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Journal of Experimental Medicine

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Atopic Dermatitis, Light, TNF super family, Fibrosis

LJI Researchers Discover Key Driver of Atopic Dermatitis

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La Jolla Institute scientists demonstrate that LIGHT, a member of the tumor necrosis factor (TNF) super family, directly controls the hyperproliferation of keratinocytes as well as the expression of periostin, a protein that contributes to the clinical features of atopic dermatitis as well as other inflammatory skin diseases such as scleroderma.

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obsesity, Type 2 Diabetes

Mechanism That Converts White Fat to Brown Identified

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An international team of researchers led from Karolinska Institutet have, in experiments on mice, pinpointed a mechanism for the conversion of energy-storing white fat into energy-expending brown fat. The study is published in the Journal of Experimental Medicine.

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Chronic Lymphocytic Leukemia, ibrutinib, Hematology, Cancer, Leukemia

Researchers Detect a Loophole in Chronic Lymphocytic Leukemia Treatment

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A team of researchers in Italy and Austria has determined that a drug approved to treat chronic lymphocytic leukemia (CLL) may be less effective in a particular subset of patients. The study, which will be published January 4 in the Journal of Experimental Medicine, reveals that ibrutinib has a diminished capacity to delocalize and kill tumor cells expressing an adhesive protein called CD49d, but combining ibrutinib treatment with drugs that block CD49d activation could prevent the tumor cells from sheltering in lymphoid organs.

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Study Explores Impact of Obesity on Bone Marrow Cells

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New research published in the Journal of Experimental Medicine highlights the pernicious effect of obesity on the long-term health of blood-making stem cells (hematopoietic stem cells). Published Dec. 27 and conducted largely in genetic models of obese mice, the study shows obesity causes durable and harmful changes to the hematopoietic stem cell compartment – the blood-making factory in our bodies.

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Beth Israel Deaconess Medical Center, Dipak Panigrahy, Cancer

Double-Edged Sword: Killing Cancer Cells can also Drive Tumor Growth

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Cancer therapies including radiation and chemotherapy seek to treat the disease by killing tumor cells. Now a team including researchers at Beth Israel Deaconess Medical Center (BIDMC) have shown that the dead and dying cancer cells generated by chemotherapy and targeted cancer therapy paradoxically trigger inflammation that promotes aggressive tumor growth. In a study published today in the Journal of Experimental Medicine, the team has illuminated the mechanism by which tumor cell death can drive primary tumor growth and metastasis.

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Cancer, Inflammation, Resolvins, Chemotherapy, Cancer Therapy

Study Reveals Cancer Therapy’s Double-Edged Sword... And How to Blunt It

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Researchers from Harvard Medical School and the Institute of Systems Biology have discovered that the remains of tumor cells killed by chemotherapy or other cancer treatments can actually stimulate tumor growth by inducing an inflammatory reaction. The study, which will be published November 30 in The Journal of Experimental Medicine, also reveals that a family of molecules called resolvins can suppress this unwanted inflammatory response, suggesting new ways to enhance the effectiveness of existing cancer therapies.

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Alzheimer's Disease, Amyloid Beta, Brain Diseases, Drug Discovery And Development, Neuroscience, Aging

How SORLA Protects Against Alzheimer’s Disease

Researchers have identified a new protective function for a brain protein genetically linked to Alzheimer’s. The findings, published in the Journal of Experimental Medicine, could inform novel treatment strategies to combat neurodegenerative diseases.

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Nyu Langone, Ken Cadwell, IBD, Tnf Alpha, Remicade, Skirball, ATG16L1, Paneth Cells, Graft-versus-host disease, Bone Marrow Transplant

Research Suggests New Way to Treat Inflammatory Gut Disease and Prevent Rejection of Bone Marrow Transplants

A new study explains how a widely used drug is effective against inflammatory bowel disease and rejection of bone marrow transplants, while suggesting another way to address both health issues.

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Neurology, Cerebral Cavernous Malformation, central nervous system, Neurosurgery

Gene Identified That May Provide Potential Therapy for Cerebral Cavernous Malformations

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Researchers at University of California San Diego School of Medicine, with national collaborators, have identified a series of molecular clues to understanding the formation of cerebral cavernous malformations (CCMs). The study offers the first genome-wide analysis of the transcriptome of brain microvascular endothelial cells after KRIT1 inactivation.

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Stem Cells, Bone Marrow, Stem Cell Transplantation

Researchers Point Way to Improved Stem Cell Transplantation Therapies

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Researchers in Germany have demonstrated that hematopoietic stem cell (HSC) transplants can be improved by treatments that temporarily prevent the stem cells from dying. The approach, which is described in a paper to be published September 7 in The Journal of Experimental Medicine, could allow those in need of such transplants, including leukemia and lymphoma patients, to be treated with fewer donor stem cells while limiting potential adverse side effects.







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