Allergy specialists like Dr. Shelly Harvey are again readying themselves for mountain cedar, the annual irritant that makes noses run and eyes itch – potentially transforming the merriest of holiday well-wishers into miserable Ebenezer Scrooges.
The most lethal form of breast cancer could have a new treatment option, according to new research out of the Case Comprehensive Cancer Center at Case Western Reserve University School of Medicine. In the Proceedings of the National Academy of Sciences, researchers showed triple-negative breast cancer cells are highly vulnerable to interferon-β—a potent antimicrobial that also activates the immune system. The new study shows interferon-β impairs breast cancer cells’ ability to migrate and form tumors. The study also suggests interferon-β treatment could improve outcomes for certain breast cancer patients.
Researchers at The Johns Hopkins University report statistical evidence that children exposed to airborne coarse particulate matter — a mix of dust, sand and non-exhaust tailpipe emissions, such as tire rubber — are more likely to develop asthma and need emergency room or hospital treatment for it than unexposed children.
Wistar scientists revealed the mechanism implicated in the defective function of tumor-associated dendritic cells (DCs), a specialized type of immune cells that expose the antigens on their surface to activate the T cells
Researchers at Rutgers Cancer Institute of New Jersey examined an association between mutational burden and response to immune checkpoint therapy in several cancer types and found that a mutational burden threshold exists in eight cancers that predict response to an immune checkpoint blockade.
Allergens are widespread, but highly variable in U.S. homes, according to the nation’s largest indoor allergen study to date. Researchers from the National Institutes of Health report that over 90 percent of homes had three or more detectable allergens, and 73 percent of homes had at least one allergen at elevated levels. The findings were published November 30 in the Journal of Allergy and Clinical Immunology.
St. Jude Children’s Research Hospital and Emory University research offers insight into origins of the T cells that provide enduring immune protection; findings should aid vaccine development and cancer immunotherapies
Research from the Monell Center documented wide individual differences to the taste of the life-saving HIV medication Kaletra and identified genetic sources of the taste variation. The findings suggest that the growing field of pharmacogenetics should assess the sensory response to medicines to promote medication compliance and treatment success.
An experimental blood test developed at UCLA that uses gene activity data from immune cells was 93 percent accurate in predicting survival rates for people with advanced heart failure who had surgery to implant mechanical circulatory support devices.
The Dubin Breast Center of The Tisch Cancer Institute at the Mount Sinai Health System held its sixth annual benefit on Monday, December 11, 2017, at the Ziegfeld Ballroom in Manhattan.
Advances in engineering T cells to treat cancer are paving the way for new immunotherapies targeted at autoimmune diseases, including type 1 diabetes. Now, researchers are also investigating therapies that reprogram T cells to “turn down” an immune response, which may hold promise for curing type 1 diabetes, as well as a number of diseases where overactive T cells attack a person’s healthy cells and organs.
Researchers at Houston Methodist believe that a significant number of people diagnosed with schizophrenia or bipolar disorder may actually have a treatable immune system condition. A new research study could have a significant impact on the millions diagnosed with schizophrenia or bipolar disorder, including many homeless.
A UCLA study in collaboration with the California Institute of Technology (Caltech) shows that skin cancer cells could be chemically changed from within to reflexively alter gene expression patterns and intracellular pathways, which allows the cells to become resistant to targeted drugs.
A blood test using infrared spectroscopy can be used to diagnose two types of cancer, lymphoma and melanoma, according to a study led by Georgia State University.
A chemical found in marijuana, known as tetrahydrocannabinol, or THC, has been found to potentially slow the process in which mental decline can occur in up to 50 percent of HIV patients, says a new Michigan State University study.
Research from the University of Illinois at Chicago suggests bond duration, not bond tightness, may be the most important differentiator between antibiotics that kill bacteria and antibiotics that only stop bacterial growth.
Pets have become an integral part of human medical research. However, a recent collaboration between Penn Med and Penn Vet has turned the tables on the arrangement.
How do killer T cells “learn” to leave their home base and amass within specific tissues like the skin, gut, and lung, or solid tumors?
Dr. Eunice Wang was invited to discuss results of a phase II clinical trial of crenolanib for adults with AML at the ASH 2017 annual meeting, and Dr. Kara Kelly, senior author of an oral abstract on outcomes disparities among children and adolescents with Hodgkin lymphoma.
A study involving the recently approved CD19-targeting chimeric antigen receptor (CAR) T cell therapy shows that 42 percent of patients with aggressive large B-cell lymphoma remained in remission at 15 months following treatment with axi-cel (marketed as Yescarta™).
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