… Stem cell–derived insulin-producing cells can theoretically be generated in endless quantities… stem cell–based therapies for type 1 diabetes. The approaches are very different. Vertex embarked on a phase I/II clinical trial in March 2021 in …
… Background: Stroke associated with transcatheter aortic valve replacement (TAVR) is a potentially devastating complication. Until recently, … of TAVR-related stroke. However, its effectiveness is still undetermined. Objectives: To explore the impact of …
Background: The COVID-19 pandemic has created a pressing need for integrating information from disparate sources in order to assist decision makers. Social media is important in this respect; however, to make sense of the textual inf...
… A meta-analysis including 7673 patients undergone to TAVR demonstrated that low stroke-volume index, a parameter of transaortic flow, was related with an increased mortality compared with patients with normal stroke volume index [36] …
Background: Multimorbidity represents a global health challenge, which requires a more global understanding of multimorbidity patterns and trends. However, the majority of studies completed to date have often relied on self-reported ...
Background: Patient education, home-based exercise therapy, and advice on returning to normal activities are established physiotherapeutic treatment options for patients with nonspecific low back pain (LBP). However, the effectivenes...
In a study published in Ibis, investigators combined the power of big data and machine learning, a type of artificial intelligence, to predict population declines for bird species with unknown population trends and used correlation analyses to identify predictors of bird population declines worldwide.
… A meta-analysis including 7673 patients undergone to TAVR demonstrated that low stroke-volume index, a parameter of transaortic flow, was related with an increased mortality compared with patients with normal stroke volume index [36] …
Background: The lifetime risk of breast and ovarian cancer is significantly higher among women with genetic susceptibility or a strong family history. However, current risk assessment tools and clinical practices may identify only 10...
Background: Digital health interventions may offer a scalable way to prevent type 2 diabetes (T2D) with minimal burden on health care systems by providing early support for healthy behaviors among adults at increased risk for T2D. Ho...
… As compared to patients with a large PA/BSA, the occurrence of a stroke at 30 days was higher in patients with a small PA/BSA in the present cohort. The risk for stroke after TAVR is likely to be multifactorial [33]. Seppelt et al. reported that balloon-expandable …
Background: Nonadherence to medication in tuberculosis (TB) hampers optimal treatment outcomes. Digital health technology (DHT) seems to be a promising approach to managing problems of nonadherence to medication and improving treatme...
Background: Sepsis is a significant cause of morbidity and mortality worldwide. Early detection of sepsis followed promptly by treatment initiation improves patient outcomes and saves lives. Hospitals are increasingly using computeri...
Background: Studies have shown a high prevalence of depression during pregnancy, and there is also evidence that cognitive behavioral therapy (CBT) is one of the most effective psychosocial interventions. Emerging evidence from rando...
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… through the regulation of p27Kip1 mRNA translation and modulates glioma stem cell differentiation via regulating Hes1 and Sirt1 translation 36,… may be a potential Aurka downstream target, regulating SC function with regards to stem cell self-renewal …
… As compared to patients with a large PA/BSA, the occurrence of a stroke at 30 days was higher in patients with a small PA/BSA in the present cohort. The risk for stroke after TAVR is likely to be multifactorial [33]. Seppelt et al. reported that balloon-expandable …
The COVID-19 pandemic accelerated the uptake of digital health worldwide and highlighted many benefits of these innovations. However, it also stressed the magnitude of inequalities regarding accessing digital health. Using a scoping review, this arti...
Big data is poised to revolutionize health care, and performance dashboards can be an important tool to manage big data innovations. Dashboards show the progress being made and provide critical management information about effectiveness and efficienc...
Background: COVID-19 forced the implementation of restrictive measures in Spain, such as lockdown, home confinement, social distancing, and isolation. It is necessary to study whether limited access to basic services and decreased fa...
Few approaches have been made toward exploring autologous NK cells in settings of cancer immunotherapy. Here, we demonstrate the feasibility of infusing multiple doses of ex vivo activated and expanded autologous NK cells in patients with …
… As compared to patients with a large PA/BSA, the occurrence of a stroke at 30 days was higher in patients with a small PA/BSA in the present cohort. The risk for stroke after TAVR is likely to be multifactorial [33]. Seppelt et al. reported that balloon-expandable …
Background: Health self-tracking is an evidence-based approach to optimize health and well-being for personal self-improvement through lifestyle changes. At the same time, user-generated health-related data can be of particular value...
Background: The need to include individuals with lived experience (ie, patients, family members, caregivers, researchers, and clinicians) in health research priority setting is becoming increasingly recognized. Social media–based m...
Background: Simple visualizations in health research data, such as scatter plots, heat maps, and bar charts, typically present relationships between 2 variables. Interactive visualization methods allow for multiple related facets suc...
An international team from Aalto University, Delft University of Technology, and Siemens Gamesa Renewable Energy is working to find out just what happens when 200-metre tall wind turbines meet seriously frosty conditions, like those seen in Northern Europe’s Baltic Sea, North America’s Great Lakes or China’s Bohai Bay.
… The presence of atrial fibrillation was also included as a risk factor for stroke after TAVR. In these models, ECG LVH by 3 different criteria … patients with severe AS undergoing TAVR to evaluate the association between clinical outcomes after TAVR …
… Stem cell–derived insulin-producing cells can theoretically be generated in endless quantities… stem cell–based therapies for type 1 diabetes. The approaches are very different. Vertex embarked on a phase I/II clinical trial in March 2021 in …
… and use of OAC in patients with TAVR and AF, we excluded all patients with a prior mechanical valve, prior stroke within 1 year, in‐… In an analysis from a large clinical data registry of US patients with AF undergoing TAVR, we found that the 1‐year …
… and use of OAC in patients with TAVR and AF, we excluded all patients with a prior mechanical valve, prior stroke within 1 year, in‐… In an analysis from a large clinical data registry of US patients with AF undergoing TAVR, we found that the 1‐year …
… For example, muscle stem cell quiescence is mediated in part by the eIF2α arm of the integrated … stem cell fitness, to safeguard the lifelong regeneration of the muscle. Fit muscle stem cells that maintain robust stress responses are permitted to …
… Stem cell–derived insulin-producing cells can theoretically be generated in endless quantities… stem cell–based therapies for type 1 diabetes. The approaches are very different. Vertex embarked on a phase I/II clinical trial in March 2021 in …
… A meta-analysis including 7673 patients undergone to TAVR demonstrated that low stroke-volume index, a parameter of transaortic flow, was related with an increased mortality compared with patients with normal stroke volume index [36] …
Chloride intracellular channel-1 (CLIC1) activity controls glioblastoma proliferation. Metformin exerts antitumor effects in glioblastoma stem cells (GSCs) inhibiting CLIC1 activity, but its low potency hampers its translation in clinical settings. We …
… We were surprised to find that GSCs are not maintained in a stem cell state during diapause, even though ovaries can rebound post-diapause to youthful stem cell numbers, proliferation, and ovary size. This remarkable recovery potential appears …
… Although our study is the only assessment of a stem cell line culture (H1 hESC), the relationship between changes in pH and dO 2 was … These data further indicate that although the H1 hESC line, and potentially also other stem cell types, can …
… In recent years, significant progress has been made in stem cell research, especially in the mechanism of stem cell activation, homing and … of stem cell ion channels. In this review, we reviewed the main ion channels found on stem cells …
… and use of OAC in patients with TAVR and AF, we excluded all patients with a prior mechanical valve, prior stroke within 1 year, in‐… In an analysis from a large clinical data registry of US patients with AF undergoing TAVR, we found that the 1‐year …
Increasing evidences indicate that unlimited capacity for self-renewal and pluripotency, two unique properties of embryonic stem cells (ESCs), are intrinsically linked to cell cycle control. However, the precise mechanisms coordinating cell fate …
… stem cell therapy has become a promising clinical approach [8], direct injection of stem cells into the target tissues will possibly result in decreasing cell viability, retention, and engraftment, which have largely limited the practical application of …
… Stem cell–derived insulin-producing cells can theoretically be generated in endless quantities… stem cell–based therapies for type 1 diabetes. The approaches are very different. Vertex embarked on a phase I/II clinical trial in March 2021 in …
In native microenvironment, diverse physical barriers exist to dynamically modulate stem cell recruitment and differentiation for tissue repair. In this study, nanoassembly‐based magnetic screens of various sizes are utilized, and they are elastically tethered over …
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