Many Targeted Cancer Therapies Suppress T Cell Immune Responses
Wistar InstituteNew research from The Wistar Institute demonstrated that dozens of these targeted therapies suppressed the activity of T cells that could actually help fight tumors. While studying the FDA-approved targeted therapy trametinib, the researchers also found that pairing it with a signaling protein “superagonist” stimulated T cell activity while preserving the cancer-blocking effects of the cancer treatment.