A team of chemists from HSE University and the Zelinsky Institute of Organic Chemistry used molecular modelling to find out that two medications that have been known for a long time can be used to fight SARS-CoV-2.
New research has revealed a surprise twist in the symbiotic relationship between a type of salamander and the alga that lives inside its eggs.
Penn Study Reveals A Molecular Mechanism That Helps The Body Mount Perfectly Balanced Responses to Deadly Infections
Summaries of recent Fred Hutch research findings and other news with links for additional background and media contacts.
Within a month following a heart attack, people are at increased risk for a second one. As a result, physicians treat these patients with medications to rapidly reduce cardiovascular risk factors for another event. Although statins are designed to reduce the risk from one underlying problem, low-density lipoprotein (LDL) or “bad” cholesterol, they often aren’t able drop it to recommended levels within 30 days. Now, testing a next-generation cholesterol-lowering drug known as a PCSK9 inhibitor, Johns Hopkins Medicine researchers showed they could lower blood cholesterol to safer levels faster when it is added to traditional therapies.
UC San Diego researchers discovered that people with an inactive RNA-editing enzyme respond better to cancer immunotherapy, and inhibitors of the enzyme help mice with difficult-to-treat cancers live longer.
Bacteria have the ability to adapt to their environment to survive the host's immune defense.
The American Society for Cell Biology (ASCB) was awarded a first-of-its-kind National Institutes of Health (NIH) grant to enhance diversity in the academic biomedical workforce.
A new study shows how chronic psychological stress leads to painful vessel-clogging episodes—the most common complication of sickle-cell disease (SCD) and a frequent cause of hospitalizations. The findings, made in mice, show that the gut microbiome plays a key role in triggering those episodes and reveals possible ways to prevent them. The research was conducted by scientists at Albert Einstein College of Medicine and published online today in Immunity.
Research from a multidisciplinary team led by Washington University may provide new insights into wound healing, scarring and how cancer spreads.
In an effort to better understand how our cells work, scientists have studied the function of 208 proteins responsible for orchestrating the regulation genes in the human genome. A paper appearing in the journal "Nature" describes the collaborative effort.
"A watched pot never boils," as the saying goes, but that was not the case for UC Santa Barbara researchers watching a "pot" of liquids formed from DNA. In fact, the opposite happened.
Animal patterns - the stripes, spots and rosettes seen in the wild - are a source of endless fascination, and now researchers at the University Bath have developed a robust mathematical model to explain how one important species, the zebrafish, develops its stripes.
A team of developmental biologists at the Morgridge Institute for Research has discovered a means by which schistosomes, parasitic worms that infect more than 200 million people in tropical climates, are able to outfox the host’s immune system.
Two groups of nerve cells may serve as “on-off switches” for male mating and aggression, suggests a new study in rodents.
A new imaging method developed by the Skala lab uses the natural autofluorescence within cells to assess T cell activity. The technique could help assess T cell involvement in immunotherapies.
An experimental messenger RNA (mRNA)-based vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) elicits protective immune responses in mice and non-human primates, researchers report on July 23rd in the journal Cell.
The immune systems of mammals - including humans - might struggle to detect and respond to germs from other planets, new research suggests.
Florida State University researchers have new insight into the tiny packages that cells use to move molecules, a structure that is key to cellular metabolism, drug delivery and more.
A chance mutation that led to spinal defects in a zebrafish has opened a little window into our own fishy past.
Danforth Center scientists, Dilip Shah, PhD, Siva Velivelli, PhD, Kirk Czymmek, PhD, and their collaborators at the Pacific Northwest National Laboratory have identified a sub class of peptides in the nodules of the legume, Medicago truncatula that proved effective in inhibiting growth of the fungus causing gray mold.
Genes linked to ageing that could help explain why some people age at different rates to others have been identified by scientists.
Researchers systematically surveyed the entire protein landscape of normal and nutrient-deprived cells to identify which proteins and organelles are degraded by autophagy, to shed light on the question of how cells decide what to recycle when they are starving.
Researchers at the University of East Anglia and University of Manchester have made an important breakthrough that could lead to 'kinder' treatments for children with bone cancer, and save lives.
After careful consideration, the ASCB Council unanimously voted to cancel the in-person meeting scheduled to be held in Philadelphia in December and instead hold Cell Bio Virtual 2020-An Online ASCB|EMBO Meeting.
The seven winners of the American Society for Cell Biology’s 2020 Public Engagement Grant Awards have created programs that share the wonder of science with vulnerable populations, such as people experiencing homelessness, the incarcerated, or refugees.
By inhibiting the molecule AKT, UC San Diego researchers favor the culture of human spermatogonial stem cells in the lab, a first step toward lab-produced sperm as a treatment for male infertility.
A team led by scientists at Scripps Research has discovered a common molecular feature found in many of the human antibodies that neutralize SARS-CoV-2, the coronavirus that causes COVID-19.
What IS baker's yeast? What does yeast do in nature? And why do scientists use it so much in the lab? University at Buffalo biologists chat about these questions.
Researchers at the Francis Crick Institute have characterised the structure of the SARS-CoV-2 spike protein as well as its most similar relative in a bat coronavirus.
A PhD student has produced the first digital reconstruction of the skull of a gigantic dormouse, which roamed the island of Sicily around two million years ago.
Researchers at Johns Hopkins University School of Medicine have discovered that breast cancer cells can alter the function of immune cells known as Natural killer (NK) cells so that instead of killing the cancer cells, they facilitate their spread to other parts of the body. The study, which will be published July 9 in the Journal of Cell Biology (JCB), suggests that preventing this reprogramming might stop breast cancer from metastasizing to other tissues, a major cause of death in breast cancer patients.
Johns Hopkins Kimmel Cancer Center investigators report they have uncovered a new mechanism by which invasive breast cancer cells evade the immune system to metastasize, or spread, to other areas of the body. They propose that therapies targeting this process could be developed to halt or prevent metastasis and reduce breast cancer deaths.
Summaries of recent Fred Hutch research findings and other news.
In the world's most in-depth study of the final steps of egg maturation, the quality of a woman's eggs was found to be significantly dependent on the important metabolic coenzyme called nicotinamide adenine dinucleotide (NAD+).
What causes African hybrid honey bees (AHB), also known as killer bees, to be highly defensive and aggressive? York University researchers have found it was the mixing of African and European genetics that led to hyper-aggression in this invasive strain of honey bees.
Scientists discovered that histones act as an enzyme that converts copper into a form that can be used by the cells. The finding refutes earlier theories that copper spontaneously converts in the body into a usable state.
Immunologist Louis Justement, Ph.D., begins his term as president of the largest coalition of biological and biomedical research associations in the United States, FASEB.
Mice that received an injection of a new experimental drug, TAT-DP-2, after a stroke had smaller areas of damage, and their long-term neurological function was better than that of untreated animals.
Scientists at Hokkaido University and collaborators have identified how inflammatory changes in tumors caused by chemotherapy trigger blood vessel anomalies and thus drug-resistance, resulting in poor prognosis of cancer patients.
How did the earliest proteins arise, given that the amino acids needed to make them are themselves produced by other proteins – enzymes? The Weizmann Institute's Prof. Dan Tawfik and colleagues recreated primordial proteins to find the answer.
Scientists have new evidence that overactive neutrophils--a common type of circulating immune cell--may drive the life-threatening blood clots and inflammation that occur in some patients with COVID-19.
Cancer researchers are turning their talents to the fight against COVID, using strategies that have lead to breakthroughs in cancer therapies for years, such as precision medicine, immunotherapy, biomarkers, and more.
UC San Diego researchers have discovered that a single treatment to inhibit a gene called PTB in mice converts native astrocytes, brain support cells, into neurons that produce the neurotransmitter dopamine. As a result, the mice’s Parkinson’s disease symptoms disappear.
When animal, insect or human embryos grow in a malnourished environment, their developing nervous systems get first pick of any available nutrients so that new neurons can be made.
UC San Diego researchers uncovered in mice how IRE1α, a molecule involved in cells’ response to stress, determines whether macrophages promote inflammation in the tumor microenvironment. Inflammation is known to promote tumor growth, making IRE1α an attractive target for drug development.
In a first-of-its-kind study, researchers have determined that genetics may play a role in how wounds heal. Caleb Phillips, an assistant professor at Texas Tech University and director of the Phillips Laboratory in the Department of Biological Sciences, and doctoral student Craig Tipton led the study, “Patient genetics is linked to chronic wound microbiome composition and healing,” published Thursday (June 18) in the open-access, peer-reviewed medical journal PLOS Pathogens.
Using an enzyme inhibitor in meniscus cells, a Penn team was able to soften their nucleus and promote access to previously impassible areas
The July special issue of SLAS Discovery, “Functional Genomics for Target Identification,” features ten articles focused on three strategic pillars that form the foundation of the functional genomics discipline.
Imagine if scientists could stop the coronavirus infection in its tracks simply by diverting its attention away from living lung cells?
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