WASHINGTON — If Black women begin mammography screening every other year starting at age 40, breast cancer deaths could be reduced by 57 percent compared to starting screening 10 years later according to analyses conducted by a modeling team that is part of the Cancer Intervention and Surveillance Modeling Network (CISNET), funded by the National Cancer Institute.

The analyses are the first to use modeling to elucidate modern breast cancer screening strategies that best achieve equity in screening outcomes and reduce mortality disparities. The research, published October 19, 2021 in Annals of Internal Medicine, suggests that a reduction in breast cancer deaths can be achieved for Black women while maintaining the same ratio of  benefits to harms as occur when white women undergo biennial screening starting at age 50. Recommendations over the past two decades have not accounted for the role of racism (structural, interpersonal, or internalized) and its impact in breast cancer treatment, length of survival and deaths among Black women. 

"There is an increasing focus on eliminating race-based medicine,” explains the study’s lead author Christina Hunter Chapman, MD, MS, adjunct assistant professor in the Department of Radiation Oncology at the University of Michigan. “However, calls to end race-based medicine that ask for the immediate cessation of any discussion on race are not likely to eliminate racial disparities. Carefully selected solutions for health inequity may involve tailoring interventions to specific racial groups.”

To address this issue, CISNET developed a model using self-reported race as a proxy for who is likely to experience the effects of racism to test a range of screening strategies. The model also considered breast density, distribution of breast cancer molecular subtypes, age-, stage-, and subtype-specific treatment effects, and non-breast cancer mortality for Blacks and whites. Using all of these data, the model compared the benefits and harms of different screening strategies in Black women to those for white women screened biennially from ages 50-74.

“For Black women, three biennial screening strategies (beginning at age 40, 45, or 50) yielded benefit-to-harm ratios that were greater than or equal to those seen in white women who started screening at age 50,” explains Chapman. “Among those three strategies, initiating mammograms at age 40 yielded the greatest mortality reduction and reduced Black-white mortality disparities by 57 percent. This approach is consistent with the US Preventive Services Task Force's overarching guidance for when women may want to consider beginning biennial mammography.”

The model the researchers used projected the lifetime impact of digital mammography under different starting ages and intervals between screenings for women who would be age 40 in the year 2020 (i.e., born in the U.S. in 1980). It compared a variety of benefits (number of years of life gained by detecting cancer early, breast cancer deaths averted and mortality reduction) to harms like undergoing a larger number of mammograms (e.g., annual vs. every other year screening) and having false positive screening results. 

“Black women have higher rates of aggressive cancers at younger ages than white women, and treatments for those types of tumors are not as effective. However, even when we account for cancer subtypes, mortality is higher for black women largely due to factors that are ultimately rooted in racism,” says the study’s senior author, Jeanne S. Mandelblatt, MD, MPH, professor of oncology and medicine at Georgetown Lombardi Comprehensive Cancer Center, and a principal investigator with CISNET.

“Therefore, in our analyses we accounted for differences in treatment attributable to racism, including access to medication, delays in treatment, dose reductions, and discontinuation of treatment -- all factors that have been shown to be sub-optimal more often in Black than white women,” she adds. 

“We hope this provides new information to help develop equity-focused recommendations for Black women and address a long-standing deficit in breast cancer screening guidelines due to the lack of data,”  Mandelblatt states.

“In the future, the harms of racism in medicine may be better rectified by developing interventions that use more direct measures of racism as instead of race,” Chapman concludes. “However, using socioeconomic status alone as a proxy for race would not be appropriate in a study like ours given that racial disparities in breast cancer are observed across socioeconomic strata."

"This project highlights how CISNET modeling can provide important new data to guideline groups seeking to increase equity in cancer outcomes,” says Brandy Heckman-Stoddard, Ph.D., chief, Breast and Gynecologic Cancer Research Group at the National Cancer Institute. “It also points to the need to continue to capture data on screening practices across diverse populations."  



Additional authors include Christopher J. Cadham at Georgetown Lombardi; Reshma Jagsi at the University of Michigan, Ann Arbor; Amy Trentham-Dietz and Ronald E. Gangnon at the University of Wisconsin-Madison; and Clyde B. Schechter at Albert Einstein College of Medicine, Bronx, New York.

The authors report having no personal financial interests related to the study.

This research was funded by National Cancer Institute grants U01CA199218, U01C1199218-02, and P30CA046592. The research was also supported in part by the National Cancer Institute grant R35CA197289 to Mandelblatt and P30CA014520 to Trentham-Dietz. Selected data collection and sharing were supported by the National Cancer Institute-funded Breast Cancer Surveillance Consortium.

Chapman, CH, et al.  Annals of Internal Medicine, (https://www.acpjournals.org/doi/10.7326/M20-6506)

About Georgetown Lombardi Comprehensive Cancer Center
Georgetown Lombardi Comprehensive Cancer Center is designated by the National Cancer Institute (NCI) as a comprehensive cancer center. A part of Georgetown University Medical Center, Georgetown Lombardi is the only comprehensive cancer center in the Washington D.C. area. It serves as the research engine for MedStar Health, Georgetown University’s clinical partner. Georgetown Lombardi is also an NCI recognized consortium with John Theurer Cancer Center/Hackensack Meridian Health in Bergen County, New Jersey. The consortium reflects an integrated cancer research enterprise with scientists and physician-researchers from both locations. Georgetown Lombardi seeks to improve the diagnosis, treatment, and prevention of cancer through innovative basic, translational and clinical research, patient care, community education and outreach to service communities throughout the Washington region, while its consortium member John Theurer Cancer Center/Hackensack Meridian Health serves communities in northern New Jersey. Georgetown Lombardi is a member of the NCI Community Oncology Research Program (UG1CA239758). Georgetown Lombardi is supported in part by a National Cancer Institute Cancer Center Support Grant (P30CA051008). Connect with Georgetown Lombardi on Facebook (Facebook.com/GeorgetownLombardi) and Twitter (@LombardiCancer).

About Georgetown University Medical Center
Georgetown University Medical Center (GUMC) is an internationally recognized academic health and science center with a four-part mission of research, teaching, service and patient care (through MedStar Health). GUMC’s mission is carried out with a strong emphasis on public service and a dedication to the Catholic, Jesuit principle of cura personalis -- or “care of the whole person.” The Medical Center includes the School of Medicine and the School of Nursing & Health Studies, both nationally ranked; Georgetown Lombardi Comprehensive Cancer Center, designated as a comprehensive cancer center by the National Cancer Institute; and the Biomedical Graduate Research Organization, which accounts for the majority of externally funded research at GUMC including a Clinical and Translational Science Award from the National Institutes of Health.  Connect with GUMC on Facebook  (Facebook.com/GUMCUpdate) and Twitter (@gumedcenter).


Journal Link: Annals of Internal Medicine