Feature Channels: Stem Cells

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Released: 23-Jun-2022 12:00 PM EDT
Mouse genomic rewriting and tailoring: synthetic Trp53 and humanized ACE2
Preprints

Weimin Zhang, Ilona Golynker, Ran Brosh, Aleksandra M. Wudzinska, Yinan Zhu, Lucia Carrau, Payal Damani-Yokota, Camille Khairallah, Noor Chalhoub, Emily Huang, Hannah Ashe, Kamal M. Khanna, Matthew T. Maurano, Sang Yong Kim,

Released: 22-Jun-2022 12:00 PM EDT
Combining blinatumomab and donor lymphocyte infusion in B-ALL patients relapsing after allogeneic hematopoietic cell transplantation: A study of the SFGM-TC
Preprints

Relapsed B-cell acute lymphoblastic leukemia (B-ALL) after allogeneic stem cell transplantation (allo-HCT) still represents a major concern with poor outcomes.

Released: 22-Jun-2022 12:00 PM EDT
Loss of bisecting GlcNAcylation on MCAM of bone marrow stoma determined pro-tumoral niche in MDS/AML
Preprints

Bone marrow (BM) stroma plays key roles in supporting hematopoietic stem cell (HSC) growth.

Released: 22-Jun-2022 12:00 PM EDT
Transcriptomic alterations underlying metaplasia into specific metaplastic components in metaplastic breast carcinoma
Preprints

Metaplastic breast carcinoma (MpBC) typically consists of carcinoma of no special type (NST) with varios metaplastic components.

Released: 22-Jun-2022 12:00 PM EDT
Heat shock-induced exosomes derived from neural stem cells confer marked neuroprotection against oxidative stress and amyloid-β caused neurotoxicity
Preprints

Alzheimer’s disease (AD) is the most prevalent neurodegenerative disease and a leading cause of dementia.

Released: 22-Jun-2022 12:00 PM EDT
The effect and mechanism of miRNA-140 in exosomes of hypoxic bone marrow mesenchymal stem cells on articular chondrocytes
Preprints

This study aimed to investigate the effects and mechanisms of miRNA-140 in exosomes of hypoxic bone marrow mesenchymal stem cells on articular chondrocytes. Articular chondrocytes were stimulated with IL-1β (10 μg/ml) to give them an inflammatory state.

Released: 22-Jun-2022 12:00 PM EDT
Effectiveness and safety of Stem cell therapy for Diabetic Foot: a meta-analysis update
Preprints

Diabetic foot (DF) is one of the most common and serious complications of diabetes mellitus (DM), which brings great psychological and economic pressure to patients. This study aimed to evaluate the efficacy of stem cells in the treatment of diabetic foot.

Released: 22-Jun-2022 12:00 PM EDT
Co-option of endogenous retroviruses through genetic escape from TRIM28 repression
Preprints

Endogenous retroviruses (ERVs) have rewired host gene networks through co-option of their enhancers.

Released: 22-Jun-2022 12:00 PM EDT
Folate ameliorates arrhythmia in patient-derived TANGO2-deficient iPSC-cardiomyocytes
Preprints

TANGO2-deficient disorder (TDD) is an autosomal recessive genetic disease caused by biallelic loss-of-function variants in TANGO2 gene.

Released: 22-Jun-2022 12:00 PM EDT
RBM47 is a critical regulator of mouse embryonic stem cell differentiation
Preprints

RNA-binding proteins (RBPs) are pivotal for regulating gene expression as they are involved in each step of RNA metabolism.

Released: 18-Jun-2022 12:00 PM EDT
Machine learning-based classification of binary dynamic fluorescence signals reveals muscle stem cell fate transitions in response to pro-regenerative niche factors
Preprints

Matteo Togninalli, Andrew T.V. Ho, Christopher M Madl, Colin A. Holbrook, Yu Xin Wang, Klas E.G. Magnusson, Anna Kirillova, Andrew Chang, Helen Blau

Newswise: Neurons and Glia Collaborate to Drive Neural Regeneration Following Brain Injury
Released: 17-Jun-2022 12:05 PM EDT
Neurons and Glia Collaborate to Drive Neural Regeneration Following Brain Injury
Champalimaud Centre for the Unknown

One of the most devastating aspects of stroke and traumatic brain injury is that the neurons we lose are never replaced.

Released: 17-Jun-2022 12:00 PM EDT
Active participation of people with spinal cord injury in the design of scientific research
Preprints

Fabiana Faleiros, Deyse Braga, Soraia Dornelles Schoeller, Sílvia Helena Henriques, Naira Beatriz Favoretto Cunha, Lorena Gomes Neves Videira, Adriana Cordeiro Leandro Silva Grillo

Released: 17-Jun-2022 12:00 PM EDT
The Impact of Storage Condition and Duration on Function of Native and Cargo-Loaded Mesenchymal Stromal Cell Extracellular Vesicles
Preprints

Daniel Levy, Anjana Jeyaram, Louis J Born, Kai-Hua Chang, Sanaz Nourmohammadi Abadchi, Angela Ting Wei Hsu, Talia Solomon, Amaya Aranda, Samantha Stewart, XiaoMing He, John W Harmon, Steven M Jay

Released: 17-Jun-2022 12:00 PM EDT
SOX10 Expression Levels may be a Critical Mediator of White Matter Dysfunction in Schizophrenia
Preprints

Donna L McPhie, Boyu Ren, Juan Antonio Garcıa-Leon, Catherine M Verfaillie, Bruce M Cohen

Released: 17-Jun-2022 12:00 PM EDT
AKT1-FOXO4 Axis Regulates Hemochorial Placentation
Preprints

Keisuke Kozai, Ayelen Moreno Irusta, Khursheed Iqbal, Mae-Lan Winchester, Regan L Scott, Mikaela E Simon, Masanaga Muto, Marc R Parrish, Michael J Soares

Released: 17-Jun-2022 12:00 PM EDT
Inhibition of Fas Receptor Endocytosis Sensitizes Cancer Cells to Fas-induced Apoptosis
Preprints

Mehmet Kural, Umidahan Djakbarova, Bilal Cakir, Yoshiaki Tanaka, Yasaman Madraki, Hong Qian, Jinkyu Park, Lorenzo Sewanan, Comert Kural, Laura Niklason

Released: 17-Jun-2022 12:00 PM EDT
Rescue of aged muscle stem cell intrinsic quiescence defects by AKT inhibition revealed with a 3D biomimetic culture assay
Preprints

Erik Jacques, Yinni Kuang, Allison P Kann, Robert S Krauss, Penney M Gilbert

Released: 17-Jun-2022 12:00 PM EDT
Alterations in protein kinase networks in astrocytes and neurons derived from patients with familial Alzheimers Disease
Preprints

Nicholas Daniel Henkel, Alex Joyce, Elizabeth Shedroff, Ali Sajid Imami, Khaled Alganem, Abdul-Rizaq Hamoud, Chongchong Xu, Benjamin Siciliano, Tao Ma, Zhexing Wen, Robert Erne McCullumsmith

Released: 17-Jun-2022 12:00 PM EDT
Cell fusion upregulates PD-L1 expression and promotes tumor formation
Preprints

Hisao Masai, Youichi Tajima, Futoshi Shibazaki

Released: 17-Jun-2022 12:00 PM EDT
Differentiation of intestinal epithelial stem cells from parthenogenetic embryonic stem cells
Preprints

Zhiqiang Wang, Leilei Li, Wanpu Wang, Lilin Luo, Shuai Dong, Menglong Li, Tianxing Chen, Qingyang Meng, Rui Liang

Released: 17-Jun-2022 12:00 PM EDT
De novo annotation of lncRNA HOTAIR transcripts by long-read RNA capture-seq reveals a differentiation-driven isoform switch
Preprints

Evdokiia Potolitsyna, Sarah Hazell Pickering, Ave Tooming-Klunderud, Philippe Collas, Nolwenn Briand

Released: 17-Jun-2022 12:00 PM EDT
CITED2 Is A Conserved Regulator Of Deep Hemochorial Placentation
Preprints

Marija Kuna, Pramod Dhakal, Khursheed Iqbal, Esteban M. Dominguez, Lindsey N. Kent, Masanaga Muto, Ayelen Moreno-Irusta, Keisuke Kozai, Kaela M. Varberg, Hiroaki Okae, Takahiro Arima, Henry M. Sucov, Michael J. Soares

Newswise: New Solution for Stem Cell Manufacturing
Released: 16-Jun-2022 1:30 PM EDT
New Solution for Stem Cell Manufacturing
University of Technology, Sydney

Researchers have developed a unique 3D printed system for harvesting stem cells from bioreactors, offering the potential for high quality, wide-scale production of stem cells in Australia at a lower cost.

Released: 16-Jun-2022 12:00 PM EDT
Sex-specific niche signaling contributes to sexual dimorphism following stem cell transplantation
Preprints

Julianne N.P. Smith, Brittany A Cordova, Brian Richardson, Kelsey F Christo, Jordan Campanelli, Alyssia V Broncano, Jonathan Chen, Juyeun Lee, Scott J Cameron, Justin D Lathia, Wendy A Goodman, Mark J Cameron, Amar B Desai

Released: 16-Jun-2022 12:00 PM EDT
Evaluation of targeted oxidative stress induced by oxygen-ozone gas mixtures in vitro after ischemic induction
Preprints

Jéssica Rodrigues Orlandin, Sarah Ingrid Pinto Santos, Luciana Cristina Machado, Paulo Fantinato Neto, Fabiana Fernandes Bressan, Naira Caroline Godoy Pieri, Kaiana Recchia, Meline de Paula Coutinho, Priscilla Avelino Ferreira Pinto, Annalisa Santucci, Valter Travagli, Carlos Eduardo Ambrosio

Released: 16-Jun-2022 12:00 PM EDT
Characterization of EGFR-reprogrammable temozolomide-resistant cells in a model of glioblastoma
Preprints

Lingli Gong, Ying Yin, Cheng Chen, Quan Wan, Die Xia, Mei Wang, Zhening Pu, Bo Zhang, Jian Zou

Released: 16-Jun-2022 12:00 PM EDT
Autologous hematopoietic stem cell transplantation improves long term survival – data from a national registry
Preprints

Norbert Blank, Marc Schmalzing, Pia Moinzadeh, Max Oberste, Elise Siegert, Ulf Müller-Ladner, Gabriela Riemekasten, Claudia Günther, Ina Kötter, Gabriele Zeidler, Christiane Pfeiffer, Aaron Juche, Ilona Jandova, Jan Ehrchen, Laura Susok, Tim Schmeiser, Cord Sunderkoetter, Jörg H. W. Distler, Margitta Worm, Alexander Kreuter, Gernot Keyzer, Hanns-Martin Lorenz, Thomas Krieg, Nicolas Hunzelmann, Joerg Henes

Released: 16-Jun-2022 12:00 PM EDT
Comprehensive Characterisation of Fetal and Mature Retinal Cell Identity to Assess the Fidelity of Retinal Organoids
Preprints

Hani Jieun Kim, Michelle Ohara-Wright, Daniel Kim, To Ha Loi, Benjamin Y Lim, Robyn V Jamieson, Anai Gonzalez Cordero, Pengyi Yang

Released: 16-Jun-2022 12:00 PM EDT
The Role of QRSL1 in Clinical Subtypes and Prognosis of Childhood B-cell Acute Lymphoblastic Leukemia
Preprints

Sha Yin, Wenjin Gao, Ye Fan, Rui Xia, Mingyue Duan, Xi Zhang, Ansheng Liu, Yanmin Zhang

Released: 15-Jun-2022 12:00 PM EDT
Transit-amplifying progenitor with maturation-dependent behavior contributes to epidermal renewal
Preprints

Sangeeta Ghuwalewala, Kevin Jiang, Sara Ragi, David Shalloway, Tudorita Tumbar

Released: 15-Jun-2022 12:00 PM EDT
Accelerating effect of Shilajit on osteogenic property of adipose derived mesenchymal stem cells (ASCs)
Preprints

Parisa Kangari, Leila Roshangar, Aida Iraji, Tahereh Talaei-Khozani, Mahboobeh Razmkhah

Newswise: Streamlining Stem Cells to Treat Macular Degeneration
Released: 14-Jun-2022 2:05 PM EDT
Streamlining Stem Cells to Treat Macular Degeneration
École Polytechnique Fédérale de Lausanne (EPFL)

As we age, so do our eyes; most commonly, this involves changes to our vision and new glasses, but there are more severe forms of age-related eye problems. One of these is age-related macular degeneration, which affects the macula — the back part of the eye that gives us sharp vision and the ability to distinguish details.

Released: 14-Jun-2022 12:00 PM EDT
Gla-domain mediated targeting of externalized phosphatidylserine for intracellular delivery
Preprints

Terry Hermiston, Jonathan Hardy, Maxine Bauzon, Francis G Blankenberg, Masamitsu Kanada, Ashley Makela, Charles K. F. Chan, Christopher H Contag

Released: 14-Jun-2022 12:00 PM EDT
The abnormal expression of circ-ARAP2 promotes ESCC progression through regulating miR-761/FOXM1 axis-mediated stemness and the endothelial-mesenchymal transition
Preprints

Pei Xu, Lei Wang, Qingtao Liu, Pengkai Gao, Fengqing Hu, Xiao Xie, Lianyong Jiang, Rui Bi, Fangbao Ding, Qi Yang, Haibo Xiao

Released: 14-Jun-2022 12:00 PM EDT
Structural analysis of SALL4 zinc-finger domain reveals a link between AT-rich DNA binding and Okihiro syndrome
Preprints

James A. Watson, Raphaël Pantier, Uma Jayachandran, Kashyap Chhatbar, Beatrice Alexander-Howden, Valdeko Kruusvee, Michal Prendecki, Adrian P Bird, Atlanta G. Cook

Released: 13-Jun-2022 12:00 PM EDT
Stretchable mesh microelectronics for the biointegration and stimulation of neural organoids
Preprints

Thomas L Li, Yuxin Liu, Csaba Forro, Levent Beker, Zhenan Bao, Bianxiao Cui, Sergiu P Pasca

Released: 13-Jun-2022 12:00 PM EDT
Nervous system reduction in branched-chain amino acid metabolism disrupts hippocampal neurogenesis and memory
Preprints

Khadar Abdi, Ramona Rodriguez, William C Wetsel, Michelle E Arlotto, Robert W McGarrah, Phillip J White

Released: 13-Jun-2022 12:00 PM EDT
Generation of Cerebral Organoids with Enriched Cortical Cellular Diversity and Outer Radial Glial Cell Identity from Human Pluripotent Stem Cells
Preprints

Yechiel Elkabetz, Sneha Arora, Anastasios Balaskas, Amèlia Aragonés Hernández, Daniel Rosebrock

Released: 13-Jun-2022 12:00 PM EDT
ΔNp63α Transcriptionally Represses p53 Target Genes Involved in the Radiation-Induced DNA Damage Response
Preprints

Ken-Ichi Kudo, Naohiro Tsuyama, Kento Nagata, Tatsuhiko Imaoka, Daisuke Iizuka, Misaki Sugai-Takahashi, Moe Muramatsu, Akira Sakai

Released: 12-Jun-2022 12:00 PM EDT
A Development-Inspired Niche for Homeostatic Human Mini-Intestines
Preprints

Charlie J Childs, Emily M Holloway, Caden W Sweet, Yu-Hwai Tsai, Angeline Wu, Joshua Wu, Oscar Pellon Cardenas, Meghan M Capeling, Madeline Eiken, Rachel Zwick, Brisa Palikuqi, Coralie Trentesaux, Charles Zhang, Ian Glass, Claudia Loebel, Qianhui Yu, Gray Camp, Jonathan Z Sexton, Ophir D Klein, Michael P Verzi, Jason J Spence

Released: 12-Jun-2022 12:00 PM EDT
Molecular phenotyping of colorectal neoplasia shows dynamic and adaptive cancer stem cell population admixture
Preprints

Ester Gil Vasquez, Nadia Nasreddin, Gabriel N Valbuena, Eoghan J Mulholland, Hayley L Belnoue-Davis, Holly Eggington, Ryan O Schenck, Valerie M Wouters, Pratyaksha Wirapati, Kathryn Gilroy, Tamsin R M Lannagan, Dustin J Flanagan, Arafath K Najumudeen, Sulochana Omwenga, Amy M B McCorry, Alistair Easton, Viktor H Koelzer, James E East, Dion Morton, Livio Trusolino, Timothy Maughan, Andrew D Campbell, Maurice B Loughrey, Philip D Dunne, Petros Tsantoulis, David J Huels, Sabine Tejpar, Owen Sansom, Simon J Leedham

Released: 12-Jun-2022 12:00 PM EDT
Angelman syndrome patient neuron screen identifies a potent and selective clinical ASO targeting UBE3A-ATS with long lasting effect in cynomolgus monkey
Preprints

Ravi Jagasia, Charlotte Bon, Soren V. Rasmussen, Solveig Badillo, Disa Tehler, Daniele Buchy, Marco Berrera, Megana Prasad, Marco Terrigno, Nikhil J. Pandya, Veronica Costa, Congwei Wang, Lykke Pedersen, Meghan T Miller, Kamille Dumong Erichsen, Lars Joenson, Joerg Hipp, Azad Bonni, Lutz Mueller, Annamaria Braendli-Baiocco, Thomas Kremer, Erich Koller, Marius Hoener



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