Researchers Uncover How Tumors Circumvent Prostate Cancer Therapy, Identify Promising Treatment StrategyCleveland Clinic
A Johns Hopkins Children’s Center-led national quality improvement collaborative highlights a “less is more” method that may prevent antibiotic overprescribing
Biologists have discovered an aberrant protein that’s deadly to bacteria. The discovery could help scientists unravel the lethal mechanism of certain antibiotics—and potentially point the way to future antibacterial drugs.
Researchers at UC San Diego have used a systems biology approach to parse the genetic diversity of Clostridioides difficile, a particularly problematic pathogen, particularly in health care settings.
Antibiotics have once proclaimed the salvation of the world. Today, researchers fear that antibiotics could become a threat to public health and the natural environment.
Among those hospitalised during the pandemic, both COVID-19 patients and those tested for SARS-COV-2 but negative, had higher rates of antibiotic-resistant bacterial infections compared to patients hospitalised before the pandemic, according to a study evaluating the pandemic’s impact on antimicrobial resistance (AMR) in 271 hospitals across the USA, to be presented at this year’s European Congress of Clinical Microbiology & Infectious Diseases (ECCMID) in Lisbon, Portugal (23-26 April).
Experts from the University of Nottingham have developed a ground-breaking software, which combines DNA sequencing and machine learning to help them find where, and to what extent, antibiotic resistant bacteria is being transmitted between humans, animals and the environment.
Over the past few decades, obesity has become increasingly common throughout the entire world.
A recent study published in the journal Communications Biology shows manipulating and deleting a specific gene (AMN1) from yeast could provide a foundation for a new approach to combatting drug resistance when treating microbial infections or cancer.
University of Maryland School of Medicine (UMSOM)’s Institute of Human Virology (IHV) researchers received funding from the National Institutes of Health’s National Institute of Allergy and Infectious Diseases (NIAID) for $2.7 million to study genetic changes in two genes from the HIV-1 virus that may make it resistant to antiretroviral therapy.
Demand for new kinds of antibiotics is surging, as drug-resistant and emerging infections are becoming an increasingly serious global health threat. Researchers are racing to reexamine certain microbes that serve as one of our most successful sources of therapeutics: the actinomycetes.
Dr. Oladele "Dele" Ogunseitan, UC Presidential Chair and Professor of Population Health and Disease Prevention at the University of California, Irvine Program in Public Health, discusses using a One Health approach to combating global antibiotic resistance.
Most antibiotics are double-edged swords. Besides killing the pathogen they are prescribed for, they also decimate beneficial bacteria and change the composition of the gut microbiome.
Here are some of the latest articles that have been added to the Clinical Trials channel on Newswise.
مدينة روتشستر، ولاية مينيسوتا- يموت عدد متزايد من الناس بسبب العَدوى المقاومة للمضادات الحيوية. وهذه العَدوى تغذيها أنواع الميكروبات التي تتحور لتتجنب الأدوية المطورة بهدف تدميرها. توفي أكثر من 1.2 مليون شخص حول العالم في عام 2019 بسبب العَدوى المقاومة للمضادات الحيوية.
Cada vez mais pessoas estão morrendo por infecções resistentes a antibióticos. Essas infecções são alimentadas por espécies microbianas que estão em mutação para escapar das drogas desenvolvidas para destruí-las.
Una creciente cantidad de personas muere debido a infecciones resistentes a los antibióticos. Estas infecciones son propiciadas por especies bacterianas que mutan a fin de evadir a los fármacos creados para destruirlas.
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A new study found that for telemedicine visits related to acute respiratory infection, contractor-supplied physicians prescribed antibiotics to patients nearly twice as often as emergency physicians employed by the hospital system. As the majority of acute respiratory infections are viral, researchers say the findings highlight concerns of antibiotic stewardship amid growing antibiotic resistance.
While gene mutations can lead to drug resistance, researchers in the Perelman School of Medicine at the University of Pennsylvania have identified an important, non-genetic adaptation that could also drive resistance to targeted therapy in T cell leukemia, a type of blood cell cancer.
New research from the University of Georgia found that fungal infections account for $6.7 billion in health care spending in 2018. And that’s just the cases that were directly responsible for inpatient hospital stays.
The spectacular structure of the protective armour of superbug C.difficile has been revealed for the first time showing the close-knit yet flexible outer layer – like chain mail.
Using genomic sequencing techniques and machine learning analysis of patient records, Israeli researchers have developed an antibiotic prescribing algorithm that cuts the risk of emergence of antibiotic resistance by half.
MIT chemists have discovered the structure of a protein that can pump toxic molecules out of bacterial cells. Proteins similar to this one, which is found in E. coli, are believed to help bacteria become resistant to multiple antibiotics.
Texas Tech University Health Sciences Center El Paso has received more than a quarter-million dollars to study the proteins that contribute to disease progression and drug resistance in acute myeloid leukemia.
The key to preventing another global pandemic may be found at UNC Charlotte. Expanding upon the University’s award-winning development of a novel COVID-19 wastewater surveillance program and rapidly growing success in bioinformatics, the University is bringing together experts to explore ways to combat threats to human health.
New research from the University of Georgia has shown, for the first time, that compounds used to fight fungal diseases in plants are causing resistance to antifungal medications used to treat people.
A Ludwig Cancer Research study has identified a potential vulnerability in neuroblastoma tumors that might be exploited to improve treatment of the aggressive childhood cancer, which accounts for roughly 15% of all deaths from pediatric malignancies.
Five days of antibiotics is superior to 10 days for children with community-acquired pneumonia who are not hospitalized, according to a study published in JAMA Pediatrics.
The latest research news from the Health Disparities Channel.
Using drugs in synergistic combinations may clear infections more efficiently and slow the acquisition of drug resistance. Bree Aldridge of Tufts University School of Medicine explains how researchers find the right drug cocktails, slowing AMR, and the role artificial intelligence can have in both.
Countering a rising antibiotic resistance crisis, doctors now prescribe combinations of antibiotics. Yet many risks are involved with such multi-drug combinations. Scientists have developed a way to help doctors evaluate outcomes for different drug pairs and boost the odds of successful treatment.
Australian scientists have made a surprising discovery in the origins of an antibiotic-resistant gene previously thought to have been confined to Adelaide.
Sanford Burnham Prebys professor Andrei Osterman, Ph.D., has been awarded a $3.6 million grant from the National Institutes of Health (NIH) to expand current knowledge of antibiotic resistance, which will inform more precise antibiotic prescribing practices and help researchers develop drugs that are harder for bacteria to resist.
For decades, no one really knew how the drug praziquantel treated a parasitic disease afflicting more than 200 million people around the world. Now, two independent teams of researchers have found the answer, which could help lead to improved treatments that support the W.H.O.’s goal of eliminating Schistosomiasis as a public health problem by 2025.
Conventional wet-chemistry methods used to create biocidal materials are complex, time-consuming, and expensive. In the Journal of Applied Physics, researchers present a tutorial in which they explore a promising alternative called plasma-enabled surface engineering. The technology relies on nonequilibrium plasma that produces chemical reactions to change the properties at the material surface. Reactions can be manipulated by adjusting electric power for surface activation, coating deposition, and surface nanostructuring of virtually any solid material.
More than $2 million in grants from the U.S. Centers for Disease Control and Prevention (CDC) will allow a Penn Medicine team to further develop infrastructure and clinical capacity to address antimicrobial resistance and infectious diseases in Botswana.
UCLA Jonsson Comprehensive Cancer Center researchers led the development of a melanoma model of drug resistance, enabling them to study structures and dynamics resulting in intrachromosomal and extrachromosomal changes that support resistance in cancer cells.
Treating bacterial infections associated with orthopaedic implants has often been a case of too little, too late. The traditional therapy has been a combination of prolonged antibiotics, including rifampin, a 50-year-old drug that has been a staple in the global fight against tuberculosis and other bacterial diseases.
Scientists have spotted signs of ‘pre-resistance’ in bacteria for the first time – signs that particular bacteria are likely to become resistant to antibiotics in the future – in a new study led by UCL and Great Ormond Street Hospital researchers.
Scientists have discovered a new potential treatment that has the ability to reverse antibiotic resistance in bacteria that cause conditions such as sepsis, pneumonia, and urinary tract infections.
With the knowledge that human, animal and environmental health are intertwined, researchers at five of The Ohio State University’s colleges and its medical center are uniquely positioned to collaborate on a “one health” approach to battle antibiotic resistance and prevent the next global health crisis.
Nowadays, single-cell RNA sequencing technologies and related bioinformatics tools are emerging as essential devices for dissecting tumors at single-cell resolution and understanding carcinogenesis and drug response mechanisms, representing a turning point in cancer research.
Researchers at Washington University School of Medicine in St. Louis have found that multidrug-resistant bacteria and bacterial spores can be killed by ultrashort-pulse lasers. The findings could lead to new ways to sterilize wounds and blood products without damaging human cells.
Researchers at Karolinska Institutet, Umeå University, and the University of Bonn have identified a new group of molecules that have an antibacterial effect against many antibiotic-resistant bacteria.