… -stem-cell-derived RPE cells injected subretinally were able to preserve vision in a rat model of RPE cell dysfunction (Davis et al., 2017). These studies further highlight the utility and clinical applications of stem-cell-… The developmental stage …
In mammals, white adipose tissues are largely divided into visceral epididymal adipose tissue (EAT) and subcutaneous inguinal adipose tissue (IAT) with distinct metabolic properties. Although emerging evidence suggests that subpopulations of …
… This review article mainly discusses the advances in application of stem cell and progenitor transplantation for retinitis pigmentosa. Stem cell sources such as mesenchymal stem cells, embryonic stem cells, induced pluripotent stem cells …
… patients had a more frequent history of stroke and chronic obstructive pulmonary disease [14] … TAVR is rare and its incidence declines over time after TAVR [65] . Moreover, in this study [66] , the main indication to PCI was acute coronary …
… , but the molecular mechanisms that coordinately control basal cell fate and stem cell quiescence are elusive. Here, we report an epithelium-… stem cell function to Zeb1-deficient basal cells. Thus, Zeb1 is a transcriptional regulator that maintains …
… replacement (TAVR) … TAVR programs and operators. Because of the large number of TAVRs performed annually and the attendant costs, risk-adjusted, outcomes-based performance measures are critical in fairly comparing care quality …
… Despite a known high prevalence of anemia and periprocedural stroke risk among TAVR patients, few studies have evaluated the relationship between anemia and new ischemic lesions detected by DW-MRI. In this study, we revealed that …
… In this study, we investigated the cytotoxicity and hepatoxicity of HFPO-TA using human embryonic stem cell (hESC)-based assays. Results showed that HFPO-TA reduced hESCs’ viability in a dose dependent manner, and the calculated IC50 for …
… having significantly reduced the rate of stroke as compared to the first experiences [28], TAVR is still correlated to cerebral complications. … incidence than clinical strokes in patients undergoing aortic valve replacement, and they are …
Higher levels of antioxidants – particularly manganese antioxidants – could potentially extend one’s lifespan
Background: Graft-versus-host disease (GVHD) continues to compromise the overall success of allogeneic hematopoietic cell transplantation (HCT). Although rates and severity of acute GVHD have decreased with improvements in donor selection …
Objectives: Cancer stem cells (CSCs) are a small group of cells resistant to therapy and play a major role in tumor progression, recurrence, and poor clinical outcomes of patients. This study aimed to evaluate the association of CSC markers with …
VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome is a newly described entity linked to somatic mutation of UBA1, encompassing inflammatory disorders and hematological malignancies. Patients experiments …
ABSTRACT Zinc finger protein 267 (ZNF267) is a member of the Kruppel-like transcription factor family, which regulates various biological processes such as cell proliferation and differentiation. However, the biological significance of ZNF267 and …
Methods that leverage bone marrow mesenchymal stem cells (BMSCs) and stimulating factor kartogenin (KGN) for chondrocyte differentiation have paved the way for cartilage repair. However, the scarce carriers for efficiently bridging the two …
… Second, in a study that reported the occurrence of stroke as a primary outcome, it is notable that there is no reporting on the use of neurologic … This device has shown reduced cerebral lesions on radiographic investigation after TAVR, and was …
… to the increase in stroke volume, and low-flow state alone may not account for the lower gradients immediately post-TAVR. There may be … The importance of the hemodynamic differences between TAVR prostheses on clinical outcomes and …
… Despite a known high prevalence of anemia and periprocedural stroke risk among TAVR patients, few studies have evaluated the relationship between anemia and new ischemic lesions detected by DW-MRI. In this study, we revealed that …
… One of the most debilitating complications following valve procedures is stroke. Due to the calcific nature of aortic stenosis, stroke occurrence in the setting of TAVR has received the greatest attention. The TVT registry reports the incidence of stroke …
… OD on one-year outcome following TAVR. … stroke were less prevalent, while chronic kidney disease was more prevalent in comparison with patients with no prior OD. No in-hospital death occurred in patients with prior OD while a trend for higher …
… TAVR registry. Bleeding complications were assessed according to the VARC-2 criteria. Major adverse cardiac and cerebrovascular events (MACCE) was defined as a composite of all-cause death, myocardial infarction, stroke, and heart failure …
… undergoing transcatheter aortic valve replacement (TAVR). … TAVR (median 3 [IQI 3–7] vs. 2 [IQI 1–5]; P = 0.007). COPD patients had lower survival than no COPD patients (88.1% vs. 95.5%; P = 0.048) while no difference was found in terms of one-year …
… The majority of post-TAVR strokes occur within the first 24 h and are due to embolization of debris composed of thrombus, calcification, … this debris and thereby reduce the incidence of peri-procedural stroke. Currently, only two devices …
Biophysical cues can regulate stem cell behaviours and have been considered as critical parameters of synthetic biomaterials for tissue engineering. In particular, hydrogels have been utilized as promising biomimetic and biocompatible materials …
Osteochondral lesions in weight-bearing joints often fail to heal due to their poor intrinsic repair capacity and may lead to severe complications such as osteoarthritis. This study investigated the chondrogenesis, osteogenesis, and regenerative …
Abstract Niemann-Pick Type C1 (NPC1) disease is a progressive lysosomal storage disorder caused by mutations of the NPC1 gene. While neurodegeneration is the most severe symptom, a large proportion of NPC1 patients also present with …
Simple Summary Lung cancer is still the most common cause of cancer death, worldwide with increasing incidence. In lung cancer management, chemotherapy alone, or combined with radiotherapy induces cell death of the tumor bulk, but not the …
We pursued the hypothesis that specific glycans can be used to distinguish breast cancer stem cells (CSCs) and influence their function. Comparison of CSCs and non- CSCs from multiple breast cancer models revealed that CSCs are distinguished by …
Aims: Hypoxic-ischaemic encephalopathy (HIE) is one of the most serious complications in neonates and infants. Mesenchymal stromal cell (MSC)-based therapy is emerging as a promising treatment avenue for HIE. However, despite its …
The development of three-dimensional (3D) bioprinting technology opens a door for constructing bionic nerve tissue scaffolds on demand for nerve injury repair. However, the electrical insulation of the current nerve tissue scaffolds fabricated by …
The RNA polymerase II drives the biogenesis of coding and non-coding RNAs for gene expression. Here, we describe new roles for its second-largest subunit, NRPB2, on root organogenesis and regeneration. Down-regulation of NRPB2 …
The functions of exosomes in allergic diseases including asthma have aroused increasing concerns. This paper focuses on the effects of exosomes derived from human bone marrow-mesenchymal stem cells (hBM-MSCs) on the proliferation of …
Single-cell transcriptional profiling has rapidly advanced our understanding of the embryonic hematopoiesis; however, whether and what role RNA alternative splicing (AS) plays remains an enigma. This is important for understanding the mechanisms …
Stem cells are of great interest in tissue regeneration due to their ability to modulate the local microenvironment by secreting bioactive factors (collectively, secretome). However, secretome delivery through conditioned media still requires time …
There is growing evidence that the currently available MRNA vaccines provide some protection against the Omicron variant (B.1.1.529) of the SARS-COV-2 virus, the coronavirus that causes COVID-19. According to the CDC, preliminary results for Omicron from South Africa showed that the Pfizer vaccine provided 70% protection against COVID-19 hospitalization and 33% against infection, during the current Omicron wave. Granted, the protection is reduced compared with the Delta variant (93% for hospitalization and 80% for infection).
Current treatments of facial nerve injury result in poor functional outcomes due to slow and inefficient axon regeneration and aberrant reinnervation. To address these clinical challenges, bioactive scaffold-free cell sheets were engineered using …
Rotator cuff (RC) attaches to humerus across a triphasic yet continuous tissue zones (bone-fibrocartilage-tendon), termed “enthesis”. Regrettably, rapid and functional enthesis regeneration is challenging after RC tear. The existing grafts bioengineered …
Advances in molecular technologies accelerated investigations of the hematopoietic stem cell (HSC) compartment in aplastic anemia (AA). Initially, stem cell biology approaches indicated a profound depletion of HSC pool, while studies of paroxysmal …
Dental stem cells (DSCs), an important source of mesenchymal stem cells (MSCs), can be easily obtained by minimally invasive procedures and have been used for the treatment of various diseases. Classic paradigm attributed the mechanism of their …
Since the first bone marrow transplant was performed in the 1950s, stem cell-based therapies have offered the potential to treat many chronic, degenerative conditions, and multiple sclerosis (MS) is no exception. Over the last decade, autologous …
Pancreatic β cell dysfunction is a central component of diabetes progression. During the last decades, the genetic basis of several monogenic forms of diabetes has been recognized. Genome-wide association studies (GWAS) have also facilitated the …
The Wnt/β-catenin pathway plays an important role in tumor progression and chemotherapy resistance and seems to be essential for the maintenance of cancer stem cells (CSC) in several tumor types. However, the interplay of these factors has …
Mesenchymal stem cells (MSCs) are stem cells with the potential ability to differentiate into various cells and the ability to self-renew and resemble fibroblasts. These cells can adhere to plastic to facilitate the culture process. MSCs can be used …
The role of hematopoietic stem cell transplantation (HSCT) in pediatric acute lymphoblastic leukemia (ALL) is evolving. The indications for transplant in first complete remission (CR1) has decreased over the last decade; however, it continues …
The significance of cancer stem cells (CSCs) in initiation and progression of colon cancer (CC) has been established. In this study, we investigated the utility of measuring mRNA expression levels of CSC markers EpCAM, LGR5 and LGR4 for …
… Over the past 25 years, scientific advancements in stem cell technologies have led to a new hope of fertility restoration for those at risk or who have lost their fertility. Though some couples diagnosed with infertility are successfully able to conceive by …
Simple Summary Aquaculture is expanding due to the high demand of fish for human consumption. However, since carnivorous fish are fed using fish-derived proteins and lipids, the sustainability of this food-producing sector is debated. Therefore, feed …
Histone variants and the associated post-translational modifications that govern the stemness of haematopoietic stem cells (HSCs) and differentiation thereof into progenitors (HSPCs) have not been well defined. H3. 3 is a replication-independent …
RSS
Medicine keyboard_arrow_right
Sciencekeyboard_arrow_right
Life keyboard_arrow_right
Business keyboard_arrow_right
Journal News keyboard_arrow_right
By Location keyboard_arrow_right
Meetings, Grants, and Events keyboard_arrow_right