暴露组探索:妙佑医疗国际(Mayo Clinic) 有关环境暴露对健康影响的研究
Mayo Clinic来自空气、食物、产品和水中的环境化学物质、污染物、微生物和微粒可能会蓄积在我们每个人的体内。这些有时有害的暴露物会与我们的基因发生相互作用,从而引发疾病。妙佑医疗国际个体化医学中心的研究人员正在研究终生环境暴露(称为暴露组),并评估对这些暴露产生的生物反应。
来自空气、食物、产品和水中的环境化学物质、污染物、微生物和微粒可能会蓄积在我们每个人的体内。这些有时有害的暴露物会与我们的基因发生相互作用,从而引发疾病。妙佑医疗国际个体化医学中心的研究人员正在研究终生环境暴露(称为暴露组),并评估对这些暴露产生的生物反应。
تحتوي أجسادنا على تراكمات سنوات طويلة من المواد الكيميائية والملوّثات والميكروبات والجسيمات المتواجدة في البيئة المحيطة به، والتي نتعرّض لها يومياً عبر الهواء الذي نتنشّقه والطعام الذي نتناوله والمنتجات التي نلمسها والماء الذي نشربه.
Dentro de cada uno de nosotros puede existir una acumulación de sustancias químicas y contaminantes del ambiente, de microbios y de partículas adquiridas del aire que respiramos, de los alimentos que comemos, de los productos que tocamos y del agua que bebemos.
Heart failure is a common and devastating disorder for which there is no cure. Many cardiomyopathies —conditions that make it difficult for the heart to pump blood such as dilated cardiomyopathy (DCM) and arrhythmogenic cardiomyopathy (ACM) — can lead to heart failure, but treatments for patients with heart failure do not take these distinct conditions into account.
Children’s Hospital of Philadelphia (CHOP) has helped launch a new computational platform that will harmonize pediatric cancer data, allowing researchers, pharmaceutical companies, and advocacy groups to accelerate the pace of drug development for pediatric cancer. With funding from the National Cancer Institute (NCI) via a subcontract with Leidos Biomedical Research, current operator of the NCI’s Frederick National Laboratory for Cancer Research, CHOP researchers have created the Molecular Targets Platform to facilitate pediatric research in response to the Research to Accelerate Cures and Equity (RACE) for Children Act, which requires companies to test cancer drugs in children that are used in adults when there is a shared molecular target.
After an injury or surgery, physical therapy often plays an essential role in recovery. It can also improve fitness and function for people dealing with chronic pain. Experts from Hospital for Special Surgery offer tips on what to look for in a PT facility.
Here are some of the latest articles that have been added to the Drug Resistance channel on Newswise, a free source for journalists.
PASS (Point-Assisted Spinal Sonography), an ultrasound-guided lumbar puncture device from Chula doctors and engineers, helps increase the precision and confidence in spinal tap procedures while reducing risks and pain for patients.
A new position paper from the American College of Physicians (ACP) offers guidance regarding ethical decision-making for the integration of precision medicine and genetic testing into internal medicine. ACP's advice is published in Annals of Internal Medicine.
Leaders with Vanderbilt University Medical Center announced plans today for construction of the largest expansion to date for Vanderbilt University Hospital (VUH). Through this project a new inpatient tower will be built atop an existing parking structure located between 21st Avenue South and Medical Center Drive.
At the 2022 AACC Annual Scientific Meeting & Clinical Lab Expo, laboratory medicine experts will present the cutting-edge research and technology that is revolutionizing clinical testing and patient care.
A University of Minnesota Twin Cities team has developed a new tool to predict and customize the rate of DNA editing, paving the way for more personalized, efficient genetic and cell therapies for diseases such as diabetes and cancer.
The latest research news in Climate Science on Newswise.
Antisense oligonucleotides, or ASOs, are molecules that can be used to control protein levels in cells.
In Biomicrofluidics, scientists reveal their development of a new type of prosthetic using microfluidics-enabled soft robotics that promises to greatly reduce skin ulcerations and pain in patients who have had an amputation between the ankle and knee. They started with a recent device that uses pneumatic actuators and miniaturized the actuators by designing a microfluidic chip with 10 integrated pneumatic valves to control each actuator. The control box is small and light enough to be worn as part of the prosthesis.
The latest expert commentary and research on SCOTUS decisions, including the overturn of Roe v. Wade
MD Anderson and Turning Point Therapeutics announced a strategic research and development alliance to evaluate Turning Points investigational targeted therapies against ROS1, NTRK, MET and other cancer drivers.
A team of investigators from Texas Heart Institute, Texas Children’s Hospital and Baylor College of Medicine uncovered new insights into the mechanisms underlying the progression of congenital heart disease (CHD) ― a spectrum of heart defects that develop before birth and remain the leading cause of childhood death.
There is a long history of confusion and controversy regarding the use of polypropylene mesh materials for pelvic floor disorders in women, such as stress urinary incontinence (SUI) or pelvic organ prolapse (POP). So what option would specialist surgeons choose if they were to undergo these procedures themselves? That's the question asked in a survey study in Urology Practice®, an Official Journal of the American Urological Association (AUA). The journal is published in the Lippincott portfolio by Wolters Kluwer.
University of Maryland Medicine, the joint enterprise of the University of Maryland School of Medicine, the University of Maryland Medical Center, and University of Maryland Medical System, today launched a landmark initiative called My Healthy Maryland Precision Medicine Research.
A collaborative team of scientists led by Mayo Clinic's Center for Individualized Medicine has discovered 15 additional genetic mutations in the KCNK9 gene that cause a neurodevelopmental syndrome.
Here are some of the latest articles that have been added to the Aging channel on Newswise, a free source for journalists.
A team of researchers from National University of Singapore, in collaboration with clinicians from the National University Cancer Institute, Singapore which is part of the National University Health System, has reported promising results in using CURATE.AI, an artificial intelligence tool that identifies and better allows clinicians to make optimal and personalised doses of chemotherapy for patients.
Researchers discuss their findings in an expert panel.
The American Medical Society for Sports Medicine (AMSSM) recently updated its Choosing Wisely® recommendations to include five new suggestions to reduce low-value or overutilized medical services.
The behind-the-scenes story detailing the pursuit of a transformative cancer cure will unfold onscreen at the Tribeca Film Festival in New York City this weekend. “Of Medicine and Miracles,” which will premiere during the renowned international festival, is an emotional journey, revealing decades of research – and one young patient’s family’s last hopes to save their daughter – that culminated in the world’s first CAR T-cell therapy, an approach that reprograms patients’ own immune cells to kill their cancer.
The U.S. Food and Drug Administration (FDA) has expanded its approval for a personalized cellular therapy developed at the University of Pennsylvania’s Abramson Cancer Center, this time for the treatment of adults with relapsed or refractory follicular lymphoma (FL) after two or more lines of systemic therapy. The accelerated approval was granted today to Novartis for the chimeric antigen receptor (CAR) T-cell therapy Kymriah® (tisagenlecleucel), making it the third indication for the nation’s first personalized cellular therapy for cancer. It remains the only CAR-T cell therapy approved for both adult and pediatric patients.
Penn Medicine and Children’s Hospital of Philadelphia (CHOP), who together pioneered the research and development of the world’s first personalized cellular therapy for cancer — also known as CAR T cell therapy — have announced plans with Costa Rica’s CCSS, or the Caja Costarricense de Seguro Social (Social Security Program), to facilitate CAR T research in Costa Rica.
Scientists at Yale Cancer Center have found that patients with breast cancer and high levels of insulin in the blood may be responsive to metabolism-targeting treatments, which in turn may improve the effectiveness of subsequent chemotherapy treatments.
Investigators from Rutgers Cancer Institute of New Jersey, New Jersey’s only National Cancer Institute- Designated Comprehensive Cancer Center, led a collaborative study to examine the patterns of druggable oncogenic fusions in colon cancer specimens including microsatellite-stable and unstable (MSI) tumors.
A major donation has enabled the launch of an exciting new interdisciplinary collaboration at UT Austin involving the Oden Institute for Computational Engineering and Sciences, Machine Learning Labs and Dell Medical School.
The University of Maryland Medical Center celebrates the groundbreaking of a nine-story patient care tower – the Roslyn and Leonard Stoler Center for Advanced Medicine – that will become the new home of the University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center. The $219 million building will enable the cancer center to provide the most technologically advanced, integrated care to cancer patients throughout Maryland and the region well into the future
Rensselaer Polytechnic Institute and the Icahn School of Medicine at Mount Sinai today announced the creation of the Center for Engineering and Precision Medicine (CEPM), one of the first centers in the nation to bridge engineering and engineering science with medicine. This undertaking will build on a wealth of shared basic research discoveries, explore unique therapeutic innovations in cancer, Alzheimer’s and a myriad of infectious diseases; educate a new generation of biomedical leaders; and develop new technologies and processes that enhance patient outcomes in unprecedented ways. CEPM represents an evolution in the successful partnership between Mount Sinai and RPI, one that has secured over $70 million in shared research funding since 2013 with 90 percent of that provided by the National Institutes of Health.
Rensselaer Polytechnic Institute and the Icahn School of Medicine at Mount Sinai today announced the creation of the Center for Engineering and Precision Medicine (CEPM), one of the first centers in the nation to bridge engineering and engineering science with medicine.
A new study is the first to investigate brain connectivity patterns at rest in veterans with both chronic pain and trauma, finding three unique brain subtypes potentially indicating high, medium, and low susceptibility to pain and trauma symptoms.
The presence of Cervical Cancer Stem Cells (CCSCs) in cases of Cervical Cancer (CC) represent a small subpopulation of tumor cells with a high potential for resistance to conventional treatments.
Get the latest insights from leading nutrition scientists and practitioners at NUTRITION 2022 LIVE ONLINE, the flagship online meeting of the American Society for Nutrition. Explore the meeting program for scientific sessions, special events and featured speakers.
妙佑医疗国际(Mayo Clinic)个体化医学中心的研究人员设计出一种免疫治疗技术,通过将嵌合抗原受体-T细胞疗法,即CAR-T细胞疗法与一种抗癌病毒相结合,更有效地靶向和治疗实体癌肿瘤。
ابتكر باحثون من مركز مايو كلينك للطب الفردي أسلوبًا للعلاج المناعي يجمع بين العلاج بالخلايا التائية ذات مستقبلات المستضد الخيمرية، أو العلاج بخلايا CAR-T، والفيروس قاتل السرطان لاستهداف الأورام السرطانية الصلبة وعلاجها بشكل أكثر فعالية
Pesquisadores do Centro de Medicina Individualizada da Mayo Clinic criaram uma técnica de imunoterapia que combina terapia de células T com receptor de antígeno quimérico, ou terapia celular CAR-T, com um vírus que mata o câncer para direcionar melhor o alvo e tratar com mais eficiência tumores de câncer sólidos.
Los investigadores del Centro para Medicina Personalizada en Mayo Clinic inventaron una técnica de inmunoterapia que combina la terapia de células T con receptor de antígeno quimérico (CAR-T, por sus siglas en inglés) con un virus que elimina el cáncer a fin de apuntar de forma más eficiente el tratamiento contra el cáncer de tumor sólido.
It’s been 50 years since the Tuskegee Study was disclosed to the American public. In May, a new riveting account of the Study, when government doctors intentionally withheld effective therapy for syphilis for 40 years in 400 African American men, will be published in the American Journal of Respiratory and Critical Care Medicine. The article explains the deeper everlasting lessons of the study.
New research has identified the role of the immune response within bowel cancer tissue, which could lead to new lifesaving treatments for bowel cancer patients.
There are myriad ways in which people can experience physical wounds – from minor scrapes and abrasions to the effects of surgery, critical injuries, burns and other major traumas.
A person’s risk of developing diseases such as type 2 diabetes or breast cancer may be influenced by thousands of genetic differences.
In the U.S. today, there are an estimated 1.4 million homeless veterans, which makes up about eight percent of the country’s homeless population. Though it has been difficult to accurately predict homelessness before it occurs, a new collaborative study using a “personalized medicine” approach, led by the Uniformed Services University (USU), suggests self-reported lifetime depression and posttraumatic stress disorder were among the most important factors that put veterans at risk for becoming homeless.
Researchers at Mayo Clinic's Center for Individualized Medicine have devised an immunotherapy technique that combines chimeric antigen receptor-T cell therapy, or CAR-T cell therapy, with a cancer-killing virus to more effectively target and treat solid cancer tumors.
Here are some of the latest articles that have been added to the Clinical Trials channel on Newswise.
Despite COVID-19 forcing the hand of digitally reticent governments and health organizations to update, upskill and adopt digital health tools, evidence of scaled up mobile phone health (mHealth) initiatives being accessible to the poorest and those most in need, is so far, thin on the ground, according to the review released today in the Annual Review of Public Health.