Crippling Life Support for SARS-CoV-2 Through Synthetic LethalitySeattle Children's Hospital
Although children don’t typically fall seriously ill from the new coronavirus, doctors in Europe are now expressing concern that children with COVID-19 have developed mysterious symptoms that mimic those appearing with Kawasaki disease.On the Pulse asked Dr. Michael Portman, pediatric cardiologist and director of the Kawasaki Disease Clinic at Seattle Children’s Hospital, to help break this emerging issue down for parents and caregivers.
Hospital food has traditionally gotten a bad rap, but Seattle Children’s Nutrition and Culinary team is changing that.
Seattle Children’s Research Institute is one of three recipients of $30 million in first-year-funding provided by the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, to establish centers for immunology research to accelerate progress in tuberculosis vaccine development.
Seattle Children’s today announced the opening of Building Cure™, a new 540,000 square-foot pediatric research facility located at Stewart Street and Terry Avenue in downtown Seattle’s biotech corridor. Building Cure is the latest step in Seattle Children’s quest to revolutionize pediatric medicine and improve the lives of children worldwide.
Arabella Smygov, 7 months, of Lynnwood, Washington was one of the first babies in the state to receive the gene therapy, Zolgensma. The U.S. Food and Drug Administration approved Zolgensma for the treatment of Spinal Muscular Atrophy in children less than 2 years of age this month.
Scientists at Seattle Children’s Research Institute are paving the way to use gene-edited B cells – a type of white blood cell in the immune system – to treat a wide range of potential diseases that affect children, including hemophilia and other protein deficiency disorders, autoimmune diseases, and infectious diseases.
The first findings to result from a collaboration between Seattle Children’s Research Institute and Microsoft data scientists provides expecting mothers new information about how smoking before and during pregnancy contributes to the risk of an infant dying suddenly and unexpectedly before their first birthday.
In honor of National Kawasaki Disease Awareness Day on January 26, we are sharing the story of Olivia, a 9-year-old who lives with the disease. Research at Seattle Children’s aims to improve life for children with this condition who are at risk for aneurysms. When Olivia Nelson was 3 years old, her parents noticed that she had a fever that wouldn’t get better.
Digital devices like the iPad have only been around for about 10 years, but in that short amount of time, they have become ingrained into everyday life and research examining their impact on young children is limited.Tune into 60 Minutes this Sunday, Dec. 9 at 7 p.m. ET/PT as Dr. Dimitri Christakis, director of the Center for Child Health, Behavior and Development at Seattle Children’s Research Institute, discusses with Anderson Cooper the evolving digital age children are growing up in today and how his research hopes to uncover the impact this new era has on a child’s developing mind.
New research from Seattle Children’s Research Institute and UW Medicine’s Sports Health and Safety Institute found concussion rates among football players ages 5-14 were higher than previously reported, with five out of every 100 youth, or 5%, sustaining a football-related concussion each season.
Seattle Children's today announced that Steve Ballmer, former Microsoft CEO, and his wife, Connie Ballmer, both of who are founders of the Ballmer Group, have graciously donated $20 million to help advance the ability for Odessa Brown Children's Clinic (OBCC) to better serve families in the community who need it most.
At Seattle Children's Research Institute, scientists are genetically-engineering zebrafish to harbor human DNA mutations known to contribute congenital conditions in children.
Gene therapy holds promise of a potentially safer, more effective path to a cure in infants born without the critical infection-fighting cells of the immune system.Out of every 60,000 births, a baby arrives to face the world without a fully functioning immune system leaving them unequipped to fight even the most common infections.
Seattle Children’s today announced the opening of its newest regional clinic, Seattle Children’s North Clinic, which will provide convenient access to pediatric specialty care services for families in north King, Snohomish, Whatcom and Skagit counties. The 37,000-square-foot clinic is located on Providence Regional Medical Center Everett’s Colby Campus at 1815 13th St.
Seattle Children’s has opened a chimeric antigen receptor (CAR) T-cell immunotherapy trial for children and young adults with relapsed or refractory non-central nervous system EGFR-expressing solid tumors. In the phase 1 trial, STRIvE-01, cancer-fighting CAR T cells will target the EGFR protein expressed in many childhood sarcoma, kidney and neuroblastoma tumors.
Seattle Children’s today announced it will be opening a new Odessa Brown Children’s Clinic (OBCC) adjacent to the Othello Link light rail station in the Rainier Valley. OBCC is a community clinic that provides medical, dental, mental health and nutrition services to all families, regardless of their ability to pay. OBCC has been committed to delivering equitable health and wellness care to lower-income and ethnically diverse children for nearly half a century. The clinic will be approximately 35,000 square feet to meet the wellness needs of the growing pediatric population in south Seattle and south King County.
After 42 years as the oldest and largest, independent non-profit organization in the United States solely focused on infectious disease research, The Center for Infectious Disease Research (CIDR) will join Seattle Children’s Research Institute to create a world-class team of researchers working to find viable solutions to infectious diseases that can pose risks to our communities, and disproportionately impact children and those in poverty.
Seattle Children’s has opened a pioneering chimeric antigen receptor (CAR) T-cell immunotherapy trial for children and young adults with relapsed or refractory HER2-positive central nervous system (CNS) tumors where CAR T cells will be delivered directly into the brain. In the phase I trial, BrainChild-01, cancer-fighting CAR T cells will be infused through a catheter, either into the cavity where the tumor has been removed or the CNS ventricular system, depending on the location of the tumor.
Seattle Children’s, with participating members Children’s National Health System, BC Children’s Hospital and Children's Hospital Los Angeles, has launched CureWorks, an international collaborative of leading academic children’s hospitals determined to accelerate the development of immunotherapy treatments for childhood cancer. CureWorks focuses on expanding immunotherapy trials and patient access around the world, as well as sharing data and collective expertise to advance novel cell therapies.
There is a tremendous need for improved access to mental health care and resources for children and teens nationwide. At Seattle Children’s, its commitment to helping address this need spans not only within the Seattle community, but throughout the region.
A study conducted by an international research team, which included investigators from Seattle Children’s Research Institute, implicates variants in four genes as a primary cause of non-syndromic cleft lip and palate in humans. The genes, associated for the first time with cleft lip and palate, encode proteins that work together in a network, providing important insight into the biological basis of one of the most common physical malformations.
At 4 months old, Raegen was diagnosed with congenital nephrotic syndrome.Early on in Raegen Allard’s life, her mother, Francisca Allard, noticed something wasn’t quite right with her beautiful daughter. Raegen would seem upset after she ate and her stomach was enlarged. She also had a bruise around her belly button, which worried Allard further.
With the unexpected discovery of a panel of peptides from several proteins encoded by the parasite that causes malaria, new research underway at Seattle Children’s Research Institute could pave the way for a rapid screening test capable of diagnosing submicroscopic infections.
Despite its substantial impact on pregnancy outcomes, scientists know little about how group B streptococcus (GBS) establishes an in utero infection. In a paper published in the Journal of Clinical Investigation, Dr. Lakshmi Rajagopal, a principal investigator in Seattle Children’s Research Institute Center for Global Infectious Disease Research describes a newly uncovered mechanism by which GBS gains access to a woman’s uterus.
A decade ago, the late Seattle Children’s surgeon, Dr. Richard Grady, began traveling to India to provide urgent surgical care to children with a complex disorder called bladder exstrophy. An article in JAMA Surgery documents Grady's work through an international collaborative aimed at alleviating the global burden of this treatable disease.
Seattle Children’s today announced it has received the second largest single charitable gift in its 111-year history as the residual beneficiary of the estate of Bruce Leven. The landmark bequest is expected to exceed $60 million.
Eight years ago, Dr. Jeff Avansino, a surgeon at Seattle Children’s, and his wife, Dr. Amy Criniti, welcomed their third child – a boy named Luke.
Advances in engineering T cells to treat cancer are paving the way for new immunotherapies targeted at autoimmune diseases, including type 1 diabetes. Now, researchers are also investigating therapies that reprogram T cells to “turn down” an immune response, which may hold promise for curing type 1 diabetes, as well as a number of diseases where overactive T cells attack a person’s healthy cells and organs.
Results from a phase 2 clinical trial, presented by Seattle Children’s Research Institute at the 59th American Society of Hematology (ASH) Annual Meeting, show that the drug Abatacept (Orencia) nearly eliminated life-threatening severe acute graft-versus-host disease (GvHD) in patients receiving hematopoietic stem cell transplants.
Scientists at Seattle Children’s Research Institute have unlocked the ability to engineer B cells, uncovering a potential new cell therapy that could someday prevent and cure disease.
Seattle Children’s has opened the first chimeric antigen receptor (CAR) T-cell immunotherapy trial in the U.S. for children and young adults with relapsed or refractory CD19- and CD22-positive acute lymphoblastic leukemia (ALL) that will simultaneously attack two targets on cancer cells.
Seattle Children’s today launched a $1 billion initiative, It Starts With Yes: The Campaign for Seattle Children’s, with a bold vision: to transform children’s health. It Starts With Yes is the largest campaign in Seattle Children’s 110-year history.
Seattle Children’s researchers will launch an innovative program in early 2018 aimed at shifting the culture of safety in youth sports and building concussion awareness during competitive play with the help of pre-game safety huddles.
To pass the nearly 180 days she was a patient in Seattle Children’s Cancer Unit with graft-versus-host disease (GVHD), London Bowater took orders from her doctors, nurses and other patients and families for friendship bracelets that she would braid from her hospital bed.
After seeing promising results in phase 1 of the Pediatric Leukemia Adoptive Therapy (PLAT-02) trial with 93 percent of patients with relapsed or refractory acute lymphoblastic leukemia (ALL) achieving complete initial remission, researchers at Seattle Children’s are continuing their quest to improve the experimental therapy and reduce the rate of relapse, which is about 50 percent. Researchers have now opened a phase 1 clinical trial, PLAT-04, for children and young adults with relapsed or refractory CD22-positive ALL.
Talon, 11, contracted hepatitis C from his birth mother's opioid addiction. After enrolling into a clinical drug trial offered at Seattle Children's, Talon is now free of both the virus and social stigma.
Life did not start out easily for Emmett Seymer. He and his twin brother, Dashiell, were born at 29 weeks in Allentown, Pennsylvania. Emmett spent the first 30 days of his life on a ventilator because his lungs were underdeveloped. Doctors at the hospital had little optimism for Emmett and told his mother to prepare herself for him to pass away.
In an effort to find new strategies to personalize treatment for pediatric patients, Seattle Children’s has opened the first clinical trial applying precision medicine to better understand how the immune system drives both inflammatory bowel disease and graft-versus host disease in pediatric patients.
A study published today in The Journal of Pediatrics suggests that early-onset pancreatitis in children is strongly associated with certain genetic mutations and family history of pancreatitis.
After phase 1 results of Seattle Children’s Pediatric Leukemia Adoptive Therapy (PLAT-02) trial have shown T-cell immunotherapy to be effective in getting 93 percent of patients with relapsed or refractory acute lymphoblastic leukemia (ALL) into complete initial remission, researchers have now opened a first-in-human clinical trial aimed at reducing the rate of relapse after the therapy, which is about 50 percent.
Food is the most likely source of exposure to the most harmful phthalates, which can also be found in household and personal care products.Exposure during early pregnancy to some phthalates—man-made chemicals commonly found in household plastics, food and personal care products—can have adverse impacts on developing fetuses, according to a new study led by Dr.
Seattle Children’s Research Institute succeeded in a GUINNESS WORLD RECORDS attempt for most people conducting a DNA isolation experiment simultaneously.
Seattle Children’s has launched PAL Plus, a pilot program that increases access to mental and behavioral health services for underserved and economically disadvantaged children in Benton and Franklin counties. PAL Plus, the first program of its kind in the state, offers in-person counseling sessions with local behavioral health providers and will track the mental health treatment progress and outcomes of its patients.
Study results show pediatric patients with active Crohn’s disease and ulcerative colitis can reach remission with diet alone.
Imagine conquering childhood cancer, only to find out that years down the road your heart may fail. Unfortunately, many children who have battled cancer face this reality. While often lifesaving, the effects of chemotherapy treatment (drugs that kill cancer cells) can take a toll on the developing body of a child, potentially resulting in life-threatening late side effects like cardiac damage.
A new study in the Journal of Dental Research suggests that dental problems commonly associated with cleft lip and palate may be caused by abnormalities in salivary glands and an imbalance of immune compounds in the mouth.
Sudden Infant Death Syndrome (SIDS) may be linked to the build up of carbon dioxide and existing inner ear damage according to a new study in the journal Neuroscience. Author Dr. Daniel Rubens, an anesthesiologist and researcher at Seattle Children’s Research Institute, says the finding could help researchers understand the sequence of events and risk factors that lead to SIDS deaths.
In our digital age, it’s not uncommon to see a toddler on an iPad at the airport or a teenager at the mall fixated on a smartphone. To help families establish healthy habits for media use, the American Academy of Pediatrics (AAP) released new media and screen time policies for children. Co-authors of the policy, Drs. Megan Moreno and Dimitri Christakis of Seattle Children's Research Institute, share their insight.