New research from Massachusetts General Hospital describes how CD4+ T cells activated by an immune factor called thymic stromal lymphopoietin suppress breast cancer by differentiating cancer into benign cyst-like structures. Here, T cells (yellow) are inducing cyst formation in breast cancer (green), which prevents the cancer cells from proliferating (Ki67 as the marker of cell proliferation, red).
Research Alert
METHOD OF RESEARCH
Experimental study
SUBJECT OF RESEARCH
Animals
ARTICLE TITLE
CD4+ T helper 2 cells suppress breast cancer by inducing terminal differentiation
ARTICLE PUBLICATION DATE
3-Jun-2022
COI STATEMENT
Disclosures: M. Boieri is an employee of Zelluna Immunotherapy. S. Iyer is an employee of and has equity in Verve Therapeutics. M.N. Rivera reported grants from Advanced Cell Diagnostics and non-financial support from Merck/Serono outside the submitted work. No other disclosures were reported.
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