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In 2010, scientists discovered that African Americans who are born with certain variants of a gene called apolipoprotein L1 (APOL1) have a higher-than-average risk for experiencing chronic kidney disease (CKD). Now, in a new study of African Americans with hypertension, researchers at the Icahn School of Medicine at Mount Sinai find that a community-based approach to reporting APOL1 genetic test results back to individuals may have beneficial effects.

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Findings suggest this region as a promising treatment target

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Study shows better outcomes and fewer complications compared to mechanical or biological aortic valve replacement

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The Icahn School of Medicine at Mount Sinai has been awarded a three-year, $2.1 million Health Workforce Resiliency grant from the Health Resources & Services Administration (HRSA) to develop a new training initiative that will promote well-being, enhance resilience, and aim to reduce the burden of mental health conditions, substance abuse, and suicidal ideation among the health professional workforce.

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Mount Sinai researchers conducting clinical trials of a drug targeting a cancer gene found that it increased metastatic cancer patients’ survival and was able to work within the brain, according to a study published in Clinical Cancer Research in February.

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The Dubin Breast Center of The Tisch Cancer Institute at Mount Sinai, a National Cancer Institute-designated cancer center, raised over $2.5 million during its 11th annual online benefit at the end of 2021.

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Researchers from the Icahn School of Medicine at Mount Sinai have found that nirmatrelvir, molnupiravir, and remdesivir—COVID-19 antiviral therapeutics that have been approved for emergency use by the U.S. Food and Drug Administration—maintain their in vitro antiviral activity against all SARS-CoV-2 variants of concern, including Omicron.

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The Tisch Cancer Institute (TCI) at Mount Sinai and the Samuel Waxman Cancer Research Foundation (SWCRF) are launching a unique research program that will fund collaborations between TCI physician-scientists and colleagues from other established cancer research institutions to address the rising rates of cancer due to aging around the world.

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Cardiologists emphasize importance of exercise, nutrition, mental health to prevent heart disease during COVID-19 pandemic

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The Phillips School of Nursing at Mount Sinai Beth Israel (PSON) announced today the launch of the Upward Mobility Program, a first-of-its kind 15-month degree program that will enable nurses with associate degrees to earn a bachelor of science in nursing (BSN) and advance their careers with their tuition fully covered through a two-year service commitment to the Mount Sinai Health System.

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Vaccination against COVID-19 did not affect fertility outcomes in patients undergoing in-vitro fertilization (IVF).

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Researchers from the Icahn School of Medicine at Mount Sinai have found that greater increases, decreases, or variability in body mass index (BMI) over time are associated with an accelerated rate of cognitive decline, irrespective of whether a person has normal, overweight or obese body mass index at baseline.

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Immunotherapy given before surgery caused liver cancer tumors to die off in one-third of the patients enrolled in a first-of-its-kind clinical trial, Mount Sinai researchers reported in The Lancet Gastroenterology & Hepatology in January.

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The Cathedral of St. John the Divine closes out the year with celebration and song online with the annual New Year’s Eve Concert for Peace, part of the 2021-2022 season of Great Music in a Great Space.

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This year the medical and research advancements from the Icahn School of Medicine at Mount Sinai and the Mount Sinai Health System ranged from COVID-19, to PTSD, to the first ever successful trachea transplant surgery. Our doctors and researchers were not only at the forefront of the pandemic providing expertise and new studies surrounding the virus, its symptoms and effects, but also excelling in revolutionary surgeries and progressive research to continue showcasing Mount Sinai as a top medical institution and medical school in the country. Here are some of Mount Sinai’s breakthrough stories of the year:

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Generalized pustular psoriasis (GPP) is a rare, life-threatening skin condition for which there are no approved treatments. It is characterized by episodes of widespread eruptions of painful, sterile pustules (blisters of non-infectious pus). There is a high unmet need for treatments that can rapidly and completely resolve the signs and symptoms of GPP flares. Flares greatly affect a person’s quality of life and can lead to hospitalization with serious complications, including heart failure, renal failure, sepsis, and death.

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Mount Sinai Health System is proud to announce that Kenneth L. Davis, MD, its Chief Executive Officer, was recognized by Modern Healthcare as one of the “100 Most Influential People in Healthcare” for 2021.

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A recent, substantial decline in lung cancer deaths is associated with earlier diagnosis of lung cancer than in the past, supporting the need for increased use of screening to save lives, according to a Mount Sinai study published in JAMA Network Open in December.

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Mount Sinai’s Center for Stress, Resilience and Personal Growth (CSRPG) has expanded its resilience training program to people in its surrounding communities through a partnership with faith-based organizations in Harlem, the Bronx, Brooklyn, and Queens, all disproportionately affected by COVID-19

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The Phillips School of Nursing at Mount Sinai Beth Israel (PSON) was granted re-accreditation of its baccalaureate degree program by the Commission on Collegiate Nursing Education (CCNE), a prestigious national accreditation agency that contributes to the improvement of the public's health by ensuring the quality and integrity of baccalaureate and other degree programs in nursing.

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One of the top researchers worldwide studying itch and inflammatory skin conditions, Brian S. Kim, MD, MTR, FAAD, will join Mount Sinai Health System as Director of the newly established Mark Lebwohl Center for Neuroinflammation and Sensation.

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Mount Sinai researchers have solved a major mystery in cancer research: How cancer cells remain dormant for years after they leave a tumor and travel to other parts of the body, before awakening to create metastatic cancer.

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Mount Sinai physician-scientists have found that a novel therapy for the bone marrow cancer myelofibrosis is safe and well-tolerated and is associated with modest improvements in patients in a Phase 1b clinical trial. They shared their findings during an oral presentation at the American Society of Hematology annual meeting in December.

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Mount Sinai scientists have become the first to report a potentially serious side effect related to a new form of immunotherapy known as CAR-T cell therapy, which was recently approved for the treatment of multiple myeloma. Their findings were published as a case study in Nature Medicine in December.

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New York City’s former Chief Medical Examiner, Barbara Sampson, MD, PhD, has joined the Icahn School of Medicine at Mount Sinai as Vice Chair for Laboratory Strategic Initiatives and Academic Affairs, and Professor of Pathology, Molecular, and Cell-Based Medicine.

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New study suggests persistent exposure to air pollutants in residential communities can impact health outcomes for COVID-19 patients

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Mount Sinai researchers have delineated four new subgroups of COVID-19 that can be identified in patients within 24 hours of admission to the intensive care unit (ICU). The finding will help match patients to specific treatments, improving their overall care and outcomes.

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The National Cancer Institute has awarded Mount Sinai researchers $3.15 million in grant funding to assess the potential of a multidisciplinary drug development platform to identify new biological targets for precision-based therapeutics for hepatocellular carcinoma (HCC). The platform includes precision mouse models, tumor 3D organoids, and a proprietary library of small molecule inhibitors.

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An international consortium of scientists dissects the shared genetic architecture of suicide attempts, psychiatric disorders, and non-psychiatric risk factors

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The Icahn School of Medicine at Mount Sinai will serve as a hub site for two cohort studies contributing to a nationwide health consortium study by the National Institutes of Health (NIH) on the long-term effects of SARS-CoV-2, the virus that causes COVID-19.

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The Icahn School of Medicine at Mount Sinai is among the 22 recipient institutions of the largest U.S. collaborative funding effort for equity in biomedicine, a $12.1 million effort made possible by the Doris Duke Charitable Foundation.

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Both rare and commonly observed differences in the DNA letters strung along a person’s chromosomes can explain about a third of the risk for being diagnosed with obsessive-compulsive disorder (OCD), according to a new study led by scientists at the Icahn School of Medicine at Mount Sinai.

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Mount Sinai researchers have developed a new model that uses DNA and RNA sequencing data from hundreds of patients to identify specific genes and genetic alterations responsible for never-before-defined subtypes of a blood cancer called multiple myeloma. They also identified potential targeted treatments based on the findings, as reported in Science Advances in November.

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Women who use cannabis during pregnancy, potentially to relieve stress and anxiety, may inadvertently predispose their children to stress susceptibility and anxiety, according to a study conducted by researchers from the Icahn School of Medicine at Mount Sinai and the City University of New York published Monday, November 15, in the Proceedings of the National Academy of Science (PNAS).

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A new, updated risk score can help predict possible contrast-associated acute kidney injury (CA-AKI) among patients undergoing percutaneous coronary intervention (PCI), Mount Sinai researchers report.

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Study outlines better way to identify where stents are necessary