Predicting Drug Safety; Integrating Mechanistic Data in Assessment of Carcinogens; All-Trans Retinoic Acid and Fetal Testicular Development; and More Featured in February 2019 Toxicological Sciences
Issue Also Contains Papers on Developmental Nrf2 Regulation by AHR in Zebrafish; In Vitro Mechanistic Assays and Drug Hepatotoxicity; and Concentrated Ambient Particles and TRPA1
Newswise — The February 2019 issue of Toxicological Sciences features a contemporary review on predicting drug safety and a systematic review, the first in this new article category, on integrating mechanistic data in assessments of potential human carcinogens. There also are highlighted papers on the aryl hydrocarbon receptor, TCDD, and zebrafish; in vitro mechanistic assays and drug hepatotoxicity; concentrated ambient particles and the transient receptor potential cation channel A1 (TRPA1); and retinoic acid and testicular toxicity.
Highlights of Toxicological Sciences Volume 167, Issue 2 include:
- Contemporary Review: Today’s Challenges to Derisk and Predict Drug Safety in Human “Mind-the-Gap”
- Systematic Review: A Framework for Systematic Evaluation and Quantitative Integration of Mechanistic Data in Assessments of Potential Human Carcinogens
- Editor’s Highlight: All-Trans Retinoic Acid Disrupts Development in Ex Vivo Cultured Fetal Rat Testes. I: Altered Seminiferous Cord Maturation and Testicular Cell Fate
- Editor’s Highlight: Ambient Particulate Matter and Acrolein Co-exposure Increases Myocardial Dyssynchrony in Mice via TRPA1
- Editor’s Highlight: Quantitative Systems Toxicology Analysis of In Vitro Mechanistic Assays Reveals Importance of Bile Acid Accumulation and Mitochondrial Dysfunction in TAK-875-Induced Liver Injury
- Editor’s Highlight: Developmental Regulation of Nuclear Factor Erythroid-2 Related Factors (nrfs) by AHR1b in Zebrafish (Danio rerio)
Toxicological Sciences is the official journal of the Society of Toxicology (SOT), a professional and scholarly organization of more than 8,000 scientists from academic institutions, government, and industry representing the great variety of individuals who practice toxicology in the United States and abroad.