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Two Ways Cancer Resists Treatment Are Actually Connected, with One Activating the Other
Perelman School of Medicine at the University of Pennsylvania
Researcher shows the two most common means of resistance to BRAF and MEK inhibitors are actually connected processes and can be targeted by other therapies.
Prostate cancer scoring method may underestimate mortality risk in black men
Dana-Farber Cancer Institute
Black men diagnosed with prostate cancer classified as low risk may actually have a more aggressive form of the disease that is more likely to be fatal than in nonblack men placed in the same prognostic category, a new study suggests.
Vaccine, Checkpoint Drugs Combination Shows Promise for Pancreatic Cancers
Johns Hopkins Medicine
Researchers at the Johns Hopkins Kimmel Cancer Center discovered a combination of a cancer vaccine with two checkpoint drugs reduced pancreatic cancer tumors in mice, demonstrating a possible pathway for treatment of people with pancreatic cancers whose response to standard immunotherapy is poor.
Cancer Caregivers: How to Manage 'Happy' During the Holidays
Cedars-Sinai
Families and caregivers of people with cancer may view the holidays as a particularly challenging time, often feeling as though they have to live up to the ideal of merry and bright, when they--and those they're tending--typically don't feel that way. Cedars-Sinai experts offer 6 tips for making the most of the holidays while caring for someone with cancer.
An Online Intervention to Reduce Skin Cancer in Young Adults
Rutgers Cancer Institute of New Jersey
Rutgers Cancer Institute of New Jersey is leading a research study aimed at improving skin cancer protection behaviors in young adults through an online intervention.
BIDMC's Research & Health News Digest: December 2018 Edition
Beth Israel Deaconess Medical Center
A monthly roundup of research briefs showcasing recent scientific advances led by Beth Israel Deaconess Medical Center faculty.
Cancer Researcher Identifying Ways to Overcome Drug-Resistance
South Dakota State University
Assistant Professor Iram Surtaj will use a new imaging technique to identify drugs that can disrupt overexpression of multidrug resistance protein 1, one of the main mechanisms through which cancer cells gain resistance to chemotherapy drugs.
E-Cigarette Users Have Lower Exposure to Toxicants -- As Long As They Don't Smoke Combustible Cigarettes Too
Roswell Park Comprehensive Cancer Center
The largest study to date to compare exposure to toxicants among users of electronic cigarettes, smokers and nonsmokers has been completed, suggesting possible benefits for smokers who switch completely to electronic cigarettes
Study identifies location of DNA that gives clues to hidden cancer mutations
University of California, Los Angeles (UCLA), Health Sciences
A new study by UCLA scientists shows that enhancers, snippets of DNA that contribute to gene regulation, fall into the same "insulated neighborhoods" or chromatin loops as the target gene and other gene-specific regulatory elements.
NIH scientists find that breast cancer protection from pregnancy starts decades later
National Institute of Environmental Health Sciences (NIEHS)
In general, women who have had children have a lower risk of breast cancer compared to women who have never given birth. However, new research has found that moms don't experience this breast cancer protection until many years later and may face elevated risk for more than 20 years.
Children's Hospital of Philadelphia Announces Endowed Chair in Pediatric Neuroblastoma Research
Children's Hospital of Philadelphia
Pediatric oncologist and researcher Yael Mosse, MD, Director of the Neuroblastoma Development Therapeutics Program at Children's Hospital of Philadelphia, has been named the inaugural holder of the Patricia Brophy Endowed Chair in Neuroblastoma Research.
Exercise Significantly Cuts the Risk of Death from Cancer
Roswell Park Comprehensive Cancer Center
New research out of Roswell Park Comprehensive Cancer Center shows that cancer patients who exercise regularly both before and after their diagnosis are significantly more likely to survive than those who are sedentary, adding to the growing body of evidence that physical activity is an important part of a cancer prevention and treatment strategy. The results were published in a recent issue of the journal Cancer Causes & Control.
The "Greying" of T Cells
Harvard Medical School
Research in mouse cells identifies defective metabolic pathway in aging immune T cells. The pathway is critical for switching T cells from dormancy into illness-fighting mode. In experiments, researchers restored lagging T-cell function by adding small-molecule compounds. Findings suggest possible mechanism behind weakened immunity common in the elderly.
The Nicola-Musso Charitable Foundation and Carol Musso Foley Commit to a Generous Donation for Cancer Care at Two Hackensack Meridian Health Hospitals
Hackensack Meridian Health
Hackensack Meridian Health and the Meridian Health Foundation are pleased to announce a gift of $750,000 from the Nicola-Musso Charitable Foundation of New York, N.Y. and Carol Musso Foley of New York and Spring Lake, NJ, to be used to enhance cancer care services at Hackensack Meridian Health Jersey Shore University Medical Center and Hackensack Meridian Health Ocean Medical Center.
New Technology for Profiling Myeloma Cells
Weizmann Institute of Science
Weizmann Institute scientists Profs. Ido Amit and Amos Tanay, working with hemato-oncologists, have created a new way to profile myeloma tumor cells. The machine-learning-based technique will allow earlier and better diagnosis of the cancer, including in terms of relapse, and improve treatment.
Pushing Closer to a New Cancer-Fighting Strategy
Johns Hopkins Medicine
A molecular pathway that's frequently mutated in many different forms of cancer becomes active when cells push parts of their membranes outward into bulging protrusions, Johns Hopkins researchers report in a new study. The finding, published Nov. 7 in Nature Communications, could eventually lead to new targets for cancer-fighting therapeutics.
Study finds higher risk of breast cancer for women after giving birth
University of North Carolina Health Care System
A collaborative group of researchers co-led by a UNC Lineberger Comprehensive Cancer Center scientist found that, in women 55 years and younger, breast cancer risk peaked about five years after they gave birth, with risk for mothers 80 percent higher compared with women who did not give birth.
Sprayable gel developed by UCLA-led team could help the body fight off cancer after surgery
University of California, Los Angeles (UCLA), Health Sciences
Many people who are diagnosed with cancer will undergo some type of surgery to treat their disease -- almost 95 percent of people with early-diagnosed breast cancer will require surgery and it's often the first line of treatment for people with brain tumors, for example. But despite improvements in surgical techniques over the past decade, the cancer often comes back after the procedure.
Workshop Promotes Patient Advocacy in Cancer Research
University of Kansas Cancer Center
The University of Kansas Cancer Center and the the Midwest Cancer Alliance co-hosted an introductory training workshop for individuals who want to learn more about KU Cancer Center's patient research advocacy program, PIVOT
Penny DeGoosh named director of Social Work at St. Jude Children's Research Hospital
St. Jude Children's Research Hospital
Penny DeGoosh, LICSW, has been named the director of Social Work at St. Jude Children's Research Hospital.
MD Anderson study shows key enzyme linked to therapy resistance in deadly lung cancer
University of Texas M. D. Anderson Cancer Center
Researchers at The University of Texas MD Anderson Cancer Center have identified a link between an enzyme tied to cancer formation and therapy resistance in patients with epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC).
Media Advisory: Young Age Associated with Worse Prognosis in Specific Breast Cancer Subtype
Johns Hopkins Medicine
Researchers at Johns Hopkins Kimmel Cancer Center are rapidly advancing the understanding of biological factors, including hormones, as predictors of longer disease-free survival for certain subtypes of breast cancer. The implications for treatment -- especially among younger women -- can be profound, but uncertainties remain and decision-making by patients and their physicians can be complicated.
Living With Cancer: Some Men With Prostate Cancer Opt Out of Surgery
Cedars-Sinai
Of the 165,000 men in the U.S. expected to be diagnosed with prostate cancer this year, about half will have low-risk disease. Many of those patients will opt for active surveillance -- a process in which men with low-risk, slow-growing prostate cancer are regularly monitored to see if the cancer starts to grow and requires treatment.
Using inkjet printers to build a new biosensor for less invasive breast cancer detection
National Institute of Biomedical Imaging and Bioengineering
NIBIB-funded researchers have created a novel, low-cost biosensor to detect HER-2, a breast cancer biomarker in the blood, allowing for a far less invasive diagnostic test than the current practice, a needle biopsy. Scientists at the Universities of Hartford and Connecticut and funded in part by NIBIB, combined microfluidic technology with diagnostics, including electrochemical sensors and biomarkers, into a powerful package that can give results in about 15 minutes.
UC San Diego Researcher Gets $4 Million NCI Award to Study Cancer Drug Resistance, Spread
University of California San Diego Health
David Cheresh, Distinguished Professor at University of California San Diego School of Medicine, received $4.2 million National Cancer Institute Outstanding Investigator Award to continue his research into cancer's ability to overcome stress, gain drug resistance and metastasize.
Some people uncomfortable discontinuing colorectal cancer screening even when benefit is low
Michigan Medicine - University of Michigan
A new study finds 29 percent of veterans who underwent recommended screening colonoscopies were uncomfortable with the idea of stopping these screenings when the benefit was expected to be low for them personally.
NYU Langone Hospital-Brooklyn Welcomes Cancer Surgeon and Skilled Researcher
NYU Langone Hospital - Brooklyn
Camilo Correa, MD, is a surgical oncologist specializing in liver, pancreas, bile duct, and intestinal cancers. A native of Colombia, Correa completed a postdoctoral research fellowship at Harvard Medical School and a clinical fellowship at Memorial Sloan Kettering Cancer Center.
New Molecular Tool Identifies Sugar-Protein Attachments
Johns Hopkins Medicine
Researchers at Johns Hopkins Medicine have developed a new molecular tool they call EXoO, which decodes where on proteins specific sugars are attached--a possible modification due to disease. The study, published in issue 14 of Molecular Systems Biology, describes the development of the tool and its successful use on human blood, tumors and immune cells.
Multidisciplinary care improves outcomes of patients with brain metastases
UT Southwestern Medical Center
New data reveals the life expectancy of patients with kidney cancer that's traveled to the brain has now stretched from months to years.
Southern Research Introduces Transgenic Mouse Model in Support of Immuno-Oncology Therapeutic Development
Southern Research
Southern Research has announced the Transgenic Mouse Human PD-1/L1 Model, its newest service offering in support of immuno-oncology (IO) therapeutic development.
Scientists Design Way to Track Steps of Cells' Development
Washington University in St. Louis
Scientists at Washington University School of Medicine in St. Louis have developed a new tool described as a "flight data recorder" for developing cells, illuminating the paths cells take as they progress from one type to another. This cellular tracking device could one day help scientists guide cells along the right paths to regenerate certain tissues or organs, or help study the origins of cancer.
UC San Diego Researchers Develop Sensors to Detect and Measure Cancer's Ability to Spread
University of California San Diego Health
University of California San Diego School of Medicine researchers engineered sensors to detect and measure the metastatic potential of single cancer cells. Metastasis is attributed as the leading cause of death in people with cancer.
What Can Hair Tell About? A Non-Invasive Diagnostics of Diseases Is Discovered at SUSU
South Ural State University
It is an often case that one's health and life depend on as quick a disease is found. That is why today the ways of quick and effective revealing of a disease is one of the most important directions in medicine.
SUSU Scientists Study Light to Create Technologies of the Future
South Ural State University
Scientists of the Faculty of Physics of the SUSU Institute of Natural Sciences and Mathematics predict new optical effects in light beams which in perspective will help create technologies of the future, and even reveal cancer in early stages.
UC San Diego Medical Center Named by Leapfrog as "2018 Top Teaching Hospital"
University of California San Diego Health
UC San Diego Medical Center in Hillcrest was named a Top Teaching Hospital by The Leapfrog Group. The award is widely acknowledged as one of the most competitive honors that a U.S. hospital can receive.
Penn's Basser Center for BRCA Chooses Memorial Sloan Kettering, Cornell University Researcher Maria Jasin for 2018 Basser Global Prize
Perelman School of Medicine at the University of Pennsylvania
The Basser Center for BRCA at Penn Medicine's Abramson Cancer Center, the world's first comprehensive center aimed at advancing research, treatment, and prevention of BRCA-related cancers, has announced Maria Jasin, PhD, as the recipient of the sixth annual Basser Global Prize. Jasin is a member of the Developmental Biology Program at Memorial Sloan Kettering Cancer Center and a professor at the Weill Graduate School of Medical Sciences at Cornell University.
New Cancer Immunotherapy Approach Turns Immune Cells into Tiny Anti-Tumor Drug Factories
University of California San Diego Health
In lab and mouse experiments, UC San Diego School of Medicine researchers developed a method to leverage B cells to manufacture and secrete tumor-suppressing microRNAs.
Early results show promise for using genetically engineered immune cells to fight relapsed blood cancer
University of North Carolina Health Care System
At the 60th Annual American Society of Hematology Annual Meeting in San Diego on Monday, UNC Lineberger researchers revealed preliminary results from a clinical study of an investigational cellular immunotherapy for Hodgkin lymphoma and non-Hodgkin lymphoma expressing the CD30 protein marker.
Researchers Develop Accurate, Non-Invasive Method to Detect Bladder Cancer
Tufts University
A research team has developed a non-invasive method for detecting bladder cancer that might make screening easier and more accurate than current invasive clinical tests involving visual inspection of bladder. In the first successful use of atomic force microscopy (AFM) for clinical diagnostic purposes, the researchers have been able to identify signature features of cancerous cells found in patients' urine by developing a nanoscale resolution map of the cells' surface.
New tumor model helps researchers treat pancreatic cancer
South Dakota State University
Patients diagnosed with pancreatic cancer face a poor prognosis because the tumor forms dense scar-like tissue that is difficult for chemotherapy drugs to penetrate, but a new model may help researchers develop new therapies.
MDCalc Launches Beta GI Guideline Summaries with American College of Gastroenterology
American College of Gastroenterology (ACG)
NEW YORK, NY -- December 3, 2018 -- MDCalc, the global leader in online evidence-based medical calculators, has launched its new guideline summaries in a public beta. The first set of 11 summaries debuted at the annual scientific meeting of the American College of Gastroenterology (ACG) in Philadelphia in early October 2018.
UC San Diego Health is First in San Diego to offer CAR T-cell Therapy for Some Cancers
University of California San Diego Health
Following the Food and Drug Administration's approval of chimeric antigen receptor (CAR) T-cell therapies for the treatment of certain types of non-Hodgkin lymphomas, UC San Diego Health was the first medical center in San Diego to be certified to offer this type of immunotherapy outside of a clinical trial.
Experts in immunotherapy, medical physics and cervical cancer named 2018 ASTRO Gold Medalists
American Society for Radiation Oncology (ASTRO)
The American Society for Radiation Oncology (ASTRO) recently named three leaders in radiation oncology as the recipients of its Gold Medal award. Patricia Eifel, MD, FASTRO, David Jaffray, PhD, and Ralph Weichselbaum, MD, were awarded the highest honor bestowed upon ASTRO members and recognized for their achievements at ASTRO's 60th Annual Meeting in San Antonio.
Targeting tumors with 3D animation
Oregon State University, College of Engineering
Oregon State University engineers are using 3D animations techniques to increase the precision of radiation therapy for prostate cancer so that neighboring healthy tissues and organs are not affected.
More than half of patients alive two years after receiving CAR-T therapy for diffuse large B-cell lymphoma in ZUMA-1 trial
University of Texas M. D. Anderson Cancer Center
A follow-up analysis of patients enrolled in a Phase I/II multi-center trial for diffuse large B-cell lymphoma (DLBCL) reported 51 percent of patients receiving an anti-CD19 chimeric antigen receptor (CAR T) called axi-cel were still alive two years post-treatment. The study, co-led by Sattva Neelapu, M.D., professor of Lymphoma & Myeloma at The University of Texas MD Anderson Cancer Center, reported its findings in the Dec. 2 online issue of The Lancet Oncology and during a presentation at the 60th American Society of Hematology Annual Meeting & Exposition in San Diego.
Calcium Signaling May Play Role in Addressing Drug Resistance to Non-Hodgkin Lymphoma Treatment
Rutgers Cancer Institute of New Jersey
Systems biology analyses by Rutgers Cancer Institute of New Jersey researchers examining drug resistance to a common antibody therapy for non-Hodgkin lymphoma suggest calcium signaling may have an influence in addressing this treatment obstacle.
Exploring Clinical Activity of an Immunotherapy Drug that Targets Lymphomas
Rutgers Cancer Institute of New Jersey
An investigational immunotherapy drug has demonstrated efficacy and an acceptable safety profile in the treatment of follicular lymphoma, diffuse large B-cell lymphoma and other B cell non-Hodgkin lymphoma subtypes. The lead investigator from Rutgers Cancer Institute of New Jersey shares more on the phase 1 trial.
CAR-T cell update: therapy improves outcomes for patients with B-cell lymphoma
University of Chicago Medical Center
An international phase-2 trial of a CAR-T cell therapy--to be published on-line Dec. 1 in the New England Journal of Medicine (and presented at the ASH annual meeting in San Diego)--found that 52% of patients responded favorably to the therapy; 40% had a complete response and 12% had a partial response. One year later, 65% of those patients were relapse-free, including 79% of complete responders. The median progression-free survival "has not been reached."
Immunotherapy Better than Chemotherapy for Subtype of Head and Neck Cancer
University of California San Diego Health
A randomized clinical trial involving 97 medical centers in 20 countries, including Moores Cancer Center at UC San Diego Health, found that treating patients with head and neck cancer with the immunotherapy drug pembrolizumab is more effective and less toxic than standard chemotherapy.
App Helps Breast Cancer Survivors Improve Health After Treatment
Houston Methodist
Breast cancer survivors who used a smartphone app created at Houston Methodist consistently lost weight, largely due to daily, real-time interactions with their health care team via the mobile app.
A cancer drug may help treat human papillomavirus infections
University of Alabama at Birmingham
Preclinical experiments by University of Alabama at Birmingham researchers suggest the cancer drugs vorinostat, belinostat and panobinostat might be repurposed to treat infections caused by human papillomaviruses, or HPVs.
St. Jude research into leukemia, sickle cell and other blood disorders presented at ASH
St. Jude Children's Research Hospital
The 60th Annual Meeting of the American Society of Hematology will feature research from St. Jude Children's Research Hospital on topics ranging from the genomic basis and vulnerabilities of leukemia to an update on gene therapy for hemophilia B to advances in sickle cell disease and beta-thalassemia.
UT Southwestern Leads the Way in Single-Incision Surgery
UT Southwestern Medical Center
UT Southwestern Medical Center this week became the first hospital in Texas to perform single-incision, robotic surgery.
Prevention and Screening Clinic at UC San Diego Health Helping to Reduce Pancreatic Cancer
University of California San Diego Health
Moores Cancer Center at UC San Diego Health launched the Pancreatic Cancer Prevention and Screening Clinic in an attempt to reduce the number of people who develop the disease and improve survival for those who do. Every day in the U.S., 145 people are diagnosed and every 12 minutes someone dies.
"A 4 percent chance is nothing to me"
University of Alabama at Birmingham
Former MLB player Frank Baker says his experience at UAB's Pancreatobiliary Disease Center was a home run.
Venetoclax Combination Approved for Elderly AML
Dana-Farber Cancer Institute
A new option - a combination of a standard drug and the novel agent venetoclax - has been granted accelerated approval by the Food and Drug Administration for certain AML patients after a large, multicenter phase 1 clinical trial showed the combination had "promising efficacy" and was well tolerated in older AML patients.
Synthetic Cells Command New Powers of Communication
University of California San Diego
Researchers at UC San Diego used materials like clay and plastic to create synthetic cells--or "cell-mimics"--capable of gene expression and communication rivaling that of living cells. According to some scientists, these newly published research results could be among the most important in synthetic biology this year.
FDA Approves New Targeted Drug for Leukemia Tested at University of Pennsylvania
Perelman School of Medicine at the University of Pennsylvania
The U.S. Food and Drug Administration (FDA) has approved the first ever inhibitor drug specifically approved for treating patients with relapsed or refractory acute myeloid leukemia (AML) with a mutation in the Fms-like tyrosine kinase 3 (FLT3) gene.
UCLA research suggests widely used breast cancer therapy doesn't cause cognitive decline
University of California, Los Angeles (UCLA), Health Sciences
UCLA researchers have found that commonly used hormone therapies for women diagnosed with breast cancer do not appear to cause significant cognitive dysfunction following the treatment.
Easy to use 3D bioprinting technique creates lifelike tissues from natural materials
University of California San Diego
Bioengineers have developed a 3D bioprinting technique that works with natural materials and is easy to use, allowing researchers of varying levels of technical expertise to create lifelike tissues, such as blood vessels and a vascularized gut. The goal is to make human organ models that can be studied outside the body or used to test new drugs ex vivo.
High-Tech Surgical Suites Let Doctors Scan Patients without Either Leaving the Operating Room
University of California San Diego Health
Inside Jacobs Medical Center at UC San Diego Health resides the only intra-operative magnetic resonance imaging surgical suites in Southern California -- a high-tech hybrid that gives surgeons access to advanced MRI technology during procedures.
Brain Cancer Immunotherapy SurVaxM Extends Survival, Even in Hard-to-Treat Patients
Roswell Park Comprehensive Cancer Center
The latest results from an ongoing clinical study incorporating the immunotherapy SurVaxM as part of combination treatment for glioblastoma show that this investigational drug is safe, well-tolerated and extended survival even among the hardest-to-treat subgroups of patients. The findings were presented at the Society for Neuro-Oncology Annual Meeting in New Orleans.
The future of fighting cancer: zapping tumors in less than a second
SLAC National Accelerator Laboratory
New accelerator-based technology being developed by the Department of Energy's SLAC National Accelerator Laboratory and Stanford University aims to reduce the side effects of cancer radiation therapy by shrinking its duration from minutes to under a second. Built into future compact medical devices, technology developed for high-energy physics could also help make radiation therapy more accessible around the world.
WVU Cancer Institute studies new treatment for colorectal cancer using novel drug combination
West Virginia University
Richard Goldberg, who directs the West Virginia University Cancer Institute, is searching for new ways to slow colorectal cancer's progression. In a recent study, he and an international team of scientists investigated a new drug combination for treating metastatic colorectal cancer in patients who had no--or only temporary--success with conventional chemotherapy treatments.
$2M Grant Expands Social Media Intervention to Reduce Skin Cancer Burden
Rutgers Cancer Institute of New Jersey
A $2 million grant from the National Cancer Institute will support the expansion of Rutgers Cancer Institute of New Jersey research focused on sun protective behaviors among young melanoma survivors -- an intervention delivered through social media.
ASRA's Chronic Pain Medicine Grant Will Evaluate Spinal Cord Stimulation in the Treatment of Cancer Pain
American Society of Regional Anesthesia and Pain Medicine (ASRA)
ASRA has awarded the 2018 Chronic Pain Medicine Research Grant to Eellan Sivanesan, MD, for a project looking at the effectiveness of spinal cord stimulation (SCS) for the treatment of chemotherapy-induced painful neuropathy (CIPN). Sivanesan is an assistant professor in the department of anesthesiology and critical care medicine at Johns Hopkins University School of Medicine in Baltimore, MD.
Advanced cancer patients can live longer with palliative care, Tulane study says
Tulane University
Researchers sampled more than 2,000 patients with advanced cancers to examine the impact of outpatient palliative care on patients' survival and quality of life.
Lozano named winner of 2018 E.E. Just Award
American Society for Cell Biology (ASCB)
The 2018 recipient of the E.E. Just Award is Guillermina (Gigi) Lozano, professor and chair of the Department of Genetics, Division of Basic Science Research at the University of Texas MD Anderson Cancer Center in Houston. Lozano will present the E.E. Just Award Lecture on Sunday, December 9, at 11:00 am at the 2018 ASCB|EMBO Meeting.
UCLA health expert available to comment on FDA approval of targeted cancer therapy, larotrectinib, for patients with a wide variety of cancers.
University of California, Los Angeles (UCLA), Health Sciences
Research Review Underscores Progress in Treating Kidney Cancer, Importance of Close Patient Monitoring
Roswell Park Comprehensive Cancer Center
In an effort to compile and summarize the latest knowledge about these immunotherapy combinations and their implications, a group of kidney cancer immunotherapy experts led by Saby George, MD, of Roswell Park Comprehensive Cancer Center have written a new research review article assessing current approaches to treating patients newly diagnosed with kidney cancer and also looking ahead to some of the most pressing questions still to be answered related to these emerging therapies. Published online Nov. 21 by the journal JAMA Oncology, the review article highlights the path to approval for the new standard of care for these patients -- ipilimumab, also known as Yervoy, together with nivolumab, also known as Opdivo.
With Sozo, lymphedema screening easier, faster
University of Kansas Cancer Center
Staff at The University of Kansas Cancer Center are using a new device that makes it remarkably easy and convenient to screen for lymphedema.
Study Identifies a Genetic Driver of Deadly Prostate Cancer
Cedars-Sinai
A new study has identified a novel molecular driver of lethal prostate cancer, along with a molecule that could be used to attack it. The findings were made in laboratory mice. If confirmed in humans, they could lead to more effective ways to control certain aggressive types of prostate cancer, the second-leading cause of cancer death for men in the U.S.
CAR T Studies Highlight Abramson Cancer Center Research at ASH Annual Meeting
Perelman School of Medicine at the University of Pennsylvania
Penn researchers will present findings at the 60th American Society of Hematology Annual Meeting and Exposition in San Diego, including studies that evaluate CAR T combinations, how the timing of CAR T therapy may impact its effectiveness, and which patients who currently aren't eligible for CAR T therapy should have greater access.
Johns Hopkins Researchers Advance Role of Circulating Tumor DNA to Detect Early Melanoma Growth, Uncover Treatment Options
Johns Hopkins Medicine
Researchers at the Johns Hopkins Kimmel Cancer Center say they have added to evidence that measuring and monitoring tumor DNA that naturally circulates in the blood of melanoma patients can not only reliably help reveal the early stages of cancer growth and spread but also uncover new treatment options that tumor genetic analysis alone may not.
Breast Cancers Enhance Their Growth by Recruiting Cells From Bone Marrow
The Rockefeller University Press
Researchers in Israel have discovered that breast tumors can boost their growth by recruiting stromal cells originally formed in the bone marrow. The study, which will be published November 23 in the Journal of Experimental Medicine, reveals that the recruitment of bone marrow-derived fibroblasts lowers the odds of surviving breast cancer, but suggests that targeting these cells could be an effective way of treating the disease.
As Vaping Increased in Popularity, Use of Cigarettes Declined
Georgetown University Medical Center
Cigarette smoking dramatically decreased between 2013 and 2017 just as e-cigarette use became more popular, according to a comprehensive analysis examining the relationship between vaping and smoking among youth and young adults led by a Georgetown University investigator.
Jefferson Lab Shares 2018 R&D 100 Award for Cancer Treatment Monitoring System
Thomas Jefferson National Accelerator Facility
The OARtrac(r) system, built by RadiaDyne and including technologies developed by scientists at the U.S. Department of Energy's Thomas Jefferson National Accelerator Facility, has been awarded a 2018 R&D 100 Award by R&D Magazine.
Enzyme Discovery Points Researchers Toward Starving Lung Cancer as a Potential Treatment
UT Southwestern Medical Center
UT Southwestern researchers have found that an enzyme on the surface of some lung cancer cells helps feed the cancer, making it a tempting treatment target.
Stand Up To Cancer Grant Funds UC San Diego Health Research in Pancreatic Cancer
University of California San Diego Health
A team of University of California San Diego School of Medicine researchers have been awarded a $1 million Stand Up To Cancer grant to test drugs that block signals that play a critical role in driving growth and progression of pancreatic cancer.
Pancreatic Cancer Collective awards Dana-Farber Cancer Institute researchers "New Therapies Challenge" grant
Dana-Farber Cancer Institute
* $1 million in initial funding to evaluate DNA repair inhibitors in pancreatic cancer * Aim to accelerate pancreatic cancer research and improve patient outcomes for pancreatic cancer
Researchers stop 'sneaky' cancer cells in their tracks
University of Minnesota College of Science and Engineering
A new study by University of Minnesota biomedical engineers shows how they stopped cancer cells from moving and spreading, even when the cells changed their movements. The discovery could have a major impact on millions of people undergoing therapies to prevent the spread of cancer within the body.
Abramson Cancer Center Joins National Comprehensive Cancer Network
Perelman School of Medicine at the University of Pennsylvania
The Abramson Cancer Center at the University of Pennsylvania announced today that it is joining the National Comprehensive Cancer Network(r) as its 28th member institution.
Scientists trained a computer to classify breast cancer tumors
University of North Carolina Health Care System
In a study published in the journal NPJ Breast Cancer, researchers reported they used a form of artificial intelligence called machine learning, or deep learning, to train a computer to identify certain features of breast cancer tumors from images.
Research Focuses on a New Frontier in Circadian Rhythms
Rensselaer Polytechnic Institute (RPI)
A new frontier in the science of circadian rhythms - whose disruption is linked to major diseases like cancer and diabetes - suggests a previously unknown mechanism at work in our daily biological cycle.
New Guidelines from NCCN Help People with Mouth Cancers Understand Treatment Options
National Comprehensive Cancer Network(r) (NCCN(r))
NCCN Guidelines for Patients(r): Oral Cancers provides information about mouth cancers for patients and caregivers.
The Association of American Cancer Institutes Debuts New Website
Association of American Cancer Institutes (AACI)
The Association of American Cancer Institutes is excited to announce the launch of its redesigned website (aaci-cancer.org). The revamped internet presence will enhance communication between AACI and its 98 cancer center members and within the cancer research and advocacy community.
Kids with cancer will celebrate an early Thanksgiving together
University of Illinois at Chicago
The Children's Hospital University of Illinois will host a pre-holiday Thanksgiving meal and celebration for pediatric cancer and sickle cell patients and their families Nov. 17.
Latino Men are Much Less Likely to Receive Optimal Treatment for High Risk Prostate Cancer than White Men, According to New Research in JNCCN
National Comprehensive Cancer Network(r) (NCCN(r))
New research published in JNCCN-Journal of the National Comprehensive Cancer Network found Latino men were 21% less likely to receive definitive treatment compared to non-Latino white men, with significant differences for younger patients, the uninsured, and those treated at NCI-designated centers.
National study testing drug to treat graft-versus-host disease after stem cell transplants
University of Nebraska Medical Center (UNMC)
University of Nebraska Medical Center leading national team to determine if ruxolitinib is effective for treating a certain type of graft versus host disease (GVHD) called sclerotic. The grant is funded by Incyte, a global biopharmaceutical company.
St. Jude Announces Extensive Resource to Advance Leukemia Research
St. Jude Children's Research Hospital
The Public Resource of Patient-derived and Expanded Leukemias (PROPEL) offers patient-derived xenograft samples free of charge for researchers worldwide.
Research on imaging in radiation oncology featured in Red Journal special issue
American Society for Radiation Oncology (ASTRO)
A new special edition of the International Journal of Radiation Oncology*Biology*Physics (Red Journal) focuses on the roles of imaging in radiation oncology. The collection explores topics such as improving accuracy with patient positioning, defining radiation therapy volumes using imaging, imaging of functional biomarkers, the role of imaging in post-treatment care, machine learning and artificial intelligence.
Researchers identify a mechanism that fuels cancer cells' growth
University of California, Los Angeles (UCLA), Health Sciences
The study, led by UCLA professors Claudio Scafoglio and David Shackelford, suggests that a biomarker can help scientists detect lung cancer earlier, when it is much easier to treat.
Rutgers Cancer Institute of New Jersey Research Identifies Metabolic Vulnerability in Cancer
Rutgers Cancer Institute of New Jersey
Research from investigators at Rutgers Cancer Institute of New Jersey shows that the cell recycling process of autophagy maintains an important tumor nutrient, arginine, in the blood supply, identifying a metabolic vulnerability of cancer.
NYU Langone Hospital-Brooklyn Welcomes Director of Pediatric Urology
NYU Langone Hospital - Brooklyn
Grace S. Hyun, MD, director of pediatric urology at NYU Langone Hospital-Brooklyn, treats newborns to adolescents for conditions involving the urinary system--the kidneys, bladder, and urinary tract.
Investigational Drug Shows Promising Results in Phase II Study of Aggressive, Often Fatal Blood Disorder with No Approved Therapies
University of Texas M. D. Anderson Cancer Center
A Phase I/II study, led by investigators at The University of Texas MD Anderson Cancer Center, reports an investigational drug called tagraxofusp has demonstrated high response rates in patients with blastic plasmacytoid dendritic cell neoplasm (BPDCN), a rare but highly aggressive - and often fatal bone marrow and blood disorder - for which there are no existing approved therapies.
Active living researcher @UCSDMedSchool available to discuss the newly updated @HHSGov physical activity guidelines
University of California San Diego Health
Immunotherapy combination and chemotherapy show encouraging results in Phase II acute myeloid leukemia study
University of Texas M. D. Anderson Cancer Center
A triple therapy combining two immune checkpoint inhibitors (ICPIs) with the standard-of-care chemotherapy, a hypomethylating agent called azacitidine, has shown promising results for treatment of relapsed or refractory acute myeloid leukemia (AML), according to findings from a Phase II study at The University of Texas MD Anderson Cancer Center.
'Waltzing' nanoparticles could advance search for more effective drug delivery methods
Indiana University
IU scientists have found that drug-delivering nanoparticles attach to their targets differently based upon their position in time. The discovery could improve methods for screening drugs for therapeutic effectiveness.
Cancer stem cells get energy from protein, and it's proving to be their Achilles' heel
University of Colorado Cancer Center
CU Cancer Center study shows that cancer stem cells switch from metabolizing sugar to metabolizing protein. Turning off protein metabolism kills these cells.
Obesity both feeds tumors and helps immunotherapy kill cancer
UC Davis Comprehensive Cancer Center
A groundbreaking new study by UC Davis researchers has uncovered why obesity both fuels cancer growth and allows blockbuster new immunotherapies to work better against those same tumors. The paradoxical findings, published today in Nature Medicine, give cancer doctors important new information when choosing drugs and other treatments for cancer patients.