Feature Channels: Biotech

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Prilenia Therapeutics B.V., a clinical stage biotechnology company focused on the urgent mission to develop novel therapeutics to slow the progression of neurodegenerative and neurodevelopmental disorders, today announced publication of its research in the peer-reviewed journal Autophagy which support pridopidine’s potential neuroprotective properties by enhancing autophagy in an amyotrophic lateral sclerosis (ALS) model.

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A stomach adult stem cell population can fulfill two distinct functions: either help with digestion under normal conditions or take the lead on injury response.

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Yi Liu, Bowen Zheng, Yuan Zhong

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TianLei Xie, Zhongqing Zhang, Wenmin Cao, Wei Chen, Hongqian Guo, Junlong Zhuang

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Lijun Wang, Lihui Wang, Rongli Wang, Ting Xu, Jingyuan Wang, Zhiwei Cui, Feiyan Cheng, Wei Wang, Xinyuan Yang

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Daniel Richard, Steven Pregizer, Divya Venkatasubramanian, Pushpanathan Muthuirulan, Zun Liu, Terence D. Capellini, April M. Craft

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Fabiën Belle, Tomáš Sláma, Christina Schindera, Tamara Diesch, Mutlu Kartal-Kaess, Claudia Kuehni, Luzius Mader

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Raquel Rua Martins, Michael Rera, Catarina M. Henriques

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Tahir Haideri, Alessandro Howells, Yuqian Jiang, Jian Yang, Xiaoping Bao, Xiaojun Lian

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Yaiza Nunez-Alvarez, Tristan Espie--Caullet, Reini F Luco

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Belen Alvarez-Palomo, Anna Veiga, Angel Raya, Margarita Codinach, Silvia Torrents, Laura Ponce Verdugo, Clara Rodriguez-Aierbe, Leopoldo Cuellar, Raquel Alenda, Cristina Arbona, Dolores Hernández-Maraver, Cristina Fusté, Sergi Querol

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Hojjatollah Nazari, Asieh Heirani, Masoud Soleimani, Reza Akbari Asbagh, Behnam Behboudi, Mohammad Sadegh Fazeli, Mojgan Rahimi, Mohammad Reza Keramati, Amir Keshvari, Alireza Kazemeini, Foroogh Alborzi, Seyed Mohsen Ahmadi Tafti

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Yuki Nakafusa, Naoyoshi Nitta, Kazunari Ishii, Naoto Shirasu, Takahiro Iwamoto, Takayuki Nemoto, Masafumi Nakamura, Masafumi Goto, Hiroo Iwata, Masaru Taniguchi, Yohichi Yasunami

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Ishan Goswami, Eleonora de Klerk, Phichitpol Carnese, Matthias Hebrok, Kevin Healy

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Min Luo, Hui Zhang, Chaoke Bu, Zhiyong Peng, Guangchao Li, Zhao Zhou, Wen Ding, Yongwei Zheng, Yingyi He, Zhengbin Hu, Kunlin Pei, Chunfu Li

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Hyo Sung Jung, Seyoung Koo, Miae Won, Seeun An, Haebeen Park, Jonathan Sessler, Jiyou Han, Jong Seung Kim

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Sudip Paul, Masamitsu Sone, Ashwini Patil, Hisaya Kato, Yoshiro Maezawa, Motohiko Oshima, Masaki Fukuyo, Bahityar Rahmutulla, Yasuo Ouchi, Kyoko Tsujimura, Mahito Nakanishi, Atsushi Kaneda, Atsushi Iwama, Koutaro Yokote, Koji Eto, Naoya Takayama

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Hana Najahi, Nicola Alessio, Tiziana Squillaro, Gea Oliveri Conti, Margherita Ferrante, Giovanni Di Bernardo, Umberto Galderisi, Imed Messaoudi, Sergio Minucci, Mohamed Banni

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Jixian Xiong, Yuting Li, Xiangyu Tan, Tie Chen, Baohua Liu, Li Fu

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Takeshi Fujimori, Yuki Shibayama, Takahiro Kanda, Kenta Suzuki, Daisuke Ogawa, Ryo Ishikawa, Kyuichi Kadota, Toru Matsunaga, Keisuke Miyake, Akira Nishiyama, Takashi Tamiya

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Zhihua Chen, Yilin Lin, Suyong Lin, Xiaoyu Yang, Shao-Qin Chen

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Maxime Fredon, Margaux Poussard, Sabeha Biichle, Francis Bonnefoy, Evan Seffar, Elodie Bôle-Richard, Florian Renosi, Romain Boidot, François Anna, Maria Loustau, Julien Caumartin, Philippe Saas, Eric Deconinck, Etienne Daguindeau, Xavier Roussel, Olivier Adotevi, Fanny Angelot-Delettre, Jeanne Galaine, Francne Garnache-Ottou

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Roqaye Karimi, Amir Atashi, Mina Soufi Zomorrod, Monireh Agami, Mansoureh Ajami

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Negin Samadi Kharajouei

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Vyriad, Inc., a clinical-stage biotechnology company developing oncolytic virus therapies to treat a wide range of cancers, today announced $29.5M in new funding led by Mr. Harry Stine of Stine Seed Farms, Inc.

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Céline Hervieu, Mireille Verdier, Gaëlle Bégaud, Niki Christou, Magali Sage, Julie Pannequin, Serge Battu, Muriel Mathonnet

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Jingan Chen, Yi Liu, Jingwen Zhang, Haowei Liang, Ting Li, Li Yan, Li Zhou, Letian Shan, Hui Wang

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Hitomi Nagayama, Jun Ooi

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Li-E Zhu, Hui-Ping Huang, Yi-Peng Cai, Yan Wang, Bao-Hua Xu, Mao-Bai Liu, Xue-Mei Wu

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Rajib Shome, Plaboni Sen, Siddhartha Sankar Ghosh

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Factor Bioscience Inc., a Cambridge-based biotechnology company focused on developing mRNA and cell-engineering technologies, announced its participation in the American Society of Gene & Cell Therapy (ASGCT) 25th Annual Meeting to be held in Washington, D.C. from May 16-19, 2022.

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Background Relapse is the leading cause of death from myeloid malignancies after allogeneic hematopoietic stem cell transplantation (HSCT). Azacitidine has gained attention in recent years in the prophylaxis of relapsed refractory hematologic …

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Conditioning with treosulfan and fludarabine (Treo/Flu) has been proven to be feasible and efficient in several types of malignancies before allogeneic hematopoietic stem cell transplantation (allo-HSCT). Given its favorable reduced …

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It is known that Rho GTPases control different aspects of the biology of skin stem cells (SSCs). However, little information is available on the role of their upstream regulators under normal and tumorigenic conditions in this process. To address this …

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… Given the important function of PTBP1 in directing lineage choice in diverse stem cell systems and the overall relevance of mRNA splicing in hematopoiesis, we hypothesized that PTBP1 might play a role as a regulator of posttranscriptional …

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… To investigate the status of the T-cell compartment of UPN1 up to 51 years post-HSCT in the context of a stem cell boost at 37 years after HSCT, we aimed to combine detailed phenotyping with TCR repertoire analysis. Development of a T-cell-focused …

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Jing Yuan, Zhen-Zhen Wang, Han-Yun Ren, Fu-Xu Wang

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The Organ-on-a-Chip (OoC) technology shows great potential to revolutionize the drugs development pipeline by mimicking the physiological environment and functions of human organs. The translational value of OoC is further enhanced when …

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… for Atg5, the stem cell loss in vivo was more pronounced than in vitro, suggesting that additional cell populations likely depend upon Atg5 function to support ileum health. We first tested whether ATG5-dependent WNT signaling was required for …

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… With Select-seq, we analyse the cancer stem cell-like microniches in relation to the tumour microenvironment of triple-negative breast cancer patients. We identify alternative splice variants, perform complementarity-determining region analysis of …

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Over the last 30 years, allogeneic haematopoietic stem cell transplantation (allo‐HSCT) has been adopted as a therapeutic strategy for many inborn errors of metabolism (IEM), due to the ability of donor‐derived cells to provide life‐long enzyme delivery to …

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Youxiang Su, Nianhu Li, Jian Xin, Shang Gao, Yun Song, Xintian Qu, Yan Liu, Xiusen Ma

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Renal fibrosis is a common pathological process of chronic kidney diseases induced by multiple factors. Hypoxic pretreatment of mesenchymal stem cells can enhance the efficacy of secreted extracellular vesicles (MSC-EVs) on various diseases, but it …

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Despite advances in the understanding of the pathophysiology of cytomegalovirus (CMV) infection, it remains as one of the most common infectious complications after allogeneic hematopoietic stem cell transplantation (allo-HSCT). The aim of this study …

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Ross Ferguson, Vasanta Subramanian

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Robert Thimme, Matthias Reinscheid, Hendrik Luxenburger, Vivien Karl, Anne Graeser, Sebastian Giese, Kevin Ciminski, David Reeg, Valerie Oberhardt, Natascha Röhlen, Julia Lang-Meli, Kathrin Heim, Nina Gross, Christina Baum, Siegbert Rieg, Claudius Speer, Florian Emmerich, Susanne Breisinger, Daniel Steinmann, Bertram Bengsch, Tobias Boettler, Georg Kochs, Martin Schwemmle, Christoph Neumann-Haefelin, Maike Hofmann

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Zai-Ling Yang, Xiang-Qing Zhu, Tian Chuan, Zhao Jing, Guang-Ping Ruan, Pan Hang, He Jie, Wang Kai, Wang Wei, Xing-Hua Pan

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… Also, and most importantly, when comparing results across laboratories we need to bear in mind that no embryonic stem cell line is a tabula rasa. Different cell lines have been shown to exhibit biases in differentiation potential (Ortmann et al., 2020) …

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… has led to the development of trophoblast stem cell lines which retain the capacity to … –OFF switch to regulate various hallmark processes of stem cell biology like self-renewal [15, 16… pools with temporal replenishment of the trophoblast stem cell hub …