Curated News: National Cancer Institute (NCI)

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25-Aug-2023 11:05 AM EDT
Study could help explain why certain brain tumors don’t respond well to immunotherapy
University of California, Los Angeles (UCLA), Health Sciences

A study led by researchers at the UCLA Jonsson Comprehensive Cancer Center sheds new light on why tumors that have spread to the brain from other parts of the body respond to immunotherapy while glioblastoma, an aggressive cancer that originates in the brain, does not.

Newswise: Enhancing Immune Defenses: Researchers Unveil the Secrets of Specialized T Cells to Conquer Tumors
28-Aug-2023 7:00 PM EDT
Enhancing Immune Defenses: Researchers Unveil the Secrets of Specialized T Cells to Conquer Tumors
University of California San Diego

Immunologists have uncovered new approaches to enhance protection from tumors and infections.

14-Aug-2023 7:05 PM EDT
Immunotherapy drug combo helps extend the lives of patients with metastatic melanoma
University of California, Los Angeles (UCLA), Health Sciences

A research team co-led by UCLA investigators has shown that an immunotherapy drug combination can be an effective second-line therapy for patients with an aggressive and deadly type of melanoma that is resistant to the widely used immunotherapy drugs known as PD-1 inhibitors.

Released: 17-Aug-2023 10:00 AM EDT
Moffitt Awarded $5.5 Million to Study Virus-Associated Tumors Among Those Living with HIV in Sub-Saharan Africa
Moffitt Cancer Center

The Center for Immunization and Infection Research in Cancer at Moffitt Cancer Center is expanding its viral infection research in Africa. The cancer center has received a $5.5 million, five-year specialized research center grant (U54CA277834) from the National Cancer Institute to investigate virus-associated tumors that disproportionately impact men and women living with HIV in sub-Saharan Africa.

Released: 17-Aug-2023 8:45 AM EDT
Sylvester Comprehensive Cancer Center Tip Sheet - August 2023
Sylvester Comprehensive Cancer Center

New research shows blood cancers are often misdiagnosed, an NCI grant to develop a urine test for prostate cancer, a surgeon-scientist receives Sylvester’s first DoD grant to study pancreatic cancer, bolstering emergency preparedness for climate-driven disasters, and more are included in this month’s tip sheet .

Released: 17-Aug-2023 8:40 AM EDT
UC Irvine-led study links low-dose radiation to higher cancer risk
University of California, Irvine

Long-term exposure to low-dose radiation is linked to an increased risk of cancer, according to a study led by the University of California, Irvine. In the U.S., radiation exposure for the average person doubled between 1985 and 2006, mainly from medical imaging procedures such as CT scans, highlighting the need for its judicious use.

Released: 15-Aug-2023 11:35 AM EDT
Moffitt Researchers Use Mathematical Modeling and Dynamic Biomarkers to Characterize Metastatic Disease During Adaptive Therapy
Moffitt Cancer Center

In a new study published and included on the cover of the journal Cancer Research, Moffitt Cancer Center researchers demonstrate how mathematical modeling combined with dynamic biomarkers can be used to characterize metastatic disease and identify appropriate therapeutic approaches to improve patient outcomes.

Newswise: Sylvester Researcher Leads NCI Grant to Develop Urine Test to Lessen Need for Invasive Biopsies in Prostate Cancer Detection
Released: 15-Aug-2023 8:45 AM EDT
Sylvester Researcher Leads NCI Grant to Develop Urine Test to Lessen Need for Invasive Biopsies in Prostate Cancer Detection
Sylvester Comprehensive Cancer Center

A study to explore a new way to noninvasively detect prostate cancer is under way at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine. The $2.5 million, five-year National Cancer Institute (NCI) grant is led by Sanoj Punnen, M.D.

Released: 14-Aug-2023 4:05 PM EDT
Scientists reveal how proteins drive growth of multiple cancer types
Washington University in St. Louis

Led by Washington University School of Medicine in St. Louis and other institutions around the world, the Clinical Proteomic Tumor Analysis Consortium has completed a deep analysis of the proteins driving cancer across multiple tumor types, information that can’t be assessed by genome sequencing alone. Understanding how proteins operate in cancer cells raises the prospect of new therapies.

Released: 14-Aug-2023 11:25 AM EDT
Study shows a new approach to target a deadly form of prostate cancer
Michigan Medicine - University of Michigan

A study from the University of Michigan Rogel Cancer Center uncovers a new mechanism to explain why some prostate tumors switch from a common, treatable form to a more rare and aggressive form of prostate cancer.

Newswise: Sanford Burnham Prebys Cancer Center earns merit extension from NCI
Released: 9-Aug-2023 4:05 PM EDT
Sanford Burnham Prebys Cancer Center earns merit extension from NCI
Sanford Burnham Prebys

Sanford Burnham Prebys’ Cancer Center has received a rare and prestigious Merit Extension Award from the National Cancer Institute (NCI), recognizing and rewarding its earlier accomplishments as well as current research plans. The award extends the center’s current 5-year Cancer Center Support Grant (CCSG) for an additional two years.

Newswise: New Yale Study Shows Aerobic Exercise Relieves Pain for Ovarian Cancer Survivors
Released: 7-Aug-2023 11:30 AM EDT
New Yale Study Shows Aerobic Exercise Relieves Pain for Ovarian Cancer Survivors
Yale Cancer Center/Smilow Cancer Hospital

One common side effect of treatment for ovarian cancer is chemotherapy-induced peripheral neuropathy (CIPN), which can damage peripheral nerves, causing severe pain and numbness. The effects can last for months – or even years — after completing chemotherapy. Currently, there is only one treatment with limited efficacy for CIPN.

Newswise: Researcher Leads NCI Grant to Develop Urine Test to Lessen Need for Invasive Biopsies in Prostate Cancer Detection
Released: 7-Aug-2023 11:10 AM EDT
Researcher Leads NCI Grant to Develop Urine Test to Lessen Need for Invasive Biopsies in Prostate Cancer Detection
University of Miami Health System, Miller School of Medicine

Sanoj Punnen, M.D., co-chair of the Genitourinary Site Disease Group at Sylvester Comprehensive Cancer Center and associate professor and vice chair of research, Desai Sethi Urology Institute, at the University of Miami Miller School of Medicine, is leading a $2.5 million, five-year National Cancer Institute (NCI) grant to explore a new way to noninvasively detect prostate cancer.

Newswise: New grant seeks to parse how the variegated nature of human breast cancer tumors helps cancer cells resist treatment
Released: 4-Aug-2023 8:00 AM EDT
New grant seeks to parse how the variegated nature of human breast cancer tumors helps cancer cells resist treatment
Sanford Burnham Prebys

The National Cancer Institute (NCI) has awarded a 5-year, $2.7 million grant to researchers at Sanford Burnham Prebys to investigate and elucidate the underlying cellular mechanisms that drive the most common form of breast cancer.

Newswise: Ovarian Cancer: New Biological Markers Found That May Predict Which Patients Won't Respond to Chemotherapy
31-Jul-2023 7:50 PM EDT
Ovarian Cancer: New Biological Markers Found That May Predict Which Patients Won't Respond to Chemotherapy
Mount Sinai Health System

Using a novel proteogenomic strategy and a variety of machine learning tools, investigators from the Icahn School of Medicine at Mount Sinai and colleagues have identified a 64-protein signature that may predict a subset of ovarian cancer patients who are unlikely to respond to chemotherapy. The multicenter study, published online August 3 in Cell, reports on a pioneering analysis of chemo-refractoriness in high-grade serous ovarian cancer (HGSOC). The work also implicates possible therapeutic targets for these patients.

2-Aug-2023 6:05 PM EDT
Major Ovarian Cancer Discovery; Findings Published in Cell
University of Arkansas for Medical Sciences

The Birrer Laboratory at the University of Arkansas for Medical Sciences (UAMS) Winthrop P. Rockefeller Cancer Institute helped discover a proteogenomic signature in ovarian cancer that may improve the way the disease is treated around the world. The discovery, which identifies a 64-protein-gene signature that can predict primary treatment resistance in patients with high grade ovarian cancer, was published Aug. 3 in the journal Cell.

Newswise: Bladder Cancer: Cedars-Sinai Begins Project to Study Sex Differences
Released: 2-Aug-2023 10:45 AM EDT
Bladder Cancer: Cedars-Sinai Begins Project to Study Sex Differences
Cedars-Sinai

Cedars-Sinai Cancer investigators are spearheading a project, funded by a five-year, $11.2 million grant from the National Cancer Institute, part of the National Institutes of Health, to advance scientific knowledge of how biological differences between men and women affect bladder cancer.

Newswise: Children’s Hospital Los Angeles Researcher to Lead First-Ever International Liquid Biopsy Retinoblastoma Study
Released: 1-Aug-2023 6:05 AM EDT
Children’s Hospital Los Angeles Researcher to Lead First-Ever International Liquid Biopsy Retinoblastoma Study
Children's Hospital Los Angeles

The National Cancer Institute of the National Institutes of Health (NIH) has awarded Dr. Berry $2.8 million to lead the first prospective international retinoblastoma liquid biopsy study to date.

Newswise: Transcription Factors Contribute to Subtypes of Colorectal Cancers
Released: 27-Jul-2023 11:05 AM EDT
Transcription Factors Contribute to Subtypes of Colorectal Cancers
Johns Hopkins Medicine

New research in colorectal cancers directed by investigators at the Johns Hopkins Kimmel Cancer Center suggests that expression of transcription factors — proteins that help turn specific genes on or off by binding to nearby DNA — may play a central role in the degree of DNA methylation across the genome, contributing to the development of different subtypes of these cancers. Methylation is a process in which certain chemical groups attach to areas of DNA that guide genes’ on/off switches.

Newswise: New RNA-based Therapy Combats Melanoma in Mouse Models
24-Jul-2023 11:30 AM EDT
New RNA-based Therapy Combats Melanoma in Mouse Models
Mount Sinai Health System

Investigators at the Icahn School of Medicine at Mount Sinai have designed an innovative RNA-based strategy to activate dendritic cells—which play a key role in immune response—that eradicated tumors and prevented their recurrence in mouse models of melanoma.

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This news release is embargoed until 26-Jul-2023 5:00 PM EDT Released to reporters: 26-Jul-2023 3:05 PM EDT

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Newswise: PSMA PET imaging improves accuracy of predicting prostate cancer recurrence
Released: 25-Jul-2023 10:55 AM EDT
PSMA PET imaging improves accuracy of predicting prostate cancer recurrence
University of California, Los Angeles (UCLA), Health Sciences

A molecular imaging tool developed by researchers at UCLA and UCSF, helps improve the accuracy of predicting the risk of cancer recurrence in patients with intermediate to high-risk prostate cancer who undergo surgery.

18-Jul-2023 10:20 AM EDT
CHOP and Penn Researchers Find Behavioral Economics Strategies Can Help Patients Quit Smoking After a Cancer Diagnosis
Children's Hospital of Philadelphia

Researchers found that cancer patients who continued to smoke after their diagnosis were significantly more likely to receive treatment for tobacco use when “nudges” to provide tobacco treatment were directed at clinicians through the electronic health record.

Released: 12-Jul-2023 10:25 AM EDT
Gene mutations linked to hereditary kidney cancer predisposition but potential Achilles' heel identified
University of California, Los Angeles (UCLA), Health Sciences

Researchers at the UCLA Jonsson Comprehensive Cancer Center have confirmed that a large number of genetic variants of unknown significance are in fact verified mutations that predispose patients to a rare hereditary syndrome that increases the risk of kidney cancer.

Newswise: Missing a Rare Cause of Hereditary Cancer
Released: 12-Jul-2023 8:25 AM EDT
Missing a Rare Cause of Hereditary Cancer
Cedars-Sinai

New research from Cedars-Sinai Cancer investigators could warrant reconsideration of current screening guidelines to include a poorly recognized cause of Lynch syndrome, the most common cause of hereditary colorectal and endometrial cancers.

Newswise: Changing the way we deliver immune-based cancer drugs could reduce costs by 14%
Released: 11-Jul-2023 11:45 AM EDT
Changing the way we deliver immune-based cancer drugs could reduce costs by 14%
Michigan Medicine - University of Michigan

A new analysis finds that up to millions of dollars could be saved annually on cancer immunotherapy treatments across the Veterans Health Administration by reconsidering how those drugs are delivered.

Newswise: 10 Quick Facts about Sarcoma, one of the Rarest Cancers
Released: 7-Jul-2023 2:20 PM EDT
10 Quick Facts about Sarcoma, one of the Rarest Cancers
Rutgers Cancer Institute of New Jersey

Sarcoma can be a difficult disease to detect and is often called ‘the forgotten cancer,’ that can grow in connective tissue like bones, nerves, muscles, tendons, cartilage and blood vessels of the arms and legs. It causes abdominal pain, lump, bone pain, and weight loss, and makes up approximately 1 percent of all adult cancer diagnoses. Understanding more about this disease can help people to identify it early. Learn more about Sarcoma in this blog.

Newswise: Preclinical Studies Led by Johns Hopkins Medicine Researchers Advance Potential New Target to Treat HIV Infection
Released: 6-Jul-2023 12:05 PM EDT
Preclinical Studies Led by Johns Hopkins Medicine Researchers Advance Potential New Target to Treat HIV Infection
Johns Hopkins Medicine

Researchers at Johns Hopkins Medicine, in collaboration with researchers at the National Institutes of Health, report that two new studies in mice with a humanized immune system and human cell lines have identified an enzyme that plays a critical role in the late stages of HIV replication.

Newswise: New single-cell study provides novel insights into gastric cancer
6-Jul-2023 10:40 AM EDT
New single-cell study provides novel insights into gastric cancer
University of Texas MD Anderson Cancer Center

A single-cell study led by MD Anderson researchers and published in Cancer Cell provides a deeper understanding of the evolution of the tumor microenvironment during gastric cancer progression.

Released: 5-Jul-2023 9:30 AM EDT
Moffitt Investigates Association between Inflammation and Treatment Related Symptoms in Gynecologic Cancers
Moffitt Cancer Center

Moffitt Cancer Center researchers having been investigating what may trigger treatment related symptoms in patients with gynecologic cancers. In a new study published in the journal Cancers, they evaluated the relationship between inflammatory biomarkers and self-reported treatment related symptoms among this patient population.

27-Jun-2023 4:00 PM EDT
Blood test aids in predicting lung cancer mortality risk
University of Texas MD Anderson Cancer Center

A blood-based four-protein panel (4MP), when combined with a lung cancer risk model (PLCOm2012), can better identify those at high risk of dying from lung cancer than the current U.S. Preventive Services Task Force (USPSTF) criteria.

Newswise: Rogel Cancer Center awarded $37M from NCI
Released: 27-Jun-2023 10:50 AM EDT
Rogel Cancer Center awarded $37M from NCI
Michigan Medicine - University of Michigan

The National Cancer Institute has awarded the University of Michigan Rogel Cancer Center a grant worth $37 million over five years. At the same time, the center’s designation as a “comprehensive cancer center” was renewed.

Newswise: AI model could help improve outcomes of prostate cancer focal therapy
Released: 27-Jun-2023 9:00 AM EDT
AI model could help improve outcomes of prostate cancer focal therapy
University of California, Los Angeles (UCLA), Health Sciences

A new study shows that an artificial intelligence (AI) model co-developed by researchers in the UCLA Jonsson Comprehensive Cancer Center and department of Urology at UCLA can help doctors determine the extent of cancer within the prostate.

   
Released: 26-Jun-2023 12:05 PM EDT
UCLA researchers uncover potential biomarkers of positive response to immunotherapy
University of California, Los Angeles (UCLA), Health Sciences

Scientists at the UCLA Jonsson Comprehensive Cancer Center have identified potential new biomarkers that could indicate how someone diagnosed with metastatic melanoma will respond to immunotherapy treatment.

Newswise: Study Sets New Standard for Graft-Versus-Host Disease Prevention After Stem Cell Transplant
Released: 22-Jun-2023 1:15 PM EDT
Study Sets New Standard for Graft-Versus-Host Disease Prevention After Stem Cell Transplant
Johns Hopkins Medicine

Clinicians have a new standard for graft-versus-host disease (GVHD) prevention after allogeneic hematopoietic stem cell transplantation, according to results from a phase III study published in the New England Journal of Medicine. The new standard is more effective at preventing GVHD and came with less side effects, compared with the current gold standard.

Newswise: Bringing the Power Of
Released: 22-Jun-2023 11:45 AM EDT
Bringing the Power Of "Multiplex" Imaging to Clinical Pathology
Ludwig Cancer Research

Researchers at the Ludwig Center at Harvard have developed a platform technology for imaging that enables integration of the methods of microscopic analysis long employed in pathology laboratories with the visualization of multiple molecular markers in individual cells that is now rapidly advancing in research labs.

   
Newswise: A New Tool for Diagnosing Cancer
15-Jun-2023 3:40 PM EDT
A New Tool for Diagnosing Cancer
Harvard Medical School

A team led by researchers at Harvard Medical School has developed a new tool that promises to improve the way pathologists see and evaluate a tumor by providing detailed clues about the cancer.

Newswise: Breakdown of ‘protective mechanisms’ can drive lung cancer development
Released: 22-Jun-2023 10:45 AM EDT
Breakdown of ‘protective mechanisms’ can drive lung cancer development
Van Andel Institute

Loss of two key “protector” proteins initiates epigenetic changes that transform healthy lung cells into cancerous ones, according to new research from Van Andel Institute scientists.

Newswise: Scientists develop universal donor stem cell therapy to treat degenerative brain diseases in a preclinical study
Released: 15-Jun-2023 5:10 PM EDT
Scientists develop universal donor stem cell therapy to treat degenerative brain diseases in a preclinical study
City of Hope

Scientists at City of Hope have developed universal donor stem cells that could one day provide lifesaving therapy to children with lethal brain conditions, such as Canavan disease, as well as to people with other degenerative diseases, such as Alzheimer’s and multiple sclerosis.

Newswise: Manipulating mitochondrial shape may limit metastatic cancer, UT Southwestern study finds
Released: 14-Jun-2023 10:05 AM EDT
Manipulating mitochondrial shape may limit metastatic cancer, UT Southwestern study finds
UT Southwestern Medical Center

Mitochondria that power cellular activity fragment and change shape in breast cancer cells that migrate to the brain, an adaptation that appears necessary for the cells to survive, UT Southwestern Medical Center researchers report in a new study. The findings, published in Nature Cancer, could lead to new ways to prevent brain metastases, or the spread of cells from primary tumors to the brain.

Newswise:Video Embedded rideshare-removes-hurdle-to-colonoscopy-pilot-study-shows
VIDEO
Released: 13-Jun-2023 5:35 PM EDT
Rideshare removes hurdle to colonoscopy, pilot study shows
University of Washington School of Medicine and UW Medicine

In prior studies, explained senior author Dr. Rachel Issaka, transportation was cited as one of the main barriers to completing a colonoscopy. Issaka directs the UW Medicine/Fred Hutch Population Health Colorectal Cancer Screening Program and is an assistant professor of medicine, Division of Gastroenterology, at the University of Washington School of Medicine.

Released: 12-Jun-2023 2:10 PM EDT
Research sheds light on low rates of genetic testing for cancer
Michigan Medicine - University of Michigan

Not enough people are getting genetic testing for cancer, according to recent research.

Released: 9-Jun-2023 7:05 AM EDT
Treatment decisions in new era of individualized therapy for metastatic hormone-sensitive prostate cancer guided by Dana-Farber case study
Dana-Farber Cancer Institute

This case study by Dana-Farber gives evidence-based guidance for how to navigate decision-making for individual patients with metastatic hormone-sensitive prostate cancer.

Newswise: How the combination of advanced ultrasound and AI could upgrade cancer diagnostics
Released: 6-Jun-2023 9:20 AM EDT
How the combination of advanced ultrasound and AI could upgrade cancer diagnostics
National Institute of Biomedical Imaging and Bioengineering

Researchers have shown that an automated cancer diagnostic method, which pairs cutting-edge ultrasound techniques with artificial intelligence, can accurately diagnose thyroid cancer, of which there are more than 40,000 new cases every year.

   
31-May-2023 7:15 PM EDT
Personalizing Prostate Cancer Screening May Improve the Accuracy of Detection
University of California, San Francisco (UCSF)

The accuracy of prostate-specific antigen (PSA) screening for prostate cancer can be improved by accounting for genetic factors that cause changes in PSA levels that are not associated with cancer, according to a multi-center study led by UC San Francisco and Stanford University, publishing June 1 in Nature Medicine.

Newswise: Pan-cancer T cell atlas reveals new details of tumor microenvironment
26-May-2023 9:55 AM EDT
Pan-cancer T cell atlas reveals new details of tumor microenvironment
University of Texas MD Anderson Cancer Center

A new study led by researchers at The University of Texas MD Anderson Cancer Center, published today in Nature Medicine, provides a deeper understanding of the vast diversity of T cell states as well as their relationships and roles within the complex tumor microenvironment, bringing a fresh perspective to understanding immunotherapy efficacy in cancer.

Newswise: Markey Cancer Center's NCI designation: A decade of impact on cancer research
Released: 25-May-2023 8:05 AM EDT
Markey Cancer Center's NCI designation: A decade of impact on cancer research
University of Kentucky

When the University of Kentucky Markey Cancer Center earned a designation the National Cancer Institute (NCI) in 2013, it instantly established Markey as one of the top cancer research centers in the U.S.The distinction is only awarded to centers that meet the NCI’s rigorous standards for research in cancer treatment, diagnosis and prevention.

Newswise: SWI/SNF complexes “bookmark” cell identity during division
Released: 24-May-2023 11:15 AM EDT
SWI/SNF complexes “bookmark” cell identity during division
St. Jude Children's Research Hospital

Read about how Scientists at St. Jude determined how the SWI/SNF chromatin remodeling complex helps cancer cells remember how to be cancerous after division.

Released: 23-May-2023 1:20 PM EDT
Few Adult Smokers and Nonsmokers Think E-Cigarettes Have Lower Levels of Harmful Chemicals Than Cigarettes
Rutgers University-New Brunswick

About half of cigarette smokers and young adult non-smokers think that nicotine-based electronic cigarettes have the same amount or even more harmful chemicals than regular tobacco-based cigarettes, according to a Rutgers study.



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