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Top Cancer Clinician-Scientist Appointed Director of Samuel Oschin Comprehensive Cancer Institute at Cedars-Sinai
Cedars-Sinai
Renowned cancer clinician and scientist Dan Theodorescu, MD, PhD, has been named director of the Samuel Oschin Comprehensive Cancer Institute at Cedars-Sinai.
By Forming Clots in Tumors, Immune Cell Aids Lung Cancer's Spread
University of North Carolina Health Care System
In the journal Nature Communications, researchers report for a particular subset of lung cancer tumors, there is a high prevalence of immune cells called inflammatory monocytes. These immune cells, which normally help to build clotting scaffolds to promote wound healing, also make it possible for tumor cells to migrate and spread to other parts of the body.
New Grant Funds Cutting-Edge UCLA Clinical Trial for Late-Stage Lung Cancer
University of California, Los Angeles (UCLA), Health Sciences
Scientists at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA a have been awarded a $12M grant from the California Institute for Regenerative Medicine - also known as CIRM - to initiate a phase 1 clinical trial to test a novel cancer treatment for advanced-stage lung cancer.
St. Jude Children's Research Hospital Expands International Reach with St. Jude Global
St. Jude Children's Research Hospital
Hospital invests more than $100 million in unique initiative aimed at accelerating efforts to improve childhood cancer survival rates worldwide
A Cascade of Immune Processes Offers Insights to Triple-Negative Breast Cancer
Michigan Medicine - University of Michigan
Researchers at the University of Michigan Rogel Cancer Center have discovered that tumor cells reprogram metabolic pathways to gain control over a type of immune cell that allows cancer growth.
Cancer Cells Co-Opt Pain-Sensing 'Wasabi Receptor' to Survive Oxidative Stress
Harvard Medical School
Some cancers express unusually high levels of a neural calcium channel known as the 'wasabi receptor,' which plays a role in detecting pain, cold and other sensations. New research finds cancer cells co-opt this neural channel to increase their tolerance against toxic oxidative stress.
New Jersey Health Care Providers, Community Members, and Researchers Come together to Address Disparities and Improve Screening Opportunities for Colorectal and Lung Cancers
Rutgers Cancer Institute of New Jersey
Health care providers, community members, and researchers from across New Jersey came together at the 'Conference for Change' event, hosted by the New Jersey Primary Care Association and sponsored by ScreenNJ to address the need to improve screening rates for colorectal and lung cancers.
Breast Cancer Survivors Aren't Getting Recommended Number of Mammograms Post-Surgery, Study Finds
National Comprehensive Cancer Network(r) (NCCN(r))
A new study in JNCCN finds that, contrary to screening recommendations, mammography rates decline over time as women get further out from their breast cancer diagnosis; African-American women in particular were less likely to receive the recommended amount of screening.
Sun Safety: Planning is Your Best Protection
Rutgers Cancer Institute of New Jersey
Longer days means more exposure to the sun and harmful UV rays. A Rutgers Cancer Institute of New Jersey expert shares some tips on how to keep your skin safe this season and all year long.
U-M Rogel Cancer Center First in Michigan to Offer All FDA Approved Car T-Cell Therapies
Michigan Medicine - University of Michigan
With the recently announced FDA approval of Kymriah to treat adults with lymphoma, the University of Michigan Rogel Cancer Center is the first center in Michigan to offer all currently available CAR T-cell therapies.
The Gene Editing Institute of Christiana Care Receives First-Ever Life Sciences and Bio Innovation Award from Philadelphia-Israeli Chamber of Commerce
Christiana Care Health System
For ground-breaking scientific research in gene editing and an innovative partnership with Jerusalem-based NovellusDx to advance personalized cancer treatment, the Gene Editing Institute of the Helen F. Graham Cancer Center & Research Institute at Christiana Care received the inaugural Life Sciences and Bio Innovation Award from the Philadelphia-Israeli Chamber of Commerce on May 22.
How a Cell Knows When To Divide
Rensselaer Polytechnic Institute (RPI)
How does a cell know when to divide? We know that hundreds of genes contribute to a wave of activity linked to cell division, but to generate that wave new research shows that cells must first grow large enough to produce four key proteins in adequate amounts.
AVATS Surgery Shown to Be Option for Patients Deemed "Inoperable"
American Thoracic Society (ATS)
A new study demonstrates that awake video-assisted thoracoscopic surgery (AVATS) - a minimally invasive procedure that is done under local anesthesia and sedation - is a safe and effective alternative for patients with poor lung function and lung cancer who would normally be precluded from having surgery due to its risks. The study was presented at the 2018 American Thoracic Society International Conference.
Rapamycin Lotion Reduces Facial Tumors Caused by Tuberous Sclerosis, UTHealth Reports
University of Texas Health Science Center at Houston
Addressing a critical issue for people with a genetic disorder called tuberous sclerosis complex (TSC), doctors at The University of Texas Health Science Center at Houston (UTHealth) reported that a skin cream containing rapamycin significantly reduced the disfiguring facial tumors affecting more than 90 percent of people with the condition.
Rusk Rehabilitation Launches Specialized Program to Optimize Quality of Life in Cancer Survivors
NYU Langone Health
Rusk Rehabilitation at NYU Langone Health has opened a new specialized program to address the complex rehabilitative needs of individuals with cancer, with a principal goal of helping them re-establish optimal function during and following treatment.
New Paper Highlights Role of Immune-Stimulating Cells that Shrink Breast Cancer Tumors
BriaCell Therapeutics Corp
Targeted cancer immunotherapy with irradiated, granulocyte-macrophage colony-stimulating factor (GM-CSF)-secreting, allogeneic cancer cell lines has been an effective approach to reduce tumor burden in several patients. A new paper in the Frontiers in Immunology highlights GM-CSF ability to shrink breast cancer tumors.
Surveillance Intensity Not Associated with Earlier Detection of Recurrence or Improved Survival in Colorectal Cancer Patients
University of Texas M. D. Anderson Cancer Center
A national retrospective study led by researchers at The University of Texas MD Anderson Cancer Center found no association between intensity of post-treatment surveillance and detection of recurrence or overall survival (OS) in patients with stage I, II or III colorectal cancer (CRC). Published in the Journal of the American Medical Association, the study is the largest of surveillance intensity in CRC ever conducted.
CFN User Spotlight: Laura Fabris Develops Nanoparticle-Based Tags to Detect Cancer and Viruses at the Single-Cell Level
Brookhaven National Laboratory
Physical chemist Laura Fabris--an associate professor in the Materials Science and Engineering Department at Rutgers University and principal investigator of the Fabris NanoBio Group--uses the transmission electron microscopes at Brookhaven Lab's Center for Functional Nanomaterials (CFN) to visualize nanoparticles and understand how to optimize their morphology to improve clinical diagnoses.
Palliative Care May Reduce Suicide Risk in Veterans with Advanced Lung Cancer
American Thoracic Society (ATS)
Palliative care appears to reduce the risk of suicide in veterans diagnosed with advanced stage lung cancer, according to new research presented at the ATS 2018 International Conference.
Ice Cream Funds Research Showing New Strategy Against Thyroid Cancer
University of Colorado Cancer Center
University of Colorado Cancer Center study shows that stereotactic body radiation (SBRT) may be better against anaplastic thyroid cancer, and with fewer side effects.
Stony Brook Medicine Adds Port Jefferson Pulmonary Practice to Community Network
Stony Brook Medicine
Stony Brook Medicine welcomed New York Pulmonary Consultants into Stony Brook Community Medical , its expanding network of community practices and physicians. The group offers comprehensive and integrated pulmonary care in Port Jefferson and Riverhead, with other satellite offices to be announced soon.
Bladder Cancer Model Could Pave the Way for Better Drug Efficacy Studies
University of North Carolina Health Care System
In the journal Cancer Research, UNC Lineberger Comprehensive Cancer Center researchers report they have developed a model of luminal bladder cancer, one of the two subtypes of advanced bladder cancer. The researchers said this model may help them to determine which patients may respond to checkpoint inhibitors.
$30m in Gifts to Establish Chad Carr Pediatric Brain Tumor Center at the University of Michigan
Michigan Medicine - University of Michigan
An incurable brain tumor took Chad Carr's life when he was just 5 years old, but now his name will be synonymous with research to fight the lethal pediatric brain cancer.
Analysis Shows Lymph Node Dissection Performed most often for Early Stage Kidney Cancer; Overall Survival Benefit not Shown
Rutgers Cancer Institute of New Jersey
An analysis of lymph node dissection in non-metastatic renal cell carcinoma indicates the procedure is often performed for stage 1 disease and shows no overall survival benefit. Investigators from Rutgers Cancer Institute of New Jersey presented the work at the Annual Meeting of the American Urological Association.
New Guidelines May Slightly Increase Reliability, Accuracy of Melanoma Diagnoses
University of California, Los Angeles (UCLA), Health Sciences
Researchers have developed updated guidelines for classifying a serious form of skin cancer called invasive melanoma.
Practicing Declining Patient Simulations Help Improve Clinician Responses
Johns Hopkins Medicine
A project in the radiation oncology outpatient unit at Johns Hopkins Hospital showed an improvement in clinician's comfort level in responding to urgent patient care situations after a department-wide exercise focused on recognizing the signs when a patient's condition was declining during their appointments.
Keck School of Medicine of USC Urologists Present Latest Research at the American Urological Association 2018 Annual Meeting
Keck Medicine of USC
From robotics and machine learning to new applications for MRIs, Keck School of Medicine of USC scientists will present research highlighting the impact of technology on patient outcomes and the field of urology at the American Urological Association 2018 annual meeting May 18-21 in San Francisco.
Fight Colorectal Cancer Advocate Walking 2,800 Miles Across the U.S. To Raise Awareness of Preventable Disease
Fight Colorectal Cancer
Chad Schrack, a Fight Colorectal Cancer advocate is walking from Washington, D.C. to Venice Beach, California to honor his wife, a colorectal cancer survivor and all those affected by the second-leading cancer killer in the U.S.
New Blood Test Rapidly Detects Signs of Pancreatic Cancer
University of California San Diego
UC San Diego researchers have developed a test that can screen for pancreatic cancer in just a drop of blood. The test, which is at the proof-of-concept stage, provides results in under an hour. It's simple: apply a drop of blood on a small electronic chip, turn the current on, wait several minutes, add fluorescent labels and look at the results under a microscope. If a blood sample tests positive for pancreatic cancer, bright fluorescent circles will appear.
Single Surface Protein Boosts Multiple Oncogenic Pathways in Acute Myeloid Leukemia, Study Reveals
The Rockefeller University Press
Researchers from the Albert Einstein College of Medicine in New York have discovered that a signaling protein elevated in patients with acute myeloid leukemia (AML) plays a much wider role in the disease than previously thought. The study, which will be published May 17 in the Journal of Experimental Medicine, raises hopes that current efforts to target this signaling protein could be a successful strategy to treat AML and other blood cancers.
Aiming to Improve Oncology Patient Outcomes Through Nursing Research
Rutgers Cancer Institute of New Jersey
From peer and patient education to addressing treatment side effects, nurses at Rutgers Cancer Institute of New Jersey researched a number of topics with an aim of enhancing the patient experience. Their findings are being presented at the Oncology Nursing Society's Annual Congress.
Improving Survival in Pancreatic Cancer with Platinum-Based Chemotherapy
Johns Hopkins Medicine
A small study of adults with the most common form of pancreatic cancer adds to evidence that patients with BRCA1 or BRCA2 gene mutations long linked to a high risk of breast cancer have poorer overall survival rates than those without the mutations.
Beaumont Researchers Invent New Mode of Proton Treatment for Lung Cancer
Beaumont Health
Beaumont's proton therapy team presented research on a new treatment for patients with lung cancer at a recent ESTRO conference in Spain.
Cancer Research Institute Celebrates Sixth Annual Cancer Immunotherapy Month(tm) in June
Cancer Research Institute
Month-long awareness and education campaign in June highlighting breakthroughs in cancer treatment with immunotherapy and the urgent need for more research funding
Christian Recording Artist Pursues Career as Military Doctor
Uniformed Services University of the Health Sciences (USU)
Former contemporary Christian singer-songwriter Paden Smith once sought to heal others with his music and lyrics. Today, now a Navy linguist, he will continue his selfless journey of healing others as he takes the next steps on his path to become a military physician.
Cell Type Switch Helps Colon Cancer Evade Treatment, Study Suggests
The Rockefeller University Press
Researchers in Germany have discovered that colon cancers are often resistant to existing drug treatments because they are composed of two different cell types that can replace each other when one cell type is killed. The study, which will be published May 16 in the Journal of Experimental Medicine, suggests that combination therapies targeting both cell types at once may be more effective at treating colorectal cancer, the third highest cause of cancer-related death in the United States.
VA Health Care System Successfully Reduces "Rush to Treatment" Rates for Low-Risk Prostate Cancer, Study Shows
NYU Langone Health
Record numbers of American veterans diagnosed with non-aggressive prostate cancer are heeding the advice of international medical experts and opting out of immediate surgery or radiation to treat their cancer.
Scientists Find Missing Factor in Gene Activation
University of California San Diego
Scientists have unraveled a mystery on how genes are activated. Genes are blocked by structures known as nucleosomes, which package DNA. How do these roadblocks clear out to allow genes to turn on? Scientists have identified a key factor that unravels nucleosomes and clears the way. They say the finding is useful in understanding diseases such as cancer.
Different Diseases Elicit Distinct Sets of Exhausted T Cells
Perelman School of Medicine at the University of Pennsylvania
The battle between the human immune system and long-term, persisting infections and other chronic diseases such as cancer results in a prolonged stalemate. Over time battle-weary T cells become exhausted, giving germs or tumors an edge. Using data from multiple molecular databases, researchers have found nine distinct types of exhausted T cells, which could have implications for fighting chronic infections, autoimmunity, and cancer.
UAB Recruiting for Clinical Trial to Determine Therapies for Eradication of Multiple Myeloma
University of Alabama at Birmingham
The UAB-led clinical trial intends to provide multiple myeloma patients a treatment plan that eradicates their disease and enables them to live a life without ongoing treatment.
Research Finds 'Achilles Heel' for Aggressive Prostate Cancer
UCSF Helen Diller Family Comprehensive Cancer Center
UC San Francisco researchers have discovered a promising new line of attack against lethal, treatment-resistant prostate cancer. Analysis of hundreds of human prostate tumors revealed that the most aggressive cancers depend on a built-in cellular stress response to put a brake on their own hot-wired physiology.
First Description of mEAK-7 Gene Could Suggest Path Toward Therapies for Cancer, Other Diseases
University of California, Los Angeles (UCLA), Health Sciences
For years, researchers have known that a gene called EAK-7 plays an important role in determining how long worms will live. But it remained unclear whether the gene had a counterpart in humans and - if it did - how that human version would work. Now, researchers led by UCLA's Dr. Paul Krebsbach are the first to characterize the mechanism of the human equivalent, which they call mammalian EAK-7, or mEAK-7.
New Approach to Cancer Research Aims to Accelerate Studies and Reduce Cost
University of Texas M. D. Anderson Cancer Center
A new model for improving how clinical trials are developed and conducted by bringing together academic cancer experts and pharmaceutical companies is being tested by research experts at The University of Texas MD Anderson Cancer Center.
New Tool Helps People with Leukemia Better Understand Their Treatment Options
National Comprehensive Cancer Network(r) (NCCN(r))
National Comprehensive Cancer Network releases NCCN Guidelines for Patients: AML
Tumor-Like Spheres Help Scientists Discover Smarter Cancer Drugs
Scripps Research Institute
The technique makes use of tiny, three-dimensional ball-like aggregates of cells called spheroids.
New 'Scoring' System Improves Survival Forecasting Before and After Surgery for Advanced Colorectal Cancer
Johns Hopkins Medicine
Georgios Margonis, M.D., Ph.D., a surgical oncology fellow at the Johns Hopkins University School of Medicine, and Matthew Weiss, M.D., surgical director of the Johns Hopkins Liver and Pancreas Cancer Multidisciplinary Clinics, report advances in efforts to improve the treatment and prognosis of colorectal cancers
Dr. Benjamin Movsas Named President-Elect of American Radium Society
Henry Ford Health System
Benjamin Movsas, M.D., Chair of the Department of Radiation Oncology at the Henry Ford Cancer Institute, has been named President-Elect of the American Radium Society.
How Signals Get Inside Cancer Cells and Spur Aggressive Growth
Michigan Medicine - University of Michigan
A new study provides a surprising model of the process by which signals enter and influence a cancer cell. The finding could open up a potential new avenue to pursue new therapies against cancer.
Depleted Metabolic Enzymes Promote Tumor Growth in Kidney Cancer
Perelman School of Medicine at the University of Pennsylvania
By integrating data on the function of essential metabolic enzymes with genetic, protein, and metabolic abnormalities associated with "clear cell" renal cell carcinoma (ccRCC), researchers have determined that enzymes important in multiple pathways are universally depleted in ccRCC tumors.
Genetic Counseling and Testing Proposed for Patients with the Brain Tumor Medulloblastoma
St. Jude Children's Research Hospital
Researchers have created the first genetic screening guidelines for medulloblastoma patients after identifying gene variations that make carriers susceptible to develop the brain tumor and possibly other cancers
Experts Available to Discuss New USPSTF Prostate Cancer Screening Guidelines
American Society for Radiation Oncology (ASTRO)
Two Penn Clinicians Among This Year's Melanoma Research Foundation Honorees
Perelman School of Medicine at the University of Pennsylvania
The Melanoma Research Foundation is honoring two Penn clinicians for their tireless work in caring for patients.
Metastasis Enablers: Findings Could Unlock New Ovarian Cancer Treatments
University of Wisconsin-Madison
New research from the lab of Pamela Kreeger, a University of Wisconsin-Madison biomedical engineering professor, has identified one way ovarian cancer cells appear to successfully spread.
Device Captures Vesicles Shed by Brain Tumors, Offering Patient-Specific Diagnosis and Treatment
National Institute of Biomedical Imaging and Bioengineering
Bioengineers have developed micro-technologies that capture extracellular vesicles (EVs) released by brain tumors. The vesicles carry samples of the mutated genetic material and proteins causing malignancy that researchers can analyze to optimize precision cancer treatment.
Amplification of Key Cellular Organizer May Initiate Cancer, Study Suggests
The Rockefeller University Press
Cells begin to accumulate centrosomes--organelles that play a vital role during cell division--before they transform into cancer cells, according to a new study of patients with Barrett's esophagus condition, which is associated with esophageal cancer. The research, which will be published May 8 in the Journal of Cell Biology, suggests that similar cases of centrosome amplification may contribute to the initiation and progression of a variety of human cancers.
Study Confirms Curable State Between Single and Widespread Cancers
University of Chicago Medical Center
Using molecular determinants combined with clinical data, UChicago physicians confirm their oligometastasis hypothesis in colorectal cancers with limited spread of disease to the liver.
Chemical Octopus Catches Sneaky Cancer Clues, Trace Glycoproteins
Georgia Institute of Technology
Certain minuscule cancer signals easily evade detection, but perhaps no longer. Biomarkers made of glycoproteins are bound to get snared in the tentacles of this chemical octopus that Georgia Tech chemists devised over several years. The monstrous molecule could also be a windfall for the rising field of glycoscience.
Study Shows How Companies Can Help Safeguard Intellectual Property When Expanding Into Risky Countries
University of Notre Dame
Notre Dame researchers found that firms operating regionally through downstream commercialization activities can offer complementary assets to the upstream R&D activities that help protect the firms' intellectual property.
Nuclear Pore Functions Are Essential for T Cell Survival
Sanford Burnham Prebys Medical Discovery Institute
A new study by Sanford Burnham Prebys (SBP) researchers describes how a specific nuclear pore component is critical for the survival of circulating T cells. The findings, published in Nature Immunology, identify a new node of T cell receptor signaling and could pave the way for the development of future immunotherapies.
Preclinical MD Anderson Study Suggests ARID1a May Be Useful Biomarker for Immunotherapy
University of Texas M. D. Anderson Cancer Center
Functional loss of ARID1a, a frequently mutated tumor suppressor gene, causes deficiencies in normal DNA repair and may sensitize tumors to immune checkpoint blockade therapies, according to researchers from The University of Texas MD Anderson Cancer Center. The preclinical study suggests that mutations in ARID1a could be beneficial in predicting immunotherapy success.
For Mothers with Advanced Cancer, Parenting Concerns Affect Emotional Well-Being
University of North Carolina Health Care System
A new study from the UNC Lineberger Comprehensive Cancer Center shows that parenting concerns have a significant impact on the mental and emotional health of women with advanced cancer. In particular, they found that a mother's emotional well-being was significantly linked with whether she had communicated with her children about her illness, and her concerns about how her illness will financially impact her children.
ProMedica and The University of Toledo College of Medicine and Life Sciences Open $57 Million Joint Neurosciences Center
ProMedica
The new 122,000-square-foot, three-story Neurosciences Center provides a highly collaborative environment for clinical care, research and academic services related to neurological disorders and diseases.
Cancer Cells Thrive in Stiff Tissue, According to New Study
University of Notre Dame
Scientists studying tumor growth and metastasis at the University of Notre Dame fabricated a human tissue model to examine how cancer cells interact with connective tissue in the breast.
Osteoporosis Drug Could Be Used to Treat Aggressive Form of Breast Cancer, Researchers Say
The Rockefeller University Press
Researchers in China have discovered that an enzyme called UGT8 drives the progression of basal-like breast cancer, an aggressive form of the disease that is largely untreatable. But the study, which will be published May 4 in the Journal of Experimental Medicine, reveals that the widely used osteoporosis drug zoledronic acid inhibits UGT8 and prevents the spread of basal-like breast cancer in mice, suggesting that this drug could also be used to treat the disease in humans.
Ophthalmologists Link Immunotherapy with a Serious Eye Condition
Michigan Medicine - University of Michigan
Eye inflammation and uveal effusion develop among patients taking anti-cancer immune checkpoint inhibitor therapy.
Study: Alcohol-Related Cirrhosis Patients are Sicker, Costlier and Often Female
Michigan Medicine - University of Michigan
A new review by Michigan Medicine finds that women drinkers are disproportionately affected in alcohol-related cirrhosis cases. Why -- and what's next.
Riverview Medical Center Secures Second Surgical Robot, Bringing the Latest Technology in Surgery to the Community
Hackensack Meridian Health
Hackensack Meridian Health Riverview Medical Center is thrilled to announce the addition of the da Vinci Xi Surgical System, providing its surgeons with unparalleled precision, dexterity and control that allows for a minimally invasive surgical approach for many complex surgical procedures. Already home to the da Vinci Si(tm), the addition of the da Vinci Xi Surgical System adds to the already robust robotic surgery program at Riverview Medical Center, where surgeons perform a multitude of minimally invasive surgeries for complex diseases and conditions in gynecology, urology, thoracic, cardiac, and general surgery.
Cancer Center at BIDMC Launches Immunotherapy Institute
Beth Israel Deaconess Medical Center
The Cancer Center at Beth Israel Deaconess Medical Center (BIDMC) today announced the launch of a new clinical and research institute that will build on BIDMC's long history of leadership in immunotherapy and cell therapeutics.
Study Offers New Approach to Starve p53 Deficient Tumors
Sanford Burnham Prebys Medical Discovery Institute
SBP researchers recently discovered an alternative metabolic pathway that might be used by cancer cells to survive nutrient deprivation. Targeting these proteins to disrupt autophagy in cancer cells is an exciting therapeutic strategy that could minimize toxicity.
NCCN Offers Free Webinar to Address Patient and Caregiver Questions About a Group of Rare Blood Cancers
National Comprehensive Cancer Network(r) (NCCN(r))
NCCN and MPN Research Foundation present Know What Your Doctors Know: Myeloproliferative Neoplasms (MPN), a free webinar for experts to provide information and answer questions on diagnosis and treatment options.
American Academy of Dermatology Provides Tips for Skin Self-Exams
American Academy of Dermatology
Skin cancer is the most common cancer in the United States. It is estimated that one in five Americans will develop skin cancer in their lifetime, and one person dies from melanoma, the deadliest form of skin cancer, every hour. In recognition of Skin Cancer Awareness Month in May and Melanoma Monday(r) on May 7, the American Academy of Dermatology is encouraging the public to be a "Skin Cancer Hero" by learning how to detect skin cancer early, when it's most treatable. The campaign aims to save lives by teaching the public how to identify the warning signs of melanoma, perform a skin self-exam and find free SPOTme(r) skin cancer screenings in their area.
Penn Neurosurgeons and Otolaryngologists Perform First-in-World Robot-Assisted Spinal Surgery
Perelman School of Medicine at the University of Pennsylvania
Penn Medicine performed the first robot-assisted spinal surgery in a three-part, two-day procedure. The robotic arms made it possible for the multidisciplinary team at Penn to successfully remove a rare tumor from the patient's neck, where the skull meets the spine.
Rutgers Researchers Help Validate Discovery Method to Identify Antibodies that Target Tumors
Rutgers Cancer Institute of New Jersey
The development of targeted tools for therapy is a major focus in oncology. A new study by investigators at Rutgers Cancer Institute of New Jersey at University Hospital, Rutgers New Jersey Medical School and other collaborators describes what they call a "major advance" to a screening technique they pioneered that searches for molecular signatures intrinsic to normal or diseased tissues.
The DES Saga: Death Risk High for Young Women Exposed in Utero
University of Chicago Medical Center
A letter in the May 3, 2018, NEJM updates reports on the risks of exposure during pregnancy to a supplement, diethylstilbestrol (DES), that is linked to a rare cancer. DES-exposed patients with clear-cell adenocarcinoma had "increased mortality across their life span."
AACI to Honor Pioneer in Breast Cancer Research, Precision Medicine
Association of American Cancer Institutes (AACI)
Charles M. Perou, PhD, will receive the Association of American Cancer Institutes Distinguished Scientist Award on October 1, during the 2018 AACI/CCAF Annual Meeting, in Chicago. The award recognizes Dr. Perou's research in the field of precision medicine and in the characterization of the diversity of human tumors.
Firefighters Who Were Exposed to World Trade Center Debris Found to Have an Increased Risk for a Precancerous Condition
Memorial Sloan Kettering Cancer Center
Researchers at Memorial Sloan Kettering (MSK) report that firefighters at the World Trade Center (WTC) scene in September 2001 were nearly twice as likely as the general population to have a multiple myeloma precursor condition called monoclonal gammopathy of undetermined significance (MGUS).
Reconsidering the 'Magic Bullet' Approach to Drug Discovery
Vanderbilt University
Vanderbilt researchers have developed a new process that can rapidly and inexpensively identify personalized cancer drugs derived from nature.
Ocular Melanoma Expert Available to Discuss Diagnosis, Treatment and Prevention
University of Alabama at Birmingham
FDA Approves CAR T Therapy for Large B-Cell Lymphoma Developed at University of Pennsylvania
Perelman School of Medicine at the University of Pennsylvania
The U.S. Food and Drug Administration (FDA) has expanded approval for a personalized cellular therapy developed at the University of Pennsylvania's Abramson Cancer Center, this time for the treatment of adult patients with relapsed or refractory large B-Cell lymphoma after two or more lines of systemic therapy. Today's approval includes treatment of diffuse large B-cell lymphoma (DLBCL) - the most common form of non-Hodgkin's lymphoma - as well as high grade B-cell lymphoma and DLBCL arising from follicular lymphoma.
GLUT5 Fluorescent Probe Fingerprints Cancer Cells
Michigan Technological University
Getting the results of a cancer biopsy can take up to two weeks. What if it could happen in 10 minutes? In two new papers, a team of chemists and engineers from Michigan Technological University lay the groundwork for cancer detection and diagnostics based on a fluorescent GLUT5 probe. Documented in the new research, a cancer's type and malignancy changes the GLUT5 activity in a cell, creating a detectable "fingerprint" of cancer.
Commentary: Clinical Trials Exclude Too Many Patients
UT Southwestern Medical Center
Unfortunately, many sick patients are being denied the opportunity to test new drugs that might save their lives. It's time for this to change.
Persistence Pays Off in Discovery That Could Lead to Improved Treatment and Survivability of Patients with Brain Tumors
Huntsman Cancer Institute at the University of Utah
Gliomas are the most common type of central nervous system cancer but how these tumors develop is not fully understood. Sheri Holmen, PhD a researcher at Huntsman Cancer Institute (HCI) and professor of surgery at the University of Utah just published the results of her research on gliomas in Cell Reports. The work is focused on a mutated gene that is a critical piece of the puzzle for glioma development, according to Holmen's work.
Study: Wearable Fitness Monitors Useful in Cancer Treatment
UT Southwestern Medical Center
Wearable fitness trackers, such as Fitbits, that measure steps taken per day may be a useful tool to evaluate and help treat cancer patients, researchers at UT Southwestern's Simmons Cancer Center have shown.
Drug Danger Exposed (and Handled)
Johns Hopkins School of Nursing
Oncology nurses at Johns Hopkins Hospital learn to treat chemotherapy medications, like their patients, with extreme care
Surgery Soon After Clinical Staging of Non-Small Cell Lung Cancer Reduces Cancer Progression and Improves Likelihood of Cure
American Association for Thoracic Surgery (AATS)
Significant upstaging or reclassification to a more advanced stage due to cancer progression in non-small cell lung cancer (NSCLC) can occur with each successive week from initial clinical staging to surgery, according to data presented at the American Association for Thoracic Surgery's 98th Annual Meeting. The same study showed that early intervention after completion of clinical staging leads to increased survival rates.
Genomicist Jeramiah Smith Delivers 3rd Annual NIGMS Early Career Investigator Lecture
NIH, National Institute of General Medical Sciences (NIGMS)
In an archived webcast, University of Kentucky genomicist Jeramiah Smith describes the sea lamprey's innovative strategy for avoiding cancer: shedding 20 percent of its genome following development. He also talks with NIGMS director Jon Lorsch about the challenges faced by early career scientists.
Surgeons Preserve Patients' Hearing with Innovative Brainstem Implant
University of California San Diego Health
Patients with rare brain tumors on the auditory nerve now have an option to prevent complete deafness at UC San Diego Health. The device, called an auditory brainstem implant or ABI, fits behind the ear and connects directly to the brainstem. The device enables patients with neurofibromatosis type 2 (NF2) who develop bilateral hearing nerve tumors to be aware of environmental sounds, such as a door opening, a phone ringing or a car approaching.
T Cell Biomarker Predicts Which CLL Patients Will Respond to CAR T Cell Therapy
Perelman School of Medicine at the University of Pennsylvania
Penn Medicine researchers may have found the reason why some patients with advanced chronic lymphocytic leukemia (CLL) don't respond to chimeric antigen receptor (CAR) T cell therapy, and the answer is tied to how primed patients' immune systems are before the therapy is administered.
Magnetic Nanoparticles Leap From Lab Bench to Breast Cancer Clinical Trials
Sandia National Laboratories
A long-standing collaboration between Sandia National Laboratories and Imagion Biosystems produced precise magnetic nanoparticles for a breast cancer clinical trial later this year. The nanoparticles stick to breast cancer cells, allowing the detection and removal of even small metastases.
Size Matters When Fighting Cancer, Groundbreaking UTHealth Study Finds
University of Texas Health Science Center at Houston
Doctors could be a step closer to finding the most effective way to treat cancer with a double whammy of a virus combined with boosting the natural immune system, according to a pioneering study by researchers at The University of Texas Health Science Center at Houston (UTHealth) and The Ohio State University.
Multiple Sclerosis Drug Could Reduce Painful Side Effects of Common Cancer Treatment, Researchers Suggest
The Rockefeller University Press
Researchers from the Saint Louis University School of Medicine have discovered why many multiple myeloma patients experience severe pain when treated with the anticancer drug bortezomib. The study, which will be published April 27 in the Journal of Experimental Medicine, suggests that a drug already approved to treat multiple sclerosis could mitigate this effect, allowing myeloma patients to successfully complete their treatment and relieving the pain of myeloma survivors.
Largest-Ever Study of Thyroid Cancer Genetics Finds New Mutations, Suggests Immunotherapy
University of Colorado Cancer Center
CU researchers mine data of 583 patient samples of advanced differentiated thyroid cancer and 196 anaplastic thyroid cancers, showing genetic alterations, and "high mutation burden" that is an FDA-approved marker for immunotherapy.
Blood Cancer Precursor Found in 9/11 Firefighters
Albert Einstein College of Medicine
A study in today's issue of JAMA Oncology reports that New York City firefighters exposed to the 9/11 World Trade Center disaster site face an increased risk for developing myeloma precursor disease (MGUS), which can lead to the blood cancer multiple myeloma. The study was conducted by researchers at Albert Einstein College of Medicine, Montefiore Health System, the Fire Department of the City of New York (FDNY) and Memorial Sloan Kettering Cancer Center.
RNA Editing Study Shows Potential for More Effective Precision Cancer Treatment
University of Texas M. D. Anderson Cancer Center
If there is one thing all cancers have in common, it is they have nothing in common. A multi-center study led by The University of Texas MD Anderson Cancer Center has shed light on why proteins, the seedlings that serve as the incubator for many cancers, can vary from cancer to cancer and even patient to patient, a discovery that adds to a growing base of knowledge important for developing more effective precision therapies.
PARP-1 May be Key to Effectiveness of PARP Inhibitors, and Now Researchers Can Image It
Perelman School of Medicine at the University of Pennsylvania
Penn Medicine researchers have used CRISPR/Cas9 gene editing technology to isolate a key genetic feature that could cause resistance to PARP inhibitors in patients with ovarian cancer - and they've also proven they have a way to see that feature using PET imaging.
New Leaders Named in Pediatric Cancer at NYU Langone Health
NYU Langone Health
NYU Langone recruits two nationally recognized leaders in the field of pediatric cancer.
Genomic Gymnastics of a Single-Celled Ciliate and How It Relates to Humans
NIH, National Institute of General Medical Sciences (NIGMS)
Molecular Biologist Laura Landweber describes the bizarre sex lives of the single-celled critter she studies and how it can inform cancer research.
New Translations of NCCN Guidelines for Patients(r) Advance Global Mission to Empower People with Cancer
National Comprehensive Cancer Network(r) (NCCN(r))
The NCCN Foundation(r) announces Chinese, Czech, German, Italian, and Spanish translations of patient-focused booklets designed to help people with cancer make shared decisions about their treatment.
New Metric Defines Areas of Highest Prostate Cancer Burden
Thomas Jefferson University
To improve the impact of outreach efforts, researchers develop a better way to identify areas with high risk patients
Noninvasive Brain Tumor Biopsy on the Horizon
Washington University in St. Louis
Taking a biopsy of a brain tumor is a complicated and invasive surgical process, but a team of researchers at Washington University in St. Louis is developing a way that allows them to detect tumor biomarkers through a simple blood test.