Feature Channels: Personalized Medicine

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Scientists from the UCLA Jonsson Comprehensive Cancer Center have developed a new method to bioprint miniature tumor organoids that are designed to mimic the function and architecture of real tumors. The improved process allows researchers to use an advanced imaging method to study and analyze individual organoids in great detail, which can help researchers identify personalized treatments for people with rare or hard-to-treat cancers.

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The accuracy of prostate-specific antigen (PSA) screening for prostate cancer can be improved by accounting for genetic factors that cause changes in PSA levels that are not associated with cancer, according to a multi-center study led by UC San Francisco and Stanford University, publishing June 1 in Nature Medicine.

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Para vislumbrar o futuro da medicina, conheça o Centro de Medicina Individualizada de última geração da Mayo Clinic. No Centro, médicos, pesquisadores, cientistas de dados, engenheiros de inteligência artificial e especialistas em bioética estão trabalhando em estreita colaboração para investigar os massivos conjuntos de dados “ômicos”.

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Para vislumbrar el futuro de la medicina, ingrese al Centro de Medicina Personalizada de última generación en Mayo Clinic. Allí, médicos, investigadores, analistas de datos, ingenieros de inteligencia artificial y bioéticos trabajan a la par para investigar los inmensos conjuntos de datos de las ómicas.

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Investigators from Cedars-Sinai Cancer, working in collaboration with colleagues in Colorado and the Netherlands, have identified a specific type of bladder cancer most likely to resist first-line treatment.

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A gene regulating the F-Box and WD Repeat Domain Containing 7 (FBXW7) protein is frequently mutated or deleted in various types of human cancer, including gynecological cancers.

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Skin cancer is the most prevalent form of cancer in the United States, with over 5 million cases diagnosed annually. The Centers for Disease Control and Prevention reports that melanoma alone accounts for more than 8,000 deaths each year. Thankfully, skin cancer is highly preventable, making it crucial to prioritize protection. Below are some of the latest headlines in the Dermatology channel.

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El Departamento de Biomedicina Computacional de Cedars-Sinai recientemente refinó su enfoque en el avance de la inteligencia artificial y el aprendizaje automatizado al establecer el Centro de Investigación y Educación de Inteligencia Artificial.

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EXI – the Software as a Medical Device (SaMD) that delivers personalized physical activity prescription and behavior change support for people with long-term health conditions – has unveiled its first Exercise is Medicine® (EIM) deployment alliances. Freedom Aquatic & Fitness Center (FAFC) – located onsite at George Mason University Science & Technology campus in Manassus, Virginia, with a specialist team that delivers EIM in the community and via health provider referrals – and Logan Health, a Montana healthcare system offering EIM programs through its medical fitness center in Kalispell, Montana, will be the first facilities to deploy Exercise is Medicine® using EXI’s digital platform.

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Eimear Kenny, PhD, had just completed undergrad and was working in her first computational genomics job more than 20 years ago when scientists announced the first (nearly) complete sequencing of the human genome—what was considered at the time to be the fundamental blueprint for all humans. The Human Genome Project aimed to map the entire genome in an effort to accelerate the diagnosis and eventual treatment of common and rare diseases.

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May is a month to recognize the importance of cancer research, with both Brain Tumor Awareness Month and National Cancer Research Month taking center stage. Virginia Tech’s Fralin Biomedical Research Institute at VTC is dedicated to advancing our understanding of cancer and developing new ways to treat and prevent it. Teams of investigators are working to uncover the molecular mechanisms that drive cancer growth, migration, and metastasis.

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An exhaustive cost-benefit analysis of population genetic testing published in Annals of Internal Medicine concludes with a recommendation to U.S. health policymakers to adopt routine testing of adults ages 40 and under for three genetic conditions posing high risk of life-threatening illness.

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Researchers from the University of California, Irvine have developed a DNA enzyme – or DNAzyme – that can distinguish between two RNA strands inside a cell and cut the disease-associated strand while leaving the healthy strand intact. This breakthrough “gene silencing” technology could revolutionize the development of DNAzymes for treating cancer, infectious diseases and neurological disorders.

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Mayo Clinic Platform is expanding its distributed data network, Mayo Clinic Platform_Connect, to include Hospital Israelita Albert Einstein in Brazil, Sheba Medical Center in Israel and University Health Network (UHN) in Canada, joining Mercy, Connect’s first member. The first-of-its-kind global alliance establishes a data-sharing network that transcends language barriers and accelerates AI-based solutions by using current data science and years of clinical data to create better patient outcomes around the world.

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University of Maryland School of Medicine (UMSOM) Dean Mark T. Gladwin, MD, announced today that Bradley A. Maron, MD, Associate Professor of Medicine at Brigham & Women’s Hospital (BWH) and Harvard Medical School (HMS), and Co-Director of the Pulmonary Vascular Disease Center at the VA Boston Healthcare System, has been appointed Co-Director of the UMB’s new Institute for Health Computing (UM-IHC), Director of Scientific Operations for the UM-IHC at UMSOM, as well as Senior Associate Dean for Precision Medicine at the UMSOM, effective May 1, 2023.

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Ann & Robert H. Lurie Children’s Hospital of Chicago is the first in Illinois to receive designation as a NORD Rare Disease Center of Excellence, becoming one of 40 U.S. academic medical centers selected to be a part of the first-of-it-kind national network of U.S. medical institutions dedicated to diagnosing, treating, and researching all rare diseases. The network is led by the National Organization for Rare Disorders (NORD) and is designed to foster knowledge sharing between rare disease experts across the country to help meet the unmet needs of more than 25 million Americans living with a rare disease.

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Cleveland Clinic has been designated a Rare Disease Center of Excellence by the National Organization for Rare Disorders (NORD). The new Cleveland Clinic Center for Rare Diseases is one of 40 U.S. academic medical centers selected to join the first-of-it-kind national network dedicated to diagnosing, treating and researching all rare diseases.

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Physician-scientist Paul Noble, MD, chair of the Department of Medicine at Cedars-Sinai, was named president-elect of the Association of American Physicians (AAP) at the group's annual meeting in Chicago on April 22.