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Four myths about colorectal cancer debunked
University of California, Los Angeles (UCLA), Health Sciences
Colorectal cancer is one of the most common cancers in both men and women - but it needn't be. Oncologist Zev Wainberg, MD, debunks four common myths about the disease.
Study Finds Way to Potentially Improve Immunotherapy for Cancer
Cedars-Sinai
EMBARGOED: A new study has identified a drug that potentially could make a common type of immunotherapy for cancer even more effective. The study in laboratory mice found that the drug dasatinib, which is FDA-approved to treat certain types of leukemia, greatly enhances responses to a form of immunotherapy that is used against a wide range of other cancers.
Hospital staff, community to go bald for cancer research
University of Illinois at Chicago
The Children's Hospital University of Illinois will host an annual head-shaving event to raise money for the St. Baldrick's Foundation on Feb. 22.
New Method to Detect Cancer Cells Faster, Potentially Improving Outcomes
Purdue University
The days - or even weeks - spent waiting for the results of a cancer-screening test can feel like an eternity. Especially when early diagnosis and quick action are tied to better outcomes.
Integrating Heart Disease and Cancer Care Could Reduce Overall Health Care Costs, According to Researchers
National Comprehensive Cancer Network(r) (NCCN(r))
Study in JNCCN finds coronary artery disease costs increase dramatically in patients who are diagnosed with cancer.
Study finds melanoma brain metastases are immunosuppressive with treatment-resistant metabolism
University of Texas M. D. Anderson Cancer Center
Melanoma tumors that have spread to the brain are equipped to thwart immunotherapies and targeted therapies that succeed against tumors growing in other sites. Researchers at The University of Texas MD Anderson Cancer Center report in Cancer Discovery that the heavy reliance of these tumors on a specific metabolic pathway presents a potentially new therapeutic against these lethal tumors.
Yale Cancer Center researchers combine targeted therapies to fight head and neck cancers
Yale Cancer Center
Yale Cancer Center researchers have identified a potential therapy that combines two types of molecularly targeted drugs to produce a synergistic effect against head and neck cancer.
Jobs vs. death toll: Calculating corporate death penalties
Michigan Technological University
What misdeeds warrant corporate death penalties? A new study explores two case studies focused on industries that kill more people than they employ. The study lays out the rationale for establishing an actionable threshold and offers insights into solutions. Using case studies in coal and tobacco, it calculates the number of deaths attributed to the coal and tobacco industries and finds surprising results.
Researchers Develop New One-Two Punch Against Melanoma in Mouse Model
Johns Hopkins Medicine
Researchers at the Bloomberg~Kimmel Institute for Cancer Immunotherapy at Johns Hopkins and the Johns Hopkins University School of Medicine report two new forms of an older anti-cancer agent they developed appear to enhance the immune system's ability to fight melanoma in mice. The agents, dubbed s-DAB-IL-2 and s-DAB-IL-2(V6A), comprise a regulatory protein called human interleukin-2 fused to chemically modified portions of diphtheria toxin.
Researchers Key to Advance Care Planning With Cancer Clinical Trial Patients
University of Pennsylvania School of Nursing
Cancer clinical trials are an important option for patients with cancer. Yet, once a trial ends, patients still need care plans. Little is known at what point during clinical trial transitions to initiate advance planning discussions or how to educate research teams to communicate with and prepare patient-participants and their families for the next steps after they leave a cancer clinical trial.
Great White Shark Genome Decoded
Nova Southeastern University
Researchers studying genome of Great White Shark to see what secrets may be applicable to the human condition
Mimicking Metastasis in a Dish
University of Kansas Cancer Center
Researchers at The University of Kansas Cancer Center have developed a first-of-its-kind organoid that mirrors the process of cancer spreading to the lung.
New Project Seeks Enhanced Lung Disease Care in Appalachia
University of Virginia Health System
A new program will use telehealth to bring together a University of Virginia Health System team with primary care providers in the Appalachian region of Virginia to improve lung disease prevention, diagnosis and treatment. UVA will partner with Stone Mountain Health Services and The Health Wagon - which serve patients in Wise, Russell, Dickenson, Washington, Buchanan, Lee, Smyth, and Russell counties - with the support of a $10,000 National Science Foundation Grant.
Small cell lung cancer may respond to combination of immunotherapy and DNA damage repair inhibitors
University of Texas M. D. Anderson Cancer Center
Researchers at The University of Texas MD Anderson Cancer Center have discovered that a combination of immune checkpoint blockade and targeted therapies that block normal DNA damage repair (DDR) achieved significant tumor regression in mouse models of small cell lung cancer (SCLC), suggesting a promising new approach for treating patients with this aggressive cancer.
Drug combination may become new standard treatment for advanced kidney cancer
Dana-Farber Cancer Institute
A combination of two drugs - one of them an immunotherapy agent - could become a new standard, first-line treatment for patients with metastatic kidney cancer, says an investigator from Dana-Farber Cancer Institute, reporting results from a phase 3 clinical trial.
Novel App Uses AI to Guide, Support Cancer Patients
Georgia Institute of Technology
Artificial Intelligence is helping to guide and support some 50 breast cancer patients in rural Georgia through a novel mobile application that gives them personalized recommendations on everything from side effects to insurance.
Next Generation Precision Oncology Symposium Celebrates Survivors, Current and Future
University of California San Diego Health
The Next Generation Precision Oncology Symposium, a novel meeting of industry and academic leaders in cancer science and medicine, will be held February 21, 2019 at UC San Diego Moores Cancer Center.
Genetic testing of women diagnosed with breast cancer could be "impactful." @LombardiCancer medical oncologist reacts to new guidelines issued by breast surgeons' organization.
Georgetown Lombardi Comprehensive Cancer Center
Notre Dame expert Graham Peaslee is available to speak to the EPA's announcement to reduce exposure to PFAS.
University of Notre Dame
The Medical Minute: Helping caregivers address mental health concerns
Penn State Health
Caregiver jobs often come loaded with pressures. In fact, caregivers face a higher risk of developing a mental health disorder because of the stress that can accompany taking care of others.
Genetic Variations in a Fourth Gene Linked to Elevated Leukemia Risk in Hispanic Children
St. Jude Children's Research Hospital
St. Jude Children's Research Hospital scientists have completed one of the largest studies yet designed to advance understanding of why Hispanic children are more likely to develop leukemia and less likely to survive
"They made me feel like a person": Palliative care counseling changes lives for patients, families
University of Alabama at Birmingham
The psychosocial care team helps patients and their caregivers and family members address issues including managing distress, depression, anxiety or post-traumatic stress associated with diagnoses and treatments. The team also helps patients and caregivers to feel less overwhelmed and more in control, as well as improving self-care and communication with loved ones and their health care providers.
UW study: Exposure to chemical in Roundup increases risk for cancer
University of Washington
Exposure to glyphosate--the world's most widely used, broad-spectrum herbicide and the primary ingredient in the weedkiller Roundup--increases the risk of some cancers by more than 40 percent, according to new research from the University of Washington.
Researchers Develop Reversible, Drug-Free Antiplatelet Therapy to Fight Dangerous Blood Clots and Cancer Metastasis
George Washington University
A new reversible, drug-free antiplatelet therapy could reduce the risk of blood clots and potentially prevent cancer metastasis, according to a study published today in Science Translational Medicine.
St. Jude Children's Research Hospital Honored as Recipient of the 2019 Microsoft Health Innovation Award
St. Jude Children's Research Hospital
St. Jude Children's Research Hospital has been named a recipient of Microsoft Corp.'s 2019 Health Innovation Award for the St. Jude Cloud, a data-sharing resource for the global research community that gives scientists immediate access to genomics data that previously could take weeks to download.
New research findings could be key to improving outcomes for some brain cancers
Michigan Medicine - University of Michigan
Researchers from the University of Michigan Rogel Cancer Center have found that a genetic mutation seen in about half of all brain tumors produces a response that prevents radiation treatment from working. Altering that response using FDA-approved drugs restores tumors' sensitivity to radiation therapy, extending survival in mice.
Supercomputing Effort Reveals Antibody Secrets
Vanderbilt University Medical Center
Using sophisticated gene sequencing and computing techniques, researchers at Vanderbilt University Medical Center (VUMC) and the San Diego Supercomputer Center have achieved a first-of-its-kind glimpse into how the body's immune system gears up to fight off infection.
Noninvasive Liquid Biopsies Rapidly, Accurately Determine Response to Cancer Treatment
Johns Hopkins Medicine
Results of two clinical studies have added to evidence that blood-based liquid biopsies can accurately track lung cancer treatment responses by measuring circulating tumor DNA (ctDNA) during immunotherapy and related treatments.
Bioluminescent Deep-Sea Creatures Illuminate the Effectiveness of New Cancer Therapies
University of Southern California (USC) Health Sciences
A new tool from the Keck School of Medicine of USC can improve development and effectiveness of leading-edge cancer therapies derived from patients' immune systems.
How breast tissue stiffening promotes breast cancer development
University of California San Diego
By examining how mammary cells respond in a stiffness-changing hydrogel, researchers discovered that several pathways work together to signal breast cells to turn cancerous. The work could inspire new approaches to treating patients and inhibiting tumor growth.
USC Norris Comprehensive Cancer Center Names Caryn Lerman as New Director
University of Southern California (USC) Health Sciences
USC Norris Comprehensive Cancer Center names Caryn Lerman as new director to bolster interdisciplinary science and leverage the cancer center's entrepreneurial spirit
Ora-curcumin formulation on its way to health product market
South Dakota State University
A unique formulation will allow the development of nutraceutical products by increasing the bioavailability of curcumin, a powerful anti-inflammatory, through the start-up company Turmeric Ultra Inc.
Lymph Node Removal Procedure as First-Line Treatment for Testicular Seminoma Associated with Favorable Survival Rates
Rutgers Cancer Institute of New Jersey
Investigators at Rutgers Cancer Institute of New Jersey have found that a surgical procedure, when used as a first-line therapy for a form of testicular cancer known as seminoma, is associated with favorable survival rates.
Some Primary Care Doctors Not Prepared to Help with Cancer Treatment Decisions
Michigan Medicine - University of Michigan
Research has shown patients are discussing initial cancer treatment options with their primary care doctors. And now a new study finds that a significant number of these physicians report notable gaps in their knowledge of cancer treatment options.
University of Minnesota researchers 3D bio-print a model that could improve anticancer drugs and treatments
University of Minnesota College of Science and Engineering
University of Minnesota medical researchers and engineers have developed a way to study cancer cells which could lead to new and improved treatment. They have developed a new way to study these cells in a 3D in vitro model (i.e. in a culture dish rather than in a human or animal).
Study Finds Upsurge in 'Active Surveillance' for Low-Risk Prostate Cancer
Dana-Farber Cancer Institute
Many men with low-risk prostate cancer who most likely previously would have undergone immediate surgery or radiation are now adopting a more conservative "active surveillance" strategy, according to an analysis of a new federal database by scientists from Dana-Farber Cancer Institute.
Scientists to Test Light Therapy as Relief From Painful Side Effect of Cancer Treatment
University at Buffalo
University at Buffalo researchers have received part of a $1.5 million grant to investigate light therapy as a replacement for prescription opioids in treating oral mucositis, painful ulcers and swelling in the mouth that result from chemotherapy and radiation treatment for cancer.
NYU Langone Hospital-Brooklyn Addresses Growing Need for Specialized Gastrointestinal Treatment in the Borough
NYU Langone Health
Sam Serouya, MD, joins NYU Langone Hospital-Brooklyn as a gastroenterologist specializing in advanced therapeutic endoscopy to better detect and evaluate digestive disorders and diseases.
University of Maryland Thoracic Surgeons Identify Lymph Nodes That May Help To Determine Prognosis for Patients with Pleural Mesothelioma
University of Maryland Medical Center/School of Medicine
University of Maryland School of Medicine (UMSOM) surgeons have identified a group of lymph nodes in the chest that appear highly significant in predicting the prognosis for patients with malignant pleural mesothelioma - a deadly cancer of the chest lining that is usually caused by asbestos. The researchers found that the presence of cancer in these lymph nodes increased the risk of recurrence or death more than two-fold in patients undergoing surgery for mesothelioma, according to new research presented recently week at the Society of Thoracic Surgeons (STS) annual meeting in San Diego, Calif.
Immunotherapy can be effective in treating people with recurrent glioblastoma
University of California, Los Angeles (UCLA), Health Sciences
A UCLA-led study suggests that for people with recurrent glioblastoma, administering an immunotherapy drug before surgery is more effective than using the drug afterward.
New therapeutic target found for aggressive pediatric cancers with few treatment options
University of Texas M. D. Anderson Cancer Center
Researchers at The University of Texas MD Anderson Cancer Center have discovered that malignant rhabdoid tumors (MRT), a rare pediatric cancer without effective treatments, may be sensitive to drugs that block the cancer cell's ability to dispose of misfolded proteins. The findings provide a much-needed therapeutic target for these and other cancers caused by mutations in the SMARCB1 gene.
CFN User Spotlight: Morgan Huse Measures the Mechanical Forces Generated by Immune Cells
Brookhaven National Laboratory
Immunologist Morgan Huse of Memorial Sloan Kettering Cancer Center takes advantage of the microfabrication tools and electron microscopes at the CFN to generate micropatterned elastic surfaces composed of flexible micropillars that he then uses to measure the mechanical forces exerted by T cells.
Shorter Course of Radiation Therapy Effective in Treating Men with Prostate Cancer
University of California, Los Angeles (UCLA), Health Sciences
A new UCLA-led study shows that men with low- or intermediate-risk prostate cancer can safely undergo higher doses of radiation over a significantly shorter period of time and still have the same, successful outcomes as from a much longer course of treatment.
Researchers develop human cell-based model to study small cell lung cancer
The Rockefeller University Press
Researchers from Weill Cornell Medicine have used human embryonic stem cells to create a new model system that allows them to study the initiation and progression of small cell lung cancer (SCLC). The study, which will be published February 8 in the Journal of Experimental Medicine, reveals the distinct roles played by two critical tumor suppressor genes that are commonly mutated in these highly lethal cancers.
Blood Cells Could Hold Master Clock Behind Aging
Case Western Reserve University
Blood cells could hold the key to aging, according to new research out of Case Western Reserve University School of Medicine. In a study published in Aging Cell, researchers found human blood cells have an intrinsic clock that remains steady even after transplant. The researchers say the clock could control human aging and may underlie blood cancers.
Immunotherapy Appears Better Than Chemotherapy for Aggressive Type of Skin Cancer
Johns Hopkins Medicine
The first study of the immunotherapy drug pembrolizumab as the initial treatment for patients with a rare but aggressive form of skin cancer known as Merkel cell carcinoma reports better responses and longer survival than expected with conventional chemotherapy.
Circular RNA Holds Promise as Cancer Biomarker
Michigan Medicine - University of Michigan
Researchers at the University of Michigan Rogel Cancer Center have cataloged circular RNA in multiple cancers and conducted initial research that suggests these stable structures could serve as cancer biomarkers in blood or urine.
Case Study Documents Bone Cancer in 240-Million-Year-Old Stem-Turtle
JAMA - Journal of the American Medical Association
This research letter documents bone cancer in a 240-million-year-old stem-turtle from the Triassic period, helping to provide more data about the history of cancer in tetrapod evolution. This is a case study about a highly malignant bone tumor on the femur of a shell-less stem-turtle. The appearance of the tumor in the fossilized specimen conforms with present-day periosteal osteosarcoma in humans.
Aspirin to Prevent Colon Cancer Underutilized in High Risk Patients
Florida Atlantic University
The U.S. Preventive Services Task Force concluded that aspirin reduces the risk of colorectal cancer by 40 percent as well as recurrence of advanced polyps, which are a major risk factor. To explore whether high risk patients are adhering to USPSTF guidelines, FAU researchers analyzed data from structured interviews with 84 patients and found that less than half (42.9 percent) reported taking aspirin. These findings pose major challenges that require multifactorial approaches by physicians and patients.
Jersey Shore University Medical Center Launches High Risk Genetics Clinic Targeting Cancer Risk Assessment
Hackensack Meridian Health
Hackensack Meridian Health Jersey Shore University Medical Center now offers one of the only comprehensive High Risk Genetics Clinics in the region. The clinic provides support for men, women and families who are predisposed to cancer causing genes, or are currently living with cancer.
Nullifying protein YTHDF1 enhances anti-tumor response
University of Chicago Medical Center
Identifying molecular pathways that boost the immune response to tumor neoantigens opens up new ways to develop and amplify cancer immunotherapy.
The Hoffberger Breast Center at Mercy Receives Renewal of NAPBC Accreditation
Mercy Medical Center, Baltimore
The Hoffberger Breast Center at Mercy has been granted a 3-year, Full Accreditation renewal by the National Accreditation Program for Breast Centers (NAPBC), marking 10 years Mercy's center has held this designation.
UI Cancer Center Teams with Wellness House on Survivorship Programs
University of Illinois at Chicago
Free supportive therapy and survivorship programs now offered in Chicago, thanks to a collaboration between Wellness House and the University of Illinois Cancer Center.
UC San Diego Health Expands Leading-Edge Cancer Care in Hillcrest
University of California San Diego Health
To make it easier for patients to receive world-class cancer care, UC San Diego Health has added a new multidisciplinary cancer clinic in Hillcrest and expanded its infusion center for both oncology patients and others in need of infusion services.
Tree of life: Poplar studies yield human cancer insights
Oak Ridge National Laboratory
While studying the genes in poplar trees that control callus formation, scientists at Oak Ridge National Laboratory have uncovered genetic networks at the root of tumor formation in several human cancers.
Dr. Prateek Sharma Named President of International Society for Diseases of the Esophagus
University of Kansas Cancer Center
Prateek Sharma, MD, gastroenterologist and member of The University of Kansas Cancer Center, has been named president of The International Society for Diseases of the Esophagus (ISDE). The ISDE is a multidisciplinary international organization comprised of approximately 1,000 esophageal disease experts.
Study links protein, clusterin, to cardiac and metabolic diseases
Houston Methodist
During a study spanning nearly a decade, researchers at The Ohio State University College of Medicine, Houston Methodist Research Institute and Houston Methodist Cancer Center have linked the protein clusterin - for the first time -- to many different facets of cardiometabolic syndrome risk through its actions in the liver.
On World Cancer Day, National Comprehensive Cancer Network Announces National Endorsements for Guidelines to Improve Cancer Care in Sub-Saharan Africa
National Comprehensive Cancer Network(r) (NCCN(r))
The National Comprehensive Cancer Network(r) (NCCN(r)) announces formal endorsements from the governments of Ethiopia, Nigeria, and Tanzania for the NCCN Harmonized Guidelines(tm) for Sub-Saharan Africa, while joining cancer leaders across the globe to raise awareness and take action for World Cancer Day on February 4.
Leaders meet in Colorado to set research agenda for early-onset colorectal cancer
University of Colorado Cancer Center
While overall rates of colorectal cancer are down, the rate of young people getting the disease is up 22 percent over two decades. International leaders meet in Colorado to set the research agenda to figure out why.
Commonly Used Anti-Rejection Drug Could be Repurposed to Treat Some Liver Cancers
Health Sciences at the University of Pittsburgh
Research in animal models suggest that liver cancers with a mutation in the β-catenin gene could respond to treatment with rapamycin, a commonly used immunosupressant.
Opposite Effect: Protein Widely Known to Fight Tumors Also Boosts Cancer Growth
University of California San Diego
UC San Diego researchers studying p53, the heralded cancer-fighting "guardian of the genome," have found that the human protein also plays a role in promoting tumors, in addition to suppressing them.
High-dose radiation therapy improves long-term survival in patients with stage-IV cancers, trial finds
American Society for Radiation Oncology (ASTRO)
The first report from a phase II, multi-center clinical trial indicates that a newer, more aggressive form of radiation therapy -- stereotactic radiation -- can extend long-term survival for some patients with stage-IV cancers while maintaining their quality of life. The study is published in the January issue of International Journal of Radiation Oncology * Biology * Physics (Red Journal), the flagship scientific journal of the American Society for Radiation Oncology (ASTRO).
Big fat lies about obesity: ASU professor says health risks of obesity have been exaggerated
Arizona State University (ASU)
FSU Team Breaks New Ground in Study of Malignant Pediatric Brain Tumor
Florida State University
FSU researchers identified a series of cancer-causing driver gene mutations and discovered that medulloblastoma is perhaps an even more dynamic and variable tumor than expected.
Many Women Get Unnecessary Mammograms Before Breast Reduction Surgery
Michigan Medicine - University of Michigan
Getting a mammogram before breast reduction surgery is not required or recommended. But thousands of young women with no known breast cancer risk still get them, a Michigan Medicine study shows.
Translating Patient Feedback Into Better Cancer Treatments
Cedars-Sinai
New experimental cancer treatments are raising hopes among clinicians and patients for longer survival times and cures. But clinical trials that test such treatments also need to analyze the impact on patients of potentially harsh side effects, known as adverse events. A major new study now underway aims to better incorporate patient feedback into clinical trials that help determine which new cancer treatments will be approved for use.
Minoff Family makes visionary gift to University Hospitals
University Hospitals Cleveland Medical Center
The Minoff Family of Northeast Ohio has made a generous gift to the University Hospitals system. In their honor, UH will rename one of its health centers to the Minoff Health Center at Chagrin Highlands.
John Theurer Cancer Center Leading Enrollment for Global Phase 2 WIZARD Study Evaluating DSP-7888 in Patients with Recurrent Glioblastoma
Hackensack Meridian Health
John Theurer Cancer Center at Hackensack Meridian Health Hackensack University Medical Center announced today that it is leading enrollment worldwide for WIZARD 201G, a global Phase 2 study in glioblastoma (GBM). The trial, sponsored by Boston Biomedical, is evaluating DSP-7888, an investigational cancer vaccine, in combination with bevacizumab for recurrent disease.
OCTN: A Small Transporter Subfamily with Great Relevance to Human Pathophysiology, Drug Discovery and Diagnostics
SLAS (Society for Laboratory Automation and Screening)
A new review by researchers from the University of Calabria (Italy) explores OCTNs, a small but intriguing group of transporters that are opening new frontiers in drug design research for improving drug delivery and predicting drug-drug interactions.
Innovative Ice-Free Scalp Cooling During Chemotherapy Prevents, Reduces Hair Loss for Breast Cancer Patients
Henry Ford Health System
Breast cancer patient Laura Carey returned to work one week after beginning chemotherapy, but without a demoralizing side-effect indicative of this type of cancer treatment - hair loss. Carey is among the first breast cancer patients at the Henry Ford Cancer Institute to successfully prevent and reduce hair loss during chemotherapy by using an ice-free cooling cap system, called Paxman. Dr. Haythem Ali explains more about this innovative treatment option, and what it means for breast cancer patients like Laura.
National Comprehensive Cancer Network Updates Resources for Improving Cancer Care in the Middle East & North Africa
National Comprehensive Cancer Network(r) (NCCN(r))
The National Comprehensive Cancer Network(r) (NCCN(r)) has published updated resources for improving and facilitating quality, effective, efficient, and accessible cancer care in the Middle East and North Africa (MENA).
Novel endoscopy tool opens new doors for pancreatic cancer treatment
Penn State College of Engineering
A significantly more effective, minimally invasive treatment for pancreatic tumors may be on the horizon, thanks to a new endoscopy tool created in the Penn State Department of Mechanical Engineering.
Eleven Health Screening Tests Every Woman Should Have
University Hospitals Cleveland Medical Center
A list of screening tests for women recommended by family medicine specialist Lili Ann Lustig, DO, of University Hospitals.
Targeting an 'Energy Crisis' in the Treatment of Non-Small Cell Lung Cancer
Rutgers Cancer Institute of New Jersey
Research from Rutgers Cancer Institute of New Jersey examined a potential approach to cancer therapy that disrupts a cancer cell's 'fuel supply' by targeting a cellular survival mechanism known as autophagy. Using laboratory models for LKB1-deficient KRAS-mutant non-small cell lung cancer, they found that autophagy ablation reduced the frequency of tumor initiation and tumor growth in Lkb1-deficient lung tumors.
TTP El Paso ALS Clinics Complete First Year of Service
Texas Tech University Health Sciences Center El Paso
Few words can be as surprising and heartbreaking as when a doctor tells a patient, "I wish I could tell you that you have cancer, because at least we could do something about that."
MD Anderson study shows FGL2 protein may be an effective target for glioblastoma
University of Texas M. D. Anderson Cancer Center
Glioblastoma (GBM) does not attract robust T cell immune responses. FGL2 is highly expressed in GBM and when present in tumor cells, controls a specialized group of dendritic cells which activates T cells.
Study Suggests Aspirin May Help Some Patients Survive Head and Neck Cancer
The Rockefeller University Press
Regular use of aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs) may help some patients with head and neck cancer survive the disease, according to a study led by Professor Jennifer Grandis at the University of California, San Francisco. The study, which will be published January 25 in the Journal of Experimental Medicine, indicates that NSAIDs are effective in patients with mutations in a gene called PIK3CA, likely by lowering the levels of an inflammatory molecule called prostaglandin E2.
Exploring Targeted Therapy for Non-Small Cell Lung Cancer
Rutgers Cancer Institute of New Jersey
Rutgers Cancer Institute of New Jersey researcher Sharon R. Pine, PhD, has received a $200,000 Lung Cancer Discovery Award from the American Lung Association to examine potential new treatment options for patients with a sub-type of non-small cell lung cancer.
Announcing the 2018 SLAS Technology Ten: Translating Life Sciences Innovation
SLAS (Society for Laboratory Automation and Screening)
The SLAS Technology Ten annually showcases ten individual articles that stand out as the most innovative scientific achievements published in SLAS Technology in the past 12 months.
New findings may help oncologists determine effectiveness of checkpoint inhibitors
University of Alabama at Birmingham
In an article recently published in JCI Insight, researchers from the University of Alabama at Birmingham and Vanderbilt University have identified checkpoint inhibitor resistance mechanisms in many solid tumor cancers, including melanoma, lung cancer and breast cancer.
UC San Diego Researchers First to Use CRISPR/Cas9 to Control Genetic Inheritance in Mice
University of California San Diego
Using active genetics technology, UC San Diego biologists have developed the world's first CRISPR/Cas9-based approach to control genetic inheritance in a mammal. The achievement in mice lays the groundwork for further advances based on this technology, including biomedical research on human disease.
Gene-Expression Profiling Raises Costs for Cancer Care without Improving Outcomes for Low-Risk Breast Cancer Patients, According to Researchers
National Comprehensive Cancer Network(r) (NCCN(r))
Researchers from Yale School of Public Health find that genetic profiling for cancer tumors is cost-effective for high- and medium-risk patients with breast cancer, but is unlikely to make a meaningful impact on treatment for low-risk patients, in study published in January 2019 issue of JNCCN-Journal of the National Comprehensive Cancer Network
Targeted treatment shrinks deadly pediatric brain tumors
Sanford Burnham Prebys Medical Discovery Institute
For children--whose tiny bodies are still growing--chemotherapy and radiation treatments can cause lifelong damage. Now, scientists at Sanford Burnham Prebys Medical Discovery Institute (SBP) have reported that a targeted therapy that blocks a protein called LSD1 was able to shrink tumors in mice with a form of pediatric brain cancer known as medulloblastoma. LSD1 inhibitors are currently under evaluation in clinical trials for other cancers. The study was published in Nature Communications.
Study Shows Low-Sugar Diet Effective in Boys with Nonalcoholic Fatty Liver Disease
University of California San Diego Health
Researchers at University of California San Diego School of Medicine found that a diet low in free sugars (those added to foods and beverages and occurring naturally in fruit juices) resulted in significant improvement in nonalcoholic fatty liver disease (NAFLD) in adolescent boys.
Test for Esophageal Cancer Could Save Millions of Lives
Johns Hopkins Medicine
Cancer of the esophagus claims more than 400,000 lives around the world each year. With no efficient, reliable method of screening for the disease, by the time symptoms become apparent, it's often too late to save the patient.
Intermountain Precision Genomics Program Unveils New Myeloid Malignancies Panel to Help Clinicians More Accurately Classify Risk and Treatment for Patients
Intermountain Healthcare
Intermountain Healthcare Precision Genomics has developed a new gene panel that will provide clinical utility to classify and diagnose certain types of blood cancers.
Heating Up Cold Tumors
Ludwig Cancer Research
A Ludwig Cancer Research study has uncovered a cellular mechanism by which melanomas that fail to respond to checkpoint blockade may be made susceptible to such immunotherapies. Led by Ping-Chih Ho of the Lausanne Branch of the Ludwig Institute for Cancer Research and reported in the current issue of Nature Immunology, the study also identifies an existing diabetes drug that could be used to accomplish that feat.
Energizing the Immune System to Eat Cancer
Perelman School of Medicine at the University of Pennsylvania
Researchers at the Abramson Cancer Center of the University of Pennsylvania say they've identified how to fuel macrophages with the energy needed to attack and eat cancer cells.
No substantial benefit from transplantation reported for a high-risk leukemia subtype
St. Jude Children's Research Hospital
Study led by St. Jude Children's Research Hospital found treatment guided by measuring minimal residual disease was associated with better outcomes for hypodiploid acute lymphoblastic leukemia patients
NCI awards $1.7 million to UIC for research on Southeast Asian fruit
University of Illinois at Chicago
A new $1.7 million grant from the National Cancer Institute will enable researchers at the University of Illinois at Chicago to study the fruit and its potential as a treatment for prostate cancer.
Can Drinking Oolong Tea Help Prevent Breast Cancer?
Saint Louis University Medical Center
SLU scientists and their colleagues have found that oolong tea can damage breast cancer cells and inhibit the growth and progression of tumors in the lab, potentially offering a non-toxic strategy to prevent breast cancer.
UCLA scientists create a renewable source of cancer-fighting T cells
University of California, Los Angeles (UCLA), Health Sciences
A study by UCLA researchers is the first to demonstrate a technique for coaxing pluripotent stem cells -- which can give rise to every cell type in the body and which can be grown indefinitely in the lab -- into becoming mature T cells capable of killing tumor cells.
Low-Intensity Electric Fields Applied to Scalp Can Stop, Slow Growth of Tumor Cells in Newly-Diagnosed Glioblastoma
Henry Ford Health System
Henry Ford Cancer Institute is one of the few cancer programs in Southeast Michigan fighting the most common and deadly brain cancer with tumor-treatment fields, a low-intensity alternating electric field applied with a wearable device that stops or slows the growth of tumor cells in patients with newly diagnosed glioblastoma (GBM).
Child survivors of Hodgkin lymphoma have increased risk of second cancer
University of Alabama at Birmingham
Survivors of childhood Hodgkin lymphoma are at an increased risk of developing an entirely new cancer later in life, according to new research published in Cancer -- the American Cancer Society's international peer-reviewed scientific journal -- and conducted at University of Alabama at Birmingham.
Whole Genome Sequencing Method May Speed Personalized Treatment Of Drug-Resistant Infections
Johns Hopkins Medicine
Researchers at Johns Hopkins Medicine say they have added to evidence that rapid resistance gene sequencing technology can accurately speed the identification of specific antibiotic-resistant bacteria strains that sicken and kill some patients. A report on a proof of concept study, published in the January 2019 issue of Antimicrobial Agents and Chemotherapy, suggests the technology has the potential to hasten the "personalized" choice of antibiotics critically ill patients need.
Jean-Pierre Issa, MD, Expert in Cancer Epigenetics, to Lead Coriell Institute for Medical Research as President and CEO
Coriell Institute for Medical Research
Jean-Pierre Issa, MD, a world-renowned expert in the epigenetics of cancer and director of Temple University's Fels Institute for Cancer Research and Molecular Biology, will join the Coriell Institute for Medical Research as its new President and Chief Executive Officer, Coriell's Board of Trustees Chairman Robert Kiep, III, announced today.
Rutgers Scientist Identifies Gene Responsible for Spread of Prostate Cancer
Rutgers University-New Brunswick
A recent study has found that a specific gene in cancerous prostate tumors indicates when patients are at high-risk for the cancer to spread, suggesting that targeting this gene can help patients live longer.
Breast cancer up to 5 times more likely to metastasize even 10 years after childbirth
University of Colorado Cancer Center
University of Colorado Cancer Center study shows that doctors may be underestimating the risk of and thus under-treating stage I and II breast cancers diagnosed within 10 years of childbirth.
Novel Imaging Technology May Help Reduce Biopsies for Breast Tumors
Washington University in St. Louis
Scientists at Washington University in St. Louis plan to use a new imaging technique to get a better look at breast tumors and reduce unnecessary biopsies.
Acupressure relieves long-term symptoms of breast cancer treatment, study finds
Michigan Medicine - University of Michigan
A new study finds acupressure could be a low-cost, at-home solution to a suite of persistent side effects that linger after breast cancer treatment ends.