Newswise — Restricting how much you eat without starving has been shown to robustly extend lifespan in more than 20 species of animals including primates. How this works is still unclear. In a new study published in PLOS Genetics, neuroscientists from Florida Atlantic University show that it’s not just what or how much you eat that matters. Smelling food in addition to consuming calories could influence the aging process. And, what’s “eating” you or more specifically your cells may provide clues to healthy aging.  

Using a tiny worm called C. elegans, these researchers are the first to demonstrate how autophagy, a garbage disposal-like process where cells “eat” debris they produce through basic metabolism, combined with food absorption through the gastrointestinal (GI) tract and food smell through olfactory neurons impact the aging process mainly by diet restriction.

This study reveals that autophagy is an essential component in a neuroendocrine pathway that allows sensory neurons and nutrient levels to work together to influence lifespan. It also reduces the insulin growth factor signaling pathway, part of a complex system that cells use to communicate with their physiologic environment. These new findings could help to better understand the human aging process, extend lifespan as well as develop treatments for diseases like obesity.

“We found that autophagy works in both the brain and the intestine to mediate communication between the GI tract and the brain and in turn to the GI tract. We were specifically looking for how this interaction influences aging,” said Kailiang Jia, Ph.D., corresponding author of the study, associate professor of biological sciences in FAU’s Charles E. Schmidt College of Science, and a member of FAU’s Brain Institute.

Jia and the study’s first author Justin Minnerly, Ph.D., who graduated from FAU in 2017, suspect that both the calorie of food or perhaps the combination of the food together with the smell of the food influences the aging process through diet restriction. Olfaction is simply how a neuron detects the smell of a food.

“When people are on a diet they might say something like ‘I didn’t eat a lot of food,’” said Jia. “Except it’s not only the calories that count, but also the smell of food that can influence the function of the brain and the GI tract.”

Prior research on fruit flies confirms this notion. When they were on restricted diets, the fruit flies lived longer. But when they were allowed to smell the food while on this restricted diet their life expectancy was not as dramatic as it was without smelling the food.

“If you want to extend the lifespan of any animal, after limiting their diet, you have to have functional autophagy in this animal otherwise you won’t see this lifespan extending effect,” said Jia. “This is especially true for autophagy in the olfactory neuron since it appears that it mediates this effect for the smell of food. Autophagy in the GI tract also is required for this lifespan extension mechanism, which indicates that the nutrients we absorb into the GI tract also regulates autophagy and in turn controls the aging process.”

There are a number of hypotheses as to why restricting calories extends lifespan and most physicians and scientists today believe that diet or caloric restrictions adjust the metabolism and physiology of the human body on a cellular level.

“We now know which molecules are responsible for the aging process and autophagy is one of these processes,” said Jia. “So potentially, autophagy in the olfactory neuron, at least in the worm, can sense the food smell and then secrete neuron signals, which in turn influence the aging process.”

Now that Jia and the research team know that autophagy is involved in the aging process they have to figure out which proteins regulate this process. They also plan to establish a protocol to screen a compound library to look for autophagy inhibitors and activators. They hope ultimately to develop treatments for obesity and other diseases like cancer and neurodegenerative diseases.

“Autophagy can be activated and enhanced when you restrict calories and we can actually see the autophagy process activated through caloric restriction,” said Jia. “With disease, when you decrease autophagy the disease process is exacerbated and when you increase it you get the opposite effect.”  

The study is supported by the National Institutes of Health (NIH) (grant number 1R15HD080497-01) and the Ellison Medical Foundation Aging Scholarship awarded to Jia.

Co-authors of the study, titled “The Cell Non-autonomous Function of ATG-18 is Essential for Neuroendocrine Regulation of Caenorhabditis elegans Lifespan,” are technician Jiuli Zhang; graduate student Thomas Parker; and undergraduate student Tiffany Kaul, all in FAU’s Department of Biological Sciences in the College of Science.

- FAU -

About the FAU Brain Institute:

Inaugurated in 2016 on the John D. MacArthur Campus in Jupiter, Fla., the FAU Brain Institute supports research, education and community outreach among more than 70 neuroscience faculty investigators at FAU and its affiliate research centers. One of FAU’s four pillars that guide the University’s goals and strategic actions, the Institute seeks to unlock the secrets of brain development, function and plasticity and how the mechanisms uncovered can be compromised to drive devastating brain disorders. From human behavior such as mother/infant bonding, addiction and communication disorders to devastating brain diseases like Parkinson’s and Alzheimer’s disease, neuroscientists and other researchers from FAU’s Brain Institute are at the forefront of innovative research that will generate knowledge to benefit society. For more information, visit


About Florida Atlantic University:

Florida Atlantic University, established in 1961, officially opened its doors in 1964 as the fifth public university in Florida. Today, the University, with an annual economic impact of $6.3 billion, serves more than 30,000 undergraduate and graduate students at sites throughout its six-county service region in southeast Florida. FAU’s world-class teaching and research faculty serves students through 10 colleges: the Dorothy F. Schmidt College of Arts and Letters, the College of Business, the College for Design and Social Inquiry, the College of Education, the College of Engineering and Computer Science, the Graduate College, the Harriet L. Wilkes Honors College, the Charles E. Schmidt College of Medicine, the Christine E. Lynn College of Nursing and the Charles E. Schmidt College of Science. FAU is ranked as a High Research Activity institution by the Carnegie Foundation for the Advancement of Teaching. The University is placing special focus on the rapid development of critical areas that form the basis of its strategic plan: Healthy aging, biotech, coastal and marine issues, neuroscience, regenerative medicine, informatics, lifespan and the environment. These areas provide opportunities for faculty and students to build upon FAU’s existing strengths in research and scholarship. For more information, visit



Journal Link: PLOS Genetics