Domenico  Pratico, MD, FCPP

Domenico Pratico, MD, FCPP

Alzheimer's Center at Temple University Lewis Katz School of Medicine

Scott Richards North Star Charitable Foundation Chair for Alzheimer’s Research, Director and Professor at Alzheimer's Center at Temple, Professor of Neural Sciences

Expertise: Alzheimer's DiseaseAlzheimer's DiseaseBrain HealthBrain HealthDementiaDementiaDown SyndromeDown SyndromeGeneticsGeneticsNeurodegenerationNeurodegeneration

Lewis Katz School of Medicine
Alzheimer's Center at Temple

Domenico Praticò is a Professor of Neural Science at the Lewis Katz School of Medicine. He obtained his medical degree from the University of Rome “La Sapienza” School of Medicine, where he also completed a residency program in Internal Medicine. He continued his post-graduate training as a Research Fellow of the Center for Cardiovascular Science at the University College, Dublin, Ireland. Next, he pursued a postdoctoral fellowship in the biology of aging at the University of Pennsylvania, where shortly after he was promoted to Assistant Professor, and later Associate Professor. In 2007 he joined Temple University, School of Medicine, as Associate Professor and Director of the Neurodegenerative Diseases Research Laboratory. Since 2011 he has been Professor of Neural Sciences at the Lewis Katz School of Medicine. In December 2017, he was nominated the Scott Richards North Star Foundation Chair in Alzheimer’s research and appointed as the founding Director of the Alzheimer’s Center at Temple. His main area of investigation is clinical pharmacology with a special focus on the cellular and molecular mechanisms involved in brain health, brain aging, and the pathogenesis of neurodegenerative diseases such as Alzheimer’s Disease and Frontotemporal Dementia. His early research includes pioneering work on the development of specific and sensitive methods to measure oxidative stress in vivo, which was instrumental for the first demonstration that brain oxidative stress is an early event in Alzheimer’s Disease pathogenesis. In addition, his work helped in defining the source and functional role that neuroinflammation plays in neurodegeneration. Pratico’s lab has been on the forefront in the effort to unravel the mechanisms responsible for the effect that dietary lifestyle has on brain health, providing evidence that extra virgin olive oil beneficial effects are secondary to the activation of important intracellular degradation pathways of unwanted materials. His group was the first to demonstrate that intracellular sorting and transport of protein is essential for neuronal health and that it can be a viable therapeutic target when it is dysfunctional. During these years, the main goal of his work has always been translating studies of the basic biology of brain aging and neurodegeneration into new therapeutics by implementing a comprehensive experimental approach which combines in vitro and in vivo models as well as human studies. Internationally known for his work on Alzheimer’s disease, brain health, aging and neurodegeneration, Dr. Pratico has authored over 290 original articles in high impact journals, and more than 25 chapters in thematic books. During his career, he has received many awards for his research accomplishments including the Irvine H. Page Award, Neuroscience Education and Research Award, Zenith Award from the Alzheimer’s Association, and Dorothy Dillon Eweson Lectureship from the American Federation for Aging Research, and the Paul W. Eberman Faculty Research Award, and The Marconi Science Award.


Cited By


Alzheimer’s disease: using gene/protein network machine learning for molecule discovery in olive oil


Down-Regulation of ABCA7 in Human Microglia, Astrocyte and THP-1 Cell Lines by Cholesterol Depletion, IL-1β and TNFα, or PMA


The Neurobiology and Therapeutic Potential of Multi-Targeting β-secretase, Glycogen Synthase Kinase 3β and Acetylcholinesterase in Alzheimer’s Disease


Retromer Stabilization Improves Cognitive Function and Synaptic Plasticity in a Mouse Model of Down Syndrome


Inflammaging: mechanisms and role in the cardiac and vasculature


QTC-4-MeOBnE Ameliorated Depressive-Like Behavior and Memory Impairment in 3xTg Mice



Overexpression of 5-Lipoxygenase Worsens the Phenotype of a Mouse Model of Tauopathy (Retraction of Vol 55, art no 5926, 2018)


Gene knockout of 5-lipoxygenase rescues synaptic dysfunction and improves memory in the triple-transgenic model of Alzheimer's disease (Retraction of Vol 19, Pg 511, 2014)


VPS35 regulates tau phosphorylation and neuropathology in tauopathy (Retraction of Vol 26, Pg 6992, 2021)


Beneficial effect of a small pharmacologic chaperone on the established Alzheimer’s disease phenotype



Extra-Virgin Olive Oil Enhances the Blood–Brain Barrier Function in Mild Cognitive Impairment: A Randomized Controlled Trial



Retromer‐dependent mechanisms of tau dysregulation in Down syndrome


Role of ABCA7 in Neural Lipid Metabolism and Its Association with Alzheimer's Disease Neuropathology


The contribution of altered neuronal autophagy to neurodegeneration



Early Alzheimer’s Detection with Artificial Intelligence

“AI-driven neuroimaging techniques have the potential to improve prediction models for Alzheimer’s progression and facilitate personalized treatment strategies,” says Domenico Praticò, MD, the Scott Richards North Star Foundation Chair for Alzheimer’s Research, Professor in the Departments of Pharmacology and Microbiology, and Director of the Alzheimer’s Center at Temple (ACT), at the Lewis Katz School of Medicine at Temple University (LKSOM).
29-Apr-2024 06:05:25 PM EDT

Young-Onset Dementia Tied to New Risk Factors

“Are the risk factors for early onset Alzheimer’s the same as late onset?” asks Domenico Praticò, MD, the Scott Richards North Star Foundation Chair for Alzheimer’s Research, Professor in the Departments of Pharmacology and Microbiology, and Director of the Alzheimer’s Center at Temple (ACT), at the Lewis Katz School of Medicine at Temple University (LKSOM)
12-Apr-2024 08:05:52 AM EDT

Can Olive Oil Reverse Genetic Predisposition for Alzheimer’s?

Clinical studies suggest the Mediterranean diet, and one of its main components, extra virgin olive oil (EVOO), improves cognitive function and slows Alzheimer's disease (AD) progression. Researchers will now investigate whether this is true even for people with a family history of AD and signs of genetic predisposition caused by dysfunction in the APOE gene.
14-Feb-2024 04:05:56 AM EST

How reliable is a home test in predicting Alzheimer's disease?

The test alone will not provide enough information to reach a diagnosis of memory problems/cognitive decline. Only a trained physician can do it.
01-Nov-2023 09:05:25 AM EDT

World Alzheimer’s Month 2023: Shining a Light on Alzheimer's – Domenico Praticò

Since 2012, September has been celebrated as World Alzheimer’s Month. Back then, and only eleven years ago, an average of 2 out of 3 people had little understanding of Alzheimer's disease and associated dementias.
21-Sep-2023 09:30:18 AM EDT

Brain Injury Prevention in Contact Sports is Essential, Expert Says

“There is abundant evidence of a link between contact sports, such as football, and dementia later in life,” comments Domenico Pratico, M.D., Director of the Alzheimer’s Center at Temple University (ACT).
19-Sep-2023 09:05:16 AM EDT

Cholesterol and Inflammation Demonstrate Alzheimer’s Link

A recent study shows that a protein called ABCA7 plays a functional role as a potential biological link between cholesterol and inflammation in Alzheimer’s disease. The new work was published online August 25 in the journal Cells.
19-Sep-2023 08:05:07 AM EDT

AI Study Uncovers Olive Oil's Potential in Combating Alzheimer's Disease

A recent study has used Artificial Intelligence (AI) to reveal the remarkable potential of extra virgin olive oil (EVOO) in the fight against Alzheimer's disease (AD). Researchers combined AI technology, chemistry, and omics research to identify specific bioactive compounds in EVOO that show promising effects in treating and preventing AD.
25-Jul-2023 12:50:28 PM EDT

Potential Improvement of Learning and Memory in Down Syndrome

A new approach could enhance memory and learning in individuals with Down syndrome by stabilizing a key component in the body's protein sorting system called the retromer complex.
13-Jun-2023 11:40:17 AM EDT

The Search For Alzheimer's Disease Biomarkers

A biomarker is a characteristic that can be measured and evaluated as an indicator of normal biological processes, pathogenetic processes, or pharmacologic responses to a therapeutic intervention. In the context of Alzheimer’s disease (AD), an AD biomarker indicates the presence or progression of the disease that may be altered by drug treatment, thereby demonstrating that it is hitting its target. Today, all clinical trials for Alzheimer’s disease utilize biomarkers of some form to assess whether the drug is actually affecting the disease in the brain.
29-May-2023 05:05:20 PM EDT

Katz School of Medicine opens Alzheimer’s Center

The Lewis Katz School of Medicine created the Alzheimer’s Center at Temple from funds donated by Board of Trustees member Phil Richards earlier this month. Richards’s gift created the center and established the Scott Richards North Star Charitable Foundation Chair for Alzheimer’s Research.
29-May-2023 04:50:23 PM EDT

Can Music Help Patients with Alzheimer's Disease?

Did you know that music might be able to connect you with your family members affected by Alzheimer's disease (AD) in a way that words cannot? Many studies have shown that music can evoke a response or a memory in people with Alzheimer's Disease.
29-May-2023 04:05:51 PM EDT

Medications to avoid for a patient with Alzheimer’s disease

The risk of side effects can rise if drugs are taken for conditions other than Alzheimer's disease (AD) treatment. Some sedatives and antidepressants can deteriorate cognitive function, make people drowsy and confused, and worsen cognitive impairment, which increases the risk of falls.
29-May-2023 03:30:13 PM EDT

Mechanism Underlying Alzheimer-Like Damage in the Brain of Patients with Down Syndrome

Alzheimer-like changes – marked by the build-up of harmful amyloid and tau proteins – occur in the brain in Down syndrome has been unclear. But now, in new research, scientists at the Lewis Katz School of Medicine at Temple University show that reduced efficiency of a key protein transport system is partly to blame.
29-May-2023 03:20:59 PM EDT

Diagnosing Alzheimer's Disease: Neuro-Psychological and Memory Testing

Diagnosing Alzheimer's disease (AD) is a complex process that doesn't rely on a single test.
29-May-2023 03:05:53 PM EDT

Alzheimer's Center at Temple Awarded $3.8 Million from Pennsylvania Department of Health to Lead Col

Alzheimer's disease is the most common form of dementia in the elderly. Memory loss and difficulty thinking worsen progressively, with some patients eventually becoming delusional, disoriented, and vulnerable to mood swings and depression. Finding ways to slow or reverse this progression, or even prevent symptoms from developing in the first place, are major goals in Alzheimer's research.
29-May-2023 02:55:07 PM EDT

Cognitive Changes in Normal Aging

People may endure cognitive changes as they get older, including forgetfulness and a loss of their capacity for multitasking or concentration. Although these changes are typical, they can be upsetting for elderly people.
29-May-2023 02:45:28 PM EDT

Common Myths about Alzheimer’s disease

Alzheimer's disease is a debilitating condition that affects millions of people around the world, but there is also a lot of misinformation about it. One of the most common myths is that memory loss is a natural part of aging.
29-May-2023 02:05:55 PM EDT

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