An investigational therapy using modified poliovirus to attack cancer tumors appears to unleash the body’s own capacity to fight malignancies by activating an inflammation process that counter’s the ability of cancer cells to evade the immune system.
Workers who were likely exposed to dispersants while cleaning up the 2010 Deepwater Horizon oil spill experienced a range of health symptoms including cough and wheeze, and skin and eye irritation, according to scientists at the National Institutes of Health (NIH). The study appeared online Sept. 15 in Environmental Health Perspectives and is the first research to examine dispersant-related health symptoms in humans.
Researchers at Duke Cancer Institute have not only untangled an unusual wiring system that cancer cells use for carbohydrate metabolism, but also identified a natural compound that appears to selectively shut down this system in laboratory studies.
The calculator estimates the impact of differences in breastfeeding rates, providing policy makers and advocates with ways to approximate return on investment for measures that help enable breastfeeding.
Science educators at Wake Forest University are testing how automated feedback combined with new one-on-one teaching methods can improve scientific writing from STEM undergraduates – and result in better explanation of research to the public.
Researchers are rolling out a new manufacturing process and chip design for silicon carbide (SiC) power devices, which can be used to more efficiently regulate power in electronics. The process was developed to make it easier for companies to enter the SiC marketplace and develop new products.
Cost savings fell below expectations for generic versions of an orally administered cancer treatment in an analysis by University of North Carolina Lineberger Comprehensive Cancer Center researchers. The findings raise questions about the extent to which generic drugs can help control care costs for cancer treatments.
The North Carolina economy is expected to continue the slow growth pattern of the past eight years, with strong indicators from low unemployment rates and long-term projections for GDP growth, UNC Charlotte professor and economist John Connaughton says.
A new study finds that the Supplemental Nutrition Assistance Program (SNAP) only covers 43-60 percent of what it costs to consume a diet consistent with federal dietary guidelines for what constitutes a healthy diet.
Hidden in plain sight – that’s how researchers describe their discovery of a new genus of large forest tree commonly found, yet previously scientifically unknown, in the tropical Andes. Researchers from the Smithsonian and Wake Forest University detailed their findings in a study just released the journal PhytoKeys.
Mucin levels – the proteins that make mucus thick – is abnormally high in chronic bronchitis and mucin concentrations are associated with disease severity. This finding could become the first-ever objective marker of chronic bronchitis and lead to the creation of diagnostic and prognostic tools.
Compared to people who live in predominantly white neighborhoods, those who live in predominantly black areas are much less likely to receive CPR or defibrillation from a bystander when their heart suddenly stops beating while they are at home or out in the community.
Scientists have known that abnormal protein deposits and swarms of activated immune cells accumulate in brains of people with Alzheimer’s. Now researchers have untangled how these proteins and inflammation interact in lab experiments to reveal how therapies might reverse the disease process.
In a large, international study led by the Duke Clinical Research Institute and five coordinating centers around the world, an informational campaign aimed at patients, families and physicians led to a 9-percent absolute increase in the use of anticoagulation therapies. The increased drug adherence was accompanied by a small, but notable reduction in the risk of stroke.
Working at a health center in rural Uganda, researchers from the University of North Carolina at Chapel Hill demonstrated for the first time the potential of using a low-cost, routinely available rapid diagnostic test to distinguish between severe and uncomplicated malaria in children.
A recent study finds that 21 percent of recent mothers experiencing postpartum mood disorders, such as anxiety and depression, do not disclose their symptoms to healthcare providers.
A new imaging technique helps UNC researchers study tiny, time-sensitive biological processes – the crucial underpinnings of human health and disease.
Modern Healthcare has named Dr. William L. Roper, CEO of UNC Health Care, dean of the UNC School of Medicine and vice chancellor for medical affairs at the University of North Carolina at Chapel Hill, to its annual list of the 100 Most Influential People in Health Care for 2017.
Like any aspiring engineer, first-year student Meredith Vaughn gets excited about building something from the ground up, so Wake Forest University’s new undergraduate engineering program immediately appealed to her. Vaughn is one of approximately 50 students in Wake Forest’s first cohort of undergraduate engineering students who will begin taking classes at Wake Downtown later this month.
A protein called COUP-TFII determines whether a mouse embryo develops a male reproductive tract, according to researchers at the National Institutes of Health and their colleagues at Baylor College of Medicine, Houston. The discovery, which appeared online August 17 in the journal Science, changes the long-standing belief that an embryo will automatically become female unless androgens, or male hormones, in the embryo make it male.
Computerized models have not replaced crash dummies in assessing the protective properties of motor vehicles, military equipment and other products. But virtual figures offer many advantages over mechanical manikins and are becoming more widely used in injury biomechanics and other fields.
A third of insured people with cancer end up paying more out-of-pocket than they expected, despite having health coverage, researchers at the Duke Cancer Institute have found.
UNC Lineberger scientists led a multi-institution research team to identify key features linked to amelanotic melanoma, a form of skin cancer that lacks the brown or black color that stems from the pigment melanin.
UNC Charlotte College of Computing and Informatics Dean Fatma Mili officially began her tenure Aug. 1.
How can parents help their student-athletes gain a competitive edge? By boning up on nutrition basics.
Gender, racial, socioeconomic and other equity gaps in STEM-related careers are more than a “pipeline problem.” That being said, what are colleges and universities like Wake Forest doing to help close these gaps?
An antenna-like structure on cells, once considered a useless vestige, can cause defects in the brain’s wiring similar to what’s seen in autism, schizophrenia, and other disorders. In the lab, UNC scientists prevented defects by restoring signaling though these structures called primary cilia.
A new study by RTI International found that low Medicaid payment rates for services in assisted living and similar settings discourage residential care providers from serving Medicaid beneficiaries, which limits their access to community-based residential care.
In the Journal of the National Cancer Institute, UNC Lineberger researchers published results of an analysis of approximately 1,000 invasive breast tumors. The study confirmed that young black women are more likely to have “triple negative,” or “basal-like,” breast cancers, a subtype that does not express any of the receptors for targeted biologic therapies. The study also identified variation by race within a clinical breast cancer type that has the greatest mortality disparity.
Researchers from UNC and NC State are developing a potential stem cell treatment for several lung conditions, such as idiopathic pulmonary fibrosis (IPF), chronic obstructive pulmonary disease (COPD), and cystic fibrosis – often-fatal conditions that affect tens of millions of Americans.
Nearly 100 North Carolina child care centers that use public water supplies are partnering with RTI International to test for lead. Additional child care centers and elementary schools can enroll in the study through mid-August. Participation in the study is free and participant results are private.
Researchers at the University of North Carolina at Chapel Hill have found Ebola RNA in the semen of survivors two years after infection. They are calling on the World Health Organization to update its guidelines on sexual transmission.
For the first time researchers at the University of North Carolina at Chapel Hill have developed an assay that can measure antigen production and clearance caused by a latency-reversing agent.
The push to develop treatments for Alzheimer’s disease has yielded a greater understanding of the disease, but has failed to generate successful new drugs. To blame are the many undefined subtypes of mild cognitive impairment, a precursor to Alzheimer’s disease. But if scientists grouped people with similar types of cognitive impairment, they could more precisely test the impact of investigational drugs, according to findings in a July 28 article in the journal Scientific Reports, a publication of Nature Research.
African-Americans typically have worse outcomes from smoking-related cancers than Caucasians, but the reasons for this remain elusive. However, scientists at Wake Forest Baptist Medical Center have taken a big step toward solving this puzzle.
The National Institutes of Health has awarded the University of North Carolina more than $5.6 million to test a therapeutic vaccine for HIV. The study's principal investigator says the goals are to redirect and strengthen the immune response to the virus.
The protein TDP-43 is thought to cause muscle degeneration in patients with ALS. UNC and NC State researchers found that a specific chemical modification promotes TDP-43 clumping in animals. In muscle cells, scientists reversed protein clumping and prevented the sIBM-related muscle weakness.
A new study has found that children born extremely premature to women who are overweight or obese before the pregnancy are at an increased risk for low scores on tests of intelligence and cognitive processes that influence self-regulation and control, according to researchers at Wake Forest Baptist Medical Center.
Cancer drug Vorinostat given every 72 hours can awaken sleeping HIV in the body, says researchers at the University of North Carolina at Chapel Hill. However, it does not clear or deplete infection, meaning additional advances will be needed to achieve a cure.
Can the kinds of microbes colonizing the gut at age 1 predict later cognitive development? Findings from the UNC School of Medicine shed light on the surprising role of bacteria in how our brains develop during the first years of life.
Scientists from an international consortium have identified a large number of new genetic markers that predispose individuals to lupus.
Researchers affiliated with the Anna Julia Cooper Center at Wake Forest University are seeking young black adults for a research study investigating the impact of watching high-profile videos of police violence on social media.
Depending on what generation you belong to, the term “improvisational dance” may conjure up images of beatniks grooving to the beat of bongos in a darkened coffeehouse or the black-clad Dieter gyrating to techno pop in a Sprockets sketch on “Saturday Night Live”.
UNC Health Care is one of only 27 systems in the United States to be recognized as a “Most Wired Advanced” health system by the American Hospital Association (AHA) for its use of information technology to improve patient care and clinical integration.
For humanitarian contributions to the field of industrial-organizational psychology, UNC Charlotte professor Steven Rogelberg was named the inaugural recipient of the Society of Industrial and Organizational Psychology Humanitarian Award.
If emotional intelligence is a key—and possibly the most important—component to student success, how do we ensure schools foster it?
For the subset of women with BRCA mutations who have already had ovarian cancer, risk-reducing mastectomy might not be worth the price tag. New research from the Duke Cancer Institute finds that for many women in this unique group, prophylactic mastectomy does not produce a substantial survival gain versus breast cancer screening alone and is not cost-effective.
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