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Released: 1-Sep-2022 4:05 PM EDT
Individual risk-factor data could help predict the next Ebola outbreak, new study shows
Lehigh University

Several years ago, a team of scientists at Lehigh University developed a predictive model to accurately forecast Ebola outbreaks based on climate-driven bat migration.

Newswise: Developing Antivirals for Pandemic-Level Viruses
Released: 10-Aug-2022 11:30 AM EDT
Developing Antivirals for Pandemic-Level Viruses
University of Illinois Chicago

Researchers at the University of Illinois Chicago are working with the National Institutes of Health and University of Minnesota to establish a center for antiviral drug development for pandemic-level viruses, including Ebola and SARS-CoV-2.

Newswise: LJI Scientists Discover Clue to Stopping Lassa Virus Infection
Released: 19-Jul-2022 2:10 PM EDT
LJI Scientists Discover Clue to Stopping Lassa Virus Infection
La Jolla Institute for Immunology

In a new study, researchers show how a critical Lassa virus protein, called polymerase, drives infection by harnessing a cellular protein in human hosts. Their work suggests future therapies could target this interaction to treat patients.

Newswise: Viruses of a Feather
Released: 12-Jul-2022 5:05 AM EDT
Viruses of a Feather
Kyoto University

Helical nucleocapsids in infected cells are composed of Marburg viral genomic RNA and nucleoproteins, or NPs, that are structurally similar to those of the Ebola virus. Future drug development may be possible based on the targeting of nucleocapsid formation, which may inhibit the Marburg virus' ability to replicate.

Newswise: Rapid Ebola Diagnosis May Be Possible with New Technology
7-Jun-2022 2:05 PM EDT
Rapid Ebola Diagnosis May Be Possible with New Technology
Washington University in St. Louis

A new tool can quickly and reliably identify the presence of Ebola virus in blood samples, according to a study by researchers at Washington University School of Medicine in St. Louis and colleagues at other institutions.

Newswise: Targeting a human protein may stop Ebola virus in its tracks
Released: 22-Mar-2022 12:15 PM EDT
Targeting a human protein may stop Ebola virus in its tracks
La Jolla Institute for Immunology

Ebola virus polymerase hijacks a cellular protein called GSPT1. An experimental drug that targets GSPT1 for degradation can also halt Ebola virus infection in human cells.

Newswise:Video Embedded promising-antibody-cocktail-takes-on-ebola-virus-and-its-deadly-cousin
VIDEO
15-Mar-2022 2:10 PM EDT
Promising antibody cocktail takes on Ebola virus—and its deadly cousin
La Jolla Institute for Immunology

The team's latest study, published in Cell, shows that two clever human antibodies can target two ebolavirus species at once: Ebola virus and Sudan virus. These two species are responsible for the biggest, deadliest outbreaks. The new report suggests researchers could combine these two potent antibodies to make a powerful antiviral therapy.

Newswise: Ebola Vaccine Being Used in Congo Produces Lasting Antibody Response, Study Finds
Released: 8-Feb-2022 5:10 PM EST
Ebola Vaccine Being Used in Congo Produces Lasting Antibody Response, Study Finds
UCLA Fielding School of Public Health

A new study by UCLA researchers and colleagues demonstrates that the Ebola vaccine known as rVSVΔG-ZEBOV-GP results in a robust and enduring antibody response among vaccinated individuals in areas of the Democratic Republic of Congo (DRC) that are experiencing outbreaks of the disease. Among the more than 600 study participants, 95.6% demonstrated antibody persistence six months after they received the vaccine. The study is the first published research examining post–Ebola-vaccination antibody response in the DRC, a nation of nearly 90 million. While long-term analyses of the study cohort continue, the findings will help inform health officials’ approach to vaccine use for outbreak control, the researchers said.

Released: 14-Jan-2022 1:35 PM EST
Researchers identify a set of cellular receptors in humans and other species for the eastern equine encephalitis virus, other members of the alphavirus family
Harvard Medical School

• Researchers have identified a set of receptors shared across human, mosquito, and other animal cells for the eastern equine encephalitis virus (EEEV) and two related viruses, a crucial first step for developing preventive and curative treatments. • In experiments with cells and mouse models with a related virus, the scientists were able to prevent infection and disease progression using decoy molecules to hamper viral entry into cells. • In a 2019 outbreak of eastern equine encephalitis (EEE, or triple E) in New England, 30 percent of infected people died and half of those who survived had long-term neurologic damage. • Done between major outbreaks, this type of research into highly pathogenic viruses with pandemic potential can help improve preparedness for future outbreaks.

28-Sep-2021 1:30 PM EDT
Gene Found in Monkeys and Mice Could Work as a New Type of Antiviral to Block HIV, Ebola, and Other Deadly Viruses in Humans
University of Utah Health

A nationwide team of researchers, led by scientists at University of Utah Health and The Rockefeller University, has determined how a genetic mutation found in mice and monkeys interferes with viruses such as HIV and Ebola. They say the finding could eventually lead to the development of medical interventions in humans.

Released: 14-Sep-2021 2:15 PM EDT
Proteins that outwit emerging and re-emerging viruses
Ohio State University

A family of proteins best known for their role in diminishing HIV infectivity may have the goods to outwit other emerging and re-emerging viruses, scientists have found.

Released: 19-Aug-2021 3:00 PM EDT
VIDEO AND TRANSCRIPT AVAILABLE: Breakthrough Cases and COVID Boosters: Live Expert Panel for August 18, 2021
Newswise

Expert Q&A: Do breakthrough cases mean we will soon need COVID boosters? The extremely contagious Delta variant continues to spread, prompting mask mandates, proof of vaccination, and other measures. Media invited to ask the experts about these and related topics.

Released: 15-Jul-2021 9:00 AM EDT
Global Virus Network (GVN) Adds Senegal’s IRESSEF As Newest Member to Mitigate Viral Threats
Global Virus Network

The Global Virus Network (GVN), representing 63 Centers of Excellence and 11 Affiliates in 34 countries comprising foremost experts in every class of virus causing disease in humans, and the Institut de Recherche en Santé, de Surveillance Epidémiologique et de Formation [Institute for Health Research, Epidemiological Surveillance and Training], or the IRESSEF, announced the addition of the IRESSEF as GVN’s newest Center of Excellence.

Released: 6-Jul-2021 5:30 PM EDT
Mount Sinai Research Reveals How the Ebola Virus Manages to Evade the Body’s Immune Defenses
Mount Sinai Health System

Mount Sinai researchers have uncovered the complex cellular mechanisms of Ebola virus, which could help explain its severe toll on humans and identify potential pathways to treatment and prevention. In a study published in mBio, the team reported how a protein of the Ebola virus, VP24, interacts with the double-layered membrane of the cell nucleus (known as the nuclear envelope), leading to significant damage to cells along with virus replication and the propagation of disease.

Released: 17-Jun-2021 2:05 PM EDT
Trojan horses and tunneling nanotubes: Ebola virus research at Texas Biomed gets NIH funding boost
Texas Biomedical Research Institute

Scientists have a general idea of how viruses invade and spread in the body, but the precise mechanisms are actually not well understood, especially when it comes to Ebola virus. Olena Shtanko, Ph.D., a Staff Scientist at the Texas Biomedical Research Institute (Texas Biomed), has received more than $1 million from the National Institutes of Health (NIH) to explore different aspects of Ebola virus infection.

20-Apr-2021 9:00 AM EDT
Researchers Design Sensor for Fast, Inexpensive On-Site Ebola Detection
Federation of American Societies for Experimental Biology (FASEB)

Researchers are developing a new sensor that can detect Ebola in a single drop of blood and provides results in just an hour. With further development, the technology might also enable fast and inexpensive detection of other viruses, including the virus that causes COVID-19.

Released: 20-Apr-2021 1:20 PM EDT
New Tech Makes Detecting Airborne Ebola Virus Possible
Homeland Security's Science And Technology Directorate

&T's National Biodefense Analysis and Countermeasures Center designed and conducted a study to optimize methods for collecting and measuring very small amounts of Ebola virus in the air.

   
Released: 14-Apr-2021 11:10 AM EDT
Shape-shifting Ebola virus protein exploits human RNA to change shape
La Jolla Institute for Immunology

In a new Cell Reports study, researchers at La Jolla Institute for Immunology demonstrate how Ebola virus has found a different way to get things done. The virus encodes only eight proteins but requires dozens of functions in its lifecycle. The new study shows how one of Ebola virus’s key proteins, VP40, uses molecular triggers in the human cell to transform itself into different tools for different jobs.

Released: 4-Mar-2021 11:55 AM EST
How S&T’s Past Bioagent Research Informs Current and Future Pandemic Response
Homeland Security's Science And Technology Directorate

S&T Past Research with anthrax bacteria, Ebola virus and other pathogens informs current and future pandemic response.

   
Released: 2-Mar-2021 8:25 AM EST
Vaccine development software shows promise in influenza effort, could help defeat coronavirus
Los Alamos National Laboratory

A novel computer algorithm that could create a broadly reactive influenza vaccine for swine flu also offers a path toward a pan-influenza vaccine and possibly a pan-coronavirus vaccine as well, according to a new paper published in Nature Communications.

   
Released: 8-Feb-2021 1:05 PM EST
New drug target for Ebola, Marburg viruses
University of Illinois Chicago

Researchers have identified a previously unknown site on the filovirus glycoprotein to which small drug molecules can bind and prevent infection -- blocking both sites may be more a more effective treatment with reduced risk of side effects.

Released: 20-Oct-2020 12:55 PM EDT
Using supercomputers to combat Ebola
University of Delaware

As the world grapples with COVID-19, the Ebola virus is again raging. A research team at University of Delaware is using supercomputers to simulate the inner workings of Ebola (as well as COVID-19), looking at how molecules move, atom by atom, to carry out their functions. Now, they have revealed structural features of the Ebola virus’s protein shell to provide therapeutic targets to destabilize the virus and knock it out with an antiviral treatment.

14-Oct-2020 2:05 PM EDT
Computational Study Reveals How Ebola Nucleocapsid Stabilizes
American Institute of Physics (AIP)

Scientists at the University of Delaware report a computational study of a nucleocapsid found in the Ebola virus and show that the binding of the ssRNA allows the nucleocapsid to maintain its shape and structural integrity.

   
Released: 26-May-2020 3:00 PM EDT
COVID-19: A wake-up call for the need for new antiviral weapons
Morgridge Institute for Research

Even after heroic medical and societal efforts finally break the back of the current COVID-19 pandemic, the global sigh of relief may not last long. The chilling reality is that viral threats are growing more common. And they’re getting deadlier.

Released: 7-May-2020 6:30 PM EDT
Dearth of Medical Resources in Africa for COVID-19 Reminiscent of Early HIV/AIDS Pandemic
Georgetown University Medical Center

Global health scholars have issued a clarion call about the needless loss of life expected because of a foreseeable prospect of “slow and inadequate access to supplies” to control COVID-19 in sub-Saharan Africa. They say what is unfolding now is similar to when lifesaving diagnostics and treatments came to the region long after they were available elsewhere.

Released: 21-Apr-2020 1:15 PM EDT
The PALM Trial honored with the Society for Clinical Trials’ prestigious David Sackett Trial of the Year Award for 2020
Society for Clinical Trials

Each year since 2008, SCT has awarded the David Sackett Trial of the Year Award to a randomized, controlled trial published (either electronically or in print) in the previous calendar year. The 2020 recipient is Pamoja Tulinde Maisha (PALM [“Together Save Lives”] in the Kiswahili language) trial.

   
Released: 3-Apr-2020 4:25 PM EDT
UCLA clinical trial tests anti-viral drug remdesivir and other therapies against COVID-19
University of California, Los Angeles (UCLA), Health Sciences

UCLA Health is one of 75 sites around the globe participating in a clinical trial sponsored by the National Institutes of Health to test the effectiveness of a candidate anti-viral drug against COVID-19.

Released: 19-Mar-2020 1:55 PM EDT
Pandemic Panic
University of California, Santa Barbara

After the Ebola virus tore through western Africa in 2015, two UC Santa Barbara researchers studied the xenophobia of the disease generated among people who had almost zero chance of being infected by it.

   
Released: 2-Mar-2020 2:15 PM EST
Study reveals how drug meant for Ebola may also work against coronaviruses
University of Alberta

A group of University of Alberta researchers who have discovered why the drug remdesivir is effective in treating the coronaviruses that cause Middle East respiratory syndrome (MERS) and severe acute respiratory syndrome (SARS) expect it might also be effective for treating patients infected with the new COVID-19 strain.

Released: 27-Feb-2020 1:50 PM EST
How door-to-door canvassing slowed an epidemic
Massachusetts Institute of Technology (MIT)

Liberia was the epicenter of a high-profile Ebola outbreak in 2014-15, which led to more than 10,000 deaths in West Africa.

   
21-Feb-2020 12:05 PM EST
When coronavirus is not alone
University of Vermont

Interacting contagious diseases like influenza and pneumonia—and perhaps coronavirus too—follow the same complex spreading patterns as social trends, like the adoption of new slang or technologies. This new finding, published in Nature Physics, could lead to better tracking and intervention when multiple diseases spread through a population at the same time.

12-Feb-2020 12:30 PM EST
Researchers Show How Ebola Virus Hijacks Host Lipids
Biophysical Society

Robert Stahelin studies some of the world’s deadliest viruses. Filoviruses, including Ebola virus and Marburg virus, cause viral hemorrhagic fever with high fatality rates. Stahelin, professor at Purdue University, examines how these viruses take advantage of human host cells.

   
Released: 12-Feb-2020 3:10 PM EST
Coronavirus outbreak raises question: Why are bat viruses so deadly?
University of California, Berkeley

It's no coincidence that some of the worst viral disease outbreaks in recent years -- SARS, MERS, Ebola, Marburg and likely the newly arrived 2019-nCoV virus -- originated in bats.

   
20-Dec-2019 12:55 PM EST
A Fast and Inexpensive Device to Capture and Identify Viruses
Penn State Materials Research Institute

A device to quickly capture and identify various strains of virus has been developed, according to researchers at Penn State and New York University.

   
Released: 9-Dec-2019 2:45 PM EST
Research at Argonne's Advanced Photon Source leads to new Ebola drug
Argonne National Laboratory

Scientists using specialized beamlines at Argonne's Structural Biology Center (SBC), a facility for macromolecular crystallography at the Advanced Photon Source, derived insights that led to the discovery of a promising new drug for Ebola.

   
Released: 9-Dec-2019 1:00 AM EST
La Jolla Institute for Immunology acquires Berkeley Lights Beacon® platform
La Jolla Institute for Immunology

La Jolla Institute for Immunology (LJI) is placing their confidence in Berkeley Lights’ Beacon® Optofluidic Platform and B cell antibody discovery workflow to accelerate the discovery of rare and lifesaving antibodies for the treatment of re-emerging and emerging diseases.

   
Released: 26-Sep-2019 12:05 PM EDT
Texas Biomed continues testing Ebola therapies and vaccines showing promise in outbreak areas
Texas Biomedical Research Institute

In mid-August 2019, human clinical trials were halted in the current Ebola epidemic that has claimed more than 2,100 lives in Africa. The findings resulted in the discontinuation of two of the drugs in the trial. Future patients will be randomly assigned to receive either REGN-EB3 (Regeneron) or mAb114 (Ridgeback Biotherapeutics) in an extension phase of the study. Texas Biomedical Research Institute scientists in the Institute’s Biosafety Level 4 contract research program conducted preclinical testing of several of the compounds in the trial, working with Regeneron and the Biomedical Advanced Research and Development Authority (BARDA).

Released: 28-Aug-2019 1:05 PM EDT
Community-Based Wildlife Carcass Surveillance Is Key for Early Detection of Ebola Virus
Wildlife Conservation Society

WCS (Wildlife Conservation Society) and NIH (National Institutes of Health) scientists partnered with the Republic of Congo Ministry of Health to develop a low-cost educational outreach program and surveillance system for wildlife mortality that has continued now for over a decade.

   
Released: 9-Aug-2019 3:05 PM EDT
Machine Learning Helps Create Detailed, Efficient Models of Water
Department of Energy, Office of Science

A team devised a way to better model water’s properties. They developed a machine-learning workflow that offers accurate and computationally efficient models.

Released: 8-Aug-2019 3:05 PM EDT
Existing anti-parasitic drug could offer treatment for Ebola
Boston Children's Hospital

Amid the worsening Ebola outbreak in the Congo, now threatening to spill into Rwanda, a new study suggests that an existing, FDA-approved drug called nitazoxanide could potentially help contain this deadly

Released: 18-Jul-2019 1:05 PM EDT
Declaration of PHEIC in DRC Should Spur Support, Not Fear
Infectious Diseases Society of America (IDSA) and the HIV Medicine Association (HIVMA)

The World Health Organization’s declaration today that the year-long Ebola crisis is a Public Health Emergency of International Concern is hoped to raise much-needed awareness and resources for preparedness and control efforts across the region. The decision was made following new incidents highlighting risks of repeated cross-border spread of the ongoing Ebola outbreak in the Democratic Republic of Congo.

     
Released: 25-Jun-2019 8:50 AM EDT
New Transmission Model for Ebola Predicted Latest Uganda Cases
Kansas State University

A new risk assessment model for the transmission of Ebola accurately predicted its spread into the Republic of Uganda, according to the Kansas State University researchers who developed it. They published "Risk assessment of Ebola virus disease spreading in Uganda using a multilayer temporal network" in bioRxiv before the Uganda cases.


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