Feature Channels: Biotech

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Released: 1-Nov-2022 12:00 PM EDT
Reconstitution of human adrenocortical specification and steroidogenesis using induced pluripotent stem cells
Preprints

Yuka Sakata, Keren Cheng, Michinori Mayama, Yasunari Seita, Andrea J Detlefsen, Clementina A Mesaros, Trevor M Penning, Kyosuke Shishikura, Wenli Yang, Richard J Auchus, Jerome F Strauss, Kotaro Sasaki

Released: 1-Nov-2022 12:00 PM EDT
Axon guidance pathways modulate neurotoxicity of ALS-associated UBQLN2
Preprints

Sang Hwa Kim, Kye D Nichols, Eric N Anderson, Yining Liu, Nandini Ramesh, Weiyan Jia, Connor J Kuerbis, Mark Scalf, Lloyd M. Smith, Udai Bhan Pandey, Randal S Tibbetts

Newswise: Efficient Nanovaccine Delivery System Boosts Cellular Immunity
Released: 31-Oct-2022 7:40 PM EDT
Efficient Nanovaccine Delivery System Boosts Cellular Immunity
Osaka Metropolitan University

Cancer immunotherapies, such as immune checkpoint inhibition therapy, have been attracting attention in recent years as new methods for treating cancer.

Newswise: Faster Screen of Biologicals for Growth Stimulants, Disease Protection in Wheat and Corn
Released: 31-Oct-2022 6:25 PM EDT
Faster Screen of Biologicals for Growth Stimulants, Disease Protection in Wheat and Corn
University of Johannesburg

Researchers found a much faster way to screen soil bacteria as potential biostimulants and bio-pesticides.

Released: 29-Oct-2022 12:00 PM EDT
miR-223 Plays A Critical Role in Obesogen-Enhanced Adipogenesis in Mesenchymal Stem Cells and in Transgenerational Obesity
Preprints

Richard C Chang, Erika M. Joloya, Zhuorui Li, Bassem M Shoucri, Toshi Shioda, Bruce Blumberg

Released: 28-Oct-2022 12:00 PM EDT
Protein aggregation and calcium dysregulation are the earliest hallmarks of synucleinopathy in human midbrain dopaminergic neurons
Preprints

Gurvir S Virdi, Minee Liane Choi, James R Evans, Zhi Yao, Dilan Athauda, Stephanie Strohbuecker, Anna I Wernick, Haya Alrashidi, Daniela Melandri, Jimena Perez-Lloret, Plamena R Stroh, Sergiy Sylantyev, Simon Eaton, Simon Heales,

Released: 28-Oct-2022 12:00 PM EDT
Transcriptional regulation profiling reveals PPARA-mediated fatty acid oxidation as a novel therapeutic target in phospholamban R14del cardiomyopathy
Preprints

Magdalena Harakalova, Jiayi Pei, Renee Maas, Karen Gaar-Humphreys, Johannes Gho, Emilia Nagyova, Christian Snijders Blok, Iris van Adrichem, René van Es, Shahrzad Sepehrkhouy, Dries Feyen, Noortje Van Den Dungen, Nico Lansu, Jorg Cal

Released: 28-Oct-2022 12:00 PM EDT
Human T2D associated gene IMP2/IGF2BP2 promotes the commitment of mesenchymal stem cells into adipogenic lineage
Preprints

Laura Regue, William Wang, Fei Ji, Joseph Avruch, Hua Wang, Ning Dai

Released: 28-Oct-2022 12:00 PM EDT
Induction of telomerase in p21-positive cells counteracts capillaries rarefaction in aging mice lung
Preprints

Larissa Lipskaia, Marielle Bréau, Christelle Cayrou, Dmitri Churikov, Laura Braud, Charles Fouillade, Sandra Curras-Alonso, Serge Bauwens, Frederic Jourquin, Frederic Fiore, Rémy Castellano, Emmanuelle Josselin, Carlota Sánchez-Ferrer,

Released: 28-Oct-2022 12:00 PM EDT
Extract of Plastrum Testudinis through miR-214 mediated Wnt/β-catenin signaling stimulating bone formation
Preprints

Qing Lin, Yumei Yang, Xiaoyun Li, Haoyu Wang, Yan Cui, Panpan Wang, Xiaofeng Zhu, Li Yang, Ronghua Zhang

Released: 28-Oct-2022 12:00 PM EDT
Temporary knockdown of p53 during focal limb irradiation increases the development of sarcomas
Preprints

Andrea R. Daniel, Chang-Lung Lee, Chang Su, Nerissa T. Williams, Zhiguo Li, Jianguo Huang, Omar Lopez, Lixia Luo, Yan Ma, Lorraine De Silva Campos, Sara R. Selitsky, Jennifer L. Modliszewski, Siyao Liu, Yvonne M. Mowery,

Released: 28-Oct-2022 12:00 PM EDT
Assessment Of 3D Printed Polycaprolactone, Hydroxyapatite Nanoparticles and Polyethylene Glycol Diacrylate Scaffolds for Bone Regeneration
Preprints

Ana Catarina Sousa, Sara Biscaia, Rui Alvites, Mariana Branquinho, Bruna Lopes, Patrícia Sousa, Joana Valente, Margarida Franco, José Domingos Santos, Carla Mendonça, Luís Atayde, Nuno Alves, Ana Colette Maurício

Newswise: UT Southwestern Ranked No. 1 in Texas, Fourth in Nation for Tech Transfer
Released: 27-Oct-2022 4:15 PM EDT
UT Southwestern Ranked No. 1 in Texas, Fourth in Nation for Tech Transfer
UT Southwestern Medical Center

UT Southwestern Medical Center ranked fourth in the nation and No. 1 in Texas for commercializing new biomedical technologies

   
Released: 27-Oct-2022 12:00 PM EDT
KDM6A/UTX promotes spermatogenic gene expression across generations but is dispensable for male fertility
Preprints

Benjamin William Walters, Shannon R Rainsford, Nicolas Dias, Xiaofang Huang, Dirk G de Rooij, Bluma J Lesch

Released: 27-Oct-2022 12:00 PM EDT
Influential factors for optimizing and strengthening mesenchymal stem cells and hematopoietic stem cells co-culture
Preprints

Mandana Shirdarreh, Fatemeh Amiri, Mohammad Pouya Samiee, Armita Safari

Released: 27-Oct-2022 12:00 PM EDT
Tumor-educated Gr1+CD11b+cells instigate breast cancer metastasis by twisting cancer cells plasticity via OSM/IL6-JAK signaling
Preprints

Sanam Peyvandi, Manon Bulliard, Annamaria Kauzlaric, Oriana Coquoz, Yu-Ting Huang, Nathalie Duffey, Laetitia Gafner, Girieca Lorusso, Nadine Fournier, Qiang Lan, Curzio Rüegg

Released: 27-Oct-2022 12:00 PM EDT
Antimicrobial peptide-loaded decellularized placental sponge as an excellent antibacterial skin substitute against XDR clinical isolates
Preprints

Hatef Ghasemi Hamidabadi, Sanaz Alizadeh, Leila Mahboobi, Zahra Khosrowpour, Maryam Nazm Bojnordi, Zahra Aliakbar Ahovan, Majid Malekzadeh Shafaroudi, Maria Zahiri, Narendra Pal Singh Chauhan, Mazaher Gholipourmalekabadi

Released: 27-Oct-2022 12:00 PM EDT
3D-printed Strontium-Titanium Scaffolds Incorporated with Highly Bioactive Serum Exosomes Promotes Critical Bone Defect Repair by Enhancing Osteogenesis and Angiogenesis
Preprints

Hao Liu, Ranli Gu, Wei Li, Lijun Zeng, Yuan Zhu, Siyi Wang, Xuenan Liu, Boon Chin Heng, Yunsong Liu, Yongsheng Zhou

Released: 27-Oct-2022 12:00 PM EDT
iPSC-derived cells lack immune tolerance to autologous NK-cells due to imbalance in ligands for activating and inhibitory NK-cell receptors
Preprints

Margarita E. Bogomiakova, Elizaveta K. Sekretova, Ksenia S. Anufrieva, Polina O. Khabarova, Anastasia N. Kazakova, Pavel A. Bobrovsky, Tatiana V. Grigoryeva, Artem V. Eremeev, Olga S. Lebedeva, Alexandra N. Bogomazova, Maria A. Lagarkova

Released: 27-Oct-2022 12:00 PM EDT
Transcription factor HSFA7b controls ethylene signaling and meristem maintenance at the shoot apical meristem during thermomemory
Preprints

Sheeba John, Federico Apelt, Amit Kumar, Dominik Bents, Maria Grazia Annunziata, Franziska Fichtner, Bernd Mueller-Roeber, Justyna J. Olas

Released: 26-Oct-2022 6:25 PM EDT
New Gene Editing Strategy Could Lead to Treatments for People Born with Inherited Diseases of the Immune System
University College London

A fault in cells that form a key part of the immune system can be repaired with a pioneering gene editing technique, finds new research demonstrated in human cells and mice, led by UCL scientists.

Released: 26-Oct-2022 12:00 PM EDT
Maternal inappropriate calcium intake aggravates dietary-induced obesity in male offspring by affecting the differentiation potential of mesenchymal stem cells
World Journal of Stem Cells

BACKGROUNDThe effects of inappropriate dietary calcium intake in early life on later obesity have not been fully elucidated. AIMTo raise the mechanism of maternal calcium intake on the multi-differentiation potential of mesenchymal stem cells

Released: 26-Oct-2022 12:00 PM EDT
Exosomes from circ-Astn1-modified adipose-derived mesenchymal stem cells enhance wound healing through miR-138-5p/SIRT1/FOXO1 axis regulation
World Journal of Stem Cells

BACKGROUNDWound healing impairment is a dysfunction induced by hyperglycemia and its effect on endothelial precursor cells (EPCs) in type 2 diabetes mellitus. There is increasing evidence showing that exosomes (Exos) derived from adipose-derive

Newswise: Synthetic Genetic Circuits Reprogram Plant Roots
Released: 26-Oct-2022 11:35 AM EDT
Synthetic Genetic Circuits Reprogram Plant Roots
Department of Energy, Office of Science

Controlling gene activity is important for engineering plants for improved bioenergy crops and other applications. This research developed synthetic genes that use Boolean logic gates to achieve specific patterns of gene expression within a plant. The researchers used these gene circuits to redesign the root architecture by tuning the number of root branches.

Newswise:Video Embedded fau-lands-1-2-million-nsf-grant-to-transform-prosthetic-hand-control
VIDEO
Released: 26-Oct-2022 8:30 AM EDT
FAU Lands $1.2 Million NSF Grant to Transform Prosthetic Hand Control
Florida Atlantic University

Current prosthetic hands have five individually actuated digits, yet only one grasp function can be controlled at a time, which makes sophisticated tasks largely impossible.



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