Although immunotherapy is seen as a very promising treatment for cancer, currently only 20 to 30 percent of patients respond positively. Being able to identify the people most likely to benefit from the costly therapy is a Holy Grail for oncologists.
A new systematic review provides the most comprehensive assessment to date on the scientific evidence estimating the effectiveness of various fertility awareness-based methods (FABMs) for contraception.
The Andrew W. Mellon Foundation has awarded Wake Forest University an $850,000 grant to expand its community-based partnerships through engaged teaching and research in the humanities. The four-year grant will support “The Humanities Engaged: Generating Learning, Remaking Community” through June 2022.
Researchers at Wake Forest Baptist Medical Center have shown that gene expression analysis of blood samples taken from the recipients of transplanted kidneys can be used to better understand the mechanisms that promote repair and regeneration of the transplanted organs.
All living things use the genetic code to “translate” DNA-based genetic information into proteins. Precisely how the process of translation arose in the earliest stages of life on Earth has long been mysterious, but two theoretical biologists have now made a significant advance in this field.
A small population of brain cells called "mossy cells" deep in a memory-making region of the brain controls the production of new neurons and may have a role in common brain disorders, according to a study from scientists at the University of North Carolina School of Medicine.
Immune cells that normally rush in to protect the eyes from infection might actually be disrupting moisturizing glands and causing dry eye, a disease that afflicts more than 30 million people in the United States.
Recognizing your limits, knowing where you’re going and what you might encounter there, and being aware of the environment you’re in are the best ways to avoid the bites, stings, cuts, sprains and other mishaps that can spoil outdoor activities
In a study published in the journal Science, researchers suggest that ZHX2 is a potential new therapeutic target for clear cell renal cell carcinoma, which is the most common type of kidney cancer.
A research team led by Duke Cancer Institute scientists has found that this blood cancer infiltrates the central nervous system not by breaching the blood-brain barrier, but by evading the barrier altogether.
Researchers with UNC Lineberger’s Carolina Cancer Screening Initiative, in collaboration with the Mecklenburg County Health Department in Charlotte, examined the impact of mailing tests to more than 2,100 people insured by Medicaid who were not up-to-date with colorectal cancer screening.
In late June, UNC Health Care became the first organization in North Carolina to integrate its Epic Electronic Health Record (EHR) system with the NC Controlled Substance Reporting System, a giant step forward in empowering the system’s physicians to address the opioid epidemic.
Researchers investigated whether the location of the mutation within the sequence of the PIK3CA gene affected the mutation’s ability to help drive glioblastoma growth. They also tested whether mutations within certain sequences of the gene were linked to better responses to particular drugs. They found mutational status was not linked to a response to a single targeted drug, but it was to a combination of treatments.
The National Institutes of Health (NIH) has awarded $8 million to Wake Forest Baptist Medical Center to study cognitive decline and impairment in older adults with type 2 diabetes who are overweight or obese.
Research reveals motivations and rewards of citizen scientists
A collaboration between researchers at the University of North Carolina at Chapel Hill Gillings School of Global Public Health, RTI International and the UNC School of Medicine has resulted in the first study to assess and compare United States travelers’ knowledge levels about the Zika virus across three regions
A preliminary study of prospective teachers finds that they are more likely to view the face of Black adults as angry compared to the faces of White adults. Similarly, the study participants viewed the behavior of Black children as more hostile than the behavior of White children.
Intrusion Technologies Inc. and Louroe Electronics, the world leader in the audio security industry, today announced their intent to combine technologies to help protect against active assailant threats.
Young women with high body fat have a decreased chance of developing breast cancer before menopause, according to scientists at the National Institutes of Health and their collaborators. The finding, published online in the journal JAMA Oncology, may help researchers better understand the role obesity plays in breast cancer risk.
A genetically modified poliovirus therapy developed at Duke Cancer Institute shows significantly improved long-term survival for patients with recurrent glioblastoma, with a three-year survival rate of 21 percent in a phase 1 clinical trial.
John Dinan, a Wake Forest University politics professor and author of the book “State Constitutional Politics: Governing by Amendment in the American States,” can provide context and comment on amendments to the North Carolina Constitution the legislature is considering for placement on the 2018 ballot.
University of North Carolina School of Medicine researchers have discovered that a protein called Spt6 facilitates RNA degradation so that cells have just the right amount of RNA for the creation of proteins, a key component to human health and the avoidance of disease.
Some large, publicly held companies are incorporated in tax haven countries, ostensibly to increase value for shareholders. But new research finds that many such companies are more likely to engage in practices that benefit executives at the cost of their shareholders.
The majority of skin problems – including the most common, acne – occur in people of every ethnicity and skin color. However, the amount of melanin, which is the pigment that gives skin its color, an individual has can greatly influence their risk of and reaction to many different conditions.
A study led by UNC’s Sylvia Becker-Dreps, MD, MPH, reviewed more than 675,000 pregnancies in the U.S. to determine if the Tdap vaccine given to a mother will reduce the chances of her child developing pertussis during the first 18 months of life. The results show a decrease in overall cases of pertussis, and most notably, in pertussis hospitalization in infants whose mothers were immunized during pregnancy.
Parents ranked cancer prevention as the most compelling reason health care providers can give for recommending the human papillomavirus (HPV) vaccine, according to a survey led by University of North Carolina Lineberger Comprehensive Cancer Center researchers.
The Chronic Pancreatitis and Autologous Islet Cell Transplant Program, created by Chirag S. Desai, MD, is helping patients improve their quality of life by eliminating severe pain and reducing or ending the use of narcotic pain medications, while preventing brittle diabetes.
In a collaborative, multi-institution effort to map the genetic and genomic changes in cancer, researchers led by UNC Lineberger's Katherine Hoadley, PhD, analyzed 137 testicular germ cell tumors for potential mutations and other molecular changes. They identified molecular features of testicular germ cell cancers that could inform future efforts to improve treatment decisions, and help monitor patients to see if their cancer has come back. Their findings were published in Cell Reports.
Heart defects are the most common type of birth defect, and can be caused by mutations in the gene CHD4. Researchers at the University of North Carolina School of Medicine have now revealed key molecular details of how CHD4 mutations lead to heart defects.
A new study by University of North Carolina School of Medicine researchers has found that T cells, a type of white blood cell and an essential part of the immune system, are sufficient by themselves to establish and maintain an HIV infection in the brain.
A study by UNC Lineberger Comprehensive Cancer Center's Ronald Chen, MD, MPH, and colleagues assessed whether monitoring prostate cancer patients following treatment with a PSA test every three months versus once a year would provide a long-term survival benefit.
African-American men with advanced prostate cancer might be more responsive than white men to an anti-androgen drug and steroids, according to a study led by Duke Cancer Institute researchers.
Contrary to current perceptions, certain African-American men with advanced prostate cancer have as good a chance of survival as white men and might actually have a small advantage, according to a new analysis of more than 8,000 patients who participated in clinical trials.
The UNC AFib Care Network has launched a new clinic that coordinates all of the services needed by patients with atrial fibrillation (AFib) in one convenient location.
Wake Forest Institute for Regenerative Medicine (WFIRM) scientists have developed a 3-D brain organoid that could have potential applications in drug discovery and disease modeling.
In the journal Nature Communications, researchers report for a particular subset of lung cancer tumors, there is a high prevalence of immune cells called inflammatory monocytes. These immune cells, which normally help to build clotting scaffolds to promote wound healing, also make it possible for tumor cells to migrate and spread to other parts of the body.
Designed by former law enforcement and fire department personnel, active shooter detection and mitigation systems can automatically detect gunshots, aggressive speech, breaking glass, and other violent actions.
In the journal Cancer Research, UNC Lineberger Comprehensive Cancer Center researchers report they have developed a model of luminal bladder cancer, one of the two subtypes of advanced bladder cancer. The researchers said this model may help them to determine which patients may respond to checkpoint inhibitors.
A new case report led by Maya Styner, MD, of the UNC School of Medicine describes how a patient's use of a common over-the-counter biotin supplement caused clinically misleading test results and almost resulted in an unnecessary, invasive medical procedure.
UNC School of Medicine researchers have delineated the details of one major barrier to a promising vaccine. It’s something we all have – a natural body temperature of about 98.6 degrees.
A software tool to automatically calculate how extensively bones have been infiltrated by prostate cancer is both accurate and speedy, capturing key prognostic information related to survival and the development of symptoms over time.
Sessions with patient actors give medical students and other prospective providers the opportunity to develop both clinical skills and “bedside manner” before they begin to practice medicine for real.
Do metastatic cancer tumors "break bad" or are they "born bad"? In a study publishing the week of May 14 scientists found that in the colorectal tumors they examined, invasive cancers are born to be bad, and this tendency can potentially be identified at early diagnosis.
A new tool developed by researchers at the National Institutes of Health has determined, for the first time, how two distinct sets of neurons in the mouse brain work together to control movement. The method, called spectrally resolved fiber photometry (SRFP), can be used to measure the activity of these neuron groups in both healthy mice and those with brain disease. The scientists plan to use the technique to better understand what goes wrong in neurological disorders, such as Parkinson’s disease (PD). The study appeared online May 3 in the journal Neuron.
For the first time, UNC School of Medicine scientists led by Nobel laureate Aziz Sancar analyzed whole-genome DNA repair in an animal over 24 hours to find which genes were repaired, where exactly, and when, laying the groundwork for a more precise use of anti-cancer drugs.
A new study from the UNC Lineberger Comprehensive Cancer Center shows that parenting concerns have a significant impact on the mental and emotional health of women with advanced cancer. In particular, they found that a mother’s emotional well-being was significantly linked with whether she had communicated with her children about her illness, and her concerns about how her illness will financially impact her children.
Steep declines in the use of coal for power generation over the past decade were caused largely by less expensive natural gas and the availability of wind energy – not by environmental regulations.
The future of self-driving cars seemed all but inevitable — until a fatal crash in Arizona last month prompted tech companies, automakers and lawmakers to pump the brakes.
A recent study finds that young people who get financial support from their parents have greater professional success, highlighting one way social inequality is transmitted from one generation to the next.
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