Credit: Lab of David J. Brenner, PhD/Columbia University Medical Center.
Breast-cancer rates in breast cancer-prone mice whose mammary glands were treated with different doses of prophylactic mammary irradiation (PMI ), compared with mice whose mammary glands were not treated. At moderate PMI doses of 12 or 16 Gy—much lower than that used to treat the affected breast—the breast cancer rate was reduced by about three-fold.