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Embargo will expire:
27-Apr-2018 9:00 AM EDT
Released to reporters:
23-Apr-2018 9:05 AM EDT

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  • Embargo expired:
    7-Mar-2018 9:00 AM EST

Article ID: 690247

Researchers Identify New Drugs That Could Help Prevent Hearing Loss

The Rockefeller University Press

Researchers from St. Jude Children’s Research Hospital have discovered that inhibiting an enzyme called cyclin-dependent kinase 2 (CDK2) protects mice and rats from noise- or drug-induced hearing loss. The study, which will be published March 7 in the Journal of Experimental Medicine, suggests that CDK2 inhibitors prevent the death of inner ear cells, which has the potential to save the hearing of millions of people around the world.

Released:
28-Feb-2018 10:05 AM EST
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  • Embargo expired:
    6-Mar-2018 9:00 AM EST

Article ID: 690244

How Tattoos Are Maintained by Macrophages Could Be Key to Improving Their Removal

The Rockefeller University Press

Researchers in France have discovered that, though a tattoo may be forever, the skin cells that carry the tattoo pigment are not. Instead, the researchers say, the cells can pass on the pigment to new cells when they die. The study, which will be published March 6 in the Journal of Experimental Medicine, suggests ways to improve the ability of laser surgery to remove unwanted tattoos.

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28-Feb-2018 9:05 AM EST
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  • Embargo expired:
    6-Mar-2018 9:00 AM EST

Article ID: 690436

Preventing Exhaustion in Immune Cells Boosts Immunotherapy in Mice

Health Sciences at the University of Pittsburgh

Immunotherapy does not work for a majority of cancer patients. Preventing or reversing metabolic exhaustion in cancer-killing T-cells could boost its effectiveness.

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2-Mar-2018 12:40 PM EST
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  • Embargo expired:
    14-Feb-2018 9:00 AM EST

Article ID: 689123

Researchers Successfully Reverse Alzheimer’s Disease in Mouse Model

The Rockefeller University Press

A team of researchers from the Cleveland Clinic Lerner Research Institute have found that gradually depleting an enzyme called BACE1 completely reverses the formation of amyloid plaques in the brains of mice with Alzheimer’s disease, thereby improving the animals’ cognitive function. The study, which will be published February 14 in the Journal of Experimental Medicine, raises hopes that drugs targeting this enzyme will be able to successfully treat Alzheimer’s disease in humans.

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7-Feb-2018 8:05 AM EST
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Article ID: 688756

New Explanation for Why Airways Close in Asthma Holds Promise for Future Class of Drugs

The Rockefeller University Press

Houston Methodist researchers have a new explanation for what causes the lungs’ airways to close during asthma attacks. The researchers who published the study in the Feb. 5 issue of the Journal of Experimental Medicine note that the discovery holds promise for developing a new class of drugs different from the steroids currently used to treat asthma.

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31-Jan-2018 2:05 PM EST
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Article ID: 688336

Anemia Discovery Offers New Targets to Treat Fatigue That Affects Millions

University of Virginia Health System

UVA has discovered an unknown biological process that controls the production of red blood cells, which carry oxygen to the body. The discovery could help doctors develop new treatments for anemia, which affects millions.

Released:
23-Jan-2018 12:05 PM EST
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Article ID: 688011

LJI Researchers Discover Key Driver of Atopic Dermatitis

La Jolla Institute for Allergy and Immunology

La Jolla Institute scientists demonstrate that LIGHT, a member of the tumor necrosis factor (TNF) super family, directly controls the hyperproliferation of keratinocytes as well as the expression of periostin, a protein that contributes to the clinical features of atopic dermatitis as well as other inflammatory skin diseases such as scleroderma.

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16-Jan-2018 5:05 PM EST
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Article ID: 687531

Mechanism That Converts White Fat to Brown Identified

The Rockefeller University Press

An international team of researchers led from Karolinska Institutet have, in experiments on mice, pinpointed a mechanism for the conversion of energy-storing white fat into energy-expending brown fat. The study is published in the Journal of Experimental Medicine.

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5-Jan-2018 9:05 AM EST
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  • Embargo expired:
    4-Jan-2018 9:00 AM EST

Article ID: 687335

Researchers Detect a Loophole in Chronic Lymphocytic Leukemia Treatment

The Rockefeller University Press

A team of researchers in Italy and Austria has determined that a drug approved to treat chronic lymphocytic leukemia (CLL) may be less effective in a particular subset of patients. The study, which will be published January 4 in the Journal of Experimental Medicine, reveals that ibrutinib has a diminished capacity to delocalize and kill tumor cells expressing an adhesive protein called CD49d, but combining ibrutinib treatment with drugs that block CD49d activation could prevent the tumor cells from sheltering in lymphoid organs.

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2-Jan-2018 10:05 AM EST
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