Feature Channels: Blood

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Released: 24-May-2022 6:50 PM EDT
Blood Biomarker Predicts Complicated Crohn’s Disease Years Before Diagnosis: Study
University of Toronto

An international team led by a University of Toronto researcher has found that an antibody detectable in blood predicts severe Crohn’s disease and is detectable up to seven years prior to disease diagnosis.

Released: 19-May-2022 7:30 PM EDT
Prevent BLEEDing Act introduced in Congress will advance STOP THE BLEED efforts
American College of Surgeons (ACS)

The American College of Surgeons (ACS) applauds Senators Menendez and Boozman and Representatives O’Halleran and Wenstrup for introducing the Prevent Blood Loss with Emergency Equipment Devices Act (Prevent BLEEDing Act). This legislation is crucial to support efforts to bring STOP THE BLEED® training and equipment directly to all U.S. citizens.

16-May-2022 3:15 PM EDT
How Have Changes in Anemia Care Affected Patients with Kidney Failure?
American Society of Nephrology (ASN)

2011 changes in policies and recommendations related to the use of erythropoietin-stimulating agents were associated with lower hemoglobin levels and lower risks of major adverse cardiovascular events, mortality, and stroke among adults receiving hemodialysis, but with a higher risk of heart attack.

Released: 19-May-2022 2:40 PM EDT
Standard test for multiple myeloma provides clues of a rare, more deadly type
Medical College of Georgia at Augusta University

A test for the common blood cancer multiple myeloma also holds clear clues that the patient has one of the most uncommon and deadly forms of this cancer, investigators say.

Released: 18-May-2022 5:05 PM EDT
Blood Pressure Medicine May Lower Frailty for Older Adults
University of Texas Health Science Center at Houston

A commonly used blood pressure medication may help improve measures of frailty in prefrail older adults, according to a new study by researchers with UTHealth Houston. The study was published in The Journals of Gerontology.

Newswise: Adolescent and young adult leukemia survivors have shorter life span compared to those who have never had cancer
Released: 13-May-2022 10:10 AM EDT
Adolescent and young adult leukemia survivors have shorter life span compared to those who have never had cancer
University of Texas M. D. Anderson Cancer Center

Adolescent and young adult survivors of acute lymphoblastic leukemia and acute myeloid leukemia, two of the most common leukemias for ages 15 to 39 years old, have increased risk of mortality than the general population for decades after initial diagnosis. Researchers investigated disparities specific to survivorship to learn about patients’ outcomes after they survived their initial diagnosis; and analyzed data from cancer survivors who were at least five years post treatment. Results suggest there is a gap in critical data surveillance that needs to be examined to further understand what is impacting long-term survivorship for AYAs.

Newswise: Emily Whitehead, First Pediatric Patient to Receive CAR T-Cell Therapy, Celebrates Cure 10 Years Later
11-May-2022 9:55 AM EDT
Emily Whitehead, First Pediatric Patient to Receive CAR T-Cell Therapy, Celebrates Cure 10 Years Later
Children's Hospital of Philadelphia

Ten years ago, Tom and Kari Whitehead came to Children’s Hospital of Philadelphia (CHOP) looking for a miracle. Their 6-year-old daughter, Emily, had relapsed in her battle with acute lymphoblastic leukemia (ALL), after many months of unsuccessful chemotherapy and a disease that had progressed so rapidly that she was ineligible for a bone marrow transplant to treat it. Her family came to CHOP in the hopes that Dr. Stephan Grupp, a pioneer in the field of cellular immunotherapy, could provide the miracle they were looking for.

Released: 10-May-2022 3:05 PM EDT
妙佑医疗国际的骨髓癌研究发现潜在药物靶点
Mayo Clinic

妙佑医疗国际(Mayo Clinic) 个体化医学中心(Center for individualized Medicine )的新研究发现,携带ASXL1突变体的慢性粒单核细胞白血病(一种罕见骨髓癌)患者中存在独特的表观遗传变化,可激活有害基因并导致癌细胞更快生长。ASXL1基因突变还能使疾病转化为更具侵袭性的急性髓细胞性白血病。

Released: 10-May-2022 3:05 PM EDT
Descoberta da Mayo Clinic sobre câncer de medula óssea aponta para possíveis alvos de medicamentos
Mayo Clinic

Uma nova pesquisa do Centro de Medicina Individualizada da Mayo Clinic descobre que pacientes com leucemia mielomonocítica crônica com mutação ASXL1 (um tipo incomum de câncer de medula óssea) têm alterações epigenéticas específicas que podem ativar genes nocivos e fazer com que o câncer cresça mais rapidamente.

Released: 10-May-2022 3:05 PM EDT
اكتشاف مايو كلينك في سرطان نخاع العظم يشير إلى أهداف محتملة من الأدوية
Mayo Clinic

وجد بحث جديد من مركز مايو كلينك للطب الفردي أن المرضى المصابين بابيضاض الدم المايلومونيكي المزمن بسبب طفرة ASXL1 - وهو نوع غير شائع من سرطان نخاع العظم - لديهم تغييرات لاجينية مميزة يمكنها تنشيط الجينات الضارة وتتسبب في نمو السرطان بشكل أسرع. كما يمكن لطفرة ASXL1 الجينية تحويل المرض إلى ابيضاض الدم النقوي الحاد الأكثر عدوانية.

Released: 10-May-2022 2:05 PM EDT
Descubrimiento de Mayo Clinic en cáncer de médula ósea apunta hacia posibles dianas farmacológicas
Mayo Clinic

Las nuevas investigaciones del Centro para Medicina Personalizada de Mayo Clinic descubren que los pacientes con leucemia mielomonocítica crónica con mutación en el gen ASXL1, un tipo raro de cáncer de la médula ósea, sufren cambios epigenéticos distintivos que activan genes nocivos y hacen que el cáncer se desarrolle con más rapidez.

Newswise: Exploring Dynamics of Blood Flow in Vascular, Atherosclerotic Diseases
4-May-2022 1:35 PM EDT
Exploring Dynamics of Blood Flow in Vascular, Atherosclerotic Diseases
American Institute of Physics (AIP)

In Physics of Fluids, researchers present clinicians with information about the risk factors for atherosclerotic plaque formation from a mechanical point of view. The scientists are exploring whether it is possible to screen and intervene early for people at risk for atherosclerotic disease from the perspective of hemodynamics, using color Doppler ultrasound, coronary computed tomography angiography, and other screenings. The researchers used a multipoint, noncontact laser flow measurement method called microparticle image velocimetry.

Newswise: Major discovery provides new hope for blood cancer patients
Released: 8-May-2022 9:05 PM EDT
Major discovery provides new hope for blood cancer patients
University of South Australia

Acute myeloid leukaemia is a rare and devastating blood cancer that is highly resistant to treatment. Now, Australian scientists have discovered a way to suppress a specific protein that promotes drug resistance.

Newswise: Scientists Create Tattoo-like Sensors That Reveal Blood Oxygen Levels
Released: 5-May-2022 12:40 PM EDT
Scientists Create Tattoo-like Sensors That Reveal Blood Oxygen Levels
Tufts University

Tufts engineers create a glowing sensor made from a silk gel that can be implanted under the skin to detect blood oxygen levels in real time. The sensor provides proof of concept for detecting other blood components, such as glucose

Released: 4-May-2022 4:50 PM EDT
First Report of Minimally Invasive Aortic Valve Replacement Using Real-Time CT Imaging in Elderly Man with Heart Failure and Blood Clot
Hackensack Meridian Health

Cardiologists from the Structural and Congenital Heart Center and Cardiac Surgeons at Hackensack Meridian Hackensack University Medical Center/Hackensack Meridian School of Medicine have reported what is believed to be the very first patient with heart failure and a blood clot to undergo a minimally invasive transcatheter aortic valve replacement using CT (computed tomography) fusion imaging, a technique that employs two different imaging modalities.

Newswise: UNC Blood Clot Expert Working with NASA to Study Blood Flow, Clot Formation in Zero Gravity
Released: 3-May-2022 11:15 AM EDT
UNC Blood Clot Expert Working with NASA to Study Blood Flow, Clot Formation in Zero Gravity
University of North Carolina School of Medicine

In the ultimate use of telemedicine, Stephan Moll, MD, worked with NASA to treat a U.S. astronaut’s blood clot during a mission on the International Space Station. That led to a study on how blood flows in zero gravity, and if astronauts are at greater risk of developing blood clots in space.

Newswise: Stroke Patient with Brain Injury Fully Recovers After Participating in UTHealth Houston-Led Clinical Trial
Released: 3-May-2022 8:05 AM EDT
Stroke Patient with Brain Injury Fully Recovers After Participating in UTHealth Houston-Led Clinical Trial
University of Texas Health Science Center at Houston

A stroke and subsequent brain injury qualified 65-year-old Linda Carmichael for a national, randomized clinical trial led locally by Sunil A. Sheth, MD, with McGovern Medical School at UTHealth Houston, investigating the safety and efficacy of endovascular thrombectomy plus medical management compared to medical management alone in certain LVO stroke patients.

Released: 3-May-2022 8:05 AM EDT
Anti-bleeding drug is safe for 'high-risk' patients undergoing hip fracture surgery
Wolters Kluwer Health: Lippincott

Tranexamic acid (TXA) – a medication given to reduce the risk of bleeding during some orthopaedic surgical procedures – can be safely used in patients with intertrochanteric (IT) hip fractures who are at high risk of blood clot-related complications, reports a study in The Journal of Bone & Joint Surgery. The journal is published in the Lippincott portfolio in partnership with Wolters Kluwer.

Released: 2-May-2022 2:00 PM EDT
May observes National STOP THE BLEED month, with a special commemoration set on May 19
American College of Surgeons (ACS)

May 19 will observe the fifth annual National STOP THE BLEED® Day, which falls during the broader observance of National STOP THE BLEED® Month in May.

Newswise: Hospitals Can Reduce Antibiotic Overuse by Avoiding Unnecessary Blood Draws in Critically Ill Children, Study Shows
Released: 2-May-2022 11:05 AM EDT
Hospitals Can Reduce Antibiotic Overuse by Avoiding Unnecessary Blood Draws in Critically Ill Children, Study Shows
Johns Hopkins Medicine

A Johns Hopkins Children’s Center-led national quality improvement collaborative highlights a “less is more” method that may prevent antibiotic overprescribing

Newswise: Montefiore Einstein Cancer Center Finds CAR-T Therapy Effective in Black and Hispanic Patients
27-Apr-2022 3:40 PM EDT
Montefiore Einstein Cancer Center Finds CAR-T Therapy Effective in Black and Hispanic Patients
Albert Einstein College of Medicine

CAR-T therapy, a form of immunotherapy that revs up T-cells to recognize and destroy cancer cells, has revolutionized the treatment of blood cancers, including certain leukemias, lymphomas, and most recently, multiple myeloma. However, Black and Hispanic people were largely absent from the major clinical trials that led to the U.S. Food and Drug Administration approval of CAR-T cell therapies.

Released: 27-Apr-2022 5:05 PM EDT
New research identifies blood biomarker for predicting dementia before symptoms develop
National University of Ireland, Galway (NUI Galway)

New research from NUI Galway and Boston University has identified a blood biomarker that could help identify people with the earliest signs of dementia, even before the onset of symptoms.

Newswise: jens_hillengass_myeloma_header.jpg
Released: 23-Apr-2022 10:05 AM EDT
Roswell Park Specialists to Highlight Latest Advances in Blood Cancer Treatment and Cellular Therapy
Roswell Park Comprehensive Cancer Center

oswell Park Comprehensive Cancer Center specialists will share the latest advances and developments in the treatment of blood-related cancers at the 2022 Tandem Transplantation & Cellular Therapy Meetings of American Society for Transplantation and Cellular Therapy (ASTCT) and Center for International Blood and Marrow Transplant Research (CIBMTR) in Salt Lake City, Utah, from April 23 to 26.

Released: 21-Apr-2022 11:10 AM EDT
New Chief of Bone Marrow Transplant and Cellular Therapies Named to New Jersey’s Only NCI-designated Comprehensive Cancer Center
Rutgers Cancer Institute of New Jersey

Rutgers Cancer Institute of New Jersey and RWJBarnabas Health have appointed Ira Braunschweig, MD, as chief, Section of Transplant and Cell Therapy at Rutgers Cancer Institute, chief of the Transplant and Cell Therapy Service of the RWJBarnabas Health Oncology Service Line, and director for Cell Therapy and Bone Marrow Transplantation at Robert Wood Johnson University Hospital, an RWJBarnabas facility.

Released: 15-Apr-2022 10:25 AM EDT
Rilzabrutinib for blood disorder shows promise in phase 1–2 clinical trial
Massachusetts Institute of Technology (MIT)

Drug may safely boost platelet levels in patients with immune thrombocytopenia.

Newswise:Video Embedded actors-from-two-popular-medical-tv-dramas-promote-stop-the-bleed-in-new-psa-to-bring-lifesaving-information-to-the-people-of-ukraine
VIDEO
Released: 14-Apr-2022 12:35 PM EDT
Actors from two popular medical TV dramas promote STOP THE BLEED in new PSA to bring lifesaving information to the people of Ukraine
American College of Surgeons (ACS)

Actors from two popular medical TV dramas have joined efforts with the American College of Surgeons (ACS) to spread lifesaving STOP THE BLEED® information to the people of Ukraine through a new Public Service Announcement (PSA) released today.

Released: 13-Apr-2022 4:15 PM EDT
妙佑医疗国际(Mayo Clinic) 的移植后居家护理计划重燃萨尔瓦多患癌女性的希望之火
Mayo Clinic

去年早些时候,Veronica Ciudad-Real被诊断出患有多发性骨髓瘤,一种她从未听说过的血癌,这让她感到非常惊讶和困惑。她才40岁,比该疾病的大多数患者都要年轻。随后她又了解到,在她的祖国萨尔瓦多无法获得她所需的治疗。

Released: 13-Apr-2022 4:10 PM EDT
برنامج الرعاية المنزلية للزراعة في مايو كلينك يمنح الأمل لسيدة سلفادورية مصابة بالسرطان
Mayo Clinic

عندما تم تشخيص فيرونيكا سيوداد ريال في أوائل العام الماضي بالورم النقوي المتعدد، وهو سرطان دم لم تسمع به من قبل، كان لديها أسئلة بلا إجابات. لقد كانت في الأربعين من عمرها، أي أصغر من معظم المصابين بالمرض.

Released: 13-Apr-2022 4:10 PM EDT
Transplante e programa de cuidado domiciliar da Mayo Clinic dão esperança a mulher salvadorenha com câncer
Mayo Clinic

Quando Veronica Ciudad-Real foi diagnosticada no começo do ano passado com mieloma múltiplo, um câncer do sangue do qual ela nunca tinha ouvido falar, ela teve mais perguntas do que respostas. Aos 40 anos, ela era mais jovem do que a maioria das pessoas com essa doença.

Released: 13-Apr-2022 4:10 PM EDT
Trasplante y programa de Mayo Clinic para cuidados domiciliarios ofrecen esperanza a mujer salvadoreña con cáncer
Mayo Clinic

Cuando Verónica Ciudad-Real recibió a principios del año el diagnóstico de mieloma múltiple, cáncer de la sangre del cual ella nunca había escuchado hablar, tuvo muchas preguntas y pocas respuestas. A sus 40 años, era más joven que la mayoría de las personas que sufren de esta enfermedad.

Newswise: Keeping Web-like NETs from Clogging Blood Vessels Could Improve Stroke Outcomes
Released: 12-Apr-2022 5:05 PM EDT
Keeping Web-like NETs from Clogging Blood Vessels Could Improve Stroke Outcomes
University of Utah Health

Preventing the formation of a sticky, web-like substance that can form in blood vessels after a stroke could protect the brain and lead to better outcomes for patients, studies in mice suggest. The research was reported in the Journal of Clinical Investigation and led by scientists at University of Utah Health.

Released: 6-Apr-2022 1:30 PM EDT
Tip Sheet: Fred Hutch and Partners Complete Restructure, Zinc and the Immune System – and Using Cord Blood Transplants to Treat Leukemia and HIV
Fred Hutchinson Cancer Research Center

SEATTLE — April 6, 2022 — Below are summaries of recent Fred Hutchinson Cancer Research Center research findings and other news. If you’re covering the American Association of Cancer Research’s annual meeting, April 8-13, see our list of Fred Hutch highlights for AACR and contact for help setting up interviews with experts.

Released: 6-Apr-2022 12:40 PM EDT
Third Dose of COVID-19 Vaccine Significantly Increases Immune Responses in Most Patients With Multiple Myeloma
Mount Sinai Health System

Most immunocompromised people with a blood cancer called multiple myeloma benefited from a third dose of COVID-19 vaccines, a promising sign after it was shown that two doses tended to not be sufficient for them. However, some people with multiple myeloma still remained vulnerable and may need a fourth dose or antibody treatments as restrictions lift and new variants emerge, according to a fast-tracked study in Cancer Cell.

Released: 5-Apr-2022 3:55 PM EDT
The latest news on clinical trials is here on Newswise
Newswise

Here are some of the latest articles that have been added to the Clinical Trials channel on Newswise.

Newswise: Newly Identified Neutrophil Subset Is a Promising Therapeutic Target
Released: 5-Apr-2022 3:30 PM EDT
Newly Identified Neutrophil Subset Is a Promising Therapeutic Target
University of Illinois Chicago

Using a protein nanoparticle they designed, scientists at the University of Illinois Chicago have identified two distinct subtypes of neutrophils and found that one of the subtypes can be used as a drug target for inflammatory diseases.

Newswise: 2022 Canada Gairdner Award given to Stuart H. Orkin, MD, researcher at Dana-Farber/Boston Children’s Cancer and Blood Disorders Center
Released: 5-Apr-2022 12:15 AM EDT
2022 Canada Gairdner Award given to Stuart H. Orkin, MD, researcher at Dana-Farber/Boston Children’s Cancer and Blood Disorders Center
Dana-Farber Cancer Institute

The Gairdner Foundation has announced that Stuart H. Orkin, MD, is one of the 2022 Canada Gairdner Award laureates for seminal discoveries and contributions to biomedical science.

3-Apr-2022 12:15 PM EDT
Investigational Anti-Clotting Drug Reduces Bleeding Risk Among AF Patients
Duke Health

A new type of anti-clotting drug caused fewer bleeding incidents among patients with atrial fibrillation than the commonly prescribed apixaban, according to results from a head-to-head comparison of the two.

31-Mar-2022 4:20 PM EDT
Major bleeding reduced in patients having non-cardiac surgery
McMaster University

The drug tested, tranexamic acid (TXA), was given to patients at risk of bleeding or vascular complications. The study found that TXA did not increase deep vein clotting known as VTE, heart attack, non-hemorrhagic stroke, or other major vascular complication in the 30 days after surgery. In the study, half of 9,535 patients in 22 countries were randomly assigned TXA, half placebo. Patients were 45 years or older (average age 69 years); 44% of them were female.

Newswise: CRISPR Clinical Trials: A 2022 Update
Released: 30-Mar-2022 2:35 PM EDT
CRISPR Clinical Trials: A 2022 Update
Innovative Genomics Institute

A comprehensive look at all of the active clinical trials on new CRISPR-based genome editing therapies in 2022, and perspective on what is coming next.

Newswise: Study Finds 10-Second Videos Predict Blood Cancer Relapse
Released: 29-Mar-2022 9:45 AM EDT
Study Finds 10-Second Videos Predict Blood Cancer Relapse
Vanderbilt University Medical Center

In a new study from Vanderbilt University Medical Center, 10-second videos of white blood cell motion in the skin’s microvasculature greatly improved the prediction of which stem cell and bone marrow transplant patients would have a relapse of their blood cancer.

Newswise: Use of a Smartphone App Versus Motivational Interviewing to Increase Walking Distance and Weight Loss in Overweight/Obese Adults With Peripheral Artery Disease
Released: 24-Mar-2022 4:10 PM EDT
Use of a Smartphone App Versus Motivational Interviewing to Increase Walking Distance and Weight Loss in Overweight/Obese Adults With Peripheral Artery Disease
JMIR Publications

The researchers, who hope to continue developing the app, were undaunted by its lackluster performance. “That just means we need to work more on the app and try to improve it,” Collins says. “We’re working on another app that will be more sophisticated and will be compatible with Android and Mac iOS.”

Newswise: ACS STOP THE BLEED® Program expands training and resources for the people of Ukraine
Released: 24-Mar-2022 2:45 PM EDT
ACS STOP THE BLEED® Program expands training and resources for the people of Ukraine
American College of Surgeons (ACS)

The American College of Surgeons (ACS) STOP THE BLEED® Program is supporting efforts to help people in Ukraine learn the basics of the STOP THE BLEED® course.

Newswise: Penn-Developed CAR T Cells Suppress GI Solid Tumor Cells, Without Toxicity to Healthy Tissue, in Preclinical Research
Released: 24-Mar-2022 11:05 AM EDT
Penn-Developed CAR T Cells Suppress GI Solid Tumor Cells, Without Toxicity to Healthy Tissue, in Preclinical Research
Perelman School of Medicine at the University of Pennsylvania

Chimeric antigen receptor (CAR) T cells can be remarkably effective in treating leukemias and lymphomas, but there are no successful immunotherapies for neuroendocrine tumors (NETs) and gastrointestinal cancers (GICs) yet. Researchers at Penn Medicine have discovered that CAR-T cells directed to a tumor antigen, CDH17, a cell surface marker expressed on both NETs and GICs but also found on healthy tissues, eliminated GICs in several preclinical models without toxicity to normal tissues in multiple mouse organs, including the small intestine and colon. The results from this study, the first to target CDH17 in neuroendocrine tumors, suggest a new class of tumor associated antigens accessible to CAR-T cells in tumors but sequestered from CAR-T cells in healthy tissues.

Newswise: Study Provides Clues on Why UTIs and Other Bad Infections Persist
Released: 23-Mar-2022 4:10 PM EDT
Study Provides Clues on Why UTIs and Other Bad Infections Persist
University of Utah Health

A new study led by researchers at University of Utah Health details a novel mechanism that infectious bacteria use to quickly adjust to environmental stress. The discovery could help explain why certain types of common infections—such as urinary tract and bloodstream infections like sepsis—are hard to get rid of.

Newswise: Renowned Hematology-Oncology Specialist to Lead UCSF Health’s Hematology-Oncology Program
Released: 23-Mar-2022 12:05 PM EDT
Renowned Hematology-Oncology Specialist to Lead UCSF Health’s Hematology-Oncology Program
University of California, San Francisco (UCSF)

UCSF’s Division of Hematology-Oncology is welcoming Krishna Komanduri, MD, as division chief of Hematology-Oncology at UCSF Health. Komanduri is an international leader in the fields of hematology-oncology, transplantation, and cellular immunotherapy. He will start at UCSF on July 1.

Released: 22-Mar-2022 11:00 AM EDT
Kids with rare autoimmune disease show these symptoms before blood clots
Michigan Medicine - University of Michigan

Antiphospholipid syndrome (APS) is rare in children and known to cause inflammation and recurring, potentially fatal, blood clots. Researchers found that two-thirds of children with the autoimmune disease experienced additional symptoms not formally associated with APS, including low platelet counts, hemolytic anemia and livedo reticularis, a rash indicating abnormal blood flow to the skin. Investigators say the findings underscore the importance of creating pediatric-specific criteria for the diagnosis of APS.

18-Mar-2022 4:05 PM EDT
AAN Issues Guidance on Preventing Second Stroke in Those with Plaque in Brain Arteries
American Academy of Neurology (AAN)

The use of medications and exercise is more beneficial in preventing a second stroke in people with intracranial atherosclerosis than placing a stent in the blood vessel, according to a new practice advisory issued by the American Academy of Neurology (AAN). The practice advisory is published in the March 21, 2022, online issue of Neurology®, the medical journal of the AAN, and is endorsed by the American Heart Association/American Stroke Association, Neurocritical Care Society and Society of Vascular and Interventional Neurology.


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