A Johns Hopkins team has discovered in young adult mice that a lone brain stem cell is capable not only of replacing itself and giving rise to specialized neurons and glia – important types of brain cells – but also of taking a wholly unexpected path: generating two new brain stem cells.
Researchers at UCLA have identified a new stem cell that participates in the repair of the large airways of the lungs, which play a vital role in protecting the body from infectious agents and toxins in the environment.
Columbia engineers develop new bioengineering approach to study stem cell function and factors that could lead to birth defects and disease.
A graduate student team has invented a system to significantly boost the number of stem cells collected from a newborn’s umbilical cord and placenta, so that many more patients with leukemia, lymphoma and other blood disorders can be treated.
New research shows that systematically controlling the local and global environments during stem cell development helps to effectively direct their differentiation. These findings could help in manufacturing large quantities of stem cells for diagnostic and therapeutic applications in the future.
An agreement between UCLA and Roche will provide stem cell and cancer researchers with leading-edge technologies that will drive research capabilities and further the understanding of complex disease.
Whitehead Institute researchers have identified signals impinging on breast epithelial cells that can induce those cells to acquire and stably display migratory and self-renewing characteristics. Interrupting these and other extracellular signals strips the various types of stem cells of the migratory and self-renewal abilities used by cancer stem cells to seed new tumors.
Researchers in the Department of Pathology at Stony Brook University School of Medicine have discovered a laboratory method to expand adult hematopoietic stem cells (HSCs) using the SALL4 gene.
Researchers at the University of North Carolina at Chapel Hill School of Medicine have shown in an animal study that transplantation of adult stem cells enriched with a bone-regenerating hormone can help mend bone fractures that are not healing properly.
Stem cell therapy enriched with a bone-regenerating hormone, insulin-like growth factor-I (IGF-I), can help mend broken bones in fractures that are not healing normally, a new animal study finds. The Endocrine Society’s 93rd Annual Meeting will host presentation of the results on Sunday in Boston.
Join a panel of Canadian and international experts and patients who have experienced stem cell trials first hand. They'll guide you through the basics of stem cell research into the world of clinical reality by looking specifically at three different disease areas: multiple sclerosis, blood disorders and spinal cord injury.
The National Center for Regenerative Medicine (NCRM) at Case Western Reserve University School of Medicine is teaming up with Edheads, a provider of online education tools, to launch web-based education modules about stem cells.
Adipose-Derived Stem Cells Prove Useful in Reconstructing Gaps after Skull Surgery
A group led by University of Wisconsin-Madison stem cell researcher Su-Chun Zhang reports it has been able to direct embryonic and induced human stem cells to become astrocytes in the lab dish.
In principle, genetic engineering is simple, but in practice, replacing a faulty gene with a healthy copy is anything but. Using mutated versions of the lamin A gene as an example to demonstrate the versatility of their virus-based approach, researchers at the Salk Institute for Biological Studies successfully edited a diseased gene in patient-specific induced pluripotent stem cells as well as adult stem cells.
In basic research with far-reaching impact, cell biologists Wei-Lih Lee and Steven Markus report in Developmental Cell that they have solved one of the fundamental questions in stem cell division: How dynein, the cell’s nano-scale “mitotic motor,” positions itself to direct the dividing process.
What does it take to regenerate a limb? Biologists have long thought that organ regeneration in animals like zebrafish and salamanders involved stem cells that can generate any tissue in the body. But new research suggests that cells capable of regenerating a zebrafish fin do not revert to stem cells that can form any tissue. Instead, the individual cells retain their original identities and only give rise to more of their own kind.
Philip McCarthy, Jr., MD, of Roswell Park Cancer Institute presented data from a CALGB trial at the International Myeloma Workshop. Patients receiving maintenance lenalidomide therapy had higher survival rate and lower risk of disease progression.
Whitehead Institute researchers have found that the planarian flatworm regenerates missing tissues using pluripotent adult stem cells. Until now, scientists could not determine if the dividing cells in planarians are a mix of specialized stem cells that regenerates specific tissues, or if individual neoblasts are pluripotent and able to regenerate all tissues.
Johns Hopkins researchers have demonstrated that human liver cells derived from adult cells coaxed into an embryonic state can engraft and begin regenerating liver tissue in mice with chronic liver damage.
A 59-year-old Houston man became the first individual in the United States to enroll in a study using stem cell transplantation during cardiac bypass to treat severe heart failure.
Researchers at the University of North Carolina at Chapel Hill School of Medicine, after isolating normal stem cells that form the developing placenta, have given them the same properties of stem cells associated with an aggressive type of breast cancer.
Researchers at the UCSD School of Medicine, the Gladstone Institutes in San Francisco and colleagues report a game-changing advance in stem cell science: the creation of long-term, self-renewing, primitive neural precursor cells from human embryonic stem cells (hESCs) that can be directed to become many types of neuron without increased risk of tumor formation.
Squamous cell cancers, which can occur in multiple organs in the body, can originate from hair follicle stem cells, a finding that could result in new strategies to treat and potentially prevent the disease, according to a study by researchers with UCLA’s Jonsson Comprehensive Cancer Center and the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA.
An innovative experimental treatment for boosting the effectiveness of stem-cell transplants with umbilical cord blood has a favorable safety profile in long-term animal studies, report Dana-Farber Cancer Institute, Beth Israel Deaconess Medical Center, and Children’s Hospital Boston scientists.
Certain differentiated cells in breast tissue can spontaneously convert to a stem-cell-like state, according to Whitehead Institute researchers. Until now, scientific dogma has stated that differentiation is a one-way path; once cells specialize, they cannot return to the flexible stem-cell state on their own.
Scientists from the Morgridge Institute for Research, the University of Wisconsin-Madison, the University of California and the WiCell Research Institute moved gene therapy one step closer to clinical reality by determining that the process of correcting a genetic defect does not substantially increase the number of potentially cancer-causing mutations in induced pluripotent stem cells.
Patient’s own stem cells may supercharge cardiac bypass surgery.
A new technique using "quantum dots" produced through nanotechnology is a promising approach to monitoring the effects of stem cell therapies for stroke and other types of brain damage, reports the April issue of Neurosurgery, official journal of the Congress of Neurological Surgeons. The journal is published by Lippincott Williams & Wilkins, a part of Wolters Kluwer Health.
Like bad neighbors who decide to go wreck another community, prostate and breast cancer usually recur in the bone, according to a new University of Michigan study.
A long term study reports about the effectiveness of replacing bone marrow, purposely destroyed by chemotherapy, with autologous (self) stem cell rescue for people with aggressive forms of multiple sclerosis (MS). The study is published in the March 22, 2011, print issue of Neurology®, the medical journal of the American Academy of Neurology.
The International Society for Stem Cell Research will launch a series of topical conferences focused on bringing leading stem cell research to scientists in more areas of the world.
Using skin cells from adult siblings with schizophrenia and a genetic mutation linked to major mental illnesses, Johns Hopkins researchers have created induced pluripotent stem cells (iPS cells) using a new and improved “clean” technique.
Proteins in fluids bathing the brain are essential for building the brain, discover scientists in a report published March 10 in the journal Neuron. The finding promises to advance research related to neurological disease, cancer and stem cells.
Stem cells derived from a patient’s own bone marrow were safely used in pediatric patients with traumatic brain injury (TBI), according to results of a Phase I clinical trial at (UTHealth) published in Neurosurgery.
Rensselaer Polytechnic Institute Assistant Professor of Biomedical Engineering Deanna Thompson is utilizing more than $300,000 in New York state funding as part of the state stem cell research program, NYSTEM, to study adult neural stem cells. The NYSTEM program is New York’s $600 million publicly funded grant program to advance scientific discovery in the area of stem cells.
Ordinary human cells reprogrammed as induced pluripotent stem cells may revolutionize personalized medicine by creating new and diverse therapies unique to individual patients. But important and unanswered questions have persisted about the safety of these cells, in particular whether their genetic material is altered during the reprogramming process. A new study finds that the genetic material of reprogrammed cells may in fact be compromised, and suggests that extensive genetic screening of hiPSCs become standard practice.
For children with severe traumatic brain injury (TBI), transplantation of stem cells derived from the patients' own bone marrow is a "logistically feasible and safe" treatment procedure, reports the March issue of Neurosurgery, official journal of the Congress of Neurological Surgeons.
Unique computer model calculates how long a blood stem cell will live, information that could predict the outcome of bone marrow transplants.
Pluripotent stem cells have been generated from horses by a team of researchers. The findings will help enable new stem-cell based regenerative therapies in veterinary medicine, and because horses’ muscle and tendon systems are similar to our own, aid the development of preclinical models.
An essential protein for normal stem cell renewal also promotes the growth of breast cancer stem cells when it's overproduced in those cells, researchers at The University of Texas MD Anderson Cancer Center reported in Cancer Cell.
In an opinion piece published Feb. 10 in the journal Science, a team of scholars led by a Johns Hopkins bioethicist urges the scientific community to act collectively to stem the negative effects of the patenting and privatizing of stem cell lines, data and pioneering technologies. This means grappling with the ambiguity of several fundamental distinctions typically made in ethics, law and common practice, the experts insist.
Research from The University of Texas Health Science Center at Houston (UTHealth) and Athersys reveals that a novel stem cell therapy provided multiple benefits when administered in preclinical models of ischemic stroke.
Researchers at Johns Hopkins have found a better way to create induced pluripotent stem (iPS) cells—adult cells reprogrammed with the properties of embryonic stem cells—from a small blood sample. This new method, described last week in Cell Research, avoids creating DNA changes that could lead to tumor formation.
By coaxing healthy and diseased human bone marrow to become embryonic-like stem cells, a team of Wisconsin scientists has laid the groundwork for observing the onset of the blood cancer leukemia in the laboratory dish.
Reprogramming adult cells to recapture their youthful “can-do-it-all” attitude appears to leave an indelible mark, found researchers at the Salk Institute for Biological Studies. When the team, led by Joseph Ecker, PhD., a professor in the Genomic Analysis Laboratory, scoured the epigenomes of so-called induced pluripotent stem cells base by base, they found a consistent pattern of reprogramming errors.
New technique removes several hurdles in generating induced pluripotent stem (iPS) cells, smoothing the way for disease research and drug development.
Fifty years ago today, two young, unknown scientists at the fledgling Ontario Cancer Institute (OCI) published accidental findings that proved the existence of stem cells – cells that can self-renew repeatedly for different uses.
Breakthrough discovery offers hope for new therapies for range of diseases.
Among stem cell biologists there are few better-known proteins than nestin, whose very presence in an immature cell identifies it as a "stem cell," such as a neural stem cell. As helpful as this is to researchers, until now no one knew which purpose nestin serves in a cell.
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