Patients with chest pain have similar rates of heart attacks and other major cardiac events within two years whether they were evaluated with a new type of CT scan or the traditional stress test, according to results presented today by Duke Medicine researchers at a meeting of the American College of Cardiology.
On the heels of the Federal Drug Administration's (FDA) second public workshop to explore the public health considerations associated with e-cigarettes, nonprofit research organization RTI International released a new research paper "Exhaled Electronic Cigarette Emissions: What's Your Secondhand Exposure?," which explores the composition of e-cigarette vapor and the potential health impacts of secondhand exposure.
A recently developed risk-evaluation protocol can help hospital emergency department personnel more efficiently determine which patients with acute chest pain can be sent home safely, according to a randomized trial conducted at Wake Forest Baptist Medical Center.
New Research from San Raffaele Telethon Institute for Gene Therapy and the University of North Carolina showed that a reprogrammed retrovirus could successfully transfer new clotting genes into animals with hemophilia B to safely and dramatically decrease spontaneous bleeding.
Playing games with children over the summer can boost academic and social skills - while the family has some fun, to boot.
The newest guidelines for the use of cholesterol-lowering statins in people at risk of heart disease may be too generic, excluding middle-aged adults who could benefit from the drugs, and over-prescribing in older adults, according to a new study from the Duke Clinical Research Institute.
Despite legal and ethical mandates for disclosure, results from most clinical trials of medical products are not reported promptly on a registry specifically created to make results of human studies publicly available, according to Duke Medicine researchers.
An innovative approach using a tetanus booster to prime the immune system enhances the effect of a vaccine therapy for lethal brain tumors, dramatically improving patient survival, according to a study led by Duke Cancer Institute researchers.
Acute respiratory distress syndrome (ARDS) is a life-threatening lung condition that affects approximately 200,000 people a year in the United States and has a higher mortality rate than breast and prostate cancer combined. The condition most often occurs in people who are critically ill or who have significant injuries; those who do survive it often experience profound skeletal muscle weakness.
America in the Shadow of Empires, by Wake Forest University professor David Coates, compellingly compares the development and failure of four of history’s greatest empires to the current American situation, especially regarding foreign policy and military deployment, the domestic economy, education and health care.
Purposefully and repeatedly exposing children to secondhand smoke — a known human carcinogen — is child abuse, according to an opinion piece written by Adam Goldstein, MD, MPH, a professor in the Department of Family Medicine at the University of North Carolina School of Medicine.
A new study identifies both where in the brain and how a protein in the brain, called Neuropeptide Y or NPY, can act to suppress binge alcohol drinking. These findings suggest that restoring NPY may be useful for treating alcohol use disorders and may also protect some individuals from becoming alcohol dependent.
Federal efforts to curb Medicare costs for unclogging blood vessels in the limbs slowed the growing use of the treatments, but also coincided with a marked increase in doctors using a more expensive approach, according to an analysis by Duke Medicine researchers.
Treatment for painful episodes of blood vessel obstruction in sickle cell anemia is currently limited to controlling pain, but an investigational therapy might be able to interfere with the underlying cause of these events, known as vaso-occlusion crises, researchers at Duke Medicine report.
Management of the alliance, which was created by the Arthritis Foundation and the CDC in 2011, has been transferred to the UNC Thurston Arthritis Research Center.
The prevalence of chronic kidney disease (CKD) will rise in the United States, according to a new report led by RTI International and published in the American Journal of Kidney Diseases during March's National Kidney Month
Nearly all women and people over 65 in the U.S. with atrial fibrillation are advised to take blood thinners under new guidelines based on an analysis from the Duke Clinical Research Institute.
A novel research study from the UNC School of Medicine shows that although mammals inherit equal amounts of genetic mutations from their parents – the mutations that make them unique and not some other person – they actually “use” more of the DNA that they inherited from their dads.
Research finds that strong, reliable anti-retaliation policies can encourage employees to notify internal authorities of possible wrongdoing, but that offering monetary incentives does not necessarily influence whistleblowing behavior – or at least not right away.
The South is known as the Stroke Belt with good reason. Residents of North Carolina are 20 to 40 percent more likely to die of stroke than those living in other parts of the country.
When it comes to detecting alcohol misuse, newly minted primary care physicians ask the wrong questions at the wrong times, according to a study led by researchers at Wake Forest Baptist Medical Center.
Using a portable, non-invasive imaging device, a team of Duke Medicine doctors have identified swelling in the back of the eyes of premature infants that correlates with poorer neurodevelopment as the babies grow.
When Wake Forest University chemistry professor Angela King realized how much students' expectations for a class impact their learning, she turned to a pop culture phenomenon for innovative teaching ideas.
UNC researchers found that the blood platelet protein Rasa3 is critical to the success of the common anti-platelet drug Plavix, which breaks up blood clots during heart attacks and other arterial diseases. The discovery could prove important for creating drugs to alter platelet function.
Mutation of one gene is all it takes to get cystic fibrosis, but disease severity depends on many other genes and proteins. For the first time, UNC researchers identified genetic pathways that play major roles in why one person with CF might have severe symptoms while another person might not.
Much like mapping the human genome laid the foundations for understanding the genetic basis of human health, new maps of the human epigenome may further unravel the complex links between DNA and disease. The epigenome is part of the machinery that helps direct how genes are turned off and on in different types of cells.
Duke Medicine researchers have shown how gene mutations may cause common forms of cartilage tumors. In a study published in the Feb. 16, 2015, issue of the Proceedings of the National Academy of Sciences, Duke researchers and their colleagues revealed that mutations in the isocitrate dehydrogenase (IDH) gene contribute to the formation of benign tumors in cartilage that can be a precursor to malignancies.
UNC School of Medicine researchers discovered a gene called R2d2 – Responder to meiotic drive 2 – that breaks Gregor Mendel’s century-old “law of segregation,” which states that you have an equal probability of inheriting each of two copies of every gene from both parents.
Researchers discover that the accepted theory of how Yersinia pestis microbes travel from fleabite to lymph node is off base. Most bacteria get trapped in a bottleneck and never make it to the lymph node, where infection takes root. Finding out why could lead to new ways to stop the pathogen.
Nearly nine out of 10 premenopausal and postmenopausal women in the United States experience hot flashes, night sweats or other disturbances in mood and sleep. Unfortunately, there aren’t many safe and effective therapies available to manage these symptoms.
UNC scientists have created a new research tool, based on the fruit fly, to help crack the histone code. This research tool can be used to better understand the function of histone proteins, which play critical roles in the regulation of gene expression in animals and plants.
Teens who use tobacco products are likely to use more than one product, including e-cigarettes, hookahs and pipes, and smokeless tobacco, according to a new study by RTI International.
Researchers found that a baby’s diet during the first few months of life has a profound influence on the composition, diversity, and stability of the gut microbiome. These factors influence the baby’s ability to transition from milk to solid foods and may have long-term health effects.
New grants totaling $3 million will go to six outstanding early-career scientists, bridging a funding gap to independent biomedical research. The National Institute of Environmental Health Sciences (NIEHS), part of the National Institutes of Health, created the award to encourage early stage researchers who want to discover how our environment influences human health.
UNC School of Medicine researchers have shown that brain scans can predict which patients with clinical depression are most likely to benefit from a specific kind of talk therapy.
Wake Forest University math professor receives a National Science Foundation grant in the amount of $258,354 to begin a summer research program for undergraduates interested in number theory research.
For at least 40 years, scientists who study how the body metabolizes sugar have accepted one point: there are four enzymes that kick-start the body’s process of getting energy from food. But this biochemical foursome may not deserve all of the credit. According to research by scientists at Duke and Northwestern universities, the hexokinase team actually has a fifth player.
A new study by University of North Carolina at Chapel Hill researchers finds that a collection of simple strategies used by parents can lead to significant improvements in one-year-olds at risk for autism spectrum disorder (ASD).
In an analysis of 279 head and neck cancer tumors, researchers with The Cancer Genome Atlas identified subtypes of head and neck cancer based on their genomic characteristics, changes in smoking-related tumors, as well as genomic differences in head and neck cancer tumors linked to HPV, the most common sexually transmitted disease in the United States.
RTI Health Solutions (RTI-HS), a business unit of RTI International, partnered with the U.S. Food and Drug Administration to conduct a study on patients' preferences which contributed to the Agency's regulatory decision to approve the Maestro Rechargeable System, a first-of-kind device to treat obesity.
New deep-brain imaging shows activity of individual, genetically similar neurons to particular behaviors of mice. Scientists watched as one neuron was activated when a mouse searched for food while a nearly identical neuron next to it remained inactive until the mouse began eating.
New first-destination data collected by Wake Forest’s Office of Personal and Career Development shows that 98 percent of 2014 Wake Forest grads are either employed or in graduate school.
Incisional hernia repairs among men age 65 years and older rose 24.2 percent in the United States from 2001 to 2010, according to a study by researchers from RTI International and the University of North Carolina at Chapel Hill.
For people who have celiac disease, going gluten-free isn't a lifestyle choice, it's a necessity. For everyone else, steering clear of gluten isn't necessarily a good idea.
Researchers create first mouse model of ovarian clear cell carcinoma using data from human cancer genome atlas. They show how when the genes ARID1A and PIK2CA are mutated in specific ways, the result is ovarian cancer 100 percent of the time. They show that a known drug can suppress tumor growth.
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