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Journal of Experimental Medicine

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Medicine

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Alzheimer's Disease, Amyloid Beta, Brain Diseases, Drug Discovery And Development, Neuroscience, Aging

How SORLA Protects Against Alzheimer’s Disease

Researchers have identified a new protective function for a brain protein genetically linked to Alzheimer’s. The findings, published in the Journal of Experimental Medicine, could inform novel treatment strategies to combat neurodegenerative diseases.

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Nyu Langone, Ken Cadwell, IBD, Tnf Alpha, Remicade, Skirball, ATG16L1, Paneth Cells, Graft-versus-host disease, Bone Marrow Transplant

Research Suggests New Way to Treat Inflammatory Gut Disease and Prevent Rejection of Bone Marrow Transplants

A new study explains how a widely used drug is effective against inflammatory bowel disease and rejection of bone marrow transplants, while suggesting another way to address both health issues.

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Neurology, Cerebral Cavernous Malformation, central nervous system, Neurosurgery

Gene Identified That May Provide Potential Therapy for Cerebral Cavernous Malformations

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Researchers at University of California San Diego School of Medicine, with national collaborators, have identified a series of molecular clues to understanding the formation of cerebral cavernous malformations (CCMs). The study offers the first genome-wide analysis of the transcriptome of brain microvascular endothelial cells after KRIT1 inactivation.

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Stem Cells, Bone Marrow, Stem Cell Transplantation

Researchers Point Way to Improved Stem Cell Transplantation Therapies

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Researchers in Germany have demonstrated that hematopoietic stem cell (HSC) transplants can be improved by treatments that temporarily prevent the stem cells from dying. The approach, which is described in a paper to be published September 7 in The Journal of Experimental Medicine, could allow those in need of such transplants, including leukemia and lymphoma patients, to be treated with fewer donor stem cells while limiting potential adverse side effects.

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zika, Virus, Cancer, Brain Cancer, Glioblastoma

Zika Virus Could Be Used to Treat Brain Cancer Patients, Study Suggests

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Recent outbreaks of Zika virus have revealed that the virus causes brain defects in unborn children. But in a study to be published September 5 in The Journal of Experimental Medicine, researchers from Washington University School of Medicine in St. Louis and the University of California, San Diego report that the virus could eventually be used to target and kill cancer cells in the brain.

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zika, Glioblastoma, cancer stem cell

Zika Virus Kills Brain Cancer Stem Cells

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While Zika virus causes devastating damage to the brains of developing fetuses, it one day may be an effective treatment for glioblastoma, a deadly form of brain cancer. New research from Washington University School of Medicine in St. Louis and the University of California San Diego School of Medicine shows that the virus kills brain cancer stem cells, the kind of cells most resistant to standard treatments.

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McGovern Medical School at The University of Texas Health Science Center at Houston (UTHealth), Claudio Soto Ph.D., Misfolded Protein Diseases, Prion Diseases, Mad Cow Disease, Creutzfeldt Jacob Disease, Diabetes, Type 2 Diabetes, Infectious, Mitchell Center

UTHealth Research: Misfolded Form of Pancreatic Protein Could Induce Type 2 Diabetes Symptoms

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The symptoms of type 2 diabetes can be induced by a misfolded form of a pancreatic protein and possibly be transmitted by a mechanism similar to prion diseases such as Creutzfeldt-Jakob disease or bovine spongiform encephalopathy (mad cow disease), according to researchers from McGovern Medical School at UTHealth Houston.

Medicine

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Type 2 Diabetes, Pancreas, Medicine & Health

Researchers Demonstrate Transmission of Diabetes Symptoms via Prion-Like Mechanism

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Researchers from McGovern Medical School at The University of Texas Health Science Center at Houston have discovered that the symptoms of diabetes can be induced by a misfolded form of a pancreatic protein. The findings, which are reported in a paper to be published August 1 in The Journal of Experimental Medicine, raise the possibility that type 2 diabetes can be transmitted by a mechanism similar to prion diseases such as Creutzfeldt-Jakob disease or Bovine Spongiform Encephalopathy (mad cow disease).

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human antibody therapy, therapeutic antibodies, Biotechnology, Vaccine Development

Researchers Develop New Method to Generate Human Antibodies

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An international team of scientists has developed a method to rapidly produce specific human antibodies in the laboratory. The technique, which will be described in a paper to be published July 24 in The Journal of Experimental Medicine, could speed the production of antibodies to treat a wide range of diseases and facilitate the development of new vaccines.

Medicine

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AIDS, HIV, Autoimmune Disease, Hiv Vaccine, Systemic Lupus Erythematosus (SLE), Immunology

Barrier to Autoimmune Disease May Open Door to HIV, Study Suggests

Researchers from the University of Colorado School of Medicine have discovered that a process that protects the body from autoimmune disease also prevents the immune system from generating antibodies that can neutralize the HIV-1 virus. The findings, which will be published July 11 in The Journal of Experimental Medicine, might be considered by scientists trying to develop a vaccine that can stimulate the production of these neutralizing antibodies.







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