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Active living researcher @UCSDMedSchool available to discuss the newly updated @HHSGov physical activity guidelines
University of California San Diego Health
Immunotherapy combination and chemotherapy show encouraging results in Phase II acute myeloid leukemia study
University of Texas M. D. Anderson Cancer Center
A triple therapy combining two immune checkpoint inhibitors (ICPIs) with the standard-of-care chemotherapy, a hypomethylating agent called azacitidine, has shown promising results for treatment of relapsed or refractory acute myeloid leukemia (AML), according to findings from a Phase II study at The University of Texas MD Anderson Cancer Center.
'Waltzing' nanoparticles could advance search for more effective drug delivery methods
Indiana University
IU scientists have found that drug-delivering nanoparticles attach to their targets differently based upon their position in time. The discovery could improve methods for screening drugs for therapeutic effectiveness.
Cancer stem cells get energy from protein, and it's proving to be their Achilles' heel
University of Colorado Cancer Center
CU Cancer Center study shows that cancer stem cells switch from metabolizing sugar to metabolizing protein. Turning off protein metabolism kills these cells.
Obesity both feeds tumors and helps immunotherapy kill cancer
UC Davis Comprehensive Cancer Center
A groundbreaking new study by UC Davis researchers has uncovered why obesity both fuels cancer growth and allows blockbuster new immunotherapies to work better against those same tumors. The paradoxical findings, published today in Nature Medicine, give cancer doctors important new information when choosing drugs and other treatments for cancer patients.
Fecal transplant effective against immunotherapy-induced colitis
University of Texas M. D. Anderson Cancer Center
For the first time, transplanting gut bacteria from healthy donors was used to successfully treat patients suffering from severe colitis caused by treatment with immune checkpoint inhibitors. The study from The University of Texas MD Anderson Cancer Center, which includes two patients, suggests fecal microbiota transplantation is worth investigating in clinical trials as a therapy for this common side effect of immunotherapy.
Spread of Deadly Eye Cancer Halted in Cells and Animals
Johns Hopkins Medicine
Zebrafish eye injected with retinoblastoma tumor cells (green) form a mass in areas close to the injection site. A few of these tumor cells move outside the eye. Credit: Johns Hopkins Medicine By comparing genetic sequences in the eye tumors of children whose cancers spread with tumors that didn't spread, Johns Hopkins Medicine researchers report new evidence that a domino effect in cells is responsible for the cancer spreading. Their experiments suggest that blocking part of the chain of events -- which they successfully accomplished in zebra fish and human cells -- stops the growth and spread of the eye tumor cells.
Italian-American Foundation Honors Antonio Giordano, MD, PhD Founder & President of Sbarro Health Research Organization
Sbarro Health Research Organization (SHRO)
Italian-American Foundation, Filitalia, honors Antonio Giordano, MD, PhD, Founder & President of Sbarro Health Research Organization at Temple University with the Humanitarian award at the foundation's 31st Anniversary Gala.
Decrease in Specific Gene 'Silencing' Molecules Linked With Pediatric Brain Tumors
Johns Hopkins Medicine
Experimenting with lab-grown brain cancer cells, Johns Hopkins Medicine researchers have added to evidence that a shortage of specific tiny molecules that silence certain genes is linked to the development and growth of pediatric brain tumors known as low-grade gliomas.
First-ever prostate cancer treatment uses gold nanoparticles to destroy tumorous cells
University of Texas Health Science Center at Houston
A small clinical trial using gold nanoparticles that act as tumor-seeking missiles on a mission to remove prostate cancer has begun at The University of Texas Health Science Center at Houston (UTHealth). It is the first trial of its kind in the world.
Yale Cancer Center scientists show immunotherapy drug can help patients with metastatic melanoma
Yale Cancer Center
When melanoma turns metastatic, it spreads to the brain in more than 40% of patients. Published today in the Journal of Clinical Oncology (JCO), a study by Yale Cancer Center researchers show a checkpoint inhibitor immunotherapy drug has meaningful benefit for these patients.
Grant Awarded to Rutgers Cancer Institute Augments Clinical Trial Access for Adolescent and Young Adult Patients
Rutgers Cancer Institute of New Jersey
To address challenges with clinical trial access for pediatric and young adult cancer patients, Rutgers Cancer Institute of New Jersey will utilize a $50,000 infrastructure grant from the St. Baldrick's Foundation to provide additional support for a clinical research nurse.
Scientists find great diversity, novel molecules in microbiome of tree roots
Oak Ridge National Laboratory
Researchers with the Department of Energy's Oak Ridge National Laboratory have discovered that communities of microbes living near tree roots are ten times more diverse than the human microbiome and produce a cornucopia of novel molecules that could be useful as antibiotics and anti-cancer drugs.
Researchers awarded $2.3 million to continue studies on chemotherapy-induced peripheral neuropathy
Indiana University
Indiana University cancer researchers who have been working to lessen the debilitating side effects caused by chemotherapy have been awarded $2.3 million to continue their studies.
Case Western Reserve School of Medicine and UH Rainbow Babies & Children's Hospital Awarded $1.35M to Conduct Lifesaving Childhood Cancer Research
Case Western Reserve University
Leading cancer researcher, Alex Huang MD, PhD, has been awarded a three-year, $1.35 million grant from the St. Baldrick's Foundation and the Osteosarcoma Collaborative to develop new ways to treat osteosarcoma, a rare cancer that begins in the bone.
Pioneering cancer, cryo-electron microscopy researcher to join Penn State faculty
Penn State College of Engineering
Professor Deborah Kelly, a ground-breaking researcher who developed the new field of structural oncology, will join Penn State as full professor of biomedical engineering and Lloyd and Dottie Foehr Huck Chair in Molecular Biophysics.
Combination chemotherapy and immunotherapy effective in Phase II leukemia study
University of Texas M. D. Anderson Cancer Center
A combination of the standard-of-care chemotherapy drug known as azacitidine, with nivolumab, an immune checkpoint inhibitor, demonstrated an encouraging response rate and overall survival in patients with relapsed or refractory acute myeloid leukemia (AML) according to findings from a Phase II study at The University of Texas MD Anderson Cancer Center.
Rutgers Cancer Institute of New Jersey and Robert Wood Johnson University Hospital are First in State to Offer Innovative Targeted Treatment for Rare Neuroendocrine Tumors
Rutgers Cancer Institute of New Jersey
Rutgers Cancer Institute of New Jersey, in collaboration with Robert Wood Johnson University Hospital (RWJUH) - New Brunswick, is the first in the Garden State to administer a form of targeted cancer treatment known as peptide receptor radionuclide therapy (PRRT) for rare neuroendocrine tumors that have spread beyond the initial tumor site.
Renowned Radiation Oncologist Joins Henry Ford Cancer Institute
Henry Ford Health System
Dr. Parag Parikh to lead Henry Ford Radiation Oncology Department's MR-Guided Radiation Program.
Mailed HPV tests can help find women at-risk for cervical cancer, study finds
University of North Carolina Health Care System
In the journal Obstetrics & Gynecology, researchers published the results of mailing at-home, HPV self-collection kits to 193 low-income women in North Carolina who were overdue for screening according to national guidelines.
Yale Cancer Center Finds Patients Choose Cancer Care Based on Hospital Affiliations
Yale Cancer Center
Branding matters when it comes to choosing a hospital, according to a new novel study by Yale Cancer Center (YCC) researchers published in the journal Annals of Surgical Oncology.
Quit with the Great American Smokeout
Monday Campaigns
To support the the American Cancer Society's Great American Smokeout, Quit & Stay Quit Monday, an initiative of The Monday Campaigns and the Institute for Global Tobacco Control at the Johns Hopkins University Bloomberg School of Public Health, are introducing a new "Monday Quit Kit" for individuals and tobacco cessation professionals that can help quitters stay on track over the long haul.
Open Source Machine Learning Tool Could Help Choose Cancer Drugs
Georgia Institute of Technology
Using machine learning, a new open source decision support tool could come help clinicians choose the right cancer drug based on RNA expression.
Case Western Reserve School of Medicine Awarded $1.6M for Undergraduate Research
Case Western Reserve University
Case Western Reserve University School of Medicine is preparing and inspiring a new generation of cancer investigators through Cancer-focused Summer Undergraduate Research (CanSUR). The 10-week program recently received a five-year National Institutes of Health (National Cancer Institute) research grant totaling $1.6 million. Starting in 2019, CanSUR will support 32 undergraduates each year from June through August.
Exploring Autophagy in the Development of Non-Small Cell Lung Cancer
Rutgers Cancer Institute of New Jersey
A Rutgers Cancer Institute of New Jersey researcher has received a $150,000 grant from the Lung Cancer Research Foundation to investigateautophagy in the development of lung cancers driven by mutations in tumor suppressors known as LKB1 and oncogene KRAS.
Yale Cancer Center investigators show recommended, but underused treatment for rare blood cancer saves lives
Yale Cancer Center
U.S. and European guidelines on treating Polycythemia Vera (PV), a potentially deadly blood cancer, call for two treatments for patients with high-risk disease: therapeutic phlebotomy and cytoreductive therapy with a drug called hydroxyurea (HU). HU is the most commonly used option, but evidence for HU treatment is limited and both treatments are underused. Now, researchers at Yale Cancer Center have documented reduced risk of death and incidence of blood clots in patients receiving those therapies.
Antonio Omuro named new Neuro-Oncology Chief at Yale Cancer Center
Yale Cancer Center
Antonio Omuro, M.D., has been appointed the new Chief of Neuro-Oncology and a Leader for the Brain Tumor Program at Yale Cancer Center (YCC) and Smilow Cancer Hospital.
Rutgers Cancer Institute of New Jersey Physicians Named to Annual Listing of Top Doctors
Rutgers Cancer Institute of New Jersey
A number of physicians at Rutgers Cancer Institute of New Jersey - the state's only National Cancer Institute-designated Comprehensive Cancer Center - have been recognized by New Jersey Monthly magazine as a 'Jersey Choice Top Doctor.'
USC Norris Comprehensive Cancer Center Appoints First Associate Director of Community Outreach and Engagement
Keck Medicine of USC
USC Norris Comprehensive Cancer Center has appointed Lourdes Baezconde-Garbanati as the first associate director of community outreach and engagement to help reduce the cancer burden in surrounding communities.
BIDMC Research & Health News Digest: October 2018
Beth Israel Deaconess Medical Center
A monthly roundup of research briefs showcasing recent scientific advances led by Beth Israel Deaconess Medical Center faculty.
High exposure to radio frequency radiation associated with cancer in male rats
National Institute of Environmental Health Sciences (NIEHS)
The National Toxicology Program (NTP) concluded there is clear evidence that male rats exposed to high levels of radio frequency radiation (RFR) like that used in 2G and 3G cell phones developed cancerous heart tumors, according to final reports released today. There was also some evidence of tumors in the brain and adrenal gland of exposed male rats. For female rats, and male and female mice, the evidence was equivocal as to whether cancers observed were associated with exposure to RFR. The final reports represent the consensus of NTP and a panel of external scientific experts who reviewed the studies in March after draft reports were issued in February.
New Website Aims to Save Lives by Helping Institutions Launch Lung Cancer Screening Programs
American Thoracic Society (ATS)
The American Thoracic Society and the American Lung Association's LUNG FORCE initiative have launched a new website and online toolkit to help medical institutions implement and manage a lung cancer screening program.
Low-Fat Diet Increases Cancer Survival Rate in Mice, Study Finds
University of California, Los Angeles (UCLA), Health Sciences
Something as simple as a change in diet can potentially help to increase the cancer survival rate of obese children with acute lymphoblastic leukemia, the most common childhood cancer, according to a new study by UCLA scientists.
Minimally Invasive Surgery Associated with Worse Survival for Women with Cervical Cancer Compared to Open Hysterectomy
University of Texas M. D. Anderson Cancer Center
When comparing standard-of-care surgical options for women with early-stage cervical cancer, two studies led by researchers at The University of Texas MD Anderson Cancer Center discovered that minimally invasive radical hysterectomy is associated with higher recurrence rates and worse overall survival (OS), compared to abdominal radical hysterectomy.
Relapsed leukemia flies under immune system's radar
Washington University in St. Louis
A study from Washington University School of Medicine in St. Louis offers a potential explanation for why many AML patients experience a relapse after a stem cell transplant, and suggests a therapeutic approach that may help to place relapsed patients back into remission.
Lymphedema: Why It's Important to Seek Treatment Right Away
LifeBridge Health
There is no cure for lymphedema, chronic swelling (usually in the arms and legs, though other body parts can be affected) resulting from fluid buildup caused by blockages in the lymphatic system.
A New Tool to Help Fight an Old Enemy - Lung Cancer
Rutgers Cancer Institute of New Jersey
In the U.S., lung cancer remains the leading cause of cancer death among both men and women. The primary reason for high death rates for lung cancer is the fact that this disease is typically detected in very late stages. A Rutgers University expert weighs in on new screening resources to combat the disease.
Fight Colorectal Cancer Awards Grant to Researchers Studying Early-Age Onset Colorectal Cancer.
Fight Colorectal Cancer
Scientists Neutralize Reactive Nitrogen Molecules to Enhance Cancer Immunotherapy
University of Notre Dame
Researchers at the University of Notre Dame studying tumors in prostate cancer models found that nitration of an amino acid can inhibit T-cell activation, thwarting the T-cell's ability to kill cancer cells.
Biologists Discover Source for Boosting Tumor Cell Drug Sensitivity
University of California San Diego
Biologists have discovered a new way of re-sensitizing drug-resistant tumor cells to DNA-damaging agents, the most widely used group of cancer drugs. Researchers describe how a gene known as Schlafen 11 controls the sensitivity of tumor cells to DDAs. Their research may pave the way to new strategies to overcome chemotherapeutic drug resistance.
Small risks may have big impact on breast cancer odds of childhood cancer survivors
St. Jude Children's Research Hospital
St. Jude Children's Research Hospital scientists found that the combined effect of common genetic variations can dramatically increase risk of breast cancer for female pediatric cancer survivors
Obesity Problem Starts Early Phase of Therapy in Children with Acute Lymphoblastic Leukemia
St. Jude Children's Research Hospital
Children with acute lymphoblastic leukemia (ALL) gain weight during treatment, and researchers at St. Jude Children's Research Hospital have discovered that this problem starts during remission-induction treatment and suggests that early intervention should be considered. Chemotherapy drugs to treat ALL contribute to an increased risk of becoming overweight or obese. The scientists' findings show that obesity was prevalent - and height growth, especially in patients with identified risk factors - was compromised.
Three Proteins May Play Key Roles in Female Fertility and Cancer Biology
Rutgers University-New Brunswick
Three proteins regulate each other with surprising twists and turns in female mouse eggs, a finding that may play an important role in female fertility and cancer biology, according to Rutgers-led research.
Head and Neck Cancer Survivors at Increased Risk of Suicide
Saint Louis University Medical Center
Despite improved survival rates among cancer patients, the risk of death by suicide remains high, especially among those treated for head and neck cancers (HNC).
Exploring an Oncolytic Virus Treatment Combined with Radiation against Melanoma
Rutgers Cancer Institute of New Jersey
Can the combination of radiation therapy with an oncolytic virus treatment better boost the body's immune response to melanoma than either treatment on its own? Investigators from Rutgers Cancer Institute of New Jersey further explored that question in work presented at the ASTRO Annual Meeting.
Suppression of DKK3 protein thwarts pancreatic tumor progression and prolongs survival
University of Texas M. D. Anderson Cancer Center
Researchers at The University of Texas MD Anderson Cancer Center have shed new light on why pancreatic tumors are so resistant to therapy.
T-cell biofactories find, fight disease in one fell swoop
National Institute of Biomedical Imaging and Bioengineering
NIBIB-funded researchers have transformed T cells into drug factories engineered to find cells carrying specific diseases in the body--and then produce therapeutic proteins localized to the diseased cells.
Mount Sinai's Digital 3D Mammography Van Rolls Into New York City
Mount Sinai Health System
New Program Designed to Break Down Barriers to Breast Cancer Screening
Grad Student Pursues Drug to Treat Aggressive Form of Blood Cancer
West Virginia University
Multiple myeloma doesn't play around. Within five years of being diagnosed with this form of blood cancer, about half of all patients die from it. And even if they initially respond well to treatment, the cancer can hide in their bone marrow for years before reemerging in a tougher-to-treat form.
From Self-Exams to Immunotherapy, Breast Cancer Patients Tell All
Cedars-Sinai
As women scramble to keep up with work, family and the scores of chores they tackle, it's easy for breast care to fall by the wayside. In recognition of Breast Cancer Awareness Month, Cedars-Sinai breast surgical oncologist Nimmi Kapoor, MD, breast medical oncologist Reva Basho, MD, and three breast cancer survivors offer advice--from mammograms to immunotherapy and breast reconstruction--to keep women in the know
Rutgers Cancer Institute of New Jersey Pediatric Hematology/Oncology Section Chief Honored for Contributions to Cancer and Blood Disorders
Rutgers Cancer Institute of New Jersey
Richard Drachtman, MD, clinical section chief of the Pediatric Hematology/Oncology Division at Rutgers Cancer Institute of New Jersey, has been named the 2018 recipient of the Melvyn H. Motolinsky Research Foundation Distinguished Service Award in recognition of his accomplishments and leadership in the field of pediatric cancer and blood disorders.
Researchers find potential new way to target lethal form of leukemia
UT Southwestern Medical Center
New findings raise the possibility of a novel treatment for this subtype of blood and bone marrow cancer - known as acute myeloid leukemia or AML - by attacking a harmful molecule found on the cancerous cells and also reactivating the body's white blood cells to fight them.
New combination treatment flips the switch on melanoma cells
University of Colorado Cancer Center
Navitoclax plus A-1210477 not only killed melanoma cells, but also killed the melanoma initiating cells (aka cancer stem cells) that often resist therapy.
Fight CRC Partners with No-Shave November for Fourth Straight Year
Fight Colorectal Cancer
Fight Colorectal Cancer (Fight CRC) has once again been selected by No-Shave November as one of the three recipients for all funds raised during the 2018 campaign.
AACI Launches National CAR T-cell Therapy Initiative
Association of American Cancer Institutes (AACI)
The Association of American Cancer Institutes (AACI) has established a national initiative to advance the use of chimeric antigen receptor T-cell therapies (CAR T). Joseph McGuirk, DO, division director of the Hematologic Malignancies and Cellular Therapeutics program at The University of Kansas Cancer Center, is leading the effort.
Mutation in Common Protein Triggers Tangles, Chaos Inside Brain Cells
University of Wisconsin-Madison
A pioneer in the study of neural cells revealed today (Oct. 23, 2018) how a single mutation affecting the most common protein in a supporting brain cell produces devastating, fibrous globs. These, in turn, disturb the location of cellular processing units, harm the flow of energy and signals through the brain, and reduce the formation of myelin, an essential insulator for neurons.
New study finds harmful pesticides lurking in NYS homes
Cornell University
Despite the existence of chemical-free methods to eradicate pests, Americans use more than a billion pounds of pesticides per year. These chemicals are mostly out of sight and out of mind to unsuspecting homeowners, who are typically unaware of how to prevent potential harm - something new Cornell University research is addressing.
HPV blood test shows promise for tracking head and neck cancer after treatment
University of North Carolina Health Care System
Researchers will present preliminary findings at the 60th Annual Meeting of the American Society for Radiation Oncology in San Antonio on Tuesday, Oct. 23, from a study evaluated a blood test for HPV-linked oropharyngeal squamous cell carcinoma.
Marker Found for Condition That Causes Numerous Tumors
UT Southwestern Medical Center
UT Southwestern researchers have made a major advance in uncovering the biology of how thousands of disfiguring skin tumors occur in patients troubled by a genetic disorder called neurofibromatosis type 1 (NF1). This scientific advance could slow the development of these tumors.
$4.5 Million From NIH Will Help Find Solutions to 'Chemo Brain' Symptoms and Opioid Addiction
Saint Louis University Medical Center
Pain researcher Daniela Salvemini, Ph.D., will embark on two new research projects, studying chemotherapy-induced cognitive impairment, or "chemo brain," symptoms and unwanted side effects of opioids.
21 Mercy Physicians Named Among Region's "Top Docs" in November 2018 Issue of Baltimore Magazine
Mercy Medical Center, Baltimore
A total of 21 Mercy Medical Center physicians were recognized in Baltimore Magazine's November 2018 "Top Docs" issue, representing 19 separate specialties, ranging from breast cancer surgery to pediatrics to urogynecology.
RNA Thought to Spread Cancer Shows Ability to Suppress Breast Cancer Metastasis
University of Texas M. D. Anderson Cancer Center
Researchers at The University of Texas MD Anderson Cancer Center have discovered that a form of RNA called metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) appears to suppress breast cancer metastasis in mice, suggesting a potential new area of therapeutic investigation. The findings, published in the Oct. 22 online issue of Nature Genetics, were surprising given that MALAT1, a long non-coding RNA (lncRNA), previously was described as a metastasis promoter.
Future Fertility: Giving Hope to Men Who Received Childhood Cancer Treatment
Perelman School of Medicine at the University of Pennsylvania
Researchers have discovered a way to grow human stem cells destined to become mature sperm in an effort to provide fertility options later in life to males who are diagnosed with cancer and undergo chemotherapy and radiation as children.
Johns Hopkins Researchers Present at Rheumatology Annual Meeting
Johns Hopkins Medicine
The 2018 American College of Rheumatology/American Rheumatology Health Professionals Annual Meeting.
Treatment of Aggressive Breast Cancer Improved by Immunotherapy-Chemotherapy Combination
Health Sciences at the University of Pittsburgh
Progression free survival in triple-negative breast cancer increased when immunotherapy-chemotherapy treatment combination is used as the first treatment option.
Study Aims to Build a Better Model for Brain Tumors
University of Alabama at Birmingham
A research team led by UAB is launching a study to find a better model for glioblastoma, a particularly devastating type of brain tumor, to help determine the most appropriate treatment modality.
Award-Winning Nuclear Physics Technology Monitors Cancer Treatments
Thomas Jefferson National Accelerator Facility
Nearly a half-million cancer patients are treated with radiation therapy every year in the United States. Now, technologies developed in partnership with the Department of Energy's Thomas Jefferson National Accelerator Facility (Jefferson Lab) are helping to ensure that patients are receiving just what the doctor ordered. The technologies are featured in RadiaDyne's OARtrac(r) system, which was cited as a Medical Device Engineering Breakthrough Award and as a 2018 R&D 100 award finalist by R&D Magazine.
La Jolla Institute Receives $ 4.5 Mill Cancer Moonshot Award
La Jolla Institute for Immunology
Researchers at La Jolla Institute for Immunology (LJI) and UC San Diego have been awarded $ 4.5 million as part of the National Cancer Institute's Cancer Moonshot initiative. The funding will support research to develop new and improved immunotherapeutic treatment options for patients with head and neck cancer.
Childhood Trauma, Depression Linked to Higher Risk of Longer-Term Fatigue in Breast Cancer Survivors
University of California, Los Angeles (UCLA), Health Sciences
Breast cancer survivors who experienced trauma early in life and depression after their cancer treatments are at increased risk of persistent fatigue, a new UCLA study shows. Some of the key predictors of longer-term fatigue for this group of women include elevated levels of depressive symptoms after treatment and a history of childhood adversity, such as abuse, neglect, household conflict and disorganization.
Cancer Patients Can Now Use Skin Creams During Radiation Therapy
Perelman School of Medicine at the University of Pennsylvania
Contrary to the advice most cancer patients receive when they go through radiation treatment, topical skin treatments, unless applied very heavily, do not increase the radiation dose to the skin and can be used in moderation before daily radiation treatments.
Case Comprehensive Cancer Center Receives $3M NIH Grant for Health Disparities Research
Case Western Reserve University
The Case Comprehensive Cancer Center has received a three-year, $3,194,947 grant from the National Cancer Institute to investigate colorectal and breast cancer health disparities. The grant is one of only four Specialized Programs of Research Excellence (SPORE) Planning Grant P20 awards given across the nation to address health disparities. It will provide the infrastructure for a new, comprehensive research program at Case Western Reserve University School of Medicine to study cancer health disparities at both molecular and population levels.
NYU Langone Hospital-Brooklyn Welcomes Breast Cancer Specialist
NYU Langone Hospital - Brooklyn
Based in Brooklyn and working in collaboration with the already outstanding breast cancer team at NYU Langone Hospital-Brooklyn under the auspices of Perlmutter Cancer Center at NYU Langone, Magdalena Plasilova, MD, PhD, specializes in "hidden scar" surgery, an advanced surgical technique using small incisions in the armpit or in skin folds.
Researchers Describe Novel Immune Syndrome
The Rockefeller University Press
Researchers from Australia and Japan have discovered a new human immunodeficiency syndrome in two patients on separate continents. The study, which will be published October 18 in the Journal of Experimental Medicine, reveals that a mutation in a gene called IKBKB disrupts the immune system, leading to excessive inflammation and the loss of both T and B white blood cells.
Compound Derived From Chinese Tree Bark Shows Promise as Treatment for Pancreatic Cancer
Roswell Park Comprehensive Cancer Center
A new derivative of a compound found in the bark of a rare Chinese tree has powerful anticancer properties and a low toxicity profile, according to new research from a Roswell Park Comprehensive Cancer Center published in the Journal of Experimental & Clinical Cancer Research.
Vast Leukemia Dataset Could Help Researchers Match Therapies to Patients
Howard Hughes Medical Institute (HHMI)
Data on the molecular makeup and drug sensitivity of hundreds of patient samples could accelerate progress against the aggressive blood cancer acute myeloid leukemia.
The Association of American Cancer Institutes Appoints New Executive Director
Association of American Cancer Institutes (AACI)
Jennifer W. Pegher, MA, is the new executive director of the Association of American Cancer Institutes. She is the second executive director in AACI's 19-year history, succeeding founding executive director Barbara Duffy Stewart, who retired earlier this month.
Cellular clean-up crews linked to how body handles sugar
University of Chicago
How our bodies handle glucose--the simple sugar that provides energy from the food we eat--appears to be intertwined with how cells keep themselves functioning normally, according to new University of Chicago research.
ISPOR Publishes New Report on the Application of Constrained Optimization Methods in Healthcare
ISPOR--The Professional Society for Health Economics and Outcomes Research
ISPOR--the professional society for health economics and outcomes research (HEOR), has published a new Good Practices for Outcomes Research Report that illustrates how constrained optimization methods can be used to assess the value of health technologies.
Rutgers Cancer Institute of New Jersey Biospecimen Repository and Histopathology Service Shared Resource Receives Accreditation from College of American Pathologists
Rutgers Cancer Institute of New Jersey
The Biospecimen Repository and Histopathology Service shared resource at Rutgers Cancer Institute of New Jersey has received accreditation from the College of American Pathologists (CAP) based on results of a recent on-site inspection as part of the CAP's Accreditation Programs.
Partnership Bolsters Childhood Cancer Research
University of California, Santa Cruz
The Treehouse Childhood Cancer Initiative of the UC Santa Cruz Genomics Institute and Dr. Elaine Mardis with other members of the Nationwide Children's Hospital's Institute for Genomic Medicine (IGM) recently met to bolster an ongoing collaboration focused on pediatric cancer genomics data sharing.
Young Innovators
University of Delaware
A special issue of the journal Cellular and Molecular Bioengineering will recognize assistant professors Emily Day and Jason Gleghorn as Young Innovators, while featuring their latest research.
Stem cell biologist Sean Morrison elected to the National Academy of Medicine
UT Southwestern Medical Center
UT Southwestern Professor Dr. Sean Morrison, Director of the Children's Medical Center Research Institute (CRI) at UT Southwestern, has been elected to the National Academy of Medicine (NAM), one of the highest honors in the fields of health and medicine.
Mia Levy, MD, PhD, Appointed Director of the Rush University Cancer Center
Rush University Medical Center
Mia Levy, MD, PhD, a practicing oncologist and nationally-recognized leader in biomedical informatics, has been appointed director of the Rush University Cancer Center.
Function of Neutrophils During Tumor Progression Unraveled
Wistar Institute
Wistar researchers have characterized the function of neutrophils, a type of white blood cells, during early stages of tumor progression, showing that they migrate from the bone marrow to distant sites and facilitate tumor cell seeding and establishment of metastasis.
More Clues Revealed in Link Between Normal Breast Changes and Invasive Breast Cancer
Georgetown University Medical Center
A research team, led by investigators from Georgetown Lombardi Comprehensive Cancer Center, details how a natural and dramatic process -- changes in mammary glands to accommodate breastfeeding -- uses a molecular process believed to contribute to survival of pre-malignant breast cells.
Dompe at the medical conference "The Impact of Environment and Healthy Lifestyles in Human Health" - October 13th, Washington, D.C
Sbarro Health Research Organization (SHRO)
Sbarro Health Research Organization, on the occasion of the medical conference "The impact of environment and healthy lifestyles in human health," honoured Nathalie Dompe, CEO Dompe Holdings, with a special Award for Societal Impact in Business & Biotechnology, for her work and effort in promoting social responsibility.
University Hospitals Seidman Cancer Center Becomes First in U.S. To Use Newly FDA-Approved Drug That Makes Brain Tumors Glow Hot Pink
University Hospitals Cleveland Medical Center
Dr. Andrew Sloan of University Hospitals Seidman Cancer Center becomes first neurosurgeon to use 5-ALA in the U.S. following its FDA approval for brain cancer surgery.
Is the Next Big Step in Cancer Therapy Personalized Vaccines?
University of California San Diego Health
Tamara Strauss has been living with high-grade, stage IV pancreatic neuroendocrine cancer for more than three years. Current treatments, although effective for her, are highly toxic. Tamara enrolled in a first-of-its-kind, pilot study at Moores Cancer Center at UC San Diego Health to test a personalized vaccine using her unique cancer mutations to boost an anti-tumor immune response.
Cancer Stem Cells Use "Normal" Genes in Abnormal Ways
University of Colorado Cancer Center
University of Colorado Cancer Center study shows that "normal" gene CDK1 interacts with "abnormal" gene Sox2 to keep cancer stem cells "stemmy."
Ethanol Injection a Viable Treatment Option for Some Thyroid Problems
Wake Forest Baptist Medical Center
Ultrasound-guided percutaneous ethanol ablation for thyroid conditions is a minimally invasive procedure that is quick and cost-effective, with side effects about the same as those of a flu shot.
Cedars-Sinai Expert Joins Team Researching Rare Blood Cancer
Cedars-Sinai
Ronald Paquette, MD, clinical director of the Cedars-Sinai Blood & Marrow Transplant Program at the Samuel Oschin Comprehensive Cancer Institute, recently was accepted as a member of the Myeloproliferative Neoplasm Research Consortium. The group is funded by the National Cancer Institute.
New Clinical Trials Seek Treatments for Canine Cancers, May Offer Clues on Human Cancers
Tufts University
Two studies into deadly cancers in dogs are now underway, offered through the newly formed Clinical Trials Office at Cummings Veterinary Medical Center at Tufts University. Dogs with spontaneous osteosarcoma, as well as dogs with mast cell tumors and solid tumors, may be eligible for enrollment.
Modeling how genes are expressed in specific cell types
South Dakota State University
A computational model that can track how genes are expressed in each cell type within tissue may help scientists unravel how diseases, such as cancer, progress and how they evade treatment.
Cancer Patients with Rare Deadly Brain Infection Treated Successfully with Off-the-Shelf Adoptive T-Cell Therapy in Clinical Trial
University of Texas M. D. Anderson Cancer Center
An emerging treatment known as adoptive T-cell therapy has proven effective in a Phase II clinical trial for treating progressive multifocal leukoencephalopathy (PML), a rare and often fatal brain infection sometimes observed in patients with cancer and other diseases in which the immune system is compromised. The study, led by Katy Rezvani, M.D., Ph.D., professor, Department of Stem Cell Transplantation and Cellular Therapy at The University of Texas MD Anderson Cancer Center, showed marked improvement in three PML patients infused with donor T cells targeting the BK virus. Findings were published in the Oct. 11 online issue of the New England Journal of Medicine.
More Than $41,000 Raised for Skin Cancer Prevention and Detection Through "Skin Cancer, Take a Hike!(tm) - Chicago"
American Academy of Dermatology
On Sat., Sept. 29, more than 200 dermatologists, skin cancer survivors and their families and friends hiked four miles at Busse Woods to tell "Skin Cancer, Take a Hike!" Together, they raised more than $41,000 for SPOT Skin Cancer(tm) to benefit the American Academy of Dermatology's skin cancer prevention and detection programs, including free skin cancer screenings, sunscreen dispensers, and permanent shade structures where children learn and play.
What does it mean if you have dense breasts? Breast density describes different kinds of tissue that show on your mammogram.
University Hospitals Cleveland Medical Center
New study finds that inflammatory proteins in the colon increase incrementally with weight
Tufts University
A new study from Tufts researchers finds that two inflammatory proteins in the colon increase incrementally with weight. In individuals with obesity, this was accompanied by activation of precancerous cellular pathways.
NIH awards WVU $11.2 million for interdisciplinary cancer research
West Virginia University
West Virginia University's School of Pharmacy will soon become one of the few pharmacy schools in the nation that leads a center of biomedical research excellence.
Expansion of HPV Vaccine in Adults -- @UCSDHealth experts are available to discuss HPV, the vaccine and cancer prevention
University of California San Diego Health
Crosstalk between fallopian tube, ovary may drive the spread of ovarian cancer
University of Illinois at Chicago
New research shows that cancer cells in the fallopian tube affect normal chemical signaling between reproductive tissues and stimulate the release of norepinephrine from the ovary, causing cancer cells to migrate.