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Research into engineering artificial organs that mimic the functions of human lymph nodes at The University of Alabama in Huntsville (UAH) has garnered one of its professors a $507,777 National Science Foundation (NSF) Faculty Early Career Development Program (CAREER) Award.

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Wistar scientists discovered a novel pathway that enables detection of DNA in the cytoplasm and triggers inflammation and cellular senescence. This pathway may be modulated during senescence-inducing chemotherapy to affect cancer cell response to checkpoint inhibitors.

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A team of Cambridge scientists working on the intersection between biology and computation has found that random gene activity helps patterns form during development of a model multicellular system.

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The continuing epidemic of pre-term birth includes this stark reality: tiny, fragile babies are born with underdeveloped lungs and prone to lifelong respiratory infections and related chronic illnesses. Cincinnati Children’s researchers report in Immunology the discovery of a complex biological process could in the development of cost effective treatments to help babies develop lifelong pulmonary resistance to respiratory infections.

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Researchers in Japan have identified a new quality control system that allows cells to remove damaged and potentially toxic proteins from their surroundings. The study, which will be published February 18 in the Journal of Cell Biology, finds that the Clusterin protein and heparan sulfate proteoglycans combine to bring misfolded proteins into cells for degradation. The findings may lead to new therapeutic targets for neurodegenerative disorders, including Alzheimer’s disease.

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Renowned scientists including Nobel laureates, research pioneers and celebrated educators will convene at the Experimental Biology (EB) 2020 meeting, to be held April 4–7 in San Diego. Bringing together more than 12,000 life scientists in one interdisciplinary community, EB showcases the latest advances in anatomy, biochemistry, molecular biology, investigative pathology, pharmacology and physiology.

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The piece of gold that Richard Taylor was thrilled to track down weighed less than a single bacterium. Taylor, a postdoctoral fellow at the Max Planck Institute, was working to follow individual nanogold-labeled molecules that move just nanometers, billionths of a meter.

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A new technique can label diverse molecules and amplify the signal to help researchers spot those that are especially rare. Called SABER (signal amplification by exchange reaction), Peng Yin’s lab at Harvard’s Wyss Institute first introduced this method last year and since have found ways to apply it to proteins, DNA and RNA.

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The top contributor to familial Parkinson’s disease is mutations in leucine-rich repeat kinase 2 (LRRK2), whose large and difficult structure has finally been solved, paving the way for targeted therapies.