… Adipose-derived stem cell (ADSC) or crushed adipose tissue injection into the joint cavity reportedly improve knee function and symptoms, including pain. Stem cell spheroids may be promising treatment options due to their anti-inflammatory …
Identifying novel regulatory factors and uncovered mechanisms of somatic cell reprogramming will be helpful for basic research and clinical application of induced pluripotent stem cells (iPSCs). Sin3a, a multi...
… Evidence of allogeneic haematopoietic stem-cell transplantation being beneficial in patients with late-infantile MLD appears to be very … Furthermore, allogeneic haematopoietic stem-cell transplantation did not slow down disease progression in …
… This review provides an overview of stem cell-based disease models in neuropsychiatry and considers the advantages and challenges surrounding the contributions … Summary of the key elements and challenges for each stem-cell-based …
Host microbiota crosstalk is essential for the production and functional modulation of blood-cell lineages. Whether, and if so how, the microbiota influences hematopoietic stem cells (HSCs) is unclear. Here, we show that the microbiota regulates HSC self-renewal …
Purpose: Graft-versus-host disease (GVHD) is an important complication after human leukocyte antigen (HLA) haploidentical donor (HID) hematopoietic stem cell transplantation (HSCT), which may lead to poor prognosis. Our study intends to …
… RICH1 inhibits stem cell-like properties in breast cancer and maintains the normal epithelial architecture of … 3: RICH1 inhibits stem cell-like properties in breast cancer and maintains the normal epithelial architecture … RICH1 inhibits stem cell-like …
… ) to ask if this is because senescent cells in stem cell niches impair precursor-mediated tissue maintenance. We demonstrate an aging-dependent accumulation of senescent cells, largely senescent NPCs, within the hippocampal stem cell niche …
Severe equine asthma (SEA) is a common chronic respiratory disease and a significant health and well-being problem in horses. Current therapeutic strategies improve pulmonary function and clinical signs in som...
Periodontitis is a chronic infectious disease leading to bone resorption and periodontal tissue disruption under inflammatory stimulation. The osteogenic differentiation ability of mesenchymal stem cells (MSCs...
Adipose-derived stem cells (ADSCs) and their extracellular vesicles (EVs) have therapeutic potential in ischemic brain injury, but the underlying mechanism is poorly understood. The current study aimed to expl...
Various immune cells and cytokines are present in the aftermath of peripheral nerve injuries (PNI), and coordination of the local inflammatory response is of great significance for the recovery of PNI. Mesench...
Osteoarthritis (OA), a prevalent degenerative disease characterized by degradation of extracellular matrix (ECM), still lacks effective disease-modifying therapy. Mesenchymal stem cells (MSCs) transplantation ...
… Among stem cell indicators evaluated in this study, the status of CD133 expression has a significant association with the absence of lymphatic metastasis at … The clinical significance of CD133 as a known cancer stem cell marker in gastric …
… -stem-cell-derived RPE cells injected subretinally were able to preserve vision in a rat model of RPE cell dysfunction (Davis et al., 2017). These studies further highlight the utility and clinical applications of stem-cell-… The developmental stage …
… This review outlines the discoveries in the oral stem cell field, focusing on the latest advances in biological research, such as the formation … Of the various dental stem cell populations, both stem cell populations isolated from dental pulp - DPSCs …
… Clearly, more experiments should be performed to elucidate the mechanism behind the morphology change of UCB-MSCs when co-culturing with cancer cells, as well as the effect of this stem cell type on cancer cells. Nevertheless, our initial …
In mammals, white adipose tissues are largely divided into visceral epididymal adipose tissue (EAT) and subcutaneous inguinal adipose tissue (IAT) with distinct metabolic properties. Although emerging evidence suggests that subpopulations of …
… This review article mainly discusses the advances in application of stem cell and progenitor transplantation for retinitis pigmentosa. Stem cell sources such as mesenchymal stem cells, embryonic stem cells, induced pluripotent stem cells …
… , but the molecular mechanisms that coordinately control basal cell fate and stem cell quiescence are elusive. Here, we report an epithelium-… stem cell function to Zeb1-deficient basal cells. Thus, Zeb1 is a transcriptional regulator that maintains …
… ESCs, isolated from the ICM in vitro, can propagate in vitro and differentiate into all adult cells, they therefore provide useful materials for stem cell research with strong potential in regenerative medicine. LeBlanc et al. have showed that Yap1/Tead4 …
… Despite a known high prevalence of anemia and periprocedural stroke risk among TAVR patients, few studies have evaluated the relationship between anemia and new ischemic lesions detected by DW-MRI. In this study, we revealed that …
… Emilin-2 expression was monitored in vitro in primary and mesenchymal stem cell lines under undifferentiated and adipogenic conditions. … Our data provide new insights in the contribution of bone marrow extracellular matrix microenvironment in …
… In this study, we investigated the cytotoxicity and hepatoxicity of HFPO-TA using human embryonic stem cell (hESC)-based assays. Results showed that HFPO-TA reduced hESCs’ viability in a dose dependent manner, and the calculated IC50 for …
Although 90% of infections with the novel coronavirus 2 (COVID-19) are mild, many patients progress to acute respiratory distress syndrome (ARDS) which carries a high risk of mortality. Given that this dysregu...
Orest Tsymbalyuk, Volodymyr Gerzanich, Marc Simard, Chozha Rathinam
Chenyu Lin, Wen Chen, Yong Han, Yujie Sun, Xiaoqiong Zhao, Yuan Yue, Binyu Li, Wenmei Fan, Tao Zhang, Li Xiao
Vismaya S Bachu, Pavan Shah, Adrian E Jimenez, Adham M Khalafallah, Jignesh Tailor, Debraj Mukherjee, Alan R Cohen
Kasra Khalaj, Rebeca Lopes Figueira, Lina Antounians, Sree Gandhi, Matthew Wales, Louise Montalva, George Biouss, Augusto Zani
Kun Han, Nan Kang, Xiaotong Yu, Jie Lu, Yuewen Ma
Jiaxin Gong, Niraj K. Nirala, Jiazhang Chen, Fei Wang, Pengyu Gu, Qi Wen, Y. Tony Ip, Yang Xiang
Caused by the injury to the endometrial basal layer, intrauterine adhesions (IUA) are characterized by uterine cavity obliteration, leading to impaired fertility. Human amniotic mesenchymal stem cells (hAMSCs)...
Justas Zalieckas, Ivan Rios Mondragon, Paulius Pobedinskas, Arne Skodvin Kristoffersen, Samih Mohamed-Ahmed, Cecilie Gjerde, Paul Johan Høl, Geir Hallan, Ove Nord Furnes, Mihaela-Roxana Cimpan, Ken Haenen, Bodil Holst, Martin Møller Greve
Rodrigo Orlandini de Castro, Luciana Previato, Agustin Carbajal, Victor Goitea, Courtney T. Griffin, Roberto J. Pezza
Pei Zhou, Hai-Feng Zhang, Yong-Li Wang, Ping Tao, Yu-Zhen Tan, Hai-Jie Wang
Shirley D. Wenker, Victoria Gradaschi, Carina Ferrari, Maria Isabel Farias, Corina Garcia, Juan Beauquis, Xianmin Zeng, Fernando J. Pitossi
Raman Devarajan, Hellevi Peltoketo, Valerio Izzi, Heli Ruotsalainen, Saila Kauppila, Marja-Riitta Väisänen, Gunilla Rask, Guillermo Martínez-Nieto, Sanna-Maria Karppinen, Timo Väisänen, Inderjeet Kaur, Jussi Koivunen, Takako Sasaki, Robert Winqvist, Fredrik Wärnberg, Malin Sund, Taina Pihlajaniemi, Ritva Heljasvaara
Rajeev Rai, Winston Vetharoy, Asma Naseem, Zohar Steinberg, Adrian J Thrasher, Giorgia Santilli, Alessia Cavazza
Jason Hong, Brenda Wong, Caroline Huynh, Brian Tang, Soban Umar, Xia Yang, Mansoureh Eghbali
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