A team of chemists from HSE University and the Zelinsky Institute of Organic Chemistry used molecular modelling to find out that two medications that have been known for a long time can be used to fight SARS-CoV-2.
Within a month following a heart attack, people are at increased risk for a second one. As a result, physicians treat these patients with medications to rapidly reduce cardiovascular risk factors for another event. Although statins are designed to reduce the risk from one underlying problem, low-density lipoprotein (LDL) or “bad” cholesterol, they often aren’t able drop it to recommended levels within 30 days. Now, testing a next-generation cholesterol-lowering drug known as a PCSK9 inhibitor, Johns Hopkins Medicine researchers showed they could lower blood cholesterol to safer levels faster when it is added to traditional therapies.
UC San Diego researchers discovered that people with an inactive RNA-editing enzyme respond better to cancer immunotherapy, and inhibitors of the enzyme help mice with difficult-to-treat cancers live longer.
A new study shows how chronic psychological stress leads to painful vessel-clogging episodes—the most common complication of sickle-cell disease (SCD) and a frequent cause of hospitalizations. The findings, made in mice, show that the gut microbiome plays a key role in triggering those episodes and reveals possible ways to prevent them. The research was conducted by scientists at Albert Einstein College of Medicine and published online today in Immunity.
In an effort to better understand how our cells work, scientists have studied the function of 208 proteins responsible for orchestrating the regulation genes in the human genome. A paper appearing in the journal "Nature" describes the collaborative effort.
Animal patterns - the stripes, spots and rosettes seen in the wild - are a source of endless fascination, and now researchers at the University Bath have developed a robust mathematical model to explain how one important species, the zebrafish, develops its stripes.
A team of developmental biologists at the Morgridge Institute for Research has discovered a means by which schistosomes, parasitic worms that infect more than 200 million people in tropical climates, are able to outfox the host’s immune system.
An experimental messenger RNA (mRNA)-based vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) elicits protective immune responses in mice and non-human primates, researchers report on July 23rd in the journal Cell.
Danforth Center scientists, Dilip Shah, PhD, Siva Velivelli, PhD, Kirk Czymmek, PhD, and their collaborators at the Pacific Northwest National Laboratory have identified a sub class of peptides in the nodules of the legume, Medicago truncatula that proved effective in inhibiting growth of the fungus causing gray mold.
Researchers systematically surveyed the entire protein landscape of normal and nutrient-deprived cells to identify which proteins and organelles are degraded by autophagy, to shed light on the question of how cells decide what to recycle when they are starving.
After careful consideration, the ASCB Council unanimously voted to cancel the in-person meeting scheduled to be held in Philadelphia in December and instead hold Cell Bio Virtual 2020-An Online ASCB|EMBO Meeting.
The seven winners of the American Society for Cell Biology’s 2020 Public Engagement Grant Awards have created programs that share the wonder of science with vulnerable populations, such as people experiencing homelessness, the incarcerated, or refugees.
Researchers at Johns Hopkins University School of Medicine have discovered that breast cancer cells can alter the function of immune cells known as Natural killer (NK) cells so that instead of killing the cancer cells, they facilitate their spread to other parts of the body. The study, which will be published July 9 in the Journal of Cell Biology (JCB), suggests that preventing this reprogramming might stop breast cancer from metastasizing to other tissues, a major cause of death in breast cancer patients.
Johns Hopkins Kimmel Cancer Center investigators report they have uncovered a new mechanism by which invasive breast cancer cells evade the immune system to metastasize, or spread, to other areas of the body. They propose that therapies targeting this process could be developed to halt or prevent metastasis and reduce breast cancer deaths.
In the world's most in-depth study of the final steps of egg maturation, the quality of a woman's eggs was found to be significantly dependent on the important metabolic coenzyme called nicotinamide adenine dinucleotide (NAD+).
What causes African hybrid honey bees (AHB), also known as killer bees, to be highly defensive and aggressive? York University researchers have found it was the mixing of African and European genetics that led to hyper-aggression in this invasive strain of honey bees.
Scientists discovered that histones act as an enzyme that converts copper into a form that can be used by the cells. The finding refutes earlier theories that copper spontaneously converts in the body into a usable state.
Scientists at Hokkaido University and collaborators have identified how inflammatory changes in tumors caused by chemotherapy trigger blood vessel anomalies and thus drug-resistance, resulting in poor prognosis of cancer patients.
How did the earliest proteins arise, given that the amino acids needed to make them are themselves produced by other proteins – enzymes? The Weizmann Institute's Prof. Dan Tawfik and colleagues recreated primordial proteins to find the answer.
Scientists have new evidence that overactive neutrophils--a common type of circulating immune cell--may drive the life-threatening blood clots and inflammation that occur in some patients with COVID-19.
Cancer researchers are turning their talents to the fight against COVID, using strategies that have lead to breakthroughs in cancer therapies for years, such as precision medicine, immunotherapy, biomarkers, and more.
UC San Diego researchers have discovered that a single treatment to inhibit a gene called PTB in mice converts native astrocytes, brain support cells, into neurons that produce the neurotransmitter dopamine. As a result, the mice’s Parkinson’s disease symptoms disappear.
UC San Diego researchers uncovered in mice how IRE1α, a molecule involved in cells’ response to stress, determines whether macrophages promote inflammation in the tumor microenvironment. Inflammation is known to promote tumor growth, making IRE1α an attractive target for drug development.
In a first-of-its-kind study, researchers have determined that genetics may play a role in how wounds heal. Caleb Phillips, an assistant professor at Texas Tech University and director of the Phillips Laboratory in the Department of Biological Sciences, and doctoral student Craig Tipton led the study, “Patient genetics is linked to chronic wound microbiome composition and healing,” published Thursday (June 18) in the open-access, peer-reviewed medical journal PLOS Pathogens.
The July special issue of SLAS Discovery, “Functional Genomics for Target Identification,” features ten articles focused on three strategic pillars that form the foundation of the functional genomics discipline.