… stem cell sources and differentiation lineages and is therefore useful for various stem cell–… cells and extracellular matrix components, guiding stem cell fates ex vivo is generally initiated … ultimately negatively affects the guiding efficiency of the …
… The objective of this study is to synthesise the findings of clinical studies in order to derive evidence for use of the mesenchymal stem cell (MSC) therapy in the treatment of neurodegenerative cerebellar ataxias. In order to find relevant studies …
… d Stem cell frequency of GS5 cells treated with Cas9 and the indicated sgRNAs as determined by limiting dilution assay. e–g Representative flow cytometry images (e) and corresponding quantification (f) (n = 3 biologically independent samples, black …
… methylation status, which in turn compromised periodontal stem cell function including a reduction in proliferation and differentiation … co‐regulator, which plays a key role in cell proliferation, differentiation, and stem cell self‐renewal [86]. The …
… Allogeneic hematopoietic stem cell transplantation (HSCT) can be a highly effective treatment for patients with hematological malignancies and hereditary blood disorders if a suitable HSC graft can be obtained, ideally from an HLA (human leukocyte …
As in younger patients, allogeneic stem cell transplantation (alloHSCT) offers the best chance for durable remission in older patients (≥60 years) with acute myeloid leukemia (AML). However, defining the best treatment strategy (and in particular …
… hold a patent application for the investigated stem cell product “Stem cell therapy based on adipose-derived stem cells”, WO2017068140. None of the other coauthors declare conflicts of interest. LS is an advisory board member for Takeda and Kyowa …
… In this study, we generate lung cells and macrophages from the same human pluripotent stem cell (hPSC) lines and pair them to establish a co-culture system. This strategy addresses a common concern about histocompatibility when studying …
… ABCC1 encodes the ATPase cassette transporter protein multidrug resistance 1, a stem cell marker and MYCN transcriptional target conferring … 1, 2), suggesting they share a common ependymal stem cell lineage. The mismatch repair gene …
The heterogeneous nature of human CD34+ hematopoietic stem cells (HSCs) has hampered our understanding of the cellular and molecular trajectories that HSCs navigate during lineage commitment. Using various platforms including single cell …
… The objective of this study is to assess the effect of mesenchymal stem cell (MSC) therapy on SG function after radiation-induced injury. … Accumulating literature on animal studies suggests that mesenchymal stromal/stem cell (MSC) transplantation …
… We decided to focus on stem cell therapy administered within the acute phase (<2 weeks) of the timing of the TSCI, as this would be the realistic time for administration within humans. It is likely that SC therapy may involve injections within both the …
In this work, the mechanism underlying the anticancer activity of a photoactivatable Ir(III) compound of the type [Ir(CˆN) 2 (dppz)][PF 6 ] where CˆN = 1-methyl-2-(2′-thienyl)benzimidazole (complex 1) was investigated. Complex 1 photoactivated by visible light shows …
… a decline in nutrient availability is likely to provide insight into the metabolic regulation of stem cell behavior in other tissues and organisms. … Taken together, our data describe one mechanism by which a transcription factor controls stem cell …
… stem cell commitment, the field’s mechanistic understanding of this phenomenon largely derives from simplified two-dimensional (2D) culture substrates. Here, we found a 3D matrix–specific mechanoresponsive mechanism for neural stem cell (NSC …
… cells remains eliciting the desired stem cell behavior once transplanted in the body. In their natural environment, stem cell fate is regulated by their … ECM ligands, as well as soluble cues, making MSN-ssDNA based biointerfaces a novel tool to …
… Importantly, we demonstrate that Aux interacts with EGFR and safeguards the activation of EGFR to maintain a proper stem cell proliferation rate. Thus, our data uncover the underlying mechanism of Aux in stem cell proliferation control and …
… This article briefly introduced the regulatory framework development, the progress in stem cell clinical researches and clinical trials of commercially developed stem cell-based products, as well as the clinical review concerns of stem cell-based products in …
In this review, we will outline dimensions in which outcome of patients with myelofibrosis undergoing curative treatment can be optimized: patient selection, transplant procedure, and posttransplant prevention or treatment of relapse. For …
… of etoposide and cytarabine [8], or intensive chemotherapy followed by autologous stem cell transplantation (IC-ASCT) [9, 10]. Thiotepa-based myeloablative chemotherapy followed by autologous stem cell transplantation (ASCT) …
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