An analysis of thousands of tumors across 33 different cancer types by researchers from The Cancer Genome Atlas (TCGA) Network supports an additional classification for human tumors.
UNC School of Medicine researchers have identified mutations to the bacterium Neisseria gonnorrhoeae that enable resistance to ceftriaxone that could lead to the global spread of ceftriaxone-resistant “superbug” strains.
MRIs show that babies with fragile X syndrome had less-developed white matter compared to infants that did not develop the condition. Imaging various sections of white matter from different angles can help researchers focus on the brain circuitry important for proper neuron communication.
UNC School of Medicine researchers create a new screening technique to show that e-liquids are far from harmless to human cells and contain ingredients that can vary wildly from one type of e-cigarette to another.
This week, a 40-year-old patient was treated at UNC’s Clinical and Translational Research Center (CTRC) with SB-913, an investigational genome editing therapy for individuals with mucopolysaccharidosis type II (MPS II), a rare lysosomal storage disorder also known as Hunter syndrome.
In the journal Clinical Cancer Research, researchers reported that by forcing cancer cells to slow down and developing stronger molecular traps for them, they could identify large numbers of the cells in cancer patients undergoing radiation therapy.
University of North Carolina Lineberger Comprehensive Cancer Center researchers have identified genetic clues that explain how breast cancer spreads, or metastasizes – findings that may lead to better treatments or approaches to prevent its spread at the onset.
Researchers from the University of North Carolina Lineberger Comprehensive Cancer Center and their collaborators report they modified immune cells to hunt brain tumors displaying a new molecular target, which they determined is highly prevalent on brain cancer cells. Their preclinical studies of immune cells engineered to recognize the target showed promise for controlling tumor growth in mouse and cell models for glioblastoma.
In JCI Insight, researchers reported the results of a phase I, multi-institution clinical trial for an investigational treatment for melanoma and other cancers with mutations in the BRAF or RAS genes.
UNC and NC State scientists created an injectable gel-like scaffold that can hold combination chemo-immunotherapeutic drugs and deliver them locally to tumors in a sequential manner. The results in animal models suggest this approach could one day ramp up therapeutic benefits for cancer patients.
In this study, published in Cell Reports, two labs at UNC and a group at Princeton University reprogrammed ordinary cells called fibroblasts into new and healthy heart muscle cells, and recorded changes that appear to be necessary for this reprogramming.
The UNC School of Medicine will host a continuing professional education (CPE) symposium on March 10, 2018 in Chapel Hill to educate medical professionals on the streamlining of care for patients with Atrial fibrillation or Afib.
UNC School of Medicine researchers discovered a structure on viruses that makes them better at crossing from the bloodstream into the brain – a key factor for administering gene therapies at lower doses for treating brain and spinal disorders. Experiments also showed decreased liver toxicity.
In an effort to combat new HIV infections among men who inject drugs in Vietnam, researchers at the University of North Carolina at Chapel Hill conducted the first study to explore how this population mixes together. Their results were published in the Journal of Acquired Immune Deficiency Syndromes.
In a study published in the International Journal of Cancer, researchers analyzed health indicators for children born to young breast cancer survivors in North Carolina.
In a study published in the International Journal of Cancer, researchers analyzed health indicators for children born to young breast cancer survivors in North Carolina.
Researchers found that adolescents not susceptible to smoking cigarettes and who thought e-cigarettes were less harmful were more likely to use e-cigarettes. This UNC study found that 26 percent of those surveyed were at high risk for future e-cigarette use.
Published in Nature, research from the UNC School of Medicine and UCSF revealed the first-ever crystal structure of the dopamine 2 receptor bound to an antipsychotic drug – a much-needed discovery in the quest to create effective drugs with fewer side effects.
A study led by UNC Lineberger Comprehensive Cancer Center and published in the Journal of Cell Biology examined the role of the physical structure of the nucleus in cell movement through different surfaces.
CF researchers have now shown that the lungs’ bacterial population changes in the first few years of life as respiratory infections and inflammation set in. This research offers a way to predict the onset of lung disease and suggests a larger role for preventive therapies, such as hypertonic saline.
Recent studies testing multivalent combinations of three broadly neutralizing antibodies, or bnAbs, have yielded promising results in animal models of HIV prevention. Two investigators at the University of North Carolina at Chapel Hill describe the potential of bnAbs to inform HIV prevention, treatment and cure strategies in a recent article in the New Journal of Medicine.
Dr. Thomas Egan of the University of North Carolina School of Medicine says that a recent change in donor lung allocation policy was long overdue. However, because the change happened over the Thanksgiving holiday weekend in response to litigation, it came as a “tsunami” that was “sudden, unexpected, and may have huge consequences.”
For the first time, UNC School of Medicine scientists and collaborators solved the crystal structure of the activated kappa opioid receptor bound to a morphine derivative. They then created a new drug-like compound that activates only that receptor, a key step in the development of new pain meds.
Leslie H. Nelson has been named as President of the Medical Foundation of North Carolina and Associate Dean for Development of the UNC School of Medicine effective Jan. 1, 2018. The Medical Foundation of North Carolina is the not-for-profit, philanthropic arm of the UNC School of Medicine and UNC Hospitals.
A special cluster of proteins helps unwind DNA during cell division and plays a key role in keeping stem cells in their immature state. This UNC study also points to a better understanding of how cancer cells manage to sustain rapid cell division without triggering cell death.
Researchers analyzed the impact of one viral social media post in generating awareness about skin cancer.
Researchers present their preliminary results from the ongoing phase II trial of chemotherapy and pembrolizumab in relapsed or refractory acute myeloid leukemia at the 59th American Society of Hematology Annual Meeting in Atlanta on Saturday, Dec. 9.
Researchers report at the 59th Annual American Society for Hematology Annual Meeting in Atlanta on Saturday, Dec. 9, that they were able to validate their approach for predicting markers – called minor histocompatibility antigens – in a group of patients with blood cancers.
The biological features of patients’ tumors partially explained a racial disparity for women with hormone receptor-positive, HER2-negative breast cancer, but UNC Lineberger researchers led by Katherine Reeder-Hayes, MD, MBA, MSc, said it didn’t explain it completely. The preliminary findings were reported at the 2017 San Antonio Breast Cancer Symposium.
This UNC research shows how understanding the precise mix of bacteria and their interactions could become a standard part of clinical practice in treating bacterial infections, especially the more dangerous infections involving antibiotic resistance.
While new CF drugs are life-changing for some patients, they don’t work for everyone. Now, UNC and UAB researchers present a simple test that aims to predict which treatment is most likely to work for each patient, an approach known as personalized or precision medicine.
A grant from The Leukemia & Lymphoma Society will help fund clinical research led by UNC Lineberger's Barbara Savoldo, MD, PhD, into an investigational chimeric antigen receptor (CAR) T-cell treatment for acute lymphoblastic leukemia that would include a built-in "safety switch."
UNC researchers use cognitive computing to scour large volumes of data from scientific studies and databases to find potentially relevant clinical trials or therapeutic options for cancer patients based on the genetics of their tumors.
UNC School of Medicine researchers have developed a new laboratory model to measure and compare the responses of CF and normal airway cells to CF-related infectious/inflammatory factors.
By studying the genetic makeup of people who maintain clear arteries into old age, researchers led by UNC’s Jonathan Schisler, PhD, have identified a possible genetic basis for coronary artery disease (CAD), as well as potential new opportunities to prevent it.
New research from the Research Triangle suggests that variants in a gene called ankyrin-B – carried by millions of Americans – could cause people to put on pounds through no fault of their own.
In an analysis of the impact of parity laws published in JAMA Oncology, UNC Lineberger Comprehensive Cancer Center researchers and collaborators from Harvard Medical School report modest improvements in costs for many patients. However, patients who were already paying the most for their medications, saw their monthly costs go up.
Two studies by UNC Lineberger Comprehensive Cancer Center researchers reveal trends in the marketing practices, pricing, delivery methods and other features of online e-cigarette vendors.
UNC School of Medicine neuroscientists discover a long-distance brain circuit that controls the production of new neurons in the hippocampus. Research could have implications for understanding and treating many brain disorders, including epilepsy, schizophrenia, depression, and Alzheimer’s disease
Scientists publish experimental evidence that life on Earth originated in an intimate partnership between the nucleic acids and small proteins. Their “peptide-RNA” hypothesis contradicts the widely held hypothesis that life originated from nucleic acids and only later evolved to include proteins.
Veteran sailors know that rogue waves can rise suddenly in mid-ocean to capsize even the largest vessels. Now it appears that a similar phenomenon called shear shock wave occurs in the concussed brain. It may help explain why some head knocks cause so much more harm than others.
UNC and NC State researchers have developed artificial beta cells that automatically release insulin into the bloodstream when glucose levels rise. This work was done in lab experiments but could lead to a much more patient-friendly treatment than injections.
UNC-Chapel Hill maternal-fetal medicine specialist Dr. Tracy Manuck receives nearly $4 million to study health disparities and recurrent preterm birth.
Scientists understand new details about the development of Th17, a type of immune cell that is believed to play a complex role in cancer, and is also implicated in autoimmune diseases.
A study led by UNC Lineberger Comprehensive Cancer Center researchers found that preference for preserving sexual function was not strongly reflected in the treatment choices of men with low-risk prostate cancer.
UNC researchers use their new research platform to discover new cell subpopulations and crucial cellular players in the process of turning damaged heart tissue back into healthy heart muscle. The research platform could be used to study other biological processes and create tailored therapies.
In a new study published in Cell Systems, UNC Lineberger's Jeremy Purvis, PhD, and colleagues report that the timing of when DNA damage occurs within these different checkpoints matters to a cell’s fate.
UNC-Chapel Hill and UC-San Francisco scientists solved the crystal structure of a specific dopamine receptor called D4 at an incredibly high resolution and designed a new compound that tightly binds only to D4 and none of the other 320 receptors they tested.
Using laboratory equipment readily available in developing countries, researchers from UNC and Abbott Diagnostics were able to define and map the burden of hepatitis C virus for the first time in the Democratic Republic of the Congo. Their findings were published in Clinical Infectious Diseases.
The book, titled “Drinking, Drug Use and Addiction in the Autism Community,” explores why addiction is more common among individuals with ASD than it is within the general population and investigates how addiction and autism affect one another.
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