Feature Channels: Drug Resistance

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Newswise: Researchers develop a way to make lifesaving phages accessible, transportable and much easier to use
10-Jul-2024 2:05 PM EDT
Researchers develop a way to make lifesaving phages accessible, transportable and much easier to use
McMaster University

Researchers have developed a simple new way to store, identify, and share phages, making them more accessible to clinicians trying to save patients with antimicrobial-resistant superbugs.

Released: 25-Jun-2024 8:05 AM EDT
Multidrug-resistant fungi found in commercial soil, compost, flower bulbs
University of Georgia

That pile of soil you bought at the home improvement store may contain more than just dirt, according to new research from the University of Georgia. A new UGA study found high levels of multidrug-resistant fungi in commercially available compost, soil and flower bulbs. Aspergillus fumigatus is a widespread fungus that thrives in soil. But it also poses a serious risk to human health if inhaled. People with compromised immune systems are particularly vulnerable to the opportunistic fungus, facing a near 100% fatality rate if infected with a multidrug-resistant strain.

Newswise: Study reveals unexpected mechanism of drug resistance in kidney cancer
Released: 11-Jun-2024 4:05 PM EDT
Study reveals unexpected mechanism of drug resistance in kidney cancer
UT Southwestern Medical Center

For nearly two decades, how kidney cancer becomes resistant to rapalog drugs has baffled the scientific community. Now a study by researchers at UT Southwestern Medical Center’s Kidney Cancer Program sheds light.

Released: 11-Jun-2024 11:05 AM EDT
Moffitt Study Reveals New Mechanism of Drug Resistance in Melanoma Leptomeningeal Disease
Moffitt Cancer Center

Leptomeningeal disease is a rare but lethal complication faced by late-stage melanoma patients. It occurs when cancer cells spread to the membranes covering the brain and spinal cord, or the leptomeninges. This condition, which affects 5% to 8% of melanoma patients, often leads to rapid deterioration and is notoriously resistant to therapies. However, a new Moffitt Cancer Center study, published today in Cell Reports Medicine, uncovers the mechanisms that drive this drug resistance, offering new avenues for potential treatments.

Newswise: Novel inhibitor insights offer pathway to preventing PXR-associated drug resistance
Released: 14-May-2024 4:05 PM EDT
Novel inhibitor insights offer pathway to preventing PXR-associated drug resistance
St. Jude Children's Research Hospital

Scientists at St. Jude Children’s Research Hospital uncovered a route to blocking activity of protein notorious for eliminating drugs, offering a potential boon to cancer therapy.

Newswise: 3i Symposium Inspires Interdisciplinary Insights in Immunology, Inflammation, and Infection
Released: 9-May-2024 5:05 PM EDT
3i Symposium Inspires Interdisciplinary Insights in Immunology, Inflammation, and Infection
University of Utah Health

Over 150 researchers from across the University of Utah gathered to form new connections and share groundbreaking research on topics from antibiotic resistance to autoimmune diseases.

   
Newswise: Researchers resolve old mystery of how phages disarm pathogenic bacteria
Released: 15-Apr-2024 8:05 AM EDT
Researchers resolve old mystery of how phages disarm pathogenic bacteria
Texas A&M AgriLife

New study details long-sought mechanisms and structures

Newswise: Wound Treatment Gel Fights the Battle Against Antibacterial Resistance
29-Mar-2024 11:05 AM EDT
Wound Treatment Gel Fights the Battle Against Antibacterial Resistance
American Institute of Physics (AIP)

Polymer-based hydrogels are used to treat skin ailments and in tissue engineering because of their ability to retain water, deliver drugs into wounds, and biodegrade. However, they are complicated to manufacture and not very resilient to external forces like rubbing against clothing, sheets, or wound dressings.

   
Released: 18-Mar-2024 5:05 PM EDT
UC Irvine-led research team discovers role of key enzymes that drive cancer mutations
University of California, Irvine

A research team led by the University of California, Irvine has discovered the key role that the APOBEC3A and APOBEC3B enzymes play in driving cancer mutations by modifying the DNA in tumor genomes, offering potential new targets for intervention strategies.

Newswise: Case Western Reserve University researchers report rise in global fungal drug-resistant infections
Released: 18-Mar-2024 9:00 AM EDT
Case Western Reserve University researchers report rise in global fungal drug-resistant infections
Case Western Reserve University

A global wave of infections caused by fungi growing drug-resistant has the medical community issuing precautions on how to protect yourself.

Newswise: Some lymphomas become resistant to treatment. Gene discovery may offer path to overcome it.
Released: 15-Mar-2024 3:05 PM EDT
Some lymphomas become resistant to treatment. Gene discovery may offer path to overcome it.
University of Wisconsin–Madison

Patients with some types of lymphoma that become resistant to standard treatments may benefit from a therapy that University of Wisconsin–Madison researchers are evaluating after they discovered a key process that fuels the blood cancers’ resistance to current drugs.

Newswise: Anti-vaccine conspiracies fuel divisive political discourse
Released: 26-Feb-2024 9:05 PM EST
Anti-vaccine conspiracies fuel divisive political discourse
University of Tokyo

Heightened use of social media during the coronavirus pandemic brought with it an unprecedented surge in the spread of misinformation.

   
Released: 21-Feb-2024 2:05 PM EST
Long COVID can happen to anyone. Keep up with the latest research on Long COVID on Newswise
Newswise

Stay informed! These are the latest research articles on "Long COVID" from the Coronavirus News Source on Newswise.

Newswise: RUDN pharmacists proposed ways to increase the activity of levofloxacin and overcome bacterial resistance to antimicrobial agents
Released: 21-Feb-2024 9:15 AM EST
RUDN pharmacists proposed ways to increase the activity of levofloxacin and overcome bacterial resistance to antimicrobial agents
Scientific Project Lomonosov

RUDN University pharmacists modeled derivative molecules of the antibacterial levofloxacin to find out what biological functions its individual structural fragments - pharmacophores - are responsible for. This is necessary to increase the effectiveness of the drug, as bacteria become increasingly resistant to antibiotics.

Released: 21-Feb-2024 2:05 AM EST
New model identifies drugs that shouldn’t be taken together
Massachusetts Institute of Technology (MIT)

Any drug that is taken orally must pass through the lining of the digestive tract. Transporter proteins found on cells that line the GI tract help with this process, but for many drugs, it’s unknown which of those transporters they use to exit the digestive tract.

Released: 15-Feb-2024 2:00 PM EST
UIC research helps create new antibiotic that evades bacterial resistance
University of Illinois Chicago

New drug inspired by images that captured how bacteria block antibiotic activity

   
Newswise: Mejora del proceso de evaluación de la cirugía de la epilepsia: formación y comunicación
Released: 7-Feb-2024 10:05 AM EST
Mejora del proceso de evaluación de la cirugía de la epilepsia: formación y comunicación
International League Against Epilepsy

Aunque la cirugía puede ser una opción para hasta el 40% de las personas con epilepsia resistente a los medicamentos, menos del 1% son remitidos a centros de epilepsia cada año. ¿Por qué?

Newswise: Improving the epilepsy surgery evaluation pipeline: Training and communication
Released: 7-Feb-2024 10:05 AM EST
Improving the epilepsy surgery evaluation pipeline: Training and communication
International League Against Epilepsy

Surgery may be an option for up to 40% of people with drug-resistant epilepsy, but fewer than 1% are referred to epilepsy centers each year. Why?



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