A new study from scientists at the UCLA Jonsson Comprehensive Cancer Center found that emerging drugs that activate the protein STING, a well-established regulator of immune cell activation, substantially alter the activity of metabolic pathways responsible for generating the nucleotide building blocks for DNA.
Researchers at UCLA Health have been awarded $3 million from the Governor’s Office of Planning and Research (OPR) to develop a statewide stress surveillance system and establish a network of physicians/scientists to study how stress impacts the body and what can be done to increase resiliency.
People who are prescribed the anti-coagulant apixaban cite six major reasons for failing to adhere to their prescriptions, including cost and potential bleeding.
Physicians and scientists from UCLA will be joining thousands of urology experts on Sept. 10 to Sept. 13 for the virtual American Urological Association (AUA) Annual Meeting.
The troubling news and images emerging from Afghanistan as American troops withdraw from the region after 20 years is causing a spike in post-traumatic stress among veterans at home, says UCLA Health psychiatrist Bruce Kagan, MD, PhD.
Scientists Dr. Cristina Puig-Saus and Dr. Daniel Shin from the UCLA Jonsson Comprehensive Cancer Center have received a $1 million Translational Research Award from the U.S. Department of Defense Melanoma Research Program to help advance the use of chimeric antigen receptor, or CAR, T cell therapy as a treatment for people with acral, mucosal and uveal melanomas.
A new preclinical study led by researchers at the UCLA Jonsson Comprehensive Cancer Center suggests that treating people who have aggressive cancers, including melanoma, pancreatic and colorectal cancers, with immune checkpoint inhibitors, quickly followed with mutation-targeted therapy, can help overcome treatment resistance and help people live longer.
UCLA researchers have successfully grown restorative brain cells in large batches suitable for transplantation in patients. The therapy is designed to repair damage to the brain from white matter stroke, a “silent stroke” that can kick off years of cognitive deterioration and can accelerate Alzheimer’s disease. A new paper is published in the journal Stem Cell Research.
The risk that both tobacco and electronic cigarettes can pose to regular smokers’ health has been well documented, but a new UCLA study illustrates just how quickly vaping can affect the cells of even healthy younger nonsmokers.
Emergency department physicians who saw patients with a pulmonary embolism—a blood clot in the lung—were about 15% likelier over the next 10 days to test subsequent patients for the same thing.
Women with frequent urinary tract infections say they’re unhappy with what they perceive as their doctors’ overuse of antibiotics and with the limited treatment options available to them, according to a study led by researchers from UCLA and Cedars-Sinai.
A research team from the UCLA Youth Stress and Mood Program at UCLA's Jane and Terry Semel Institute for Neuroscience and Human Behavior has been approved to lead a $13 million funding award by the Patient-Centered Outcomes Research Institute (PCORI) to compare two evidence-based interventions for reducing suicide attempts and improving patient outcomes for youth presenting to emergency departments.
New UCLA-led research indicates that simple text messages emphasizing the easy availability of COVID-19 vaccines successfully boosted the number of people who got the shot.
Researchers from UCLA and Cedars-Sinai have developed a new way to detect a potentially life-threatening condition that can occur during pregnancy. The condition, placenta accreta spectrum disorder, occurs when the placenta grows too deeply into the uterine wall and fails to detach from the uterus after childbirth. It can lead to significant blood loss during pregnancy and delivery, requiring blood transfusions and intensive care, and it can result in serious illness and infection and can even be fatal for the mother. The condition occurs in less than 0.5% of pregnancies.
Removing a protein that is often overexpressed in a rare and aggressive subtype of leukemia can help to slow the cancer’s development and significantly increase the likelihood of survival, according to a study in mice led by scientists at the UCLA Jonsson Comprehensive Cancer Center.
Internationally renowned physician-scientist Dr. Beth Karlan, director of cancer population genetics at the UCLA Jonsson Comprehensive Cancer Center, is being honored with the Lifetime Achievement Award from the International Gynecologic Cancer Society (IGCS) for her contributions to gynecologic cancer research and clinical practice.
Findings could help pave the way for cancer therapies that target TAF12, potentially stopping transcription in cancer cells and helping decrease the growth of cancerous tumors.
A chemical modification that occurs in some RNA molecules as they carry genetic instructions from DNA to cells’ protein-making machinery may offer protection against non-alcoholic fatty liver, a condition that results from a build-up of fat in the liver and can lead to advanced liver disease, according to a new study by UCLA researchers. The study, conducted in mice, also suggests that this modification — known as m6A, in which a methyl group attaches to an RNA chain — may occur at a different rate in females than it does in males, potentially explaining why females tend to have higher fat content in the liver. The researchers found that without the m6A modification, differences in liver fat content between the sexes were reduced dramatically.
A new prognostic tool helps predict which men with advanced metastatic prostate cancer will respond favorably to a novel targeted therapy.
Dr. Elizabeta Nemeth, professor of medicine and director of the Center for Iron Disorders at the David Geffen School of Medicine at UCLA, has been awarded the 2021 William Dameshek Prize by the American Society of Hematology (ASH) for her contributions to the field of hematology.
Men with high-risk prostate cancer with at least one additional aggressive feature have the best outcomes when treated with multiple healthcare disciplines, known as multimodality care, according to a UCLA study.
A UCLA-led study comparing brain cells known as astrocytes in humans and mice found that mouse astrocytes are more resilient to oxidative stress, a damaging imbalance that is a mechanism behind many neurological disorders.
UCLA Health is proud to present an online pride celebration and drag revue featuring iconic drag performers Ongina, Moi Moi Moi, Sunset Blush and others, each of whom will lip sync a song promoting community, inclusion and diversity.
UCLA Health will receive a $4.8 million grant from The National Institutes of Health to develop methods that will improve genetic risk estimates – polygenic risk scores – for specific diseases in people from diverse populations and mixed ancestries.
UCLA researchers discover MAOIs could activate immune system to shrink various types of tumors
A new study shows that tai chi mirrors the beneficial effects of conventional exercise by reducing waist circumference in middle-aged and older adults with central obesity.
A new multi-institution study led by a team of researchers at the David Geffen School of Medicine demonstrated that blocking a protein called ABCB10 in liver cells protects against high blood sugar and fatty liver disease in obese mice. ABCB10 activity also prompted insulin resistance in human liver cells.
UCLA Health has received a $750,000 grant from the U.S. Economic Development Administration to scale healthcare innovations for COVID-19 response and recovery and to support health equity through BioFutures, a new LA County workforce development program for diversity in the biosciences.
A team of researchers from UCLA, Cedars-Sinai and the Cystic Fibrosis Foundation has developed a first-of-its-kind molecular catalog of cells in healthy lungs and the lungs of people with cystic fibrosis. The findings could help scientists in their search for specific cell types that represent prime targets for genetic and cell therapies for cystic fibrosis.
Current guidelines for managing osteoporosis specifically call out hip or spine fractures for increasing the risk for subsequent bone breaks. But a new UCLA-led study suggests that fractures in the arm, wrist, leg and other parts of the body should also set off alarm bells.A fracture, no matter the location, indicates a general tendency to break a bone in the future at a different location.
The combination approach uses immune checkpoint inhibitors with ATRA, a safe medication that is widely used to treat leukemia.
Johnese Spisso, president of UCLA Health and CEO of UCLA Hospital System, has joined forces with nine other U.S. health system leaders to form the CEO Coalition and set new safety standards for the nation’s health care workers.
A UCLA-led study shows that physicians frequently order preventive medical services for adult Medicare beneficiaries that are considered unnecessary and of “low value” by the U.S. Preventive Services Task Force — at a cost of $478 million per year.
Patients with advanced colorectal cancer may be spared from a toxic side effect caused by a type of targeted therapy used to treat the cancer with the help of another drug normally used to treat melanoma, according to a study led by researchers at the UCLA Jonsson Comprehensive Cancer Center and Memorial Sloan Kettering Cancer Center.
The AIDS Clinical Trials Group (ACTG), the largest global HIV research network, has added SAB-185, a polyclonal antibody therapy, to the COVID-19 outpatient treatment study.
A one-time injection of an experimental stem cell therapy can repair brain damage and improve memory function in mice with conditions that replicate human strokes and dementia, a new UCLA study finds.
The proportion of physicians who are Black in the U.S. has increased by only 4 percentage points over the past 120 years, and that the share of doctors who are Black men remains unchanged since 1940. The research also spotlights a significant income gap between white and Black male physicians
Elderly patients of female physicians are more likely than those of male physicians in the same outpatient practice to be vaccinated against the flu. This trend holds for all racial and ethnic groups studied and could provide insight into improving vaccination rates for influenza, COVID-19 and other illnesses
Early results from a new, pioneering CAR T cell immunotherapy trial led by researchers at the UCLA Jonsson Comprehensive Cancer Center found using a bilateral attack instead of the conventional single-target approach helps minimizes treatment resistance, resulting in long-lasting remission for people with non-Hodgkin's B-cell lymphoma.
A UCLA research team has shown that using a truncated form of the CD4 molecule as part of a gene therapy to combat HIV yielded superior and longer-lasting results in mouse models than previous similar therapies using the CD4 molecule.
A study led by researchers at UCLA and CHLA has shown that a combination of modest dietary changes and exercise can dramatically improve survival outcomes for those with acute lymphoblastic leukemia, the most common childhood cancer.
For middle-aged women, exercise has many health benefits, but it may not help maintain cognitive function over the long term, according to a new UCLA Health study.
Researchers will study vaccinated and non-vaccinated health workers who get tested for the virus after experiencing common COVID-19 symptoms like fever, cough or a loss of sense of taste or smell. They will compare the incidence of positive tests and severity of illness in those who test positive.
New UCLA study shows that image guided needle based thermal ablation is a safe and effective approach for patients with localized metastatic gynecologic cancers throughout the body.
A team of researchers from the UCLA Jonsson Comprehensive Cancer Center has been awarded two research grants totaling $6 million from the National Institutes of Health to identify new ways to treat pancreatic cancer.
New research suggests that the COVID-19 crisis has exacerbated existing racial health care disparities and that during the pandemic, African Americans may have had worse access than whites to outpatient care that could have helped prevent deterioration of their non–COVID-19 health conditions
A UCLA-led research team has identified a chemical cocktail that enables the production of large numbers of muscle stem cells, which can self-renew and give rise to all types of skeletal muscle cells.
A new study involving UCLA researchers finds that mobile stroke units (MSUs) – state-of-the-art ambulances built to provide stroke patients with emergency neurological diagnosis and treatment prior to hospital arrival -- improve patient outcomes and lessen the chance for disability by delivering care faster than standard stroke care.
A new UCLA study shows that while men and women who have high muscle mass are less likely to die from heart disease, it also appears that women who have higher levels of body fat — regardless of their muscle mass — have a greater degree of protection than women with less fat.
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