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Medicine

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Shorter Radiation Use, BRCA Gene News, Staging Endometrial Cancer, and More in the Cancer News Source

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Science

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doublesex, Genetics, sexual differentiation, evolutionary development, Evolution, sexual traits, Entomology, Insects, Beetles, Biology, evodevo, dsx, Sexual Development

EMBARGOED

A reporter's PressPass is required to access this story until the embargo expires on 27-Feb-2017 5:00 AM EST

Medicine

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Ulcer, stomach bug, Helicobacter Pylori, Pathogen, Pathogen Evolution

Europeans Brought New Strains of Ulcer-Causing Bacterium to Pre-Columbian Americas

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Genome study shows mixing of European and African H. pylori strains in modern American populations.

Medicine

Science

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Neurons, Brain, Gene Expression

Playing Favorites: Brain Cells Prefer One Parent’s Gene Over the Other’s

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It has long been thought that each copy of our DNA instructions - one inherited from mom and one from dad - is treated the same. A new study from scientists at the University of Utah School of Medicine shows that it is not uncommon for cells in the brain to preferentially activate one copy over the other. The finding breaks basic tenants of classic genetics and suggests new ways in which genetic mutations might cause brain disorders.

Medicine

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Glioblastoma, Brain Cancer, PGK1 enzyme, MD Anderson Cancer Center

Study Reveals PGK1 Enzyme as Therapeutic Target for Deadliest Brain Cancer

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Discovery of a dual role played by the enzyme phosphoglycerate kinase 1 (PGK1) may indicate a new therapeutic target for glioblastoma, an often fatal form of brain cancer, according to researchers at The University of Texas MD Anderson Cancer Center.

Science

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Susan Lindquist, Hsp90, Protein Folding Stress, Genetic Mutation, Disease

Researchers Uncover a Role for HSP90 in Gene-Environment Interactions in Humans

Researchers at Whitehead Institute have now uncovered a role for the protein-folding chaperone HSP90 in humans, not only as a modifier of the effects of mutations, but as a mediator of the impact of the environment on the function of mutant proteins. And these effects of HSP90 can alter the course of human diseases.

Science

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Epigenetics, Cancer, Methylation, cytosine methylation, nanopore sequencing

New Gene Sequencing Software Could Aid in Early Detection, Treatment of Cancer

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A research team from the United States and Canada has developed and successfully tested new computational software that determines whether a human DNA sample includes an epigenetic add-on linked to cancer and other illnesses.

Medicine

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Genetics, Dna Test, direct-to-consumer genetic tests

Direct-to-Consumer Genomics: Harmful or Empowering?

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Thanks to recent scientific advances and plunging costs in genetic sequencing, consumers now can order inexpensive, mail-in genetic tests to learn more about health risks, inherited traits and ancestry. But, is it a good idea to bypass your doctor’s office when it comes to interpreting health risks?

Medicine

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Icahn School of Medicine at Mount Sinai, Mount Sinai Health System, Angioedema, Clinical Trial, New England Journal Of Medicine, New England Journal of Medicine (NEJM), Hereditary Angioedema, Genetic Disorders

In Rare Disorder, Novel Agent Stops Swelling Before It Starts

Mount Sinai researcher who treats hereditary angioedema says the drug, a potential game changer, is being studied in larger clinical trial

Medicine

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lysosomal disease , Nature, Nature (magazine), Research, Genetics, Therapy, press release, news, Cincinnati Children's Hospital Medical Center, Pediatric, Children

Nature Study Suggests New Therapy for Gaucher Disease

Scientists propose in Nature blocking a molecule that drives inflammation and organ damage in Gaucher and maybe other lysosomal storage diseases as a possible treatment with fewer risks and lower costs than current therapies. Reporting their data Feb. 22, the international research team conducted the study in mouse models of lysosomal storage disease and in cells from blood samples donated by people with Gaucher disease.

Medicine

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Cancer, Immunotherapy, CAR T cells, CRISP/Cas9, CRISPR, CAR T cell, Sloan Kettering, Memorial Sloan Kettering, Memorial Sloan Kettering Cancer Center, Michel Sadelain, Tumor, Cancer Research, genome editing, chimeric antigen receptor cells, chimeric antigen receptors

CAR T Cells More Powerful When Built With CRISPR, MSK Researchers Find

MSK researchers used the genome-editing tool CRISPR to create more potent chimeric antigen receptor (CAR) T cells that don't tire as easily when attacking cancer cells. The unexpected findings were published in the journal Nature on February 22 and underscore the potential of genome editing to advance immunotherapy for cancer.

Medicine

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Breast Cancer, Breast Cancer Treatment, Precision Medicine, Physiology, genes, Gene Expression, triple-negative breast cancer, HER2 breast cancer, Breast Cancer Advances, Afatinib, trametinib, proof of concept

The Way Breast Cancer Genes Act Could Predict Your Treatment

A Michigan State University breast cancer researcher has shown that effective treatment options can be predicted based on the way certain breast cancer genes act or express themselves.

Medicine

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Autism, Autism Research, Autism Study, Autism Genetics, Autism Spectrum Disorder, Genes & Development, genes, SPARK Study

University of Missouri Thompson Center Recruiting Children, Adults with Autism for Landmark Genetic Study

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University of Missouri’s Thompson Center for Autism and Neurodevelopmental Disorders already has enrolled 2,500 individuals with autism and their family members in the Simons Foundation Powering Autism Research for Knowledge (SPARK) project, the nation’s largest autism study, but researchers are continuing to search for more participants.

Science

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genes, agriculture and climate change, climate change adaptation

Maize Study Finds Genes That Help Crops Adapt to Change

A new study analyzed close to 4,500 maize varieties to identify more than 1,000 genes driving large-scale adaptation to the environment.

Medicine

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Micro-RNA May Amplify Effectiveness of Sorafenib in Difficult Liver Cancer Cases

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Only 25% of patients respond to sorafenib treatment, so researchers have endeavored to understand its mechanism of action and discover a way to boost its effectiveness.

Life

Law and Public Policy

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Gene Editing, Biotechnology, Ethical dilemmas, Ethical Guidelines, social acceptance, Cloning

How Do We Regulate Advanced Technologies Along Social or Ethical Lines?

The public’s wariness with new technologies, like CRISPR-9 and gene editing, is largely based on ethical, religious and social concerns, rather than concerns about safety or efficacy, which is what regulatory agencies are limited to consider.

Medicine

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CRISPR, Gene Editing, Biotech, Patent, Biochemistry, Genetics, University Of Utah, University Of California, Broad Institute

U. Biochemist Testified in CRISPR Gene Editing Patent Dispute

Science

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Wheat, wheat production, wheat consumption, wheat facts, iwgsc

A Few Facts About Wheat

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This infographic presents key facts about wheat: production, cultivation, consumption, export value.

Medicine

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Intestinal Microbes, Immune System, gut microbes, Microbes and Immune System, Microbial, Microbial influence, Gut Bacteria, Gut Bacteria and Health, Gut Interactions, Bacteria, Intestines, GUT, Immune Cells

Scientists Monitor Crosstalk Between Intestinal Microbes and Immune System

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Harvard Medical School researchers have successfully “listened in” on the crosstalk between gut microbes and the immune system.

Medicine

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hemagtology, JCI Insight, Journal of Clinical Investigation, Histiocytosis, Langerhans, HLH, hemophagocytic lymphohistiocytosis, Cincinnati Children's Hospital Medical Center, press release, news, Research

Doctors Treat Deadly Cancerous Disorders with Gene-Guided, Targeted Therapy

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Genomic testing of biopsies from patients with deadly, treatment-resistant cancerous blood syndromes called histiocytoses allowed doctors to identify genes fueling the ailments and use targeted molecular drugs to successfully treat them. Researchers report their data in Journal of Clinical Investigation Insight (JCI Insight). They recommend the regular use of comprehensive genomic profiling at diagnosis to positively impact clinical care,







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