University of Minnesota

U of M trial shows hydroxychloroquine does not prevent COVID-19 in health care workers

First randomized clinical trial to evaluate hydroxychloroquine as pre-exposure prophylaxis in health care workers
22-Oct-2020 2:10 PM EDT, by University of Minnesota

Newswise — University of Minnesota Medical School physician researchers studied hydroxychloroquine as a treatment to prevent COVID-19 for those with high-risk for exposure to the virus - health care workers.

The pre-exposure prophylaxis trial results, which were published in Clinical Infectious Diseases, determined that taking 400mg of hydroxychloroquine once or twice weekly did not prevent the development of COVID-19 in health care workers better than the placebo.

"This randomized placebo-controlled trial launched on April 6, with the objective of evaluating whether or not hydroxychloroquine taken once or twice weekly in health care workers at high risk for COVID-19 exposure could prevent COVID-19 infection," said principal investigator Radha Rajasingham, MD, an infectious diseases physician and researcher at the U of M Medical School.

The double-blind trial enrolled 1,483 health care workers and first responders from across the U.S. and Canada. Participants were randomly assigned to receive once-weekly hydroxychloroquine, twice-weekly hydroxychloroquine or placebo. Participants were followed for a minimum of four weeks and up to twelve weeks to evaluate who developed COVID-19.

Overall, 7.9% assigned the placebo developed COVID-19, while 5.9% assigned hydroxychloroquine developed COVID-19. Those results were not statistically significant, meaning there was not a meaningful difference between hydroxychloroquine and the placebo. Side effects were reported in 21% of participants assigned the placebo; 31% in the once-weekly hydroxychloroquine group and 36% in the twice-weekly hydroxychloroquine group. The most common side effects were nausea, upset stomach and diarrhea. There was no increased risk of serious side effects or cardiac complications from taking hydroxychloroquine compared to the placebo.

###

The research team from the University of Minnesota included David Boulware, MD, MPH; Sarah Lofgren, MD; Caleb Skipper, MD; and Matthew Pullen, MD, from the U of M Medical School; statisticians Ananta Bangdiwala, Nicole Engen and Kathy Hullsiek, PhD, from the U of M School of Public Health, Melanie Nicol, PharmD, PhD, from the U of M College of Pharmacy, among many students and trainees. The study was in collaboration with colleagues at Vanderbilt University and Oregon Health & Science University.

About the University of Minnesota Medical School

The University of Minnesota Medical School is at the forefront of learning and discovery, transforming medical care and educating the next generation of physicians. Our graduates and faculty produce high-impact biomedical research and advance the practice of medicine. Visit med.umn.edu to learn how the University of Minnesota is innovating all aspects of medicine.

SEE ORIGINAL STUDY




Filters close

Showing results

110 of 4204
Newswise: Pediatric ER Saw Steep Drop in Asthma Visits During Spring COVID-19 Lockdown
1-Dec-2020 8:00 AM EST
Pediatric ER Saw Steep Drop in Asthma Visits During Spring COVID-19 Lockdown
American Thoracic Society (ATS)

A new study published online in the Annals of the American Thoracic Society discusses a steep drop off from prior years in asthma-related emergency department (ED) visits at Boston Children’s Hospital during the spring 2020 COVID-19 surge and lockdown.

access_time Embargo lifts in 2 days
Embargo will expire: 9-Dec-2020 4:00 PM EST Released to reporters: 3-Dec-2020 4:50 PM EST

A reporter's PressPass is required to access this story until the embargo expires on 9-Dec-2020 4:00 PM EST The Newswise PressPass gives verified journalists access to embargoed stories. Please log in to complete a presspass application. If you have not yet registered, please Register. When you fill out the registration form, please identify yourself as a reporter in order to advance to the presspass application form.

access_time Embargo lifts in 2 days
Embargo will expire: 9-Dec-2020 4:00 PM EST Released to reporters: 3-Dec-2020 3:50 PM EST

A reporter's PressPass is required to access this story until the embargo expires on 9-Dec-2020 4:00 PM EST The Newswise PressPass gives verified journalists access to embargoed stories. Please log in to complete a presspass application. If you have not yet registered, please Register. When you fill out the registration form, please identify yourself as a reporter in order to advance to the presspass application form.

Newswise: 250384_web.jpg
Released: 3-Dec-2020 3:05 PM EST
Study finds COVID-19 hindering US academic productivity of faculty with young children
University of Tennessee Health Science Center

The academic productivity of higher education faculty In the United States in the science, technology, engineering, mathematics, and medicine (STEMM) fields with very young children suffered as a result of the stay-at-home orders during the early months of the coronavirus pandemic, according to a new study by researchers at the University of Tennessee Health Science Center, the University of Florida College of Medicine, and the University of Michigan School of Medicine.

Released: 3-Dec-2020 2:50 PM EST
Kidney disease leading risk factor for COVID-related hospitalization
Geisinger Health System

An analysis of Geisinger's electronic health records has revealed chronic kidney disease to be the leading risk factor for hospitalization from COVID-19.

Newswise: Identity Verification During the Age of COVID-19
Released: 3-Dec-2020 2:25 PM EST
Identity Verification During the Age of COVID-19
Homeland Security's Science And Technology Directorate

S&T's Biometric Technology Rally focused on the ability of acquisition systems and matching algorithms to recognize travelers without asking them to remove their masks, thereby reducing risk for frontline workers.

access_time Embargo lifts in 2 days
Embargo will expire: 10-Dec-2020 11:00 AM EST Released to reporters: 3-Dec-2020 2:20 PM EST

A reporter's PressPass is required to access this story until the embargo expires on 10-Dec-2020 11:00 AM EST The Newswise PressPass gives verified journalists access to embargoed stories. Please log in to complete a presspass application. If you have not yet registered, please Register. When you fill out the registration form, please identify yourself as a reporter in order to advance to the presspass application form.

access_time Embargo lifts in 2 days
Embargo will expire: 7-Dec-2020 4:45 PM EST Released to reporters: 3-Dec-2020 2:10 PM EST

A reporter's PressPass is required to access this story until the embargo expires on 7-Dec-2020 4:45 PM EST The Newswise PressPass gives verified journalists access to embargoed stories. Please log in to complete a presspass application. If you have not yet registered, please Register. When you fill out the registration form, please identify yourself as a reporter in order to advance to the presspass application form.

Released: 3-Dec-2020 2:00 PM EST
Testosterone May Contribute to More Severe COVID-19 Disease
American Physiological Society (APS)

New research suggests that levels of the sex hormones estrogen and testosterone could contribute to infection risk and severity of COVID-19.


Showing results

110 of 4204

close
0.86556