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New Compounds Reduce Debilitating Inflammation

Six Case Western Reserve scientists are part of an international team that has discovered two compounds that show promise in decreasing inflammation in diseases such as ulcerative colitis and arthritis. The compounds appear to curtail inflammation-triggering signals from RIPK2. These findings appear in the Journal of Biological Chemistry.

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First Step: From Human Cells to Tissue-Engineered Esophagus

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In a first step toward future human therapies, researchers at The Saban Research Institute of Children’s Hospital Los Angeles have shown that esophageal tissue can be grown in vivo from both human and mouse cells.

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A Better Prosthesis: Sandia Invents Sensor to Learn About Fit; System to Make Fit Better

Sandia National Laboratories researcher Jason Wheeler has been working to make prostheses more comfortable in a twofold approach: sensors that detect how the prosthesis fits and a system to make the fit better. He points out it doesn't matter how high-tech a prosthesis is if it's not comfortable.

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Researchers Develop New Cells Meant to Form Blood Vessels, Treat Peripheral Artery Disease

Researchers have developed a technique to jump-start the body's systems for creating blood vessels, opening the door for potential new treatments for diseases whose impacts include amputation and blindness.

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‘Programmable’ Antibiotic Harnesses an Enzyme to Attack Drug-Resistant Microbes

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The multitude of microbes scientists have found populating the human body have good, bad and mostly mysterious implications for our health. But when something goes wrong, we defend ourselves with the undiscriminating brute force of traditional antibiotics, which wipe out everything at once, regardless of the consequences.

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'Stealth' Nanoparticles Could Improve Cancer Vaccines


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Cancer vaccines have recently emerged as a promising approach for killing tumor cells before they spread. But so far, most clinical candidates haven't worked that well. Now, scientists have developed a new way to deliver vaccines that successfully stifled tumor growth when tested in laboratory mice. And the key, they report in the journal ACS Nano, is in the vaccine's unique stealthy nanoparticles.

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Unlocking Enzyme Synthesis of Rare Sugars to Create Drugs with Fewer Side Effects

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A team led by the U.S. Department of Energy's Oak Ridge National Laboratory has unlocked the enzymatic synthesis process of rare sugars, which are useful in developing drugs with low side effects using a process more friendly to the environment.

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ORNL Team First to Fully Sequence Bacterial Genome Important to Fuel and Chemical Production

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Researchers sequence the entire genome of the Clostridium autoethanogenum bacterium, which is used to sustainably produce fuel and chemicals from a range of raw materials, including gases derived from biomass and industrial wastes.

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'The Process by Which Drugs Are Discovered and Developed Will Be Fundamentally Different in the Future'

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Over the past several decades, Michael Kinch of Washington University in St. Louis says, the pharmaceutical industry has managed to dismantle itself. “It’s done a really efficient job of it,” he said. In a provocative series of articles and interviews, Kinch, the director of the Center for Research Innovation in Business at the university, has been describing the history of this dismantling and its implications for the future of medicine. The inescapable conclusion is that “The process by which drugs are discovered and developed will be fundamentally different in the future,” he says.

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Tonsil Stem Cells Could Someday Help Repair Liver Damage Without Surgery

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The liver provides critical functions, such as ridding the body of toxins. Its failure can be deadly, and there are few options for fixing it. But scientists now report in the journal ACS Applied Materials & Interfaces a way to potentially inject stem cells from tonsils, a body part we don't need, to repair damaged livers — all without surgery.

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