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Precision Medicine Identifies Key Recurring Mutation in Head and Neck Cancers
University of California San Diego Health
Researchers at UC San Diego School of Medicine and Moores Cancer Center report that an investigational drug candidate called tipifarnib showed promise in treating key recurring mutation in head and neck cancers.
Hearing loss linked to neurocognitive deficits in childhood cancer survivors
St. Jude Children's Research Hospital
Scientists at St. Jude Children's Research Hospital are studying how hearing loss can affect the neurocognitive abilities of childhood cancer survivors. Findings show that survivors with severe hearing loss are at a significant increased risk for neurocognitive deficits, independent of what type of therapy they receive.
The "M" Word
University of Kansas Cancer Center
Danny Welch, PhD, researcher at The University of Kansas Cancer Center, studies metastasis, which is responsible for more than 90% of cancer-related deaths.
FSU biologist uses genome database to investigate cancer cells
Florida State University
Florida State University Professor of Biological Science David Gilbert is using the latest information about the human genome as a guide to better understand cancer. Gilbert and his FSU colleagues were part of a team that compared different cancer cell types to a database of normal human cells using a new method he developed that can identify the cell type from which cancers derive.
Researchers Outline Need for Further Evaluation of Gene Expression Profiling in Melanoma Patients
Huntsman Cancer Institute at the University of Utah
A consensus statement published today in JAMA Dermatology by a group of melanoma researchers evaluates the use of prognostic genetic expression profiling within clinical treatment of patients with melanoma. The group cautioned against routine use of currently-available genetic expression profiling tests for patients with cutaneous melanoma.
New insights into wound healing
Washington University in St. Louis
Research from a multidisciplinary team led by Washington University may provide new insights into wound healing, scarring and how cancer spreads.
Phosphoprotein biomarkers to guide cancer therapy are identified
University of Alabama at Birmingham
Post-translational modification analysis may broadly identify new biomarkers of cancer drivers for a much more precise prediction of patient responses to treatments. A recent study demonstrates this diagnostic alternative for neuroendocrine neoplasms driven by a protein kinase called Cdk5.
Researchers make significant step toward blood test for Alzheimer's disease
The Rockefeller University Press
Researchers at Washington University School of Medicine in St. Louis have developed a technique to detect minute amounts of a protein fragment linked to Alzheimer's disease in the blood. The study, which will be published July 28 in the Journal of Experimental Medicine (JEM), shows that levels of p-tau-217 are elevated during the early stages of Alzheimer's disease and could lead to a simple blood test capable of diagnosing the neurodegenerative disorder years before any symptoms begin to appear.
BioMed Valley Discoveries' ulixertinib (BVD-523), a first-in-class ERK inhibitor cancer therapy, receives Fast Track designation and launches Phase II trial in collaboration with Cmed and Strata Oncology
BioMed Valley Discoveries
BioMed Valley Discoveries (BVD), a clinical stage biotechnology company, announces the receipt of Fast Track designation from the US Food and Drug Administration (FDA) for investigation of the ERK inhibitor ulixertinib (BVD-523) as a treatment for patients with non-colorectal, solid tumors that harbor BRAF mutations G469A/V, L485W, or L597Q. BVD has launched a Phase II multi-center study of ulixertinib for patients with advanced malignancies harboring these atypical (non-V600) BRAF alterations or a MEK alteration.
U.S. News & World Report Ranks Seattle Cancer Care Alliance Among the Top Ten Cancer Hospitals in the Nation for Over 10 years
Seattle Cancer Care Alliance
UWMC/ Seattle Cancer Care Alliance (SCCA), part of Washington state's only National Cancer Institute (NCI)-designated comprehensive cancer center, has been recognized as the 9th Best Cancer Hospital for 2020-21 by U.S. News & World Report, and the only ranked number one cancer hospital in the Pacific Northwest for more than ten years. The annual Best Hospitals rankings and ratings, now in their 31st year, are designed to assist patients and their doctors in making informed decisions about where to receive care for challenging health conditions or for common elective procedures.
Artificial Intelligence Identifies Prostate Cancer with Near-Perfect Accuracy
Health Sciences at the University of Pittsburgh
Study reports 98% sensitivity and 97% specificity in recognizing and characterizing prostate cancer using an artificial intelligence (AI) program.
10 Things to Know About HPV and Throat Cancer
Atlantic Health System
As we observe World Head and Neck Cancer Day 2020 (July 27), nationally known expert Tom Thomas, MD, MPH, has set out to clear up misunderstandings about how one type of head and neck cancer is related to human papillomavirus (HPV), which has historically been thought of primarily as a cause of cervical cancer. Dr. Thomas is medical director, Head and Neck Reconstructive Surgery and Transoral Robotic Surgery, Leonard B. Kahn Head and Neck Cancer Institute at Atlantic Health System's Morristown Medical Center and Carol G. Simon Cancer Center. He is one of the leaders of the Atlantic HPV Center.
Ludwig San Diego Study Identifies Deadly Genetic Synergy in Cancer Cells and Shows it Might Be Exploited for Therapy
Ludwig Cancer Research
A Ludwig Cancer Research study has identified a new instance in which the simultaneous mutation of two nonessential genes--neither of which is on its own vital to cell survival--can cause cancer cell death.
A New Way to Target Cancers Using 'Synthetic Lethality'
University of California San Diego Health
Researchers at Ludwig Institute for Cancer Research and University of California San Diego School of Medicine report that inhibiting a key enzyme caused human cancer cells associated with two major types of breast and ovarian cancer to die and in mouse studies reduced tumor growth.
Novel label-free imaging technique brings out the inner light within T cells
Morgridge Institute for Research
A new imaging method developed by the Skala lab uses the natural autofluorescence within cells to assess T cell activity. The technique could help assess T cell involvement in immunotherapies.
Cancer Care Can't Wait
Rutgers Cancer Institute of New Jersey
Further delaying your preventative cancer care may cause more harm than good. Expert from Rutgers Cancer Institute of New Jersey explains how most colorectal cancers can be prevented through regular screenings, and it is safe to get your screenings, even during these difficult times.
Ronald Chen named a Fellow of the American Society for Radiation Oncology
University of Kansas Cancer Center
Dr. Chen joins a group of just 19 physicians and medical physicists who are recognized this year for their contributions to the field of radiation oncology.
Cancer Clinical Trials Tested, Continue During COVID-19 Pandemic
University of California San Diego Health
During the COVID-19 pandemic, Moores Cancer Center at UC San Diego Health continues to offer potentially lifesaving treatment through cancer clinical trials.
2 immunotherapies merged into single, more effective treatment
Washington University in St. Louis
Researchers at Washington University School of Medicine in St. Louis have combined two immunotherapy strategies into a single therapy and found, in studies in human cells and in mice, that the two together are more effective than either alone in treating certain blood cancers, such as leukemia.
Heather Brandt, Ph.D., to lead cancer prevention community outreach projects for St. Jude
St. Jude Children's Research Hospital
Behavioral scientist will lead St. Jude community outreach and research programs focused on the prevention of HPV-associated cancers through vaccination
NCCN Oncology Research Program Announces Projects Selected for Funding to Study Futibatinib in Tumors with Aberrant FGFR Expression, in Collaboration with Taiho Oncology
National Comprehensive Cancer Network(r) (NCCN(r))
The NCCN Oncology Research Program (ORP) today announced four projects selected to receive funding for clinical and pre-clinical evaluation of futibatinib (TAS-120) in collaboration with Taiho Oncology.
Loyola Researchers Identify Common Characteristics, Outcomes of Rare Pediatric Brain Tumors
Loyola Medicine
In a new study, "Pediatric vestibular schwannomas: case series and a systematic review with meta-analysis," appearing in the Journal of Neurosurgery, researchers at Loyola University Medical Center and Loyola University Chicago Stritch School of Medicine performed a retrospective review of the diagnosis, treatment and outcomes of 15 patients (21 years of age or younger) with unilateral vestibular schwannomas, without neurofibromatosis type 2 (a genetic disorder that causes noncancerous tumor growth in the nervous system), who underwent surgery at Loyola University Medical Center between 1997 and 2019. The study authors also reviewed existing literature on this type of tumor in pediatric patients. Overall, the review found that pediatric patients had similar symptoms to those of adult patients with acoustic neuromas; however, the tumor size was typically larger in the pediatric patients at the time of diagnosis, and symptoms of mass effect (secondary effects caused by the tumor) were
Fine-tuning adoptive cell therapy for advanced cancers
University of California, Los Angeles (UCLA), Health Sciences
In a new study looking at adoptive cell transfer products bearing a transgenic T-cell receptor (TCR), researchers at the UCLA Jonsson Comprehensive Cancer Center have identified a discordant phenomenon in which a subset of patients displayed profoundly decreased expression of the transgenic TCR over time, despite the transgenic TCR being present at the DNA level.
Triple Negative Breast Cancer Meets Its Match
UT Southwestern Medical Center
DALLAS - July 22, 2020 - One member of a larger family of oxygen sensing enzymes could offer a viable target for triple negative breast cancer (TNBC), UTSW researchers report in a new study. The findings, published online this week in Cancer Discovery, might offer hope to this subset of patients who have few effective treatment options and often face a poor prognosis.
Edward Chu, M.D., M.M.S., To Lead Cancer Medicine at Albert Einstein College of Medicine and Montefiore Health System
Albert Einstein College of Medicine and Montefiore Health System
Albert Einstein College of Medicine and Montefiore Health System today announced that Edward Chu, M.D., M.M.S., has been named director of the National Cancer Institute-designated Albert Einstein Cancer Center; vice president for cancer medicine at Montefiore Medicine; professor of medicine and of molecular pharmacology; and will hold the Carol and Roger Einiger Professorship of Cancer Medicine at Einstein. In these roles, Dr. Chu will unite Einstein and Montefiore's cancer programs into a fully integrated research and clinical enterprise. The appointment will be effective October 1, 2020.
Sarcoma Awareness Month: Orthopaedic oncologists available to comment on the rarity of sarcoma and the work that's being done to better treatment options for patients
American Academy of Orthopaedic Surgeons (AAOS)
100th Patient Receives Final Cancer Treatment With MRI-guided Radiation at Loyola Medicine
Loyola Medicine
Loyola Medicine recently celebrated its 100th patient to complete cancer treatment with the MRIdian by Viewray radiation therapy system, a novel treatment that utilizes MRI-guided radiation to precisely treat cancerous tumors, typically with fewer treatment sessions and side effects, and better outcomes.
Huntsman Cancer Institute Receives Renewal of Prestigious Designation from the National Cancer Institute
Huntsman Cancer Institute at the University of Utah
The National Cancer Institute has renewed the designation of Huntsman Cancer Institute at the University of Utah as a Comprehensive Cancer Center, the highest federal rank possible for a cancer research organization. This grant awards HCI more than $29 million over seven years, an increase of 84% in annual funding from the previous award cycle.
Researchers ID new target in drive to improve immunotherapy for cancer
University of California, Los Angeles (UCLA), Health Sciences
Researchers at the UCLA Jonsson Comprehensive Cancer Center and UCLA School of Dentistry have identified a potential new combination therapy to treat advanced head and neck squamous cell carcinoma, the most common type of head and neck cancer.
Prostate cancer metastasis linked to revival of dormant molecular program
Dana-Farber Cancer Institute
When prostate cancer progresses to a more-dangerous metastatic state, it does so by resurrecting dormant molecular mechanisms that had guided the fetal development of the prostate gland but had been subsequently switched off, say scientists from Dana-Farber Cancer Institute.
Don't Get Burned by Sunscreen Mistakes: Some Parents May Not Properly Protect Children from the Sun
Michigan Medicine - University of Michigan
While the majority of parents recognize the importance of sunscreen, they may not always use best practices to protect children from getting burned, a new national poll suggests.
Doctors motivated by both health, malpractice concerns when ordering additional tests
University of California, Los Angeles (UCLA), Health Sciences
A UCLA-led study has found that dermatopathologists, who specialize in diagnosing skin diseases at the microscopic level, are motivated both by patient safety concerns and by malpractice fears -- often simultaneously -- when ordering multiple tests and obtaining second opinions, with a higher proportion of these doctors reporting patient safety as a concern. When ordering additional microscopic tests for patients, 90% of the dermatopathologists surveyed cited patient safety as a concern and 71% of them reported malpractice fears. Similarly, when obtaining second reviews from a consulting pathologist or recommending additional surgical sampling, 91% cited safety concerns and 78% malpractice concerns.
Seattle Cancer Care Alliance Expands South Lake Union Campus
Seattle Cancer Care Alliance
Seattle Cancer Care Alliance (SCCA) announced the beginning of construction on its South Lake Union (SLU) campus to add a new six-story, 150,000 square-foot outpatient cancer treatment clinic.
Sylvester Comprehensive Cancer Center Urologist Leads Collaborative Study on Fertility Counseling Prior to Chemotherapy
University of Miami Health System, Miller School of Medicine
For younger cancer patients, fertility counseling at the time of cancer diagnosis is important for making family planning decisions. Ranjith Ramasamy, M.D., a clinician and researcher at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine, was the lead author of a new collaborative study, "Evaluation of Reported Fertility Preservation Counseling Before Chemotherapy Using the Quality Oncology Practice Initiative Survey," published JAMA Network Open.
Latest developments on Cytoreductive Surgery & Hyperthermic Intraperitoneal Chemotherapy (CRT/HIPEC)
Mercy Medical Center
Mercy Medical Center is the first institution in the United States to study the role of CRS/HIPEC for newly diagnosed with ovarian, fallopian tube, or primary peritoneal cancers. Literature exists involving CRS/HIPEC in the role of recurrent disease and in the neoadjuvant setting; however, there is no published data on the role as a primary treatment option in the United States.
A New Approach to Tailoring Cancer Therapy: Tapping Into Signaling Activities in Cancer Cells
Weizmann Institute of Science
The Weizmann Institute's Dr. Ravid Straussman and colleagues developed a method that utilizes cellular signaling to determine the best treatment for a given tumor. The method can help tailor treatments and identify new drug-development targets. In fact, the team has already singled out a gene that serves as a target for treating BRCA-related breast cancers.
Use of Pembrolizumab Provided Long-Term Benefits in Patients With Metastatic Melanoma, 10-Year Look Shows
Roswell Park Comprehensive Cancer Center
A new 10-year analysis led by Igor Puzanov, MD, MSci, FACP, Director of Early Phase Clinical Trials and Chief of Melanoma at Roswell Park Comprehensive Cancer Center and published today in the journal JAMA Oncology provides new insights into an important question: whether BRAF V600E/K mutation status or previous BRAF inhibitor (BRAFi) therapy with or without a MEK inhibitor (MEKi) affects response to pembrolizumab (brand name Keytruda) in patients with advanced melanoma.
So You Discovered Something that Might Save Lives ... Now What?
University of California San Diego Health
New UC San Diego Dissemination and Implementation Science Center provides researchers and practitioners with the training, technical assistance, mentoring and resources needed to implement their findings in real-world settings.
Rare Mutation of TP53 Gene Leaves People at Higher Risk for Multiple Cancers
Perelman School of Medicine at the University of Pennsylvania
For the first time, researchers detai the potential implications of a specific P53 mutation, including an association with a specific type of Li-Fraumeni syndrome (LFS), an inherited predisposition to a wide range of cancers.
Huntsman Cancer Institute Announces Next Major Expansion
Huntsman Cancer Institute at the University of Utah
A $4.5 million gift from the Huntsman family will fund an expansion of a unique program at Huntsman Cancer Institute (HCI) at the University of Utah (U of U) that brings specialty cancer care directly to patients in their homes. With this major gift, HCI's Huntsman at HomeTM will expand to rural Utah, including Carbon, Emery, and Grand Counties. The goal is to provide cancer care for patients who live far from HCI in Salt Lake City by partnering with patients and their caregivers, communities, and medical teams to deliver many aspects of cancer care in a patient's own home as an alternative to hospital visits at a medical center or emergency department.
Scientists discover way to stop spread of devastating childhood cancer
University of East Anglia
Researchers at the University of East Anglia and University of Manchester have made an important breakthrough that could lead to 'kinder' treatments for children with bone cancer, and save lives.
Ludwig Cancer Research Study Finds Reprogramming of Immune Cells Enhances Effects of Radiotherapy in Preclinical Models of Brain Cancer
Ludwig Cancer Research
A Ludwig Cancer Research study has dissected how radiotherapy alters the behavior of immune cells known as macrophages found in glioblastoma (GBM) tumors and shown how these cells might be reprogrammed with an existing drug to suppress the invariable recurrence of the aggressive brain cancer.
Yale Cancer Center Receives NCI Grant Renewal to Fund Clinical Trials
Yale Cancer Center
The National Cancer Institute has awarded a UM1 grant renewal to Yale Cancer Center. The 6-year, $3 million a year grant will fund early phase investigator-initiated clinical trials to develop new potential therapies for treating both solid tumors and hematologic malignancies.
Boosting Immune Memory Could Reduce Cancer Recurrence
Health Sciences at the University of Pittsburgh
New study on how immune memory can be targeted and improve immunotherapy and prevent cancer recurrence.
Brain Cancer: UVA IDs Gene Responsible for Deadly Glioblastoma
University of Virginia Health System
The discovery of the oncogene responsible for glioblastoma could be the brain tumor's Achilles' heel, one researcher says.
Roswell Park Studies Highlight Emerging Treatment Options for Neuroendocrine Tumors
Roswell Park Comprehensive Cancer Center
Two new studies led by Renuka Iyer, MD, Section Chief for Gastrointestinal Oncology at Roswell Park Comprehensive Cancer Center, highlight possible new treatment options for patients with neuroendocrine tumors (NETs) -- a rare and hard-to-treat cancer.
Juanita L. Merchant Appointed to the Ludwig Institute's Scientific Advisory Committee
Ludwig Cancer Research
Ludwig Cancer Research welcomes Juanita L. Merchant to the Scientific Advisory Committee of the Ludwig Institute for Cancer Research.
Lung Screening Bus Brings High-Tech Health Care Directly to Patients
The Society of Thoracic Surgeons
A mobile platform for lung cancer screening with low-dose computed tomography (CT) can be developed with limited financial risk and take powerful screening tests directly to patients, including underserved rural areas where rates of new lung cancer cases tend to be higher.
Study suggests lymphoma drug acalabrutinib might offer a potential therapeutic approach for severe COVID-19 infection
Hackensack Meridian Health
The mechanisms of action of acalabrutinib led to the hypothesis it might be effective in reducing the massive inflammatory response seen severe forms of COVID19. Indeed, it did provide clinical benefit in a small group of patients by reducing their inflammatory parameters and improving their oxygenation.
Hackensack University Medical Center Becomes First in New Jersey to Perform Revolutionary Minimally Invasive Robotic Lung Biopsy Procedure
Hackensack Meridian Health
More than 70% of lung nodules that need to be biopsied (analyzed to see if they are cancer) reside far out in the periphery of the lung, making them very difficult to biopsy using conventional bronchoscopy (a tube with a camera on its tip inserted through a patient's mouth into the lungs). The Ion system combines computed tomography (CT) data and robotic-assisted surgical technology to facilitate and expedite access to these nodules. The entire procedure is performed through bronchoscopy, without the need for any external surgical incisions.
Translated Tool from NCCN Measures Mental Health "Temperature" of People with Cancer
National Comprehensive Cancer Network(r) (NCCN(r))
The NCCN Distress Thermometer enables discussion and treatment of distress as part of routine care for people with cancer. This free resource is now translated into 46 languages for global accessibility.
Dr. Marcella Nunez-Smith Named Director of Center for Community Engagement and Health Equity for Yale Cancer Center and Smilow Cancer Hospital
Yale Cancer Center
Marcella Nunez-Smith, MD, MHS, has been appointed Director of the Center for Community Engagement and Health Equity for Yale Cancer Center (YCC) and Smilow Cancer Hospital (SCH), as well as Chief Health Equity Officer & Deputy Chief Medical Officer, at SCH, and Associate Cancer Center Director for Community Outreach and Engagement at YCC.
American Society for Radiation Oncology (ASTRO) to host virtual Annual Meeting, October 25-28
American Society for Radiation Oncology (ASTRO)
The American Society for Radiation Oncology's (ASTRO) 62nd Annual Meeting, will be held October 25-28 via an interactive virtual platform. The meeting, Global Oncology: Radiation Therapy in a Changing World, will feature reports from the latest clinical trials; panels on global oncology, health disparities and the novel coronavirus; and an immersive attendee experience in a virtual convention center. Media resources are available at www.astro.org/astro2020press.
Breast Cancer Cells Turn Killer Immune Cells Into Allies
The Rockefeller University Press
Researchers at Johns Hopkins University School of Medicine have discovered that breast cancer cells can alter the function of immune cells known as Natural killer (NK) cells so that instead of killing the cancer cells, they facilitate their spread to other parts of the body. The study, which will be published July 9 in the Journal of Cell Biology (JCB), suggests that preventing this reprogramming might stop breast cancer from metastasizing to other tissues, a major cause of death in breast cancer patients.
Breast Cancer Cells Can Reprogram Immune Cells to Assist in Metastasis
Johns Hopkins Medicine
Johns Hopkins Kimmel Cancer Center investigators report they have uncovered a new mechanism by which invasive breast cancer cells evade the immune system to metastasize, or spread, to other areas of the body. They propose that therapies targeting this process could be developed to halt or prevent metastasis and reduce breast cancer deaths.
Queen's part of GBP7 million consortium to improve outcomes for patients with early stage cancer
Queen's University Belfast
The Precision Medicine Centre of Excellence (PMC) at Queen's is leading a ground-breaking collaboration with the world's largest biotech company Roche, and Artificial Intelligence (AI) specialist, Sonrai Analytics.
Study Sheds Light on How Cancer Spreads in Blood
Cedars-Sinai
A new study sheds light on proteins in particles called extracellular vesicles, which are released by tumor cells into the bloodstream and promote the spread of cancer. The findings suggest how a blood test involving these vesicles might be used to diagnose cancer in the future, avoiding the need for invasive surgical biopsies.
Yale Cancer Center Awarded NIH SPORE Renewal for Lung Cancer Research
Yale Cancer Center
Yale Cancer Center researchers were awarded a $11 million grant renewal from the National institutes of Health to fund the Yale Specialized Program of Research Excellence (SPORE) in Lung Cancer.
Muschen Named Inaugural Director of Center of Molecular and Cellular Oncology at Yale Cancer Center and Yale School of Medicine
Yale Cancer Center
Markus Muschen, M.D., Ph.D., has been named the inaugural Director of the Center of Molecular and Cellular Oncology at Yale Cancer Center and Smilow Cancer Hospital. Muschen will also be appointed Arthur H. and Isabel Bunker Professor of Medicine (Hematology) and Professor of Immunobiology at Yale School of Medicine.
A helping hand for cancer immunotherapy
Sanford Burnham Prebys Medical Discovery Institute
Scientists at Sanford Burnham Prebys Medical Discovery Institute have demonstrated the therapeutic potential of PRMT5 inhibitors to sensitize unresponsive melanoma to immune checkpoint therapy. PRMT5 inhibitors are currently in clinical trials in oncology, and this research provides a strong rationale for evaluating the drugs in tumors that are not responsive to immune checkpoint therapy. The study was published in Science Translational Medicine.
Aspirin, flavonoid metabolites may be preventing colorectal cancer
South Dakota State University
Simpler phenolic compounds, known as hydroxybenzoic acids, that result when the gut bacteria break down aspirin and flavonoids from fruits and vegetables may contribute to colorectal cancer prevention.
JNCCN Study Explores if Insurance is Keeping Pace with Trends in Targeted Cancer Therapy
National Comprehensive Cancer Network(r) (NCCN(r))
New research from the University of California, San Francisco (USCF) and City of Hope in the July 2020 issue of JNCCN--Journal of the National Comprehensive Cancer Network examines coverage trends for circulating tumor DNA testing, also known as gene sequencing of ctDNA or "liquid biopsies." The researchers found coverage rate rose from 0% to 38% in three years. The policies also increased in scope from 2017-2019, going from one cancer type to 12.
A Different Chia-PET Provides Insight Into Prostate Cancer
UT Southwestern Medical Center
DALLAS - July 6, 2020 - UT Southwestern researchers have identified vast webs of small snippets of the genome that interact with each other and with genes to promote prostate cancer. Their findings, published June 22 in the Journal of Clinical Investigation, could lead to new ways to treat the most common type of malignancy in American men other than skin cancer.
Study Suggests Method to Starve Pancreatic Cancer Cells
Michigan Medicine - University of Michigan
Rather than attacking cancer cells directly, new cell-model research probes weaknesses in pancreatic cancer's interactions with other cells to obtain nutrients needed for tumor growth.
St. Jude researchers create an analytic tool that opens a new frontier of cancer discovery
St. Jude Children's Research Hospital
St. Jude Children's Research Hospital scientists have developed software to identify cancer-causing mutations lurking in vast regions of the human genome
Tackle Kids Cancer Receives $250,000 Gift from Sohn Conference Foundation to Benefit Pediatric Cancer and Patient Care at Hackensack Meridian Health
Hackensack Meridian Health
Foundation receives generous donation from corporate partner to combat pediatric cancer and benefit patient care
July is National UV Safety Month
Rutgers Cancer Institute of New Jersey
July is UV Safety Month, the perfect time to raise awareness about the risk of developing sun-related skin cancer. Rutgers Cancer Institute expert shares tips about how to reduce skin cancer risk during the summer months when UV rays are the strongest.
Understanding The Circadian Clocks of Individual Cells
UT Southwestern Medical Center
DALLAS - July 2, 2020 - Two new studies led by UT Southwestern scientists outline how individual cells maintain their internal clocks, driven both through heritable and random means. These findings, published online May 1 in PNAS and May 27 in eLife, help explain how organisms' circadian clocks maintain flexibility and could offer insights into aging and cancer.
American Cancer Society awards Research Scholar Grant to Brooke Emerling
Sanford Burnham Prebys Medical Discovery Institute
Sanford Burnham Prebys Medical Discovery Institute is pleased to announce that the American Cancer Society (ACS) has awarded Brooke Emerling, Ph.D., a Research Scholar Grant to study a new approach to targeting tumors that have a mutation in the p53 gene--the most altered gene in human cancers. The grants are often a career-launching award for "rising stars" in the cancer research arena.
Cancer cells make blood vessels drug resistant during chemotherapy
Hokkaido University
Scientists at Hokkaido University and collaborators have identified how inflammatory changes in tumors caused by chemotherapy trigger blood vessel anomalies and thus drug-resistance, resulting in poor prognosis of cancer patients.
Study Shows Breast Cancer Detected Earlier in States with Expanded Medicaid Coverage
Yale Cancer Center
In a new study by Yale Cancer Center, researchers have demonstrated that in states with expanded Medicaid coverage through the Affordable Care Act (ACA) a higher percentage of women with breast cancer had their disease diagnosed at an early stage. No such change was seen in states that didn't expand their coverage. The findings were published today in JAMA Surgery.
Expert in Early Phase Therapeutics Joins NYU Langone Health as Associate Director for Clinical Research at Perlmutter Cancer Center
NYU Langone Health
Janice M. Mehnert, MD, a nationally recognized expert in early phase therapeutics and the treatment of skin malignancies, has been appointed associate director for clinical research at NYU Langone Health's Perlmutter Cancer Center. She assumes her post July 1, 2020.
Epigenetics Researcher Yang Shi Appointed Member of Ludwig Oxford
Ludwig Cancer Research
It is with great pleasure that Ludwig Cancer Research announces the appointment of Yang Shi as Member of the Oxford Branch of the Ludwig Institute for Cancer Research.
NCCN: What People with Cancer and their Caregivers Need to Know about CAR T-Cell Therapy
National Comprehensive Cancer Network(r) (NCCN(r))
The National Comprehensive Cancer Network (NCCN) has published a new NCCN Guidelines for Patients: Immunotherapy Side Effects focused on chimeric antigen receptor (CAR) T-cell therapy. This is book two in a series that includes another book on irAEs focused on immune checkpoint inhibitors.
Number of Hospitalizations Can Be Important Clinical Indicator for Head, Neck Cancer Patients
Roswell Park Comprehensive Cancer Center
Patients who were unexpectedly hospitalized for dehydration, fever or other ailments while undergoing radiation treatment for head and neck cancers were at a higher risk for less favorable outcomes, a new study from Roswell Park Comprehensive Cancer Center reports.
What to Wear to Protect Your Skin From the Sun
American Academy of Dermatology
Skin cancer is the most common cancer in the U.S., and nearly 20 Americans die from melanoma, the deadliest form of skin cancer, every day. As more Americans prepare to head outdoors for the 4th of July holiday, dermatologists from the American Academy of Dermatology have an important reminder: dress to protect yourself from the sun. In addition to seeking shade and applying sunscreen, wearing protective clothing goes a long way in protecting you from the sun's harmful UV rays, which can increase your risk of skin cancer. However, not all clothing is created equal when it comes to sun protection, say dermatologists. Some garments provide better UV protection than others.
School HPV vaccine policies could result in higher vaccination rates, reduction in cancers
University of California, Los Angeles (UCLA), Health Sciences
A UCLA-led study has found that in 2 of 3 states and jurisdictions with policies that require students entering school to receive the human papillomavirus vaccine, vaccination rates among 13-to-17-year-olds were significantly higher than in surrounding states without such policies.
USC Norris Comprehensive Cancer Center receives $5 million for cancer drug discoveries
Keck Medicine of USC
USC Norris Comprehensive Cancer Center receives $5 million for cancer drug discoveries
Study Validates Combination Therapy for Aggressive Endometrial Cancer
Yale Cancer Center
Yale Cancer Center (YCC) scientists have found that combining the targeted drug trastuzumab with chemotherapy significantly improves survival rates for women with a rare, aggressive form of endometrial cancer.
How to Recognize Side-Effects from Immunotherapy? New NCCN Guidelines for Patients can Help
National Comprehensive Cancer Network(r) (NCCN(r))
New NCCN Guidelines for Patients: Immunotherapy Side Effects - Immune Checkpoint Inhibitors from National Comprehensive Cancer Network and NCCN Foundation shares information for patients and caregivers on how to recognize and manage adverse events from immune checkpoint inhibitors.
St. Jude Cloud portal expands access to treasure trove of pediatric solid tumor data
St. Jude Children's Research Hospital
St. Jude Children's Research Hospital develops the Childhood Solid Tumor Network data portal to speed discoveries and novel therapies for treatment of childhood solid tumors
A Study of Early-Onset Colorectal Cancer in Young Adult Men Reveals "Hotspots" of Death in the United States
Huntsman Cancer Institute at the University of Utah
A study led by Charles Rogers, PhD, examines a trend of increasing incidence and mortality among young men diagnosed with colorectal cancer. The authors identify "hotspot" areas of the U.S. where colorectal cancer is on the rise. For men with early-onset colorectal cancer, Black men are more likely to die of the disease than other racial groups.
Poseidon Innovation Announces Funding for Three UC San Diego Researchers
University of California San Diego
UC San Diego and Deerfield Management created Poseidon Innovation to support researchers working to advance disease-curing therapeutics by funding early stage projects and expediting the drug-development cycle. Poseidon announces it is funding three researchers.
Neural network can determine lung cancer severity
National Institute of Biomedical Imaging and Bioengineering
NIBIB-funded researchers at Stanford University have created an artificial neural network that analyzes lung CT scans to provide information about lung cancer severity that can guide treatment options.
Research News Tip Sheet: Story Ideas from Johns Hopkins Medicine
Johns Hopkins Medicine
During the COVID-19 pandemic, Johns Hopkins Medicine Media Relations is focused on disseminating current, accurate and useful information to the public via the media. As part of that effort, we are distributing our "COVID-19 Tip Sheet: Story Ideas from Johns Hopkins" every Tuesday throughout the duration of the outbreak.
Inherited mutation found among Brazilians increases cancer risk
St. Jude Children's Research Hospital
Genomic research helps explain why some people with a common TP53 mutation widespread in Brazil get cancer while others do not.
American Cancer Society Updates Guidelines for Cancer Prevention
Rutgers Cancer Institute of New Jersey
The American Cancer Society recently updated its nutrition and physical activity guidelines for cancer prevention. These updates focus on increasing physical activity and developing healthy eating patterns at every age, with an emphasis on maintaining a healthy body weight through all stages of life.
Houston Methodist oncologist available to comment on NCI model predicting 10,000 additional breast/colorectal cancer deaths due to COVID-19
Houston Methodist
St. Jude creates resource for pediatric brain tumor research
St. Jude Children's Research Hospital
Researchers worldwide can access orthotopic patient-derived xenograft models to speed discovery and test novel therapies for childhood brain tumors.
St. Jude Children's Research Hospital president, CEO recognized for contributions to cancer research
St. Jude Children's Research Hospital
The American Association for Cancer Research honored St. Jude President and CEO James R. Downing, M.D., with its inaugural AACR-St. Baldrick's Foundation Award for Outstanding Achievement in Pediatric Cancer Research.
St. Jude pediatric oncologist Dylan Graetz receives Young Investigator Award from ASCO
St. Jude Children's Research Hospital
Dylan Graetz, M.D., M.P.H., a pediatric hematology-oncology fellow at St. Jude, has received a Young Investigator Award from the American Society of Clinical Oncology.
Immune Cells Infiltrating Tumors May Play Bigger Cancer Role Than Previously Thought
University of California San Diego Health
UC San Diego researchers uncovered in mice how IRE1α, a molecule involved in cells' response to stress, determines whether macrophages promote inflammation in the tumor microenvironment. Inflammation is known to promote tumor growth, making IRE1α an attractive target for drug development.
Focused ultrasound shows promise against deadliest brain tumor
University of Virginia Health System
An innovative use of focused ultrasound is showing promise against glioblastoma, the deadliest brain tumor, and could prove useful against other difficult-to-treat cancers.
Online program significantly improves insomnia in adolescent and young adult cancer survivors, study finds
Dana-Farber Cancer Institute
In a study published today by Pediatric Blood and Cancer, researchers at Dana-Farber Cancer Institute show that an online program developed specifically for AYA cancer survivors can significantly alleviate insomnia and improve overall quality of life.
Early clinical trial supports tumor cell-based vaccine for mantle cell lymphoma
The Rockefeller University Press
A phase I/II clinical trial by researchers at Stanford University suggests that vaccines prepared from a patient's own tumor cells may prevent the incurable blood cancer mantle cell lymphoma (MCL) from returning after treatment. The study, which will be published June 19 in the Journal of Experimental Medicine (JEM), reveals that the vaccines are a safe and effective way to induce the body's immune system to attack any tumor cells that could cause disease relapse.
Breakthrough discovery to transform prostate cancer treatment
University of South Australia
A novel formulation of the prostate cancer drug abiraterone acetate - currently marketed as Zytiga - will dramatically improve the quality of life for people suffering from prostate cancer, as pre-clinical trials by the University of South Australia show the new formulation improves the drug's effectiveness by 40 per cent.
Study shows sedentary behavior independently predicts cancer mortality
University of Texas M. D. Anderson Cancer Center
In the first study to look at objective measures of sedentary behavior and cancer mortality, researchers from The University of Texas MD Anderson Cancer Center found that greater inactivity was independently associated with a higher risk of dying from cancer.
Vitamin D could help mitigate chemotherapy side effects
University of South Australia
New findings by University of South Australia researchers reveal that Vitamin D could potentially mitigate chemotherapy-induced gastrointestinal mucositis and provide relief to cancer patients.
PSA screening affords men long-term benefits, study finds
University of Washington School of Medicine
Prostate cancer researchers and clinicians recommend reconsidering screening guidelines, saying benefits may outweigh potential harms.
COVID-related Delays in Colorectal Cancer Screening Jeopardizes Preventive Care, Early Treatment
Rush University Medical Center
Cancer physicians are concerned that Covid-related delays could reverse important gains in preventing colorectal cancer