Feature Channels: Stem Cells

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Released: 26-Feb-2024 12:00 PM EST
VX-509 attenuates the stemness characteristics of colorectal cancer stem-like cells by regulating the epithelial-mesenchymal transition through Nodal/Smad2/3 signaling
World Journal of Stem Cells

BACKGROUNDColorectal cancer stem cells (CCSCs) are heterogeneous cells that can self-renew and undergo multidirectional differentiation in colorectal cancer (CRC) patients. CCSCs are generally accepted to be important sources of CRC and are

Released: 26-Feb-2024 12:00 PM EST
Crosstalk between Wnt and bone morphogenetic protein signaling during osteogenic differentiation
World Journal of Stem Cells

Mesenchymal stem cells (MSCs) originate from many sources, including the bone marrow and adipose tissue, and differentiate into various cell types, such as osteoblasts and adipocytes. Recent studies on MSCs have revealed that many transcrip

Released: 26-Feb-2024 12:00 PM EST
Silencing of Jumonji domain-containing 1C inhibits the osteogenic differentiation of bone marrow mesenchymal stem cells via nuclear factor-κB signaling
World Journal of Stem Cells

BACKGROUNDOsteoporosis is a common metabolic bone disorder induced by an imbalance between osteoclastic activity and osteogenic activity. During osteoporosis, bone mesenchymal stem cells (BMSCs) exhibit an increased ability to differentiate

Released: 26-Feb-2024 12:00 PM EST
Therapeutic utility of human umbilical cord-derived mesenchymal stem cells-based approaches in pulmonary diseases: Recent advancements and prospects
World Journal of Stem Cells

Pulmonary diseases across all ages threaten millions of people and have emerged as one of the major public health issues worldwide. For diverse disease conditions, the currently available approaches are focused on alleviating clinical sympt

Released: 26-Feb-2024 12:00 PM EST
Cellular preconditioning and mesenchymal stem cell ferroptosis
World Journal of Stem Cells

In this editorial, we comment on the article published in the recent issue of the World Journal of Stem Cells. They focus on stem cell preconditioning to prevent ferroptosis by modulating the cystathionine γ-lyase/hydrogen sulfide (H2S) pa

Released: 26-Feb-2024 12:00 PM EST
Human dental pulp stem/stromal cells in clinical practice
World Journal of Stem Cells

Dental pulp stem/stromal cells (DPSCs) are fibroblast-like, neural crest-derived, and multipotent cells that can differentiate into several lineages. They are relatively easy to isolate from healthy and inflamed pulps, with little ethical c

Released: 26-Feb-2024 12:00 PM EST
Human pluripotent stem cell-derived kidney organoids: Current progress and challenges
World Journal of Stem Cells

Human pluripotent stem cell (hPSC)-derived kidney organoids share similarities with the fetal kidney. However, the current hPSC-derived kidney organoids have some limitations, including the inability to perform nephrogenesis and lack of a c

Released: 26-Feb-2024 12:00 PM EST
High quality repair of osteochondral defects in rats using the extracellular matrix of antler stem cells
World Journal of Stem Cells

BACKGROUNDCartilage defects are some of the most common causes of arthritis. Cartilage lesions caused by inflammation, trauma or degenerative disease normally result in osteochondral defects. Previous studies have shown that decellularized

Released: 26-Feb-2024 12:00 PM EST
Extracellular vesicles derived from mesenchymal stem cells mediate extracellular matrix remodeling in osteoarthritis through the transport of microRNA-29a
World Journal of Stem Cells

BACKGROUNDKnee osteoarthritis (KOA) is a common orthopedic condition with an uncertain etiology, possibly involving genetics and biomechanics. Factors like changes in chondrocyte microenvironment, oxidative stress, inflammation, and immune

Released: 26-Feb-2024 12:00 PM EST
Effects of different concentrations of nicotinamide on hematopoietic stem cells cultured in vitro
World Journal of Stem Cells

BACKGROUNDIn vitro expansion to increase numbers of hematopoietic stem cells (HSCs) in cord blood could improve clinical efficacy of this vital resource. Nicotinamide (NAM) can promote HSC expansion ex vivo, but its effect on hematopoietic

Released: 26-Feb-2024 12:00 PM EST
Unlocking the versatile potential: Adipose-derived mesenchymal stem cells in ocular surface reconstruction and oculoplastics
World Journal of Stem Cells

This review comprehensively explores the versatile potential of mesenchymal stem cells (MSCs) with a specific focus on adipose-derived MSCs. Ophthalmic and oculoplastic surgery, encompassing diverse procedures for ocular and periocular enha

Newswise: Healing Diabetes Wounds with a New Superhero: Stem Cell Magic
Released: 20-Feb-2024 10:10 AM EST
Healing Diabetes Wounds with a New Superhero: Stem Cell Magic
Chinese Academy of Sciences

Researchers unveiled a novel therapy for diabetic wound healing. This research highlights the use of exosomal miR-4645-5p from hypoxic bone marrow mesenchymal stem cells (BMSCs) to significantly enhance wound healing by promoting keratinocyte autophagy.

   
Newswise: Drug used for cocaine addiction may pave way for new treatment of advanced colon cancer
Released: 13-Feb-2024 10:05 PM EST
Drug used for cocaine addiction may pave way for new treatment of advanced colon cancer
University of Ottawa

New research from the University of Ottawa proposes using vanoxerine as a safe method for potentially eliminating cancer stem cells in colorectal tumors.

Newswise: Nutrients direct intestinal stem cell function and affect ageing
Released: 12-Feb-2024 10:05 PM EST
Nutrients direct intestinal stem cell function and affect ageing
University of Helsinki

The capacity of intestinal stem cells to maintain cellular balance in the gut decreases upon ageing.

Released: 31-Jan-2024 10:05 AM EST
UGA stroke treatment headed to clinical trial
University of Georgia

A new therapeutic for stroke based on University of Georgia research will soon enter clinical trials.

Released: 30-Jan-2024 2:05 PM EST
Our winter of discontent: Get the latest news on the flu in the Influenza channel
Newswise

The latest research and expertise on the flue can be found in the Influenza channel on Newswise.

Newswise: Re-energizing mitochondria to treat Alzheimer’s disease
Released: 29-Jan-2024 4:05 PM EST
Re-energizing mitochondria to treat Alzheimer’s disease
Scripps Research Institute

Nerve cells in the brain demand an enormous amount of energy to survive and maintain their connections for communicating with other nerve cells.

Newswise: 3rd Space Launch of Cedars-Sinai Stem Cells Slated for Jan. 29
Released: 29-Jan-2024 11:05 AM EST
3rd Space Launch of Cedars-Sinai Stem Cells Slated for Jan. 29
Cedars-Sinai

Cedars-Sinai and Space Tango are planning their third launch of pilot-scale systems for the automated in-space production of stem cells to the International Space Station.

   
Released: 26-Jan-2024 12:00 PM EST
Effects of exosomes from mesenchymal stem cells on functional recovery of a patient with total radial nerve injury: A pilot study
World Journal of Stem Cells

BACKGROUNDPeripheral nerve injury can result in significant clinical complications that have uncertain prognoses. Currently, there is a lack of effective pharmacological interventions for nerve damage, despite the existence of several small

Released: 26-Jan-2024 12:00 PM EST
Use of priming strategies to advance the clinical application of mesenchymal stromal/stem cell-based therapy
World Journal of Stem Cells

Mesenchymal stromal/stem cells (MSCs) have garnered significant attention in the field of regenerative medicine due to their remarkable therapeutic potential. MSCs play a pivotal role in maintaining tissue homeostasis and possess diverse fu



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