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Vast Leukemia Dataset Could Help Researchers Match Therapies to Patients
Howard Hughes Medical Institute (HHMI)
Data on the molecular makeup and drug sensitivity of hundreds of patient samples could accelerate progress against the aggressive blood cancer acute myeloid leukemia.
The Association of American Cancer Institutes Appoints New Executive Director
Association of American Cancer Institutes (AACI)
Jennifer W. Pegher, MA, is the new executive director of the Association of American Cancer Institutes. She is the second executive director in AACI's 19-year history, succeeding founding executive director Barbara Duffy Stewart, who retired earlier this month.
Cellular clean-up crews linked to how body handles sugar
University of Chicago
How our bodies handle glucose--the simple sugar that provides energy from the food we eat--appears to be intertwined with how cells keep themselves functioning normally, according to new University of Chicago research.
ISPOR Publishes New Report on the Application of Constrained Optimization Methods in Healthcare
ISPOR--The Professional Society for Health Economics and Outcomes Research
ISPOR--the professional society for health economics and outcomes research (HEOR), has published a new Good Practices for Outcomes Research Report that illustrates how constrained optimization methods can be used to assess the value of health technologies.
Rutgers Cancer Institute of New Jersey Biospecimen Repository and Histopathology Service Shared Resource Receives Accreditation from College of American Pathologists
Rutgers Cancer Institute of New Jersey
The Biospecimen Repository and Histopathology Service shared resource at Rutgers Cancer Institute of New Jersey has received accreditation from the College of American Pathologists (CAP) based on results of a recent on-site inspection as part of the CAP's Accreditation Programs.
Partnership Bolsters Childhood Cancer Research
University of California, Santa Cruz
The Treehouse Childhood Cancer Initiative of the UC Santa Cruz Genomics Institute and Dr. Elaine Mardis with other members of the Nationwide Children's Hospital's Institute for Genomic Medicine (IGM) recently met to bolster an ongoing collaboration focused on pediatric cancer genomics data sharing.
Young Innovators
University of Delaware
A special issue of the journal Cellular and Molecular Bioengineering will recognize assistant professors Emily Day and Jason Gleghorn as Young Innovators, while featuring their latest research.
Stem cell biologist Sean Morrison elected to the National Academy of Medicine
UT Southwestern Medical Center
UT Southwestern Professor Dr. Sean Morrison, Director of the Children's Medical Center Research Institute (CRI) at UT Southwestern, has been elected to the National Academy of Medicine (NAM), one of the highest honors in the fields of health and medicine.
Mia Levy, MD, PhD, Appointed Director of the Rush University Cancer Center
Rush University Medical Center
Mia Levy, MD, PhD, a practicing oncologist and nationally-recognized leader in biomedical informatics, has been appointed director of the Rush University Cancer Center.
Function of Neutrophils During Tumor Progression Unraveled
Wistar Institute
Wistar researchers have characterized the function of neutrophils, a type of white blood cells, during early stages of tumor progression, showing that they migrate from the bone marrow to distant sites and facilitate tumor cell seeding and establishment of metastasis.
More Clues Revealed in Link Between Normal Breast Changes and Invasive Breast Cancer
Georgetown University Medical Center
A research team, led by investigators from Georgetown Lombardi Comprehensive Cancer Center, details how a natural and dramatic process -- changes in mammary glands to accommodate breastfeeding -- uses a molecular process believed to contribute to survival of pre-malignant breast cells.
Dompe at the medical conference "The Impact of Environment and Healthy Lifestyles in Human Health" - October 13th, Washington, D.C
Sbarro Health Research Organization (SHRO)
Sbarro Health Research Organization, on the occasion of the medical conference "The impact of environment and healthy lifestyles in human health," honoured Nathalie Dompe, CEO Dompe Holdings, with a special Award for Societal Impact in Business & Biotechnology, for her work and effort in promoting social responsibility.
University Hospitals Seidman Cancer Center Becomes First in U.S. To Use Newly FDA-Approved Drug That Makes Brain Tumors Glow Hot Pink
University Hospitals Cleveland Medical Center
Dr. Andrew Sloan of University Hospitals Seidman Cancer Center becomes first neurosurgeon to use 5-ALA in the U.S. following its FDA approval for brain cancer surgery.
Is the Next Big Step in Cancer Therapy Personalized Vaccines?
University of California San Diego Health
Tamara Strauss has been living with high-grade, stage IV pancreatic neuroendocrine cancer for more than three years. Current treatments, although effective for her, are highly toxic. Tamara enrolled in a first-of-its-kind, pilot study at Moores Cancer Center at UC San Diego Health to test a personalized vaccine using her unique cancer mutations to boost an anti-tumor immune response.
Cancer Stem Cells Use "Normal" Genes in Abnormal Ways
University of Colorado Cancer Center
University of Colorado Cancer Center study shows that "normal" gene CDK1 interacts with "abnormal" gene Sox2 to keep cancer stem cells "stemmy."
Ethanol Injection a Viable Treatment Option for Some Thyroid Problems
Wake Forest Baptist Medical Center
Ultrasound-guided percutaneous ethanol ablation for thyroid conditions is a minimally invasive procedure that is quick and cost-effective, with side effects about the same as those of a flu shot.
Cedars-Sinai Expert Joins Team Researching Rare Blood Cancer
Cedars-Sinai
Ronald Paquette, MD, clinical director of the Cedars-Sinai Blood & Marrow Transplant Program at the Samuel Oschin Comprehensive Cancer Institute, recently was accepted as a member of the Myeloproliferative Neoplasm Research Consortium. The group is funded by the National Cancer Institute.
New Clinical Trials Seek Treatments for Canine Cancers, May Offer Clues on Human Cancers
Tufts University
Two studies into deadly cancers in dogs are now underway, offered through the newly formed Clinical Trials Office at Cummings Veterinary Medical Center at Tufts University. Dogs with spontaneous osteosarcoma, as well as dogs with mast cell tumors and solid tumors, may be eligible for enrollment.
Modeling how genes are expressed in specific cell types
South Dakota State University
A computational model that can track how genes are expressed in each cell type within tissue may help scientists unravel how diseases, such as cancer, progress and how they evade treatment.
Cancer Patients with Rare Deadly Brain Infection Treated Successfully with Off-the-Shelf Adoptive T-Cell Therapy in Clinical Trial
University of Texas M. D. Anderson Cancer Center
An emerging treatment known as adoptive T-cell therapy has proven effective in a Phase II clinical trial for treating progressive multifocal leukoencephalopathy (PML), a rare and often fatal brain infection sometimes observed in patients with cancer and other diseases in which the immune system is compromised. The study, led by Katy Rezvani, M.D., Ph.D., professor, Department of Stem Cell Transplantation and Cellular Therapy at The University of Texas MD Anderson Cancer Center, showed marked improvement in three PML patients infused with donor T cells targeting the BK virus. Findings were published in the Oct. 11 online issue of the New England Journal of Medicine.
More Than $41,000 Raised for Skin Cancer Prevention and Detection Through "Skin Cancer, Take a Hike!(tm) - Chicago"
American Academy of Dermatology
On Sat., Sept. 29, more than 200 dermatologists, skin cancer survivors and their families and friends hiked four miles at Busse Woods to tell "Skin Cancer, Take a Hike!" Together, they raised more than $41,000 for SPOT Skin Cancer(tm) to benefit the American Academy of Dermatology's skin cancer prevention and detection programs, including free skin cancer screenings, sunscreen dispensers, and permanent shade structures where children learn and play.
What does it mean if you have dense breasts? Breast density describes different kinds of tissue that show on your mammogram.
University Hospitals Cleveland Medical Center
New study finds that inflammatory proteins in the colon increase incrementally with weight
Tufts University
A new study from Tufts researchers finds that two inflammatory proteins in the colon increase incrementally with weight. In individuals with obesity, this was accompanied by activation of precancerous cellular pathways.
NIH awards WVU $11.2 million for interdisciplinary cancer research
West Virginia University
West Virginia University's School of Pharmacy will soon become one of the few pharmacy schools in the nation that leads a center of biomedical research excellence.
Expansion of HPV Vaccine in Adults -- @UCSDHealth experts are available to discuss HPV, the vaccine and cancer prevention
University of California San Diego Health
Crosstalk between fallopian tube, ovary may drive the spread of ovarian cancer
University of Illinois at Chicago
New research shows that cancer cells in the fallopian tube affect normal chemical signaling between reproductive tissues and stimulate the release of norepinephrine from the ovary, causing cancer cells to migrate.
New Options for Breast Cancer Drug Development Found in Estrogen Receptors
Case Western Reserve University
Many breast cancer drugs block estrogen receptors inside cancer cells. Blocking the receptors early in disease progression staves off metastasis. But most patients with advanced disease eventually develop drug resistance, leaving doctors desperate for alternatives. Now, researchers from Case Western Reserve University School of Medicine have uncovered a previously uncharacterized, bridge-like structure within the human estrogen receptor that could serve as a valuable new drug target. In Nature Communications, researchers describe a "burning the bridge" strategy to disrupting the estrogen receptor, and how to screen breast cancer drugs designed to do it.
Navigating Neuroendocrine Tumors
National Comprehensive Cancer Network(r) (NCCN(r))
New NCCN Guidelines for Patients: NET provides background and treatment information for neuroendocrine tumors, the type of cancer experienced by Aretha Franklin and Steve Jobs
Metastatic breast cancer patients report high level of financial impact
University of North Carolina Health Care System
A study led by University of North Carolina Lineberger Comprehensive Cancer Center researchers investigated the extent and severity of negative financial effects of cancer among women with breast cancer that has spread in the body. The preliminary results were presented at the American Society of Clinical Oncology's Quality Care Symposium, held Sept. 28-29 in Phoenix.
New Study Shows Promise for Targeting Breast Cancer Metastasis
University of Kentucky
A new study by University of Kentucky Markey Cancer Center researchers suggests that targeting a protein known as collagen XIII could be key for suppressing breast cancer metastasis.
Ovarian cancer: Symptoms and why it's hard to diagnose
Sanford Health
Ovarian cancer is the presence of malignant cells in the ovaries. There are three types: Epithelial, which are cancers that affect the outer surface of the ovary and comprise 90 percent of ovarian cancers. Stromal tumors in cells that produce the hormones. Tumors in germ cells, which produce the eggs.
High-Precision Proton Therapy More Effective in Treating Certain Cancers When Combined with Thermal Therapy
University of Maryland Medical Center/School of Medicine
The Maryland Proton Treatment Center (MPTC) is now offering deep-tissue external thermal therapy in combination with high-precision proton-beam radiotherapy as a potential way to boost survival chances for certain cancer patients. MPTC is the only center in the world to offer these two treatments at the same facility, an advantage to patients because these therapies are typically given within an hour of each other.
Scripps Research scientist Ben Cravatt receives Outstanding Investigator Award from National Cancer Institute
Scripps Research Institute
The prestigious award will support the Cravatt laboratory with $7.8 million over seven years.
There's a Better Way to Decipher DNA's Epigenetic Code to Identify Disease
Perelman School of Medicine at the University of Pennsylvania
A new method for sequencing the chemical groups attached to the surface of DNA is paving the way for better detection of cancer and other diseases in the blood.
Scorpion census: Researchers update global record of medically significant scorpions
Florida State University
In a new report, researchers documented 104 species spanning dozens of countries, providing a vital update to the global record of medically significant scorpions, or scorpions whose venom could be alternately gravely harmful or medically beneficial to human beings.
New Clinical Advances in Gastroenterology Presented at the American College of Gastroenterology's 83rd Annual Scientific Meeting
American College of Gastroenterology (ACG)
Philadelphia, PA (October 8, 2018) - More than 5,000 gastroenterologists and other health care professionals will convene at the Pennsylvania Convention Center in Philadelphia, PA for the premier clinical gastroenterology event--the American College of Gastroenterology's 83rd Annual Scientific Meeting and Postgraduate Course (ACG 2018)--to review the latest scientific advances in gastrointestinal research, treatment of digestive diseases and clinical practice management.
Penn Medicine's OncoLink Receives 2018 CPEN Excellence in Patient Education Award
Perelman School of Medicine at the University of Pennsylvania
The Cancer Patient Education Network (CPEN) honored the Patient Education Team from Penn Medicine's OncoLink with the 2018 Excellence in Patient Education Award.
American College of Gastroenterology Announces Winners of Fourth Annual SCOPYs: Service Award for Colorectal Cancer Outreach, Prevention and Year-Round Excellence
American College of Gastroenterology (ACG)
Philadelphia, PA (October 5, 2018) - The American College of Gastroenterology (ACG) announces the winners of the 2018 SCOPY Awards (Service Award for Colorectal Cancer Outreach, Prevention and Year-Round Excellence) to recognize the achievements of ACG members in their community engagement, education and awareness efforts for colorectal cancer prevention.
Decision Support Tool Boosts Genetic Testing Knowledge in Breast Cancer Patients
Michigan Medicine - University of Michigan
Genetic testing for newly diagnosed breast cancer patients can help guide treatment and identify whether family members are at increased risk, but many patients aren't aware of these benefits. A new study shows that decision support tools used in tandem with genetic counselors can help patients understand.
UCLA researchers discover aggressive prostate and lung cancers are driven by common mechanisms
University of California, Los Angeles (UCLA), Health Sciences
UCLA researchers have discovered a common process in the development of late-stage, small cell cancers of the prostate and lung. These shared molecular mechanisms could lead to the development of drugs to treat not just prostate and lung cancers, but small cell cancers of almost any organ.
How to talk to kids about cancer
Sanford Health
Knowing how to talk to kids about cancer when a parent or someone else close to them has been diagnosed is important for children. They often sense something is going on, so it is better to talk and explain what is going on.
Analysis Reveals Genomic Effects of a New Cancer Treatment Now in Clinical Trials
Perelman School of Medicine at the University of Pennsylvania
A twist on the molecular mechanism of how a new cancer drug works could aid in better identifying the best treatments for patients for an array of cancers. The team identified over 500 sites in DNA that require an enzyme called ATR checkpoint kinase to not break when they are replicated.
Study focused on improving radiation treatment for cancers in pet dogs
University of North Carolina Health Care System
A UNC Lineberger Comprehensive Cancer Center researcher and his colleagues have been awarded a five-year, $3.2 million grant from the National Cancer Institute to investigate how to improve radiation treatment for dogs undergoing treatment for sarcoma.
Johns Hopkins Grant Project Looks at Small Cell Lung Cancer Treatment Resistances
Johns Hopkins Medicine
Researchers at the Johns Hopkins Kimmel Cancer Center received a $3.1 million grant to study the resistance of limited stage small cell lung cancer to a combination of chemotherapy and radiotherapy (chemoradiation).
The Medical Minute: Mental health and overall wellness important for breast cancer patients
Penn State Health Milton S. Hershey Medical Center
It's bad enough that breast cancer attacks physical health, but it can also take a toll on mental health and overall wellness.
A Lesson from a Brooklyn Teacher: Mammography Is a Lifesaver
NYU Langone Hospital - Brooklyn
Teacher discovers two cancerous lumps following routine mammogram, credits annual screening and NYU Langone Hospital-Brooklyn surgeons with life-saving breast cancer treatment and reconstruction.
Atlantic Health System, TGen and Origin Partner to Lower Barriers to Innovative Cancer Therapies
Atlantic Health System
Atlantic Health System, an integrated health care delivery system, today announced a partnership with the Translational Genomics Research Institute (TGen), an affiliate of City of Hope, and Origin Commercial Ventures to create a new platform to deliver economically viable immunotherapies and other breakthrough cancer treatments to the region through expedited access and novel payment options.
Even light drinking increases risk of death
Washington University in St. Louis
Analyzing data from more than 400,000 people, researchers at Washington University School of Medicine in St. Louis have found that consuming one to two drinks four or more times per week -- an amount deemed healthy by current guidelines -- increases the risk of premature death by 20 percent.
Peering into 36-million-degree plasma with SLAC's X-ray laser
SLAC National Accelerator Laboratory
a team of researchers has used an X-ray laser to measure, for the first time, how a plasma created by a laser blast expands in the hundreds of femtoseconds (quadrillionths of a second) after it's created. Their technique could eventually reveal tiny instabilities in the plasma that swirl like cream in a cup of coffee.
Expert available to add perspective on PTSD
University of Alabama at Birmingham
MD Anderson Immunologist Jim Allison Awarded Nobel Prize
University of Texas M. D. Anderson Cancer Center
T cell discoveries led to game-changing treatment revolutionizing cancer care
Peter Wiklund, MD, PhD, Appointed Director of the Bladder Cancer Program at Mount Sinai
Mount Sinai Health System
Peter Wiklund, MD, PhD, a world-renowned surgeon who pioneered robot-assisted cystectomy, has been appointed Director of the Bladder Cancer Program at the Mount Sinai Health System and Professor of Urology in the Department of Urology at the Icahn School of Medicine at Mount Sinai.
New AACI President Jensen Aims to Create Web-based Hub of Model Legislation
Association of American Cancer Institutes (AACI)
Roy A. Jensen, MD, is the new president of the Association of American Cancer Institutes. He began his two-year term today at the close of the AACI/CCAF annual meeting in Chicago. Dr. Jensen announced plans to develop a comprehensive, cancer-specific library of model legislation.
4 common myths about breast cancer
University of California, Los Angeles (UCLA), Health Sciences
UCLA oncologist Dr. Parvin Peddi, assistant clinical professor in medicine and member of the UCLA Jonsson Comprehensive Cancer Center, discusses four myths regarding the most common cancer in U.S. women.
Computer Model May Help Scientists Split Up, Reassemble Proteins on Command
Penn State College of Medicine
Splitting up and getting back together is always hard to do, but for proteins, it's almost impossible. However, a computer-guided algorithm may help scientists find just the right spot to split a protein and then reassemble it to functionality.
Healthier Planet, Healthier People, and More Innovative Medical Science with Italian-American Researchers at Annual NIAF Convention
Sbarro Health Research Organization (SHRO)
Foundation Awards Presented for Ethics and Creativity in Medical Research, and Societal Impact in Business & Biotechnology
Busy caring for others, doctor misses signs he developed rare form of cancer
Beaumont Health
Runny noses are annoying and easy to dismiss. And that's exactly why one doctor waited so long to seek medical attention. Now, he realizes that mistake could have cost him his eyesight, or even his life.
Animal Study Suggests Deep Space Travel May Significantly Damage GI Function in Astronauts
Georgetown University Medical Center
Deep space bombardment by galactic cosmic radiation could significantly damage gastrointestinal tissue leading to long-term functional alterations, according to a study by investigators at Georgetown University Medical Center, which also raises concerns about high risk of tumor development in the stomach and colon.
Women, Society and Breast Cancer: director of the Comprehensive Breast Health Center @UCSDHealth on making informed choices
University of California San Diego Health
Case Western Reserve Scientists Develop New Method to More Efficiently Generate Brain Stem Cells
Case Western Reserve University
In two newly published papers, a scientific team at Case Western Reserve University School of Medicine reports on the discovery and implementation of a new, more efficient method for generating an important brain stem cell in the laboratory. The findings pave the way for greater understanding of the underlying mechanisms of neurological disorders of myelin and ultimately, possible new treatment and prevention options. The studies were published in the September issues of Nature Communications and Stem Cell Reports.
Doctors Issue Caution over Missed Cancer Diagnoses Tied to Immune Disorder
Cincinnati Children's Hospital Medical Center
Physicians who specialize in a devastating and aggressive immune disorder called hemophagocytic lymphohistiocytosis (HLH) report in a new study that extra care should be taken to ensure an HLH diagnosis doesn't obscure possible underlying cancers. They caution in the journal Pediatric Blood & Cancer that expediting HLH treatment may miss underlying malignancies that could end up being fatal to the patient.
Cancer Survivors Celebrate Life and Liberty at 10th Annual Celebrating Life and Liberty Event at MetLife Stadium
Hackensack Meridian Health
Hackensack Meridian Health John Theurer Cancer Center at Hackensack University Medical Center, one of the nation's top 50 hospitals for cancer, hosted its tenth annual Celebrating Life and Liberty event at MetLife Stadium. The event celebrates survivorship and generates inspiration and support to those in the cancer community who are still in treatment or recovery.
BIDMC Research Brief Digest: September 2018
Beth Israel Deaconess Medical Center
A monthly roundup of research briefs showcasing recent scientific advances led by Beth Israel Deaconess Medical Center faculty.
Cancer Hijacks the Microbiome to Glut Itself on Glucose
University of Colorado Cancer Center
A University of Colorado Cancer Center study published today in the journal Cancer Cell shows that leukemia undercuts the ability of normal cells to consume glucose, thus leaving more glucose available to feed its own growth.
World Health Organization, St. Jude Children's Research Hospital collaborate against childhood cancer
St. Jude Children's Research Hospital
St. Jude Children's Research Hospital today announced a five-year collaboration with World Health Organization aimed at transforming cancer care worldwide to cure at least 60 percent of children with six of the most common types of cancer by 2030.
UD Experts Offer Insights for Breast Cancer Awareness Month
University of Delaware
Vaccine, Anti-PD1 Drug Show Promise Against Incurable HPV-Related Cancers
University of Texas M. D. Anderson Cancer Center
A tumor-specific vaccine combined with an immune checkpoint inhibitor shrank tumors in one third of patients with incurable cancer related to the human papilloma virus (HPV) in a phase II clinical trial led by investigators at The University of Texas MD Anderson Cancer Center and reported in JAMA Oncology.
Houston Methodist Adds Depth to Cancer Biology, Surgical Oncology, and Cancer Prevention and Control Programs
Houston Methodist
Houston Methodist Cancer Center has expanded its basic cancer research program, cancer prevention and control efforts, and surgical oncology services with the addition of two national recruits.
UCI researchers awarded $3.4M NIH "Cancer Moonshot" grant to study potential breakthrough in cancer immunotherapy
University of California, Irvine
UCI School of Medicine researchers have been awarded a $3.4 million grant by the National Cancer Institute (NCI) as part of the Beau Biden Cancer Moonshot initiative. The funding will support efforts to provide proof of principal data for an entirely new class of cancer killing immunotherapeutics with the potential to treat highly diverse types of cancer, from leukemia to breast cancer.
Governor Cuomo Announces First-Ever Biotech Venture Between U.S. and Cuba to Research and Develop New Cancer Treatments
Roswell Park Comprehensive Cancer Center
Governor Andrew M. Cuomo today announced Buffalo-based Roswell Park Comprehensive Cancer Center has formed the Innovative Immunotherapy Alliance S.A., the first-ever biotech venture between the U.S. and Cuba.
T Cells in the Urine of Bladder Cancer Patients Reflect Tumor Environment
The Rockefeller University Press
Scientists in the UK have shown for the first time that immune cells in the urine of bladder cancer patients accurately reflect those in the tumor environment, according to the study "Urine-derived lymphocytes as a non-invasive measure of the bladder tumor immune microenvironment," by Wong et al., published today in the Journal of Experimental Medicine.
Roswell Park Awarded More Than $6 Million in Moonshot Funds to Lead New Data Management Resource
Roswell Park Comprehensive Cancer Center
Through a grant award provided by the Cancer MoonshotSM, Roswell Park Comprehensive Cancer Center will support and advance some of the nation's most ambitious cancer research projects.
Experts from K. Hovnanian Children's Hospital and Former NY Giants Stephen Baker to Tackle Kids Cancer at iPlay America
Hackensack Meridian Health
Hackensack Meridian Health K. Hovnanian Children's Hospital at Jersey Shore University Medical Center to host an event dedicated to pediatric cancer research and programs on September 28, from 4 p.m. to 8 p.m. Tackle Kids Cancer will take place at iPlay America in Freehold, NJ.
Two Studies Describe Improved Approach to Bone Marrow Transplants
Cincinnati Children's Hospital Medical Center
Two recent studies in the journal Leukemia present a new approach for bone marrow donation and transplant that preclinical laboratory tests suggest could make the life-saving procedure safer and more effective for patients. Researchers say their studies demonstrate that use of an experimental drug called CASIN in laboratory mice results in higher efficiency when harvesting blood stem cells from donors and less toxicity in transplant recipients.
Study finds that enzymes 'partner up' to accelerate cancer, aging diseases
Indiana University
Indiana University researchers have identified cellular processes that appear to supercharge both the growth and shrinkage of the chemical "caps" on chromosomes that control aging, called telomeres.
Genetic Testing: Not a One-and-Done Deal
UT Southwestern Medical Center
A study that reviewed genetic testing results from 1.45 million individuals found that nearly 25 percent of "variants of uncertain significance" were subsequently reclassified - sometimes as less likely to be associated with cancer, sometimes as more likely.
Arteaga Awarded $600,000 to Study Breast Cancer Therapy Resistance
UT Southwestern Medical Center
The Susan G. Komen organization has awarded a $600,000 research grant to Dr. Carlos Arteaga, Director of the Harold C. Simmons Comprehensive Cancer Center and Associate Dean of Oncology Programs at UT Southwestern Medical Center.
Identical Driver Gene Mutations Found in Metastatic Cancers
Johns Hopkins Medicine
Driver genes in different metastases from the same patient are remarkably similar, providing optimism for the success of future targeted therapies, according to a published study by Science.
Better Survival Outcomes for Advanced Prostate Cancer Patients Treated with Surgery followed by Radiation than with Radiation plus Hormone Therapy
Rutgers Cancer Institute of New Jersey
Newly published results of a study examining men with locally or regionally advanced prostate cancer show those treated with a radical prostatectomy followed by radiation treatment have a lower risk of death from prostate cancer and improved overall survival in comparison to those treated with radiation plus androgen deprivation therapy. The work was led by a Rutgers Cancer Institute of New Jersey researcher in collaboration with other regional investigators.
Brigatinib becomes potential new first-line option for ALK-positive non-small lung cancer
University of Colorado Cancer Center
Results of ALTA-1 trial: Patients given brigatinib saw a statistically significant 51 percent reduction in the risk of progression or death compared with those given crizotinib.
New Drug Blocks Pancreatic Cancer Growth in Mice, Study Finds
Cedars-Sinai
A newly developed drug can prevent the most common type of pancreatic cancer from growing and spreading in laboratory mice, according to a study led by Cedars-Sinai. The study also demonstrated in mice that the drug, Metavert, may prevent patients from developing a resistance to currently used pancreatic cancer chemotherapies.
Harnessing Artificial Intelligence to Improve Drug Combination Design and Personalized Medicine
SLAS (Society for Laboratory Automation and Screening)
A new auto-commentary looks at how an emerging area of artificial intelligence, specifically the analysis of small systems-of-interest specific datasets, can be used to improve drug development and personalized medicine.
Poziotinib Maintains High Response Rate Against Harmful Lung Cancer Mutation
University of Texas M. D. Anderson Cancer Center
A drug revived by researchers at The University of Texas MD Anderson Cancer Center continues to provide unprecedented response rates among stage 4 non-small cell lung cancer patients with genetic mutations that have previously defied treatment.
Revisiting the Mode of Cancer Evolution
Rutgers Cancer Institute of New Jersey
Analysis by investigators at Rutgers Cancer Institute of New Jersey further examines tumor evolution through genomic data captured from thousands of cancer tumor samples using a mathematical model.
Promising Phase 1/2 Results for Entrectinib Against ROS1+ Non-Small Cell Lung Cancer
University of Colorado Cancer Center
Results of phase 1 and phase 2 clinical trials of the drug entrectinib in ROS1-positive non-small cell lung cancer (NSCLC) presented on the press program of the International Association for the Study of Lung Cancer (IASLC) 19th World Conference on Lung Cancer show a response rate of 77.4 percent for 53 patients evaluable for response, with median duration of response of 24.6 months.
Study seeks to improve cancer survival for Latinos, Asians and Blacks
UC Davis Comprehensive Cancer Center
UC Davis Comprehensive Cancer Center has received a $6.3 million grant from the National Cancer Institute's (NCI) Center to Reduce Cancer Health Disparities for a 5-year study to tease out why some ethnic and racial minority groups fare worse than whites when they get cancer and to find more precise treatments to improve their chances of survival.
New Nanotherapy Offers Hope in Treating Drug-Resistant Renal Cell Carcinoma
Wayne State University Division of Research
A research team led by Arun Iyer, Ph.D., assistant professor of pharmaceutical sciences in the Eugene Applebaum College of Pharmacy and Health Sciences at Wayne State University, has developed a nanoplatform technology that works in combination with existing chemotherapeutic drugs that may reverse drug-resistance in renal cell carcinoma.
MD Anderson hosts Biden Cancer Community Summit
University of Texas M. D. Anderson Cancer Center
The University of Texas MD Anderson Cancer Center today joined with more than 450 communities and institutions across the country in hosting a Biden Cancer Community Summit, organized under the charge of the Biden Cancer Initiative. The Summit aims to encourage an ongoing dialogue about opportunities to make significant advances in cancer research, prevention, diagnosis and care.
Horwitz Prize Awarded for Work on Hormones
Columbia University Irving Medical Center
Columbia University awards the 2018 Louisa Gross Horwitz Prize to Pierre Chambon, Ronald M. Evans, and Bert W. O'Malley for their research--spanning over 50 years--decoding how steroid hormones and nuclear receptors regulate cell function. This work has transformed our understanding of human physiology and disease.
Surgery, radiation therapy equally effective in treating oropharyngeal cancer
UT Southwestern Medical Center
Adding more evidence to the comparison between radiation therapy and surgery in treating an increasingly diagnosed head and neck cancer, a new study by researchers at UT Southwestern Medical Center found no major long-term differences in the effectiveness of the two therapies.
Chicago Universities to Host Community Forum on City's Cancer Inequities
University of Illinois at Chicago
The Chicago Cancer Health Equity Collaborative (ChicagoCHEC), a National Cancer Institute-funded initiative to reduce cancer disparities in Chicago's low-income neighborhoods, will provide a detailed look at the ongoing work of the ChicagoCHEC partnership, which is led by researchers from the University of Illinois at Chicago, Northeastern Illinois University and Northwestern University, during a community forum on Sept. 21.
Cancer Immunotherapy Might Benefit From Previously Overlooked Immune Players
University of California San Diego Health
Using a bioinformatics approach, University of California San Diego School of Medicine researchers found that CD4+ T cell's binding partner, a molecule called MHC-II, may have even more influence on emerging tumors than MHC-I, the better known partner of CD8+ T cells. The finding, published September 20 in Cell, may help researchers improve cancer immunotherapies and predict which patients will respond best.
2nd Annual Skin Cancer Awareness Walk Returns to Elk Grove Village September 29
American Academy of Dermatology
Skin cancer is the most common cancer in the United States, affecting one in five Americans during their lifetime. To help raise awareness of skin cancer prevention and detection, the American Academy of Dermatology will host Skin Cancer, Take a Hike!(tm) - Chicago on Sat., Sept. 29 in Elk Grove Village. The scenic, four-mile walk at Busse Woods--part of the AAD's SPOT Skin Cancer(tm) campaign to create a world without skin cancer--will benefit skin cancer prevention and detection programs, including free skin cancer screenings, sunscreen dispensers, and permanent shade structures where children learn and play.
Moving Homegrown Ideas into the Clinic
University of Kansas Cancer Center
Physician-scientists at The University of Kansas Cancer center are designing and initiating their own clinical trials.
Novel Biomarker Found in Ovarian Cancer Patients Can Predict Response to Therapy
University of Chicago Medical Center
Researchers have identified an independent prognostic factor, cancer/testis antigen 45, that is associated with extended disease-free survival for women with advanced ovarian cancer. Patients with high levels of CT45 in their tumors lived more than seven times as long as patients who lacked sufficient CT45.
What Can Salad Dressing Tell Us About Cancer? Think Oil and Vinegar
St. Jude Children's Research Hospital
St. Jude Children's Research Hospital scientists have identified another way the process that causes oil to form droplets in water may contribute to solid tumors, such as prostate and breast cancer. The findings appear today in the journal Molecular Cell. Researchers found evidence that mutations in the tumor suppressor gene SPOP contribute to cancer by disrupting a process called liquid-liquid phase separation. Liquid-liquid phase separation is seen often in nature and is the reason why oil and vinegar separate in salad dressing.
Case Western Reserve's Dr. Ahmad Khalil Receives NIH Funding to Develop New Paradigm in Fight against Colorectal Cancer
Case Western Reserve University
Certain genes that code for proteins have long been known to contribute to cancer progression. But in a frame shift, researchers from Case Western Reserve University School of Medicine recently found that non-coding genes also contribute to the development and spreading of the disease, one of the first known examples of researchers doing so. The lead author of the study reporting this finding, Ahmad Khalil, PhD, assistant professor of genetics and genome sciences at Case Western Reserve School of Medicine, has been awarded a five-year, $1.85 million grant from the National Institutes of Health to build on the discovery, with an eventual aim of pinpointing additional targets for cancer-fighting treatments.
What Patients Don't Know (but Should) About Prostate Cancer
University of California, Los Angeles (UCLA), Health Sciences
This Prostate Cancer Awareness Week, urologist shares three things patients are surprised to learn
3 things patients don't know about prostate cancer -- but should
University of California, Los Angeles (UCLA), Health Sciences
Study Uncovers New Hurdle for Developing Immunotherapies
University of Notre Dame
The discovery made by Notre Dame researchers and their collaborators tosses a new wrench into the process of building better molecules to develop immunotherapies