A team from the GW School of Medicine and Health Sciences found emerging treatments, such as neurokinin-1 receptor antagonists, were the most promising against prurigo nodularis.
In medical chart reviews of 2,430 kidneys transplanted from 1,298 donors—585 (24 percent) of them with AKI—researchers say they found no significant differences in rates of organ rejection among kidneys from deceased donors with or without AKI. They also report they found no evidence that factors such as the amount of time an organ is chilled and left without blood supply before transplantation had any impact on recipient outcomes for those who received AKI kidneys.
Researchers at Johns Hopkins Medicine have developed a new molecular tool they call EXoO, which decodes where on proteins specific sugars are attached—a possible modification due to disease. The study, published in issue 14 of Molecular Systems Biology, describes the development of the tool and its successful use on human blood, tumors and immune cells.
Researchers at the University of Illinois at Chicago have found that men with chronic kidney disease, or CKD, are more likely to experience disease progression and death when compared with women suffering from the same condition.
You may remember a loved one making you a bowl of chicken noodle soup whenever you were feeling under the weather as a child. Just how healthy is this culinary cure-all? BIDMC clinical dietitian Sandy Allonen, RD, weighs in.
A new study led by researchers at Beth Israel Deaconess Medical Center (BIDMC) investigated rates of bloodstream infection among patients with or without catheters in outpatient hemodialysis facilities in New England.
The PhRMA Foundation awarded more than $6 million over the last two years to more than 100 leaders in scientific research in the United States. The Foundation is proud to announce another successful year supporting innovative research efforts in areas of great importance: Alzheimer’s Disease, Melanoma, Parkinson’s Disease, Schizophrenia, Breast Cancer, Lung Cancer, Leukemia, Ulcerative Colitis, Vascular Disease, and Colorectal Cancer. This year the Foundation also funded two Centers of Excellence in Value Assessment.
An abundance of high-sugar, high-salt foods in many American diets and obesity-related health problems such as diabetes are likely driving an increase in kidney disease cases, including in young adults, according to researchers at Washington University School of Medicine in St. Louis.
• Concerning adherence to certain recommended measures of kidney disease care for veterans with diabetes within the Veterans Affairs Health Care System, there is modest facility-level variation for some measures and larger facility-level variation for others.
A team of researchers led by Jonathan Stamler, MD, of Case Western Reserve University School of Medicine and University Hospitals Cleveland Medical Center, has discovered a pathway for enhancing the self-repair efforts of injured kidneys. The finding may pave the way for new drugs to stop or even reverse the progression of serious kidney disease in humans—and other potentially lethal conditions of the heart, liver, and brain as well.
In an effort to compile and summarize the latest knowledge about these immunotherapy combinations and their implications, a group of kidney cancer immunotherapy experts led by Saby George, MD, of Roswell Park Comprehensive Cancer Center have written a new research review article assessing current approaches to treating patients newly diagnosed with kidney cancer and also looking ahead to some of the most pressing questions still to be answered related to these emerging therapies. Published online Nov. 21 by the journal JAMA Oncology, the review article highlights the path to approval for the new standard of care for these patients — ipilimumab, also known as Yervoy, together with nivolumab, also known as Opdivo.
Are there changes that affect genes and fuel a person’s propensity to develop obesity? That’s a question under study at Texas Biomedical Research Institute. Associate Scientist Melanie Carless, Ph.D., is Principal Investigator of a $3 million, four-year grant from the National Institute of Diabetes, Digestive and Kidney Diseases to research this hypothesis.
Urinating into a cup may be a medical necessity at times, but it's often uncomfortable, embarrassing and messy -- especially for women. But what if there were a way to comfortably provide a sample without the splashback? Researchers have created a set of experiments using an anatomically correct female urethra that produced a jet of water with a pressure and flow equivalent to a human bladder. During the APS Division of Fluid Dynamics 71st Annual Meeting, Nov. 18-20, they’ll describe the findings and potential implications.
• A pilot program delivered by community health representatives in the homes of patients with chronic kidney disease in Zuni Pueblo in rural New Mexico promoted patients’ active involvement in their own care.
• The program also led to modest improvements in several clinical measures, including decreases in body mass index, blood glucose levels, and inflammation, and improved mental health quality of life.
New research has identified rogue cells – namely brain and muscle cells – lurking within kidney organoids. The presence of such cells indicates that the “recipes” used to coax stem cells into becoming kidney cells inadvertently are churning out other cell types.
RenalytixAI PLC, a Mount Sinai exclusive licensee and development collaborator, had completed a public listing that valued the company at $85 million on the London Stock Exchange’s Alternative Investment Market.
A widely held and controversial myth that high-protein diets may cause kidney damage in healthy adults has been debunked by scientists at McMaster University, who examined more than two dozen studies involving hundreds of participants.
• In a study that compared uninsured patients starting hemodialysis with similar patients already covered by Medicare or Medicaid, patients with Medicare or Medicaid were more likely to receive dialysis through an arteriovenous fistula or graft by their fourth dialysis month.
• Patients with Medicare at the start of dialysis also had fewer hospitalizations involving vascular access infection in dialysis months 4-12.
The American Society of Nephrology (ASN) today announced former ASN President Raymond C. Harris, Jr., MD, FASN, will serve as co-chair for its Kidney Health Initiative (KHI). Harris, a professor of medicine, molecular physiology, and biophysics, is Director of the Vanderbilt Center for Kidney Disease and former chief of the nephrology division of Vanderbilt University’s Medical Center in Nashville, Tenn.
The American College of Surgeons National Surgical Quality Improvement Program has recognized 83 of an eligible 568 hospitals participating in its adult program for achieving meritorious outcomes for surgical patient care in 2017.
PHILADELPHIA — A $17.5 million grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) will propel Penn Medicine research efforts to prevent Chronic Kidney Disease (CKD). Harold I. Feldman, MD, MSCE, chair of Biostatistics, Epidemiology and Informatics and director of the Center for Clinical Epidemiology and Biostatistics, and J.
The American Society of Nephrology (ASN), the world’s largest organization of kidney health professionals, has elected Mark E. Rosenberg, MD, FASN, as the next ASN President.
Dr. Rosenberg officially assumes his role as ASN President during the society’s annual meeting, ASN Kidney Week 2018, the largest gathering of kidney care specialists in the world, and he will begin his term on January 1, 2019.
• Frailty is associated with decreased access at multiple stages in the pathway to kidney transplantation. Improvement in physical frailty may increase access to transplantation.
• Results from the study will be presented at ASN Kidney Week 2018 October 23–October 28 at the San Diego Convention Center.
• An analysis reveals that many transplanted kidneys in France would have likely been discarded in the United States.
• Results from the study will be presented at ASN Kidney Week 2018 October 23–October 28 at the San Diego Convention Center.
• Among patients with chronic kidney disease, individuals with pro-inflammatory diets had a higher risk of developing kidney failure.
• Results from the study will be presented at ASN Kidney Week 2018 October 23–October 28 at the San Diego Convention Center.
• Nephrologists often lack confidence in managing women’s health issues that may be related to kidney disease.
• Results from the study will be presented at ASN Kidney Week 2018 October 23–October 28 at the San Diego Convention Center.
• Within one year after initiating dialysis, patients on more frequent home hemodialysis were 23% less likely to die compared with patients receiving traditional in-center hemodialysis.
• Results from the study will be presented at ASN Kidney Week 2018 October 23–October 28 at the San Diego Convention Center.
• Individuals with kidney disease have a higher likelihood of using prescription opioids, and the prevalence of prescription opioid use in the chronic kidney disease population has increased in recent years.
• Certain factors are associated with opioid drug use in patients with chronic kidney disease.
• Results from the study will be presented at ASN Kidney Week 2018 October 23–October 28 at the San Diego Convention Center.
The results of numerous high-impact clinical trials that could affect kidney-related medical care will be presented at ASN Kidney Week 2018 October 23–October 28 at the San Diego Convention Center.
• In a study of kidney transplant recipients, those with ideal BMI (18–25) had the best organ survival. There was no difference when comparing BMI 30–35 with >35.
• There were no significant differences in patient survival across different BMI groups.
• Results from the study will be presented at ASN Kidney Week 2018 October 23–October 28 at the San Diego Convention Center.
• From 1995 to 2014, patient survival after kidney transplantation improved overall for pediatric recipients in the United States; however, racial/ethnic disparities in long-term survival worsened over time.
• Results from the study will be presented at ASN Kidney Week 2018 October 23–October 28 at the San Diego Convention Center.
• Patients with acute kidney injury had more than a 3-fold higher risk of developing dementia compared with those without acute kidney injury during a median follow-up time of 5.8 years.
• Results from the study will be presented at ASN Kidney Week 2018 October 23–October 28 at the San Diego Convention Center.
• Compared with kidney transplant recipients who did not report a disability, recipients with a visual disability were at higher risk of organ failure and recipients with a walking disability were at higher risk of early death.
• Results from the study will be presented at ASN Kidney Week 2018 October 23–October 28 at the San Diego Convention Center.
• In patients with type 2 diabetes at high risk for cardiovascular disease, targeting blood sugar to normal levels (HbA1c<6.0%) reduced the risk for macroalbuminuria (a high amount of protein excreted in the urine) over an average follow-up of 7.7 years, but it had no impact on more significant kidney outcomes such as serum creatinine doubling (a marker of worsening kidney function) or the need for dialysis or transplantation.
• Targeting low blood pressures (<120mmHg) or the use of fenofibrate to lower cholesterol increased the risk for doubling of serum creatinine, although it had no impact on the need for dialysis or transplantation.
• Results from biopsies taken when kidneys were procured from donors were not reliable for determining whether the organs were suitable for transplantation.
Glyn R. Morgan, MD, MSc, FRCSC, FACS, one of the nation's leading liver and kidney transplant surgeons, has been named director of Loyola Medicine's division of intra-abdominal transplant.
The American Society of Nephrology’s Kidney Health Initiative is releasing its Technology Roadmap for Innovative Approaches to Renal Replacement Therapy.
Results of a phase II clinical trial show that novel drug sparsentan is an effective treatment for the rare kidney disease focal segmental glomerulosclerosis (FSGS), which currently has no FDA-approved therapies.
• Receiving high-dose vs. standard dose influenza vaccine in 2016-17 was associated with lower rates of hospitalization in dialysis patients, although this association was not seen in 2015-16 (when few dialysis patients received the high-dose vaccine).
• There were no differences in rates of death between patients receiving the high-dose vs. standard dose influenza vaccine during either time period.
Using a novel biomarker panel to track and measure kidney function, researchers at University of California San Diego School of Medicine and University of California San Francisco School of Medicine report that lowering systolic blood pressure to less than 120 mm Hg does not damage the kidney organ itself. Instead, any negative changes to clinical results are more likely due to decreased blood flow.
Treatment of renal cell carcinoma with stereotactic radiation therapy is as safe and effective for patients with one kidney as it is for those who have two, according to an analysis of the largest-ever, international dataset of solitary kidney patients to receive this emerging treatment. Findings will be presented in a news briefing today at noon ET from the American Society for Radiation Oncology (ASTRO) Annual Meeting.
Five leaders in the kidney health community are being honored by the American Society of Nephrology (ASN), the world’s largest organization of kidney disease specialists.