AF), a contributing factor to heart failure, had significantly lower hospitalization and mortality rates. The findings are published in the February 1 issue of the New England Journal of Medicine.
A protein involved in cognition and storing long-term memories looks and acts like a protein from viruses. The protein, called Arc, has properties similar to those that viruses use for infecting host cells, and originated from a chance evolutionary event that occurred hundreds of millions of years ago.
A research team led by scientists at University of Utah Health have developed an online interactive app to help motivate patients to be more physically activity to manage their disease.
Air pollution erodes the health of adults over age 65, a population particularly vulnerable to the effects of pneumonia.
A new cancer treatment technology is one step closer to Salt Lake City. Today Huntsman Cancer Institute (HCI) at the University of Utah (U of U) announced a plan to add a proton therapy center to its Cancer Hospital. Huntsman Cancer Foundation, HCI and the Cancer Hospital have agreed to dedicate the required funding to the project. The plan will now move forward to the next steps of approval, design and vendor selection.
When viruses infect the body’s cells, those cells face a difficult problem. How can they destroy viruses without harming themselves? Scientists at University of Utah Health have found an answer by visualizing a tiny cellular machine that chops the viruses’ genetic material into bits.
University of Utah Health today announced results of the Value in Health Care Survey, a landmark study that examines the viewpoints of patients, physicians and employers—three stakeholder groups that directly receive, provide, and pay for health care. The study explores how these groups perceive value and prioritize its components of quality, service and cost.
A new study by researchers at Huntsman Cancer Institute (HCI) at the University of Utah observed how breast cancer tumors evolve over time and demonstrated how changes within tumors may contribute to the process by which cancers no longer respond to treatment. Further, the research identifies that some of these changes may be shared across certain treatment-resistant breast cancers. The study was published this month in Nature Communications.
A multi-disciplinary team of researchers with expertise in biology, anesthesiology, pharmacology, and medicinal chemistry at U of U Health received a $10 million grant from the Department of Defense to identify new, natural compounds to develop non-opioid drugs for pain management
eople with an inherited syndrome called familial adenomatous polyposis (FAP) have a 100% lifetime risk of developing colorectal cancer if they do not seek appropriate medical care. Recent findings published by researchers at Huntsman Cancer Institute at the University of Utah identified a promising prevention treatment for patients with FAP.
Researchers at University of Utah Health have identified a protein (ARF6) that when inhibited reduces diabetic retinopathy, a condition that results when blood vessels at the back of the eye leak fluid into the eye, impairing vision.
The results of a national cancer survey find a significant number of childhood cancer survivors are worried about keeping their health insurance, to the point of letting it affect their career decisions. The findings were published today in JAMA Oncology.
U.S. Olympic and Paralympic athletes and staff who traveled to Rio de Janeiro, Brazil, for the 2016 Summer Games did not become infected with Zika virus but did test positive for other tropical, mosquito-borne viral infections, including West Nile Virus, Dengue Fever and Chikungunya. Results from the University of Utah Health-led study will be reported at IDWeek, a national infectious disease conference being held in San Diego.
New research from scientists at Huntsman Cancer Institute (HCI) at the University of Utah and collaborators at University of Utah Health (U of U Health) sheds light on the complex process that occurs in the development of human sperm stem cells.
A National Institutes of Health-supported nationwide clinical trial will test a novel approach to combat hearing loss in children infected by a relatively unknown virus, cytomegalovirus (CMV). The University of Utah Health-led study will determine whether antiviral therapy can halt progressive hearing loss in children with a confirmed CMV infection. CMV is the leading non-genetic cause of hearing loss, contributing from 6 to 30 percent of childhood cases.
Researchers at University of Utah Health clarified a molecular pathway responsible for the formation of cleft palate and identified a new treatment to reverse this defect in mouse pups in-utero.
Researchers at the University of Utah Health are collaborating with Janssen Research & Development, LLC (“Janssen”) to identify genetic variations associated with an increased risk for suicide.
Humans, like other animals, become more sensitive to cold with age. Now, scientists from University of Utah Health report that delivering a single dose of a nutritional supplement called L-carnitine to older mice restores a youthful ability to adapt to the cold. After treatment, they tolerate chilly conditions that would ordinarily trigger hypothermia. As reported online in Cell Metabolism, the supplement works by boosting levels of a newly discovered fuel source for brown fat, or “good fat”.
A new study shows radiofrequency catheter ablation lowered hospitalization and mortality rates by 47 and 44 percent respectively in patients with atrial fibrillation (AF), a contributing factor to heart failure.
Researchers at University of Utah Health devised a system that allowed zebrafish to self-administer doses of hydrocodone, an opioid commonly prescribed to people for pain, to study drug dependency.
Early placement of a hormonal IUD is a safe, long-term birth control method that does not negatively affect women who want to breastfeed their baby.
Removing a single gene from the brains of mice and zebrafish causes these animals to become more anxious than normal. Researchers from University of Utah Health show that eliminating the gene encoding Lef1 disrupts the development of certain nerve cells in the hypothalamus that affect stress and anxiety. These results are the first implication that Lef1 functions in this brain region to mediate behavior, knowledge that could one day prove useful for diagnosing and treating human brain disorders.
Two studies provide additional support for lowering systolic blood pressure to an intensive goal of 120 mmHg – far below the standard guidelines of 140 mmHg – to reduce the risk of heart disease in high-risk patients with hypertension. The new research shows that intensive blood pressure control is well-tolerated by patients and is cost-effective in terms of health-related quality of life and financial costs to the healthcare system, and appears online in NEJM on Aug. 24.
Four University of Utah Health researchers will present their research and clinical trial findings, as well as engage in critical discussions around cardiovascular medicine at the 2017 European Society of Cardiology Congress in Barcelona, Spain.
Rena D’Souza, D.D.S., Ph.D., Professor of Dentistry at the University of Utah Health received a grant from the National Institutes of Health (NIH) to build on her past research to characterize the genetics that prevent tooth formation and develop therapies to reverse this process.
Like the rest of the body, the brain loses flexibility with age, impacting the ability to learn, remember, and adapt. Now, scientists at University of Utah Health report they can rejuvenate the plasticity of the mouse brain, specifically in the visual cortex. Published today in PNAS, the study shows that manipulating a single gene triggers the shift, revealing it as a target for new treatments to recover the brain’s youthful potential.
Kensaku Kawamoto, Ph.D., has been appointed to a 3-year term on the U.S. Health Information Technology (HIT) Advisory Committee.
Researchers grow protein crystals on the International Space Station to find antidotes for nerve agents used in conflict zones.
Scientists have had limited success at identifying specific inherited genes associated with prostate cancer. Researchers at University of Utah Health studied prostate cancer patients with multiple cancer diagnoses to identify genetic mutations that may influence cancer treatment and cancer risk.
The American Heart Association (AHA) awarded investigators at University of Utah Health $3.7 million to conduct collaborative research to prevent and treat congenital heart disease. U of U Health is one of four groups across the country to join the AHA’s Strategically Focused Research Network (SFRN) for children.
“Yarraman flu is a virus quickly infecting the US…” The mock announcement was enough to make readers worry. But when the name of the hypothetical illness was changed to “horse flu”, readers reported being less motivated to get a vaccine that would prevent them from contracting the illness. Based on a survey of 16,510 participants from 11 countries, the findings show that the way health information is communicated, matters. The multi-institutional investigation appeared in Emerging Infectious Diseases.
Antibiotics were the wonder drug of the 20th century, but bacteria evolved resistance. According to the CDC, more than 2 million people in the U.S. develop MDR infections every year. Researchers at Univ. of Utah developed a rapid screen to pair existing FDA-approved drugs to combat MDR infections.
Almost 6,000 new cases of acute lymphoblastic leukemia, or ALL, are expected to be diagnosed this year in the United States. Scientists have found up to 30 percent of adult ALL patients have what’s called a Philadelphia chromosome, where two segments of chromosomes have aberrantly fused together. Adult ALL patients exposed to standard treatments often see high relapse rates, and treatment-related deaths remain high. But researchers at Huntsman Cancer Institute (HCI) at the University of Utah have discovered new science, published this week in the journal Leukemia, that could provide better therapeutic options for patients.
This automated machine could reduce a surgical procedure from two hours to two and a half minutes by replacing hand drills for one type of complex cranial surgery.
Our world seems to grow smaller by the day as biodiversity rapidly dwindles, but Mother Earth still has a surprise or two up her sleeve. An international team of researchers were the first to investigate a never before studied species a giant, black, mud dwelling, worm-like animal. The findings will be published online in the Apr. 17 issue of the Proceedings of the National Academy of Sciences.
Scientists report a significant step toward combatting two degenerative brain diseases that chip away at an individual’s ability to move, and think. A targeted therapy developed by scientists at University of Utah Health slows the progression of a condition in mice that mimics a rare disease called ataxia. In a parallel collaborative study, led by researchers at Stanford University, a nearly identical treatment improves the health of mice that model Amyotrophic Lateral Sclerosis (ALS), commonly called Lou Gehrig’s disease.
The University of Utah is one of just five institutions in the world to be awarded a $2.5 million grant to purchase a state of the art cryo-electron microscope (cryo-EM), the Beckman Foundation announced today. The microscope, which will be able to visualize the structure of proteins and DNA at an atom-by-atom scale, will be installed in the Crocker Science Center, currently under construction. The microscope’s resolution is fine enough to see details such as the double-helix and ladder structure of DNA, said biochemistry professor Wesley Sundquist.
Two screening tests often used to try to predict which pregnant women are likely to deliver prematurely aren’t effective in low-risk women, according to a national collaborative study of more than 10,000 women, led by clinician-researchers at University of Utah Health Sciences and Intermountain Healthcare. Researchers found that neither transvaginal cervical measurement or fetal fibronectin tests, used separately or together, adequately predicts preterm birth. The findings are published in March 14 issue of the Journal of the American Medical Association.
During the past decade, the gut has experienced a renaissance as investigations focus on the role of the microbiome on human health. While most studies have focused on bacteria, the dominant microbial inhabitants in the gut, scientists at University of Utah Health Sciences used mouse studies to show the role of yeast in aggravating the symptoms of Inflammatory Bowel Disease (IBD). Their work suggests that allopurinol, a generic drug already on the market, could offer some relief.
It has long been thought that each copy of our DNA instructions - one inherited from mom and one from dad - is treated the same. A new study from scientists at the University of Utah School of Medicine shows that it is not uncommon for cells in the brain to preferentially activate one copy over the other. The finding breaks basic tenants of classic genetics and suggests new ways in which genetic mutations might cause brain disorders.
A tiny snail may offer an alternative to opioids for pain relief. Scientists at the University of Utah have found a compound that blocks pain by targeting a pathway not associated with opioids. Research in rodents indicates that the benefits continue long after the compound have cleared the body.
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