Curated News: Cell (journal)

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Newswise: Protein Linked to Intellectual Disability Has Complex Role
16-May-2022 3:05 PM EDT
Protein Linked to Intellectual Disability Has Complex Role
Washington University in St. Louis

Researchers at Washington University School of Medicine in St. Louis have identified a previously unknown function for the fragile X protein, the loss of which is the leading inherited cause of intellectual disability. The researchers showed that the protein modulates how neurons in the brain’s memory center process information, a central part of learning and memory.

Newswise: 2022-05-12-9426-0005-hr.jpg
16-May-2022 2:15 PM EDT
Scientists Nail Down 'Destination' for Protein That Delivers Zinc
Brookhaven National Laboratory

New research describes a “chaperone” protein that delivers zinc, a trace element essential for survival in all living things, to where it’s needed. The chaperone could be especially important when access to zinc is limited—for example in nutrient deficient diets and for growing crops on depleted soils.

Released: 16-May-2022 1:25 PM EDT
‘Friendly’ Gut Bacteria May Eliminate Pathogens by Competing for Energy Resources
UC Davis Health

New research from scientists at UC Davis Health provides clues for how friendly bacteria in the gut — probiotics — may help eradicate bacterial pathogens like Salmonella by being able to compete with them for needed resources.

Released: 16-May-2022 5:45 AM EDT
PTBP1 promotes hematopoietic stem cell maintenance and red blood cell development by ensuring sufficient availability of ribosomal constituents
Cell Reports

… Given the important function of PTBP1 in directing lineage choice in diverse stem cell systems and the overall relevance of mRNA splicing in hematopoiesis, we hypothesized that PTBP1 might play a role as a regulator of posttranscriptional …

Newswise: Discovery of Cell Protein That Keeps Kaposi’s Sarcoma Herpesvirus Dormant
Released: 11-May-2022 12:30 PM EDT
Discovery of Cell Protein That Keeps Kaposi’s Sarcoma Herpesvirus Dormant
UC Davis Comprehensive Cancer Center

A study led by UC Davis Cancer Center identified a binding protein in cancer cell’s nucleus, known as CHD4, as a critical agent keeping Kaposi's sarcoma-associated herpesvirus (KSHV) dormant and undetected by the body’s immune system. CHD4 is linked to cancer cell growth in many types of cancers.

Released: 10-May-2022 3:05 PM EDT
A study confirms the relationship between an amino acid present in diet and depression
Universitat Pompeu Fabra- Barcelona

Researchers from the Girona Biomedical Research Institute (IDIBGI) and Pompeu Fabra University (UPF) in Barcelona, Spain, have identified the role of an amino acid in humans, mice and flies suffering depression.

Released: 10-May-2022 11:20 AM EDT
Moffitt Researchers Identify Pathway that Regulates Lipid Synthesis and Contributes to Tumor Survival
Moffitt Cancer Center

In a new study published in the journal Cell Reports, Moffitt Cancer Center researchers show that cancer cells in an acidic environment undergo lipid synthesis and accumulation. The team identified the key signaling molecules responsible for these changes and discovered that these alterations are associated with poor outcomes and disease progression among breast cancer patients.

Released: 10-May-2022 8:00 AM EDT
Taking the guesswork out of journal submission with Community Review
Cell Stem Cell

This Backstory describes the development of a research article published in Cell Stem Cell that was originally submitted to Community Review, a program wherein a manuscript is simultaneously considered at multiple Cell Press journals. The article, a

Released: 10-May-2022 5:00 AM EDT
p57Kip2 imposes the reserve stem cell state of gastric chief cells
Cell Stem Cell

… stem cell … stem cell state, accompanied by altered niche requirements and a mature chief cell/secretory phenotype. Following the constitutive expression of p57 in vivo, chief cells showed an impaired injury response. Thus, p57 is a gatekeeper …

Released: 10-May-2022 5:00 AM EDT
Nuclear factor programming improves stem-cell-derived hepatocyte phenotype
Cell Stem Cell

… In this issue of Cell Stem Cell, Ma et al. demonstrate that the activation of the nuclear receptor thyroid hormone receptor beta (NR1A2) improves the differentiation status of hepatocyte-like cells derived from human pluripotent stem cells. … In this …

Released: 9-May-2022 5:00 AM EDT
Antigen presentation safeguards the integrity of the hematopoietic stem cell pool
Cell Stem Cell

… programs maintaining stem cell integrity have been identified, safety mechanisms eliminating malignant HSPCs from the stem cell pool … HSPCs and antigen-specific CD4 + T cells, causing stem cell proliferation, differentiation, and specific exhaustion …

Released: 5-May-2022 6:05 AM EDT
Disturbance of calcium homeostasis and myogenesis caused by TET2 deletion in muscle stem cells
Cell Death Discovery

… In this study, we demonstrated that TET2 deficiency impaired muscle stem cell proliferation and differentiation, leading to notable changes in mouse body weight and muscle morphology during development. We further assayed the genome-wide …

Released: 4-May-2022 12:35 PM EDT
The role of the cerebellum in absence seizures
Ruhr-Universität Bochum

Stimulation of certain cerebellar areas could help combat absence seizures.

Newswise: Researchers Manipulate Demographic of Bacterial Community with Novel Electronic Technology
28-Apr-2022 5:05 PM EDT
Researchers Manipulate Demographic of Bacterial Community with Novel Electronic Technology
University of California San Diego

Using second-long electrical shocks, UC San Diego scientists discovered they could control the types of cells in a community of bacteria. Being able to direct the ratio of cells holds implications for settings spanning agriculture to health care, where antibiotic resistance is a significant threat.

Newswise: Experiments Measure Freezing Point of Extraterrestrial Oceans to Aid Search for Life
Released: 3-May-2022 5:05 PM EDT
Experiments Measure Freezing Point of Extraterrestrial Oceans to Aid Search for Life
University of Washington

A planetary scientist worked with engineers to measure the physical limits of a liquid for salty water under high pressure. Results suggest where robotic missions should look for life on the ice-covered oceans of Jupiter’s moon Europa and Saturn’s moon Titan.

Released: 3-May-2022 12:55 PM EDT
How a bot beamed from California to Japan may prevent cancer patients from losing their breasts unnecessarily
Global Alliance for Genomics and Health

Too many women are getting unnecessary mastectomies and other invasive procedures because of a knowledge gap about differences in cancer genes. A new study offers a path to closing the gap.

29-Apr-2022 7:05 PM EDT
Study of Promising Alzheimer’s Marker in Blood Prompts Warning About Brain-Boosting Supplements
University of California San Diego

Elevated levels of an enzyme called PHGDH in the blood of older adults could be an early warning sign of Alzheimer’s disease. Research led by UC San Diego has consistently found high levels of PHGDH expression in brain tissue and blood samples of older adults with different stages of the disease.

Released: 2-May-2022 8:00 AM EDT
Biomaterials to enhance stem cell transplantation
Cell Stem Cell

… In this review, biomaterial-based advances to improve the physiological outcome of stem cell transplantation are described. The review does not aim to provide a comprehensive list of all biofunctional materials described in the literature but …

Released: 29-Apr-2022 5:00 AM EDT
Manufacturing clinical‐grade human induced pluripotent stem cell‐derived beta cells for diabetes treatment
Cell Proliferation

… This review focuses on the key processes and guidelines for clinical translation of human induced pluripotent stem cell (hiPSC)derived β cells for diabetes cell therapy. Here, we discuss the (1) key considerations of manufacturing clinical-grade hiPSCs …

Released: 27-Apr-2022 5:00 AM EDT
Tumor stem cell-derived exosomal microRNA-17-5p inhibits anti-tumor immunity in colorectal cancer via targeting SPOP and overexpressing PD-L1
Cell Death Discovery

Exosomes are known to transmit microRNAs (miRNAs) to affect human cancer progression, and miR-17-5p has been manifested to exert facilitated effects on colorectal cancer (CRC) progression, while the role of tumor stem cells-derived …

Released: 25-Apr-2022 2:10 AM EDT
Escargot controls somatic stem cell maintenance through the attenuation of the insulin receptor pathway in Drosophila
Cell Reports

… a decline in nutrient availability is likely to provide insight into the metabolic regulation of stem cell behavior in other tissues and organisms. … Taken together, our data describe one mechanism by which a transcription factor controls stem cell …

Released: 22-Apr-2022 4:00 AM EDT
Development and regulation of stem  cell‐based therapies in China
Cell Proliferation in Basic and Clinical Sciences

… This article briefly introduced the regulatory framework development, the progress in stem  cell clinical researches and clinical trials of commercially developed stem  cell-based products, as well as the clinical review concerns of stem  cell-based products in …

Released: 22-Apr-2022 4:00 AM EDT
Mesenchymal stem  cell-derived exosomal microRNA-182-5p alleviates myocardial ischemia/reperfusion injury by targeting GSDMD in mice
Cell Death Discovery

… Owing to the fact that MSC-derived exosomes can further control stem  cell differentiation by carrying and transferring miRNAs, stem  cell-based exosome therapeutic regimens have been highlighted as effective means for cardiac …

Newswise: Circuit that focuses attention brings in wide array of inputs
Released: 21-Apr-2022 1:45 PM EDT
Circuit that focuses attention brings in wide array of inputs
Picower Institute for Learning and Memory at MIT

In a new brain-wide circuit tracing study, scientists at MIT’s Picower Institute for Learning and Memory focused selective attention on a circuit that governs, fittingly enough, selective attention.

Newswise: Lab Grown, Self-Sustainable Muscle Cells Repair Muscle Injury and Disease, Mouse Study Shows
Released: 20-Apr-2022 1:30 PM EDT
Lab Grown, Self-Sustainable Muscle Cells Repair Muscle Injury and Disease, Mouse Study Shows
Johns Hopkins Medicine

In proof-of-concept experiments, Johns Hopkins Medicine scientists say they have successfully cultivated human muscle stem cells capable of renewing themselves and repairing muscle tissue damage in mice, potentially advancing efforts to treat muscle injuries and muscle-wasting disorders in people.

Released: 19-Apr-2022 4:45 PM EDT
Mayo researchers, collaborators affirm useful blood biomarker for group of brain disorders in new study
Mayo Clinic

A test of protein in the blood gets further support as a biomarker for patients diagnosed with frontotemporal dementia (FTD), a group of brain disorders with few treatment options. These disorders are characterized by changes in behavior, cognition, language or movement.

Released: 19-Apr-2022 10:00 AM EDT
MDS/AML with del5q: An acquired “laminopathy”?
Cell Stem Cell

In this issue of Cell Stem Cell, Reilly et al. propose loss of LMNB1, the gene encoding lamin B1, often deleted in MDS/AML, as a novel genetic basis for the abnormal nuclear shape of neutrophils (known as acquired Pelger-Huët anomaly) and a cause o

Released: 19-Apr-2022 5:00 AM EDT
Androgens increase excitement in brain organoid research
Cell Stem Cell

Despite the surrounding controversy, quantitative sex-based differences exist in the human brain. In a recent issue of Nature, Kelava et al. shed light on the mechanisms underlying increased brain volume and neuron density in males, while highlighti

Released: 19-Apr-2022 5:00 AM EDT
PPARdelta activation induces metabolic and contractile maturation of human pluripotent stem cell-derived cardiomyocytes
Cell Stem Cell

Efficient maturation of in vitro-generated cells remains a challenge and the underlying mechanisms are poorly understood. Here Wickramasinghe and colleagues show that PPAR signaling acts in an isoform-specific manner to enhance metabolic and electrop

Released: 19-Apr-2022 5:00 AM EDT
Decoding the temporal and regional specification of microglia in the developing human brain
Cell Stem Cell

Our study comprehensively reveals the spatiotemporal dynamics of regional specification and state transition in the microglia of the developing human brain. By comparing microglia from mice and humans, we assess the conservation of state transitions

Released: 19-Apr-2022 5:00 AM EDT
A small-molecule cocktail promotes mammalian cardiomyocyte proliferation and heart regeneration
Cell Stem Cell

Du et al. discover a chemical cocktail of five small molecules (5SM) promoting adult mammalian CM proliferation and heart regeneration after myocardial infarction. 5SM potentially targets α1 adrenergic receptor, JAK1, DYRKs, PTEN, and MCT1 and make

Released: 19-Apr-2022 5:00 AM EDT
Stem cell-derived β cells go in monkeys
Cell Stem Cell

Du et al. transplanted β cells derived from pluripotent stem cells in diabetic monkeys for the first time, as an intermediate stage toward clinical translation. They observed benefits unfolding over months but also observed immune rejection of the

Released: 19-Apr-2022 5:00 AM EDT
Capybara: A computational tool to measure cell identity and fate transitions
Cell Stem Cell

Kong et al. present Capybara, a computational pipeline to classify discrete cell identity and intermediate “hybrid” cell states. They apply Capybara to identify hybrid states in cardiac reprogramming, off-target neural identities in motor neuron

Released: 19-Apr-2022 5:00 AM EDT
Progress in multicellular human cardiac organoids for clinical applications
Cell Stem Cell

Recent advances and current challenges in multicellular cardiac organoids and tools for assessing cardiac organoids for clinical application are discussed.

Released: 19-Apr-2022 5:00 AM EDT
Successful organoid-mediated generation of iPSC-derived CAR-T cells
Cell Stem Cell

Artificial thymic organoids (ATOs) allow the selective differentiation of chimeric antigen receptor (CAR)-transduced human iPSCs into CAR-T cells. In this issue of Cell Stem Cell, Wang et al. now use ATOs to produce human CD19+ CAR-T cells that mimi

Released: 19-Apr-2022 5:00 AM EDT
c-Maf: The magic wand that turns on LSEC fate
Cell Stem Cell

In this issue of Cell Stem Cell, Gómez-Salinero et al. (2022) identify c-Maf as a driver for murine liver sinusoidal endothelial cell (LSEC) fate and function during liver development, homeostasis, and repair. Similarly, c-Maf defines human LSECs,

Released: 19-Apr-2022 5:00 AM EDT
Lamin B1 deletion in myeloid neoplasms causes nuclear anomaly and altered hematopoietic stem cell function
Cell Stem Cell

Abnormal nuclear morphology is a hallmark of cancerous cells. Here, Reilly et al. demonstrate that deletion of lamin B1, which is common in myeloid malignancies, causes acquired Pelger-Huët nuclear anomaly and links aberrant nuclear morphology with

Released: 19-Apr-2022 5:00 AM EDT
Human pluripotent stem cell-derived myogenic progenitors undergo maturation to quiescent satellite cells upon engraftment
Cell Stem Cell

Sun et al. discover that myogenic progenitors derived from hPSCs could engraft and mature to become local satellite cells in vivo after transplantation. These engrafted MPCs not only function as satellite cells in muscle regeneration but could also

Released: 19-Apr-2022 5:00 AM EDT
Specification of fetal liver endothelial progenitors to functional zonated adult sinusoids requires c-Maf induction
Cell Stem Cell

Blood vessels adapt to the requirements of each organ. In the liver, this adaptation is a progressive specialized transition from fetal to postnatal development, which is facilitated by the transcription factor c-Maf. In vitro c-Maf induces a liver-

Released: 14-Apr-2022 5:15 AM EDT
Generation and characterization of stable pig pregastrulation epiblast stem cell lines
Cell Research

… Despite ongoing attempts since the 1990s, no stably defined pig epiblast-derived stem cell line has been established. Here, guided by … in vitro culture medium for establishing and maintaining stable pluripotent stem cell lines from pig E10 …

13-Apr-2022 11:00 AM EDT
Infectious bacteria force host plants to feed them, study finds
Ohio State University

A species of bacteria that infect corn crops compel their hosts to produce a feast of nutrients that keeps the pathogens alive and thriving long before they start to kill the plant’s cells, new research shows.

Released: 12-Apr-2022 11:20 AM EDT
Researchers Working with Brewer’s and Baker’s Yeast Species Discover Yeast Self-Destruct Pathway
Johns Hopkins Bloomberg School of Public Health

The findings suggest these single-celled organisms have programmed or regulated cell-death mechanisms like those that are known to work in animals and other complex organisms.

Newswise: Researchers Map Lung Development After Birth Into Late Childhood for the First Time
Released: 11-Apr-2022 2:05 PM EDT
Researchers Map Lung Development After Birth Into Late Childhood for the First Time
University of California San Diego

How do the lungs develop after taking their first breaths outside the womb? What cellular events and changes early in life give rise to lung malfunction and disease? To help answer these questions, scientists have constructed the first single-cell atlas of postnatal lung development in humans and mice. The research could help provide a more detailed understanding—at the level of individual cells—of which genetic and epigenetic factors affect lung health across the human lifespan, starting from birth.

Released: 11-Apr-2022 11:05 AM EDT
Researchers Identify a New Treatment for Metabolic Syndrome
University Hospitals Cleveland Medical Center

Metabolic syndrome increases a person’s risk for diabetes, heart disease, and stroke, and includes conditions such as obesity, high blood pressure and high blood sugar. In a recent mouse-model study, published in Cell Metabolism, researchers at University Hospitals (UH), Harrington Discovery Institute at UH, and Case Western Reserve University have furthered their progress to develop a drug to treat metabolic syndrome by identifying a receptor that controls appetite and body weight.

5-Apr-2022 10:05 AM EDT
Mount Sinai Develops Method to Advance Maturation of Human Pluripotent Stem Cell-Derived Heart Cells
Mount Sinai Health System

New study outlines scalable protocol to enhance development and understanding of human pluripotent stem cells in cardiac muscles

Released: 6-Apr-2022 1:45 PM EDT
Scientists Discover Gene Mutation That Signals Aggressive Melanoma
Mount Sinai Health System

Mutation of a gene called ARID2 plays a role in increasing the chance that melanoma, a deadly skin cancer, will turn dangerously metastatic, Mount Sinai researchers report.

Newswise: Discovery Provides Insight Into Neglected Tropical Disease
Released: 5-Apr-2022 1:15 PM EDT
Discovery Provides Insight Into Neglected Tropical Disease
UT Southwestern Medical Center

UTSW scientists identify key molecule produced by male parasitic worms that affects sexual maturity in females and leads to schistosomiasis

Newswise: ‘Freeze-Thaw Battery’ Is Adept at Preserving Its Energy
Released: 5-Apr-2022 12:00 AM EDT
‘Freeze-Thaw Battery’ Is Adept at Preserving Its Energy
Pacific Northwest National Laboratory

Scientists have created a battery designed for the electric grid that locks in energy for months without losing much storage capacity. It’s a step toward batteries that can be used for seasonal storage: saving renewable energy in one season, such as the spring, and spending it in another, like autumn.

Newswise:Video Embedded uci-led-study-links-early-life-adversity-microglia-dysfunction-to-aberrant-adult-stress-responses-mental-illness
Released: 29-Mar-2022 7:45 PM EDT
UCI-led study links early life adversity, microglia dysfunction, to aberrant adult stress responses, mental illness
University of California, Irvine

The poor function of microglia, the brain’s immune cells in individuals exposed to early life adversity (ELA) promotes aberrant responses to stress in adulthood that may be linked to mental illness, according to a new study led by researchers at the University of California, Irvine. During brain development, microglia prune unnecessary synapses resulting in the formation of refined, functional circuits. Disruption of that process leaves too many synapses, changing the behavioral and hormonal responses to further stresses later in life.

Newswise: UTSW researchers identify key complex for ribosome generation
Released: 29-Mar-2022 12:30 PM EDT
UTSW researchers identify key complex for ribosome generation
UT Southwestern Medical Center

UT Southwestern researchers have identified a four-protein complex that appears to play a key role in generating ribosomes – organelles that serve as protein factories for cells – as well as a surprising part in neurodevelopmental disorders. These findings, published in Cell Reports, could lead to new ways to manipulate ribosome production, which could impact a variety of conditions that affect human health.

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