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Hanna and Mark Gleiberman Give $12 Million to UC San Diego
University of California San Diego Health
Hanna and Mark Gleiberman give $12 Million to UC San Diego to support the internationally recognized head and neck cancer center at UC San Diego Health. Funding will support research and patient experience.
Scientists show how to attack the 'fortress' surrounding pancreatic cancer tumors
University of New South Wales
UNSW medical researchers have found a way to starve pancreatic cancer cells and 'disable' the cells that block treatment from working effectively.
NK cells with bispecific antibody show activity against lymphoma cells
University of Texas M. D. Anderson Cancer Center
Cord blood-derived natural killer cells combined with a bispecific antibody displayed potent activity against lymphoma cells in a preclinical study led by MD Anderson researchers.
The Medical Minute: When the caregiver needs care
Penn State Health
The commitment to give care over a long span of time is one of the most selfless and, for many, sacred things one can do for a loved one - but it is also one of the most demanding.
Bringing medical AI closer to reality
Case Western Reserve University
For AI to continue to transform cancer diagnoses, researchers will have to prove that the success of their machine-learning tools can be reproduced from site to site and among different patient populations. Biomedical engineering researchers at Case Western Reserve University say they doing just that. They say they have demonstrated that their novel algorithms for distinguishing between benign and malignant lung cancer nodules on CT scan images from one site can now be successfully reproduced with patients from other sites and locations.
Renowned Roswell Park Immunologist Promoted to Endowed Chair Role
Roswell Park Comprehensive Cancer Center
Following a national search, Roswell Park Comprehensive Cancer Center has promoted Pawel Kalinski, MD, PhD, to Jacobs Family Endowed Chair of Immunology, Chief of the Division of Translational Immuno-Oncology and Senior Vice President for Team Science.
How to Check Your Nails for Melanoma
American Academy of Dermatology
When checking the body for signs of skin cancer, many people may only think to check their skin. However, board-certified dermatologists from the American Academy of Dermatology say it's important to check the nails, too. Although rare, skin cancer, including melanoma -- the deadliest form of skin cancer -- can develop under and around the fingernails and toenails.
New Research Outlines a Critical Driver in an Immune Cell's Defense against Melanoma
Huntsman Cancer Institute at the University of Utah
Researchers at Huntsman Cancer Institute have found critical new insights into how cells defend against melanoma. In a report published in Nature Communications, the team describes how an enzyme called nicotinamide phosphoribosyltransferase, or NAMPT, initiates antitumor activity. The researchers suggest that new therapies strengthening this pathway in immune cells could be the foundation for more effective treatments against melanoma.
Mitochondrial enzyme found to block cell death pathway points to new cancer treatment strategy
University of Texas M. D. Anderson Cancer Center
MD Anderson researchers have discovered a new role for the DHODH enzyme in blocking a form of cell death called ferroptosis. Preclinical findings suggest that targeting DHODH could restore cell death and inhibit tumor growth.
Virtual Lung Cancer Screenings Being Offered by Hackensack Meridian Health
Hackensack Meridian Health
Telehealth Visits Provide Early Detection, More Treatment Options and Better Chance of Survival
The Unique Role of the Oncology Nurse: Lifelong Learning, Healing and Helping
Rutgers Cancer Institute of New Jersey
Oncology nursing is a unique specialty that requires specific knowledge of the biological and psychosocial dimensions of cancer and its effects on individuals and families. Oncology nurse at Rutgers Cancer Institute of New Jersey shares more on the role of oncology nurses and the importance of the oncology nurse certification.
Turning a pancreatic cancer cell's addiction into a death sentence
University Health Network (UHN)
Probing the unique biology of human pancreatic cancer cells in a laboratory has yielded unexpected insights of a weakness that can be used against the cells to kill them. Led by Princess Margaret Cancer Centre Scientist Dr. Marianne Koritzinsky, researchers showed that about half of patient-derived pancreatic cancer cell lines are highly dependent or "addicted" to the protein peroxiredoxin 4 (PRDX4), as a result of the altered metabolic state of the cancer cell. This addiction, which is vital for the cancer cell's survival, makes it a precise, potential target against the cancer.
Gold leaf could help diagnose viral infections in low-resource settings
American Chemical Society (ACS)
Researchers reporting in ACS Central Science have developed gold leaf electrodes that, in combination with a CRISPR-based assay, could sensitively detect human papillomavirus (HPV) DNA in human samples.
Single-cell map of early stage lung cancer and normal lung sheds light on tumor development, new therapeutic targets
University of Texas M. D. Anderson Cancer Center
MD Anderson researchers have developed a first-of-its-kind atlas of early-stage lung cancer and surrounding normal lung tissue. The single-cell map provides a valuable resource to learn about tumor development and find new therapeutic targets.
By age 10, retinoblastoma patients' learning and life skills rebound
St. Jude Children's Research Hospital
St. Jude retinoblastoma researchers studied how survivors fared years later at home and at school.
Understanding Brain Tumors
Rutgers Cancer Institute of New Jersey
To better understand brain cancer, neuro-oncologist Michael E. Salacz, MD, director of the Neuro-Oncology Program at Rutgers Cancer Institute of New Jersey and associate professor of medicine at Rutgers Robert Wood Johnson Medical School, shares some basic information on types of brain tumors, risk factors and treatment options.
Study to Examine Exosomes in Ovarian Cancer
University of Kansas Cancer Center
Researchers have been awarded a $3.1 million grant from the National Institutes of Health to investigate more effective ways to identify ovarian cancer earlier.
A Break from Chemo: PARP Inhibitor Shrinks Tumors in Pancreatic Cancer Patients with Mutations
Perelman School of Medicine at the University of Pennsylvania
More than two-thirds of pancreatic cancer patients harboring genetic mutations saw their tumor stop growing or shrink substantially after being switched from intensive chemotherapy to the PARP inhibitor rucaparib as a maintenance therapy.
The Medical Minute: Mammograms and the COVID-19 vaccine
Penn State Health
Some women who have gotten vaccinated for COVID-19 have noticed a startling development ― lumps that in the past might have meant cancer. But Penn State Health experts say that temporary swelling of the lymph nodes is normal and expected.
The 8th Annual Joseph Calello Melanoma Scholar, Dr. Charles Balch, to Present "The Surgical Management of Melanoma," a Virtual Lecture, May 6
Atlantic Health System
Atlantic Health System Cancer Care, in partnership with OncLive, invites health care professionals and others interested in the surgical management of melanoma to a virtual lecture by internationally known melanoma expert Charles M. Balch, MD, FACS, FASCO. Dr. Balch is this year's Joseph Calello Melanoma Scholar. The free lecture and Q & A will be held on May 6, 11 a.m. - 12 p.m. ET.
Chemical 'nose' sniffs critical differences in DNA structures
University of California, Riverside
Small changes in the structure of DNA have been implicated in breast cancer and other diseases, but they've been extremely difficult to detect -- until now.
John Theurer Cancer Center Patients Now Have Access to State-of-the-Art Genomic Profiling Laboratory Technology
Hackensack Meridian Health
New on-site laboratory called Key Genomics is a partnership between Regional Cancer Care Associates (RCCA) and Genomic Testing Cooperative (GTC), provides more precise testing to help improve cancer patient outcomes
Hopkins-Led Research Team Takes Gene Mutation Detection in Blood to the Next Level
Johns Hopkins Medicine
Next-generation gene sequencing (NGS) technologies --in which millions of DNA molecules are simultaneously but individually analyzed-- theoretically provides researchers and clinicians the ability to noninvasively identify mutations in the blood stream. Identifying such mutations enables earlier diagnosis of cancer and can inform treatment decisions. Johns Hopkins Kimmel Cancer Center researchers developed a new technology to overcome the inefficiencies and high error rates common among next-generation sequencing techniques that have previously limited their clinical application.
Researchers identify potential combination therapy for aggressive lung cancer
University of California, Los Angeles (UCLA), Health Sciences
The combination approach uses immune checkpoint inhibitors with ATRA, a safe medication that is widely used to treat leukemia.
The Greatest Gift for Mom: Health and Wellness
Rutgers Cancer Institute of New Jersey
Now more than ever, we are reminded that health and wellness should always be a top priority. National Women's Health Month and Mother's Day, both celebrated in May, are important reminders that women can take control of their health by making feasible lifestyle choices and focusing on preventive care to lower the risk of certain cancers.
Cancer Researchers Study Cognitive Dysfunction after Chemo
Health Sciences at the University of Pittsburgh
Following chemo, survivors suffer with memory dysfunction. The first large-scale study underway on cognitive behavioral therapy.
New class of drug gives hope to some ovarian cancer patients
University of Washington School of Medicine
Rucaparib is in a relatively new class of drugs - Poly(ADP-ribose) polymerase or PARP inhibitors - which have been approved for therapy in ovarian cancers. This study provides insights into both how the cancers resist treatments, and which patients may respond favorably to the drug.
CU Cancer Center Technology Gives Kids a Welcome Distraction During Radiation Treatment
University of Colorado Cancer Center
Thirty days of radiation treatments -- five days a week, with Saturdays and Sundays off -- are difficult for even the toughest of adults. But for a child, they're even harder to bear. They involve fasting, waking up early, and lying in a dark room alone, without even your parents there for support. But if during treatment you can take a trip to Agrabah to hang out with Aladdin, Jasmine, and the rest of the characters in Disney's live-action version of "Aladdin," it makes the sessions a lot easier to bear -- not to mention it makes time go by a lot faster. Thanks to a new innovation at the CU Cancer Center, patients like 5-year-old Piper Lardes are able to do just that -- watch their favorite show or movie during their treatment to make the whole experience just a little easier. The technology, called Radflix, has a calming effect on parents as well.
2021 Warren Alpert Prize Awarded to Two Scientists for RNA Discoveries
Harvard Medical School
The 2021 Warren Alpert Foundation Prize has been awarded to scientists Lynne Maquat and Joan Steitz for seminal discoveries in the biology and function of RNA, the workhorse molecule of cells. Their discoveries have reshaped the understanding of RNA's myriad roles in healthy cell function and in disease-causing dysfunction and have informed the conceptualization and design of RNA-based therapies in various stages of development.
Cedars-Sinai and USC to Jump-Start Young Scientists Seeking to Cure Cancer
Cedars-Sinai
Two internationally prominent cancer experts from Cedars-Sinai and USC will train a new generation of investigators to propel scientific advances in cancer through a novel grant from the U.S. Department of Defense.
What is Bladder Cancer?
Rutgers Cancer Institute of New Jersey
The bladder, a part of the urinary system, is a hollow organ in the pelvis with the primary function of storing and then eliminating urine that drains into it from the kidney. Cancer of the bladder develops when abnormal cells in the bladder start to grow out of control. Rutgers Cancer Institute expert explains what you need to know.
Nanotechnology offers new hope for bowel cancer patients
University of South Australia
Bowel cancer is the second deadliest cancer in the world, killing almost 900,000 people in 2020. New research from Indian and Australian scientists suggests that nanotechnology could provide a more effective treatment option than conventional therapy.
Antiviral T cells safe and effective for treating debilitating complication common after stem cell transplants
University of Texas M. D. Anderson Cancer Center
A Phase II trial led by researchers at The University of Texas MD Anderson Cancer Center found that BK virus (BKV)-specific T cells from healthy donors were safe and effective as an off-the-shelf therapy for BKV-associated hemorrhagic cystitis (BKV-HC), a painful complication common after allogeneic stem cell transplants for patients with leukemia or lymphoma. The study was published today in the Journal of Clinical Oncology.
NCCN Releases New Patient Guidelines on Anemia and Neutropenia
National Comprehensive Cancer Network(r) (NCCN(r))
New resource from NCCN helps cancer patients and caregivers recognize and understand blood cell production deficiencies, to better participate in their care planning; available for free at NCCN.org/patientguidelines.
Massive negative impact of COVID-19 on cancer screenings quantified in KU Medical Center faculty study published in JAMA Oncology
University of Kansas Cancer Center
Nearly 10 million cancer screenings in the U.S. failed to happen because of the COVID-19 pandemic, according to a study published in JAMA Oncology, a publication of the American Medical Association.
International Organization Honors Renowned Rutgers Microbiologist
Rutgers University-New Brunswick
Martin J. Blaser, MD, has been awarded the 2020 Prize Medal by the Microbiology Society of Great Britain in recognition of his study of the microbiome and its interactions within the human body that provide protection against and lead to disease. Dr. Blaser, the Henry Rutgers Chair of the Human Microbiome and professor of medicine and microbiology at the Rutgers Robert Wood Johnson Medical School and director of the Center for Advanced Biotechnology and Medicine at Rutgers Biomedical and Health Sciences, joins a storied list of scientists, including Nobel Prize recipients, who also have been recognized with the Prize Medal due to the impact their work has had on medicine and the care of patients worldwide.
Rutgers Cancer Institute of New Jersey Experts Available for Comment on Research Topics during National Cancer Research Month
Rutgers Cancer Institute of New Jersey
Experts from Rutgers Cancer Institute of New Jersey Comment on Skin Cancer and Sun Protection
Rutgers Cancer Institute of New Jersey
Quality Improvement Project Boosts Depression Screening Among Cancer Patients
UT Southwestern Medical Center
DALLAS - April 28, 2021 - Depression screening among cancer patients improved by 40 percent to cover more than 90 percent of patients under a quality improvement program launched by a multidisciplinary team at UT Southwestern Medical Center and Southwestern Health Resources.
#TeamTKC Captain Eli Manning Helps Launch Inaugural Virtual 5K to Tackle Kids Cancer
Hackensack Meridian Health
#TeamTKC Captain Eli Manning Helps Launch Inaugural Virtual 5K to Tackle Kids Cancer
Tanning Beds and Skin Cancer: Heeding the Call to Action
Rutgers Cancer Institute of New Jersey
Public health officials and researchers have become increasingly concerned about the health risks posed by indoor tanning. Researchers at Rutgers Cancer Institute of New Jersey recently addressed the importance of increasing efforts to limit indoor tanning among minors in a viewpoint paper published in the April 28 2021 online edition of JAMA Dermatology.
Ludwig Cancer Research Study Shows Pancreatic Cancer Cells Hit Reverse to Advance in Malignancy
Ludwig Cancer Research
A Ludwig Cancer Research study has identified a previously unrecognized mechanism by which cancer cells of a relatively benign subtype of pancreatic tumors methodically revert--or "de-differentiate"--to a progenitor, or immature, state of cellular development to spawn highly aggressive tumors that are capable of metastasis to the liver and lymph nodes.
New American Academy of Dermatology Survey Finds One-Third of Americans Fail Basic Quiz on Skin Cancer and Sun Exposure
American Academy of Dermatology
In a recent survey of 1,000 U.S. adults, the American Academy of Dermatology found that one-third of Americans lack a basic understanding of skin cancer and sun protection -- like seeking shade -- that can help reduce their risk of skin cancer, the most common cancer in the U.S. Among the findings, more than half (53%) of adults are unaware that shade can protect them from the sun's harmful ultraviolet rays.
Breast Cancer Awareness: What Women Must Know
Newswise
To share important information related to breast cancer, we have compiled some of the latest research news related to breast cancer from top research institutions around the world.
Rutgers Cancer Institute of New Jersey Leader Elected as a Member to the National Academy of Sciences
Rutgers Cancer Institute of New Jersey
Rutgers Cancer Institute of New Jersey Deputy Director, Chief Scientific Officer, and Associate Director for Basic Research Eileen White, PhD, has been elected to the National Academy of Sciences (NAS). She is among 120 members elected this year in recognition of their distinguished and continuing achievements in original research.
Virtual Lung Cancer Screenings Being Offered by Hackensack Meridian Health
Hackensack Meridian Health
Telehealth Visits Provide Early Detection, More Treatment Options and Better Chance of Survival
Few young adult men have gotten the HPV vaccine
Michigan Medicine - University of Michigan
Just 16% of men 18 to 21 years old have received at least one dose of the HPV vaccine at any age. Yet oropharyngeal cancer, which occurs in the throat, tonsils, and back of the tongue, is now the leading cancer caused by HPV -- and 80% of those diagnosed with it are men.
Amazon Alexa skill offers supportive care to breast cancer patients
Penn State College of Medicine
Individuals with metastatic breast cancer could soon have access to personalized, supplemental supportive care through their smart speaker, thanks to new research at Penn State.
$9 Million Contract from National Cancer Institute Awarded for NJ State Cancer Registry
Rutgers Cancer Institute of New Jersey
The New Jersey State Cancer Registry (NJSCR), under the direction of the State Department of Health in partnership with Rutgers Cancer Institute of New Jersey, has been awarded a seven-year, $9,085,109 contract (75N91021D00009) from the National Cancer Institute (NCI) to support core infrastructure and research activities as part of the Surveillance, Epidemiology, and End Results (SEER) Program, the most authoritative source of information on cancer incidence and survival in the United States. The funding will support ongoing cancer surveillance activities at the NJSCR, as well as support enhancements to New Jersey's electronic reporting systems such as electronic pathology and medical claims data transmissions.
Preventing Ovarian Cancer Recurrence with Coffee? Markey Launches Unique Clinical Trial
University of Kentucky
The UK Markey Cancer Center will be the first site worldwide to initiate a cancer clinical trial that evaluates its anti-cancer activity in humans using ArtemiLife(tm) Inc. coffee products, which are made using the leaves of the Artemisia annua plant.
Huntsman Cancer Institute Executive and Researcher Mary Beckerle Elected to National Academy of Sciences
Huntsman Cancer Institute at the University of Utah
The National Academy of Sciences has elected Mary Beckerle, PhD, Huntsman Cancer Institute CEO, as a member. Beckerle is among 120 newly elected members announced to the public in a press release during the annual meeting of the National Academy.
Drug Derived from Kentucky-Grown Plant Shows Promise for Ovarian Cancer Treatment
University of Kentucky
A new study from University of Kentucky Markey Cancer researchers shows that Artemisia annua, a plant that has been traditionally used for its anti-malaria components, shows promise in treating ovarian cancer.
How the Pandemic Has Exacerbated Rates of Skin Cancer
University of California San Diego Health
UVC Sterilizer - A Must-Have in the New Normal
Chulalongkorn University
The magical ultraviolet C (UVC) sterilizing devices are proven to kill 99.99% of germs, but may pose a risk of skin cancer and cataracts, Chula professors cautioned consumers to use them carefully and by being fully informed.
Dana-Farber Cancer Institute faculty recognized as 2021 ASCO leaders in cancer care
Dana-Farber Cancer Institute
The American Society of Clinical Oncology (ASCO) recognized two Dana-Farber Cancer Institute researchers as winners of ASCO's Special Awards, the Society's highest honors. The recipients of these awards have worked to transform cancer care around the world.
Carol Fabian Recognized As Fellow of the American Society of Clinical Oncology
University of Kansas Cancer Center
Carol Fabian, MD, FASCO, a nationally recognized medical oncologist and breast cancer researcher, has been named a Fellow of the American Society of Clinical Oncology (FASCO).
Rutgers Cancer Institute of New Jersey Clinical Leader Recognized as Fellow of the American Society of Clinical Oncology
Rutgers Cancer Institute of New Jersey
Rutgers Cancer Institute of New Jersey Associate Chief of Urology and Urologic Oncology and Director of the Kidney Cancer Program Eric A. Singer, MD, MA, MS, FACS, has been named a Fellow of the American Society of Clinical Oncology (FASCO). This distinction honors members for their extraordinary volunteer service and dedication to the American Society of Clinical Oncology (ASCO).
Yale Cancer Center Study Shows Cognitive Impairment for Survivors of Many Pediatric Cancers
Yale Cancer Center
In a new study led by Yale Cancer Center, researchers report many survivors of childhood cancers receive systemic therapies associated with cognitive effects and chronic health conditions that may impact long-term cognitive outcomes with downstream effects on education, employment, and income. The results were published online today in the Journal of Clinical Oncology (JCO).
Blacks, Hispanics, Impoverished People Have Worse Survival Rates Among Teens, Adults Under 40 With Cancer
UT Southwestern Medical Center
DALLAS - April 22, 2021 - Being Black or Hispanic, living in high-poverty neighborhoods, and having Medicaid or no insurance coverage are associated with higher mortality in men and women under 40 with cancer, a review by UT Southwestern Medical Center researchers found.
21st century medical needles for high-tech cancer diagnostics
Aalto University
A new type of biopsy needle - which vibrates ultrasonically - greatly increases the amount of tissue obtained for pathologists. Currently, pathologists have to use a thick, but painful needle to get large samples, but the new needle is thin and much more comfortable for patients.
Henry Ford Cancer Institute Receives Grant to Reduce Prostate Cancer Disparities Among Black Men
Henry Ford Health System
Henry Ford Cancer Institute has received a $250,000 grant from Pfizer Global Medical Grants and the American Cancer Society to reduce prostate cancer disparities among Black men. While all men are at risk for prostate cancer, Black men are at an increased risk for developing and dying from prostate cancer.
Higher mushroom consumption is associated with a lower risk of cancer
Penn State College of Medicine
Higher mushroom consumption is associated with a lower risk of cancer, according to a new Penn State study.
Roswell Park, Wilmot Cancer Institute Collaborate on First Large Study of Immunotherapy in Black Cancer Patients
Roswell Park Comprehensive Cancer Center
A new collaboration between two Western New York cancer research leaders will help oncologists learn whether Black and white cancer patients respond differently to a game-changing immunotherapy treatment, and seeks to improve the safety and effectiveness of these newer drugs in diverse populations.
'Information Theory' Recruited to Help Scientists Find Cancer Genes
Johns Hopkins Medicine
Using a widely known field of mathematics designed mainly to study how digital and other forms of information are measured, stored and shared, scientists at Johns Hopkins Medicine and Johns Hopkins Kimmel Cancer Center say they have uncovered a likely key genetic culprit in the development of acute lymphoblastic leukemia (ALL).
Exploring a New Therapeutic Strategy for T-cell Acute Lymphoblastic Leukemia
Rutgers Cancer Institute of New Jersey
Researchers from Rutgers Cancer Institute of New Jersey, recently discovered that a mitochondrial uncoupling drug is toxic against leukemic cells, revealing a potential therapeutic strategy against T-ALL.
Research News Tip Sheet: Story Ideas from Johns Hopkins Medicine
Johns Hopkins Medicine
During the COVID-19 pandemic, Johns Hopkins Medicine Media Relations is focused on disseminating current, accurate and useful information to the public via the media. As part of that effort, we are distributing our "COVID-19 Tip Sheet: Story Ideas from Johns Hopkins" every other Wednesday.
Researchers Identify New Role for Immune-Boosting Protein "STING" in Treatment of Head and Neck Cancer
Yale Cancer Center
In a study by Yale Cancer Center, researchers report on the discovery of a new role for STimulator of INterferon Genes or STING. STING has traditionally been implicated in the immune response to DNA damage, however, in this study, the focus is on STING's role in the tumor DNA damage response.
Researchers Discover Common Mechanism Causing Autoimmune Disease and Blood Cancers
Yale Cancer Center
In a study by Yale Cancer Center, researchers report on the discovery of a common mechanism that promotes both autoimmune diseases and blood cancers, including the blood diseases Acute Lymphoblastic Leukemia (ALL), Chronic Lymphocytic Leukemia (CLL) and Mantle Cell Lymphoma (MCL).
University of Colorado Inter-campus Collaboration Wins R01 Award for Salivary Gland Cancer
University of Colorado Cancer Center
Two University of Colorado Cancer Center researchers have received a five-year R01 Award for $497,893 per year from the National Institutes of Health (NIH) to study a potential new drug treatment for salivary gland cancer. The award is part of an inter-campus collaboration between Antonio Jimeno, MD, PhD, co-leader of the Developmental Therapeutics Program, and Tin Tin Su, PhD, co-leader of the Molecular and Cellular Oncology Program.
Study Uses Precision Medicine to Speed Drug Testing for Pancreatic Cancer
University of California San Diego Health
Moores Cancer Center at UC San Diego Health is among the few clinical trial sites in the U.S. for the Pancreatic Cancer Action Network's (PanCAN) newly created Precision Promise, the first large-scale precision medicine trial designed to transform outcomes for patients with pancreatic cancer.
Study: New Approach May Boost Prostate Cancer Immunotherapies
Cedars-Sinai
Researchers have discovered a new way to transform the tissues surrounding prostate tumors to help the body's immune cells fight the cancer. The discovery, made in human and mouse cells and in laboratory mice, could lead to improvements in immunotherapy treatments for prostate cancer, the second most common cancer in men in the U.S.
New Research Suggests Breast Cancer Treatment in Patients over Age 70 Can Be Safely Reduced
Health Sciences at the University of Pittsburgh
Research indicates the rate of cancer recurrence or survival may be no different in older women diagnosed with early breast cancer whether they were treated or untreated.
NCCN Foundation Announces Awards for Rising Cancer Research Leaders
National Comprehensive Cancer Network(r) (NCCN(r))
National Comprehensive Cancer Network announces recipients of 2021 NCCN Foundation Young Investigator Awards; projects from early-career investigators to advance research in cancer prevention, racial disparities in screening, immunotherapy, new insights in radiotherapy, and CAR T-cell therapy.
McMaster scientists discover trained immune cells are highly effective against cancer
McMaster University
McMaster University researchers Ali Ashkar and Sophie Poznanski have uncovered that changing the metabolism of natural killer (NK) immune cells allows these cells to overcome the hostile conditions found inside tumours and destroy advanced ovarian and lung cancer.
Novel Drug Regenerates Erectile Nerves Damaged by Prostate Surgery
Albert Einstein College of Medicine
Researchers at Albert Einstein College of Medicine have developed a topical drug that regenerates and restores the function of erectile nerves damaged by radical prostatectomy, the most common treatment for localized prostate cancer. The drug was tested in rats, and the findings were published online today in JCI Insight.
How marriage is impacted by a breast cancer diagnosis among African American women
Washington University in St. Louis
Most African American women described successfully navigating the challenges of a breast cancer diagnosis with their partners, finds a new analysis from the Brown School at Washington University in St. Louis.
Scientists identify potential drug candidates for deadly pediatric leukemia
Sanford Burnham Prebys Medical Discovery Institute
Scientists at Sanford Burnham Prebys Medical Discovery Institute have shown that two existing drug candidates--JAK inhibitors and Mepron--hold potential as treatments for a deadly acute myeloid leukemia (AML) subtype that is more common in children. The foundational study, published in the journal Blood, is a first step toward finding effective treatments for the hard-to-treat blood cancer.
A Heroic Reunion
Cedars-Sinai
At just 8 years old, Benjamin Gordon's life was flipped upside down when his father, Greg, was diagnosed with an aggressive type of brain cancer.
NCCN Announces Projects to Study Oral Decitabine and Cedazuridine in Collaboration with Taiho Oncology
National Comprehensive Cancer Network(r) (NCCN(r))
The National Comprehensive Cancer Network(r) (NCCN(r)) Oncology Research Program (ORP) today announced that three projects have been selected to study oral decitabine (35 mg) and cedazuridine (100 mg).
Rutgers Cancer Institute of New Jersey Awarded $1.3M for Cancer Metabolism and Growth Research Program
Rutgers Cancer Institute of New Jersey
Rutgers Cancer Institute has received a $1.3 million, five-year grant from the National Cancer Institute to support the Cancer Metabolism and Growth and Tumor Host Interactions Training Program which will provide postdoctoral candidates the highest quality training and research experience.
Discovery of New Element in Class of Enzymes Informs Cancer Drug Design
University of California San Diego Health
Brachytherapy May Proceed Safely, Without Delay in Cervical Cancer Patients Following Uterine Perforation
Loyola Medicine
A new study finds that brachytherapy, a common procedure that delivers radiation directly to cancer cells, may continue safely, potentially without delay or antibiotics, in cervical cancer patients following uterine perforation.
JNCCN Study: Important Potential Role for Routine Brain Imaging in Advanced Kidney Cancer
National Comprehensive Cancer Network(r) (NCCN(r))
International study finds 4% of patients with metastatic renal cell carcinoma developed asymptomatic brain metastases, which correlated to poorer outcomes.
Ludwig Cancer Research Opens New Branch Dedicated to Cancer Metabolism at Princeton University
Ludwig Cancer Research
Ludwig Cancer Research is proud to announce on its 50th anniversary the launch of the newest Branch of the Ludwig Institute for Cancer Research.
Increase your Awareness of Head and Neck Cancers
Rutgers Cancer Institute of New Jersey
Accounting for approximately four percent of all cancers nationwide according to the National Cancer Institute, head and neck cancer is the term used to describe a number of different malignant tumors that develop in or around the throat, larynx, nose, sinuses and mouth. Even though these cancers are not as prevalent as others, everyone should be aware of risk factors and symptoms.
Researchers identify surface protein as a new osteosarcoma therapeutic target for antibody-drug conjugates
University of Texas M. D. Anderson Cancer Center
Novel approach paves the way for vast expansion in the number of drugs targeting osteosarcoma
Huntsman Cancer Institute Research Shows Melanoma Incidence and Mortality Higher in Utah Compared to Rest of U.S.
Huntsman Cancer Institute at the University of Utah
A letter published today by Huntsman Cancer Institute (HCI) at the University of Utah (U of U) in the New England Journal of Medicine reports that melanoma mortality among Utahns outpaced that of the rest of the United States during the period from 1975 to 2013. Melanoma death rates have been decreasing in recent years both in Utah and the United States, a trend likely attributable to new, more effective treatments, like immunotherapy. However, melanoma remains the deadliest type of skin cancer, and the incidence of melanoma diagnoses in Utahns is higher than in any other state.
John Theurer Cancer Center Investigators Celebrate New Personalized Cell Therapy to Give Patients with Advanced Multiple Myeloma Hope
Hackensack Meridian Health
The U.S. Food and Drug Administration recently approved a new CAR-T therapy called idecabtagene vicleucel (ide-cel), or Abecma. It's the first personalized cell therapy to treat patients with multiple myeloma no longer responsive to all standard previous types of therapy. This new therapy was assessed in the pioneering phase II clinical KarMMA trial, at Hackensack Meridian John Theurer Cancer Center at Hackensack Meridian Hackensack University Medical Center.
Mutant KRAS and p53 cooperate to drive pancreatic cancer metastasis
University of Texas M. D. Anderson Cancer Center
Preclinical research identifies CREB1 as new therapeutic target downstream of frequently mutated genes
MD Anderson researchers highlight advances in clinical studies at the AACR Annual Meeting 2021
University of Texas M. D. Anderson Cancer Center
FDA-approved selpercatinib shows clinical benefits for RET fusion-positive cancers beyond lung and thyroid cancers (Abstract CT011); Combining dabrafenib and trametinib to treat BRAF V600E-mutant high-grade (HGG) and low-grade glioma (LGG) shows significant antitumor activity; Therapeutics Discovery researchers identify key biomarker for metabolic inhibitor
Men with Low Health Literacy Less Likely to Choose Active Surveillance for Prostate Cancer After Tumor Profiling
University of Illinois at Chicago
Tumor gene profiling is a tool that can help patients with a cancer diagnosis make informed decisions about treatment. In predominantly white populations, among men with early stage, favorable-risk prostate cancer, these tools have been shown to increase patient acceptance of active surveillance -- a common, evidence-based approach to monitor the tumor before a more aggressive treatment, like surgery or radiation.
An amyloid link between Parkinson's disease and melanoma
American Chemical Society (ACS)
For nearly 50 years, doctors have recognized that Parkinson's disease patients have an increased risk of melanoma. Now, scientists report a link between the two diseases in the form of protein aggregates known as amyloids. They will present their results at ACS Spring 2021.
Cancer survivors need compassion to cope with 'cancer-brain'
University of South Australia
Every day, nearly 400 new cases of cancer are diagnosed in Australia. As a major cause of illness and a leading cause of death, many of us, sadly, also know someone with cancer.
Software Package Enables Deeper Understanding of Cancer Immune Responses
Johns Hopkins Medicine
Researchers at the Bloomberg Kimmel Institute for Caner Immunotherapy at the Johns Hopkins Kimmel Cancer Center have developed DeepTCR, a software package that employs deep-learning algorithms to analyze T-cell receptor (TCR) sequencing data. T-cell receptors are found on the surface of immune T cells. These receptors bind to certain antigens, or proteins, found on abnormal cells, such as cancer cells and cells infected with a virus or bacteria, to guide the T cells to attack and destroy the affected cells.
Cervical Cancer Testing Tech Could Replace Pap Smears, Save Lives
American Institute of Physics (AIP)
Emerging technologies can screen for cervical cancer better than Pap smears and, if widely used, could save lives in areas where access to health care may be limited. In Biophysics Reviews, scientists at Massachusetts General Hospital write advances in nanotechnology and computer learning are among the technologies helping develop HPV screening that take the guesswork out of the precancer tests. That could mean better screening in places that lack highly trained doctors and advanced laboratories.
Researchers Develop New Method for Identifying Mutational Signatures in Cancer
Johns Hopkins Medicine
Researchers at the Johns Hopkins Kimmel Cancer Center used machine learning techniques to detect mutational signatures in cancer patients. Their algorithm outperformed the current standard of analysis and revealed new mutational signatures associated with obesity, which is believed by cancer prevention experts to be becoming the most significant lifestyle factor contributing to cancer in the U.S. and most of the Western world.
Scientists Identify Molecular Pathway That Helps Moving Cells Avoid Aimless Wandering
Johns Hopkins Medicine
Working with fruit flies, scientists at Johns Hopkins Medicine say they have identified a new molecular pathway that helps steer moving cells in specific directions. The set of interconnected proteins and enzymes in the pathway act as steering and rudder components that drive cells toward an "intended" rather than random destination, they say.
Surgery is a viable treatment for pancreatic cancer patients especially after chemotherapy
American College of Surgeons (ACS)
Patients with stage II pancreatic cancer who are treated with chemotherapy followed by resection (an operation that removes the cancerous part of the organ, structure or tissue) live nearly twice as long as patients who receive only chemotherapy.
'Leap forward' in risk management of rectal cancer
Washington University in St. Louis
Rectal cancer, along with colon cancer, is the third-most common type of cancer in the United States, and treatment and surgery greatly affect the quality of life of patients. A multi-disciplinary team at Washington University in St. Louis has developed and tested an innovative imaging technique that is able to differentiate between rectal tissues with residual cancers and those without tumors after chemotherapy and radiation, which could one day help to avoid unnecessary surgeries in some patients who have achieved complete tumor destruction after chemoradiation.